TakuKambayashiMD

Pathology • Philadelphia, PA

Blood Banking & Transfusion Medicine, Transplantation Immunology, Anatomic Pathology, Clinical Pathology

Penn

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Office
3400 Spruce St
3 White
Philadelphia, PA 19104
Phone+1 215-746-7610
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Education & Training

University of Pennsylvania Health SystemFellowship, Blood Banking/Transfusion Medicine, 2007 - 2008
University of Pennsylvania Health SystemResidency, Pathology-Anatomic and Clinical, 2004 - 2007
Emory University School of MedicineClass of 2004

Certifications & Licensure

PA State Medical License 2004 - 2024
American Board of Pathology Pathology - Clinical
American Board of Pathology Blood Banking/Transfusion Medicine

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012

Publications & Presentations

PubMed

The microbiota and T cells non-genetically modulate inherited phenotypes transgenerationally.
Jordan C Harris, Natalie A Trigg, Bruktawit Goshu, Yuichi Yokoyama, Lenka Dohnalová, Ellen K White, Adele Harman, Sofía M Murga-Garrido, Jamie Ting-Chun Pan, Preeti Bh...> ;Cell Reports. 2024 Apr 3
Red cell exchange for rapid leukoreduction in adults with hyperleukocytosis and leukostasis.
Ethan A Mack, Meaghan C Dougher, Ashley M Ginda, Caitlin Cahill, Melissa Murter, Kevin Schell, Yvette C Tanhehco, Vijay G Bhoj, Andrew D Fesnak, Don L Siegel, Taku Kam...> ;Blood. 2024 Mar 14
Thymic stromal lymphopoietin induces IL-4/IL-13 from T cells to promote sebum secretion and adipose loss.
Choa, R., Harris, J., Yang, E., Yokoyama, Y., Okumura, M., Kim, M., To, J., Lou, M., Nelson, A., Kambayashi, T.> ;The Journal of Allergy and Clinical Immunology. 2023 Dec 28
1 citations
Laser-Capture Microdissection-Based RNA Sequencing for Profiling Mouse and Human Sebaceous Gland Transcriptomes.
Jordan C Harris, Stephen M Prouty, Molly A Nelson, Derek C Sung, Amanda M Nelson, John T Seykora, Taku Kambayashi, Elizabeth A Grice> ;The Journal of Investigative Dermatology. 2023 Nov 17
The diacylglycerol kinase ζ inhibitor ASP1570 augments natural killer cell function.
Mariko Okumura, Yuichi Yokoyama, Taku Yoshida, Yohei Okada, Masaomi Takizawa, Osamu Ikeda, Taku Kambayashi> ;International Immunopharmacology. 2023 Dec 1
Diacylglycerol kinase zeta deficiency attenuates papain-induced type 2 airway inflammation.
Brenal K Singh, Yuichi Yokoyama, Yukinori Tanaka, Dorottya Laczkó, Deepak A Deshpande, Taku Kambayashi> ;Cellular Immunology. 2023 Oct 30
7 citations
Development of an mRNA-lipid nanoparticle vaccine against Lyme disease.
Matthew Pine, Gunjan Arora, Thomas M Hart, Emily Bettini, Brian T Gaudette, Hiromi Muramatsu, István Tombácz, Taku Kambayashi, Ying K Tam, Dustin Brisson, David Allman...> ;Molecular Therapy. 2023 Sep 6
Skin-derived TSLP stimulates skin migratory dendritic cells to promote the expansion of regulatory T cells.
Yukinori Tanaka, Yuichi Yokoyama, Taku Kambayashi> ;European Journal of Immunology. 2023 Oct 1
11 citations
Immature natural killer cells promote progression of triple-negative breast cancer.
Gatha Thacker, Samantha Henry, Ajeya Nandi, Rahul Debnath, Snahlata Singh, Anupma Nayak, Barbara Susnik, Melinda M Boone, Qing Zhang, Susan B Kesmodel, Sanjeev Gumber,...> ;Science Translational Medicine. 2023 Mar 8
4 citations
Regulation of Airway Smooth Muscle Cell Proliferation by Diacylglycerol Kinase: Relevance to Airway Remodeling in Asthma.
Miguel Angel Hernandez-Lara, Santosh K Yadav, Sushrut D Shah, Mariko Okumura, Yuichi Yokoyama, Raymond B Penn, Taku Kambayashi, Deepak A Deshpande> ;International Journal of Molecular Sciences. 2022 Oct 6
2 citations
Manipulation of diacylglycerol and ERK-mediated signaling differentially controls CD8T cell responses during chronic viral infection.
Shohei Harabuchi, Hamid Bassiri, Taku Yoshida, Yohei Okada, Masaomi Takizawa, Osamu Ikeda, Akihiro Katada, Taku Kambayashi, Khan, O.> ;Frontiers in Immunology. 2022 Jan 1
21 citations
Discovery and validation of a novel subgroup and therapeutic target in idiopathic multicentric Castleman disease.
Sheila K Pierson, Sushila A. Shenoy, Ana B Oromendia, Alexander M. Gorzewski, Ruth-Anne Langan Pai, Christopher S. Nabel, Jason R. Ruth, Sophia A. T. Parente, Daniel J...> ;Blood Advances. 2021 Sep 14
32 citations
Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion.
Ruth Choa, Junichiro Tohyama, Shogo Wada, Hu Meng, Jian Hu, Mariko Okumura, Rebecca M. May, Tanner F. Robertson, Ruth-Anne Langan Pai, Arben Nace, Christian Hopkins, E...> ;Science. 2021 Jul 30
5 citations
Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-signaling
Pawan K. Sharma, Santosh K Yadav, Sushrut D. Shah, Elham Javed, John M. Lim, Shi Pan, Ajay P. Nayak, Reynold A. Panettieri, Raymond B. Penn, Taku Kambayashi, Deepak A....> ;American Journal of Respiratory Cell and Molecular Biology. 2021 Jul 22
3 citations
Autocrine regulation of airway smooth muscle contraction by diacylglycerol kinase
Santosh K Yadav, Pawan K. Sharma, Sushrut D. Shah, Reynold A. Panettieri, Taku Kambayashi, Raymond B. Penn, Deepak A. Deshpande> ;Journal of Cellular Physiology. 2021 Jul 18
25 citations
PEGylation enables subcutaneously administered nanoparticles to induce antigen-specific immune tolerance.
Peter Y. Li, Frank Bearoff, Pu Zhu, Zhiyuan Fan, Yucheng Zhu, Mingyue Fan, Laura Cort, Taku Kambayashi, Elizabeth P. Blankenhorn, Hao Cheng> ;Journal of Controlled Release. 2021 Jan 12
63 citations
Cellular context of IL-33 expression dictates impact on anti-helminth immunity.
Li-Yin Hung, Yukinori Tanaka, Karl Herbine, Christopher F. Pastore, Brenal K. Singh, Annabel Ferguson, Nisha Vora, Bonnie Douglas, Kelly Zullo, Edward M. Behrens, Tiff...> ;Science Immunology. 2020 Nov 13
28 citations
CD28 Regulates Metabolic Fitness for Long-Lived Plasma Cell Survival
Adam Utley, Colin Chavel, Shivana M. Lightman, G. Aaron Holling, James R. Cooper, Peng Peng, Wensheng Liu, Benjamin G. Barwick, Catherine M. Gavile, Orla Maguire, Mega...> ;Cell Reports. 2020 Jun 23
35 citations
Increased mTOR activation in idiopathic multicentric Castleman disease
Daniel J. Arenas, Katherine Floess, Dale Kobrin, Ruth-Anne Langan Pai, Maya Blanka Srkalovic, Mark-Avery Tamakloe, Rozena Rasheed, Jasira Ziglar, Johnson S. Khor, Soph...> ;Blood. 2019 Oct 1
34 citations
Type I IFN response associated with mTOR activation in the TAFRO subtype of idiopathic multicentric Castleman disease
Ruth-Anne Langan Pai, Alberto Sada Japp, Michael Gonzalez, Rozena Rasheed, Mariko Okumura, Daniel J. Arenas, Sheila K Pierson, Victoria Powers, Charlly Kao, Hakon Hako...> ;JCI Insight. 2020 May 7
31 citations
PRMT5 Is Required for T Cell Survival and Proliferation by Maintaining Cytokine Signaling.
Yukinori Tanaka, Yasuhiro Nagai, Mariko Okumura, Mark I. Greene, Taku Kambayashi> ;Frontiers in Immunology. 2020 Apr 9
6 citations
The role of diacylglycerol kinases in allergic airway disease
Taku Kambayashi, Deepak A. Deshpande> ;Current Opinion in Pharmacology. 2020 Apr 1
5 citations
IL‐15 and CD155 expression regulate LAT expression in murine DNAM1+ NK cells, enhancing their effectors functions
Thuy T. Luu, Arnika Kathleen Wagner, Laurent Schmied, Stephan Meinke, Jacquelyn E. Freund, Taku Kambayashi, Inga Ravens, Adnane Achour, Günter Bernhardt, Benedict J. C...> ;European Journal of Immunology. 2020 Feb 20
18 citations
TAM receptors attenuate murine NK-cell responses via E3 ubiquitin ligase Cbl-b.
Leilani M. Chirino, Suresh Kumar, Mariko Okumura, David E. Sterner, Michael R. Mattern, Tauseef R. Butt, Taku Kambayashi> ;European Journal of Immunology. 2020 Jan 1
71 citations
Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6-blockade-refractory idiopathic multicentric Castleman disease.
David C. Fajgenbaum, Ruth-Anne Langan, Alberto Sada Japp, Helen L. Partridge, Sheila K Pierson, Amrit Singh, Daniel J. Arenas, Jason R. Ruth, Christopher S. Nabel, Kat...> ;The Journal of Clinical Investigation. 2019 Oct 1
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Abstracts/Posters

Type I Interferon Response Identified through Phenotypic and Transcriptional Profiling of Circulating Immune Cells during Idiopathic Multicentric Castleman Disease Flare
Taku Kambayashi, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019

Press Mentions

Scientists Identify Potential Weight Loss Drug in Mouse TrialMarch 8th, 2022
Scientists Discover a Way to 'Sweat' off FatAugust 9th, 2021
Scientists Accidentally Discover Weight Loss Therapy After Mice Start Sweating Fat from Their SkinAugust 5th, 2021
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Grant Support

The Role Of The T Cell Receptor In Regulatory T Cell Homeostasis And ExpansionNational Heart, Lung, And Blood Institute2012
Proximal Signaling Complexes In NK Cell Effector Function And DevelopmentNational Heart, Lung, And Blood Institute2011–2012
The Role Of Adapter Molecules In MAST Cell FunctionNational Heart, Lung, And Blood Institute2007–2011

Hospital Affiliations

Hospital of the University of PennsylvaniaPhiladelphia, Pennsylvania
Pennsylvania HospitalPhiladelphia, Pennsylvania
Penn Presbyterian Medical CenterPhiladelphia, Pennsylvania