TanyaBDorffMD

Oncology • Duarte, CA

Genitourinary Oncology, Hematologic Oncology

Associate Professor of Medicine Section Chief, Division of Genitouronary Cancers City of Hope

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Office
Medical Oncology and Therapeutics Research
1500 East Duarte Road
Duarte, CA 91010
Phone+1 626-256-4673

Fax+1 626-218-8233
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Education & Training

University of Southern California/LAC+USC Medical CenterFellowship, Medical Oncology, 2005 - 2006
University of Southern California/LAC+USC Medical CenterFellowship, Hematology, 2004 - 2005
University of Southern California/LAC+USC Medical CenterFellowship, Medical Oncology, 2003 - 2004
Icahn School of Medicine at Mount Sinai/Mount Sinai HospitalResidency, Internal Medicine, 2000 - 2003
David Geffen School of Medicine at UCLAClass of 2000

Certifications & Licensure

CA State Medical License 2003 - 2025
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

Top Doctors:LA Area Castle Connolly, 2013

Clinical Trials

177Lu Radiolabeled Monoclonal Antibody HuJ591 (177Lu-J591) and Ketoconazole in Patients With Prostate Cancer Start of enrollment: 2009 Jun 01
Active, not recruiting
Phase 2
Short-Term Fasting: Impact on Toxicity Start of enrollment: 2009 Jul 09
Active, not recruiting
Not Applicable
Abiraterone Acetate and Prednisone With or Without Dasatinib in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer Start of enrollment: 2012 Sep 01
Unknown status
Phase 2
Controlled Low Calorie Diet in Reducing Side Effects and Increasing Response to Chemotherapy in Patients With Breast or Prostate Cancer Start of enrollment: 2013 Jan 29
Active, not recruiting
Not Applicable
Diffusion-Weighted MRI in Staging Patients With Localized Prostate Cancer Start of enrollment: 2009 Jan 01
Completed
Not Applicable
sEphB4-HSA Before Surgery in Treating Patients With Bladder Cancer, Prostate Cancer, or Kidney Cancer Start of enrollment: 2016 Aug 02
Terminated
Phase 1
Enzalutamide With or Without Radium Ra 223 Dichloride in Patients With Metastatic, Castration-Resistant Prostate Cancer Start of enrollment: 2018 Nov 21
Active, not recruiting
Phase 2
A Study of Olaparib and Durvalumab in Prostate Cancer Start of enrollment: 2019 Mar 07
Terminated
Phase 2
PSCA-CAR T Cells in Treating Patients With PSCA+ Metastatic Castration Resistant Prostate Cancer Start of enrollment: 2019 Aug 20
Active, not recruiting
Phase 1
Talazoparib With Androgen Deprivation Therapy and Abiraterone for the Treatment of Castration Sensitive Prostate Cancer Start of enrollment: 2021 May 04
Recruiting
Phase 2
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Publications & Presentations

PubMed

Repeat Next-Generation Sequencing Testing on Progression in Men With Metastatic Prostate Cancer Can Identify New Actionable Alterations.
Joseph J Park, Alec Chu, Jinju Li, Alicia Ali, Rana R McKay, Clara Hwang, Matthew K Labriola, Albert Jang, Deepak Kilari, George Mo, Deepak Ravindranathan, Laura S Gra...> ;JCO Precision Oncology. 2024 Apr 1
Three- and Seven-month Prostate-specific Antigen Levels as Prognostic Markers for Overall Survival in Metastatic Hormone-sensitive Prostate Cancer: Results from SWOG S...
Mamta Parikh, Catherine Tangen, Maha H A Hussain, Shilpa Gupta, Sam Callis, Yeonjung Jo, Andrea Harzstark, Channing J Paller, Saby George, Matthew R Zibelman, Heather ...> ;European Urology Oncology. 2024 Mar 23
Phase I Study of ORIC-101, a Glucocorticoid Receptor Antagonist, in Combination with Enzalutamide in Patients with Metastatic Castration-resistant Prostate Cancer Prog...
Wassim Abida, Andrew W Hahn, Neal Shore, Neeraj Agarwal, Paul Sieber, Matthew R Smith, Tanya Dorff, Paul Monk, Matthew Rettig, Rupal Patel, Anne Page, Maureen Duff, Ro...> ;Clinical Cancer Research. 2024 Mar 15
Evaluating relugolix for the treatment of prostate cancer in real-world settings of care: the OPTYX study protocol.
Daniel E Spratt, Tanya Dorff, Rana R McKay, Benjamin H Lowentritt, Mark Fallick, Sergio C Gatoulis, Scott C Flanders, Ashley E Ross> ;Future Oncology. 2024 Apr 1
1 citations
Assessment of eligibility criteria in renal cell carcinoma trials evaluating systemic therapy.
Castro, D., Prajapati, S., Feng, M., Chan, E., Lee, K., Paul, T., Sehgal, I., Patel, J., Li, X., Zengin, Z., Ebrahimi, H., Govindarajan, A., Meza, L., Mercier, B., Cha...> ;BJU International. 2024 Mar 1
Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk.
Sebastian Brandhorst, Morgan E Levine, Min Wei, Mahshid Shelehchi, Todd E Morgan, Krishna S Nayak, Tanya Dorff, Kurt Hong, Eileen M Crimmins, Pinchas Cohen, Valter D L...> ;Nature Communications. 2024 Feb 20
Challenges in clinical trials for high-risk but curable prostate cancer.
Tanya Barauskas Dorff, Alan H Bryce> ;Cancer. 2024 May 1
Tumor Mutational Burden in Metastatic Castration-Resistant Prostate Cancer and Response to Checkpoint Inhibition.
Zang, P., Barragan-Carrillo, R., Chehrazi-Raffle, A., Chawla, N., Tripathi, A., Pal, S., Dorff, T.> ;JAMA Oncology. 2024 Feb 8
A Phase I Study of Acapatamab, a Half-life Extended, PSMA-Targeting Bispecific T-cell Engager for Metastatic Castration-Resistant Prostate Cancer.
Tanya Dorff, Lisa G Horvath, Karen Autio, Alice Bernard-Tessier, Matthew B Rettig, Jean-Pascal Machiels, Mehmet A Bilen, Martijn P Lolkema, Nabil Adra, Sylvie Rottey, ...> ;Clinical Cancer Research. 2024 Apr 15
PRESTO: A Phase III, Open-Label Study of Intensification of Androgen Blockade in Patients With High-Risk Biochemically Relapsed Castration-Sensitive Prostate Cancer (A...
Rahul Aggarwal, Glenn Heller, David W Hillman, Han Xiao, Joel Picus, Mary-Ellen Taplin, Tanya Dorff, Leonard Appleman, Douglas Weckstein, Akash Patnaik, Alan Bryce, Da...> ;Journal of Clinical Oncology. 2024 Apr 1
Author Correction: Gemcitabine and cisplatin plus nivolumab as organ-sparing treatment for muscle-invasive bladder cancer: a phase 2 trial.
Galsky, M., Daneshmand, S., Izadmehr, S., Gonzalez-Kozlova, E., Chan, K., Lewis, S., Achkar, B., Dorff, T., Cetnar, J., Neil, B., D'Souza, A., Mamtani, R., Kyriakopoul...> ;Nature Medicine. 2024 Jan 19
2 citations
Xaluritamig, a STEAP1 × CD3 XmAb 2+1 Immune Therapy for Metastatic Castration-Resistant Prostate Cancer: Results from Dose Exploration in a First-in-Human Study.
Kelly, W., Danila, D., Lin, C., Lee, J., Matsubara, N., Ward, P., Armstrong, A., Pook, D., Kim, M., Dorff, T., Fischer, S., Lin, Y., Horvath, L., Sumey, C., Yang, Z., ...> ;Cancer Discovery. 2024 Jan 12
Immuno-Oncology Advances in Genitourinary Cancers.
Zang, P., Angeles, A., Dorff, T., Pal, S., Gupta, S.> ;American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting. 2024 Jan 1
The Combined Effect of Immune Checkpoint Inhibitors and Tyrosine Kinase Inhibitors on Thyroid Function.
Ma, H., Tsai, K., Xing, Y., Chung, S., Dorff, T., Bell, D., Lechner, M., Liang, T.> ;Thyroid. 2024 Feb 1
Examining Exclusion Criteria in Advanced Prostate Cancer Clinical Trials: An Assessment of recommendations From the American Society Of Clinical Oncology and Friends o...
Hedyeh Ebrahimi, Daniela V Castro, Matthew I Feng, Sweta R Prajapati, Kyle O Lee, Elyse H Chan, Trishita Paul, Ishaan Sehgal, Jalen Patel, Xiaochan Li, Zeynep B Zengin...> ;Clinical Genitourinary Cancer. 2023 Dec 1
10 citations
Gemcitabine and cisplatin plus nivolumab as organ-sparing treatment for muscle-invasive bladder cancer: a phase 2 trial.
Galsky, M., Daneshmand, S., Izadmehr, S., Gonzalez-Kozlova, E., Chan, K., Lewis, S., Achkar, B., Dorff, T., Cetnar, J., Neil, B., D'Souza, A., Mamtani, R., Kyriakopoul...> ;Nature Medicine. 2023 Nov 1
Cardiovascular Toxicity During Advanced Prostate Cancer Treatment: Minding the Heart.
Tanya Dorff, June-Wha Rhee> ;JACC. Cardiooncology. 2023 Oct 1
Racial and ethnic differences in perceptions of germline or somatic DNA sequencing among patients with advanced prostate, urothelial, or kidney cancer.
Cristiane Decat Bergerot, Errol J Philip, Jasnoor Malhotra, Paulo Gustavo Bergerot, Daniela V Castro, Ameish Govindarajan, Sabrina Salgia, Meghan Salgia, Nicholas Salg...> ;Journal of Genetic Counseling. 2023 Sep 12
Twelve-Month Follow-up of the Immune Response After COVID-19 Vaccination in Patients with Genitourinary Cancers: A Prospective Cohort Analysis.
Meza, L., Zengin, Z., Salgia, S., Malhotra, J., Karczewska, E., Dorff, T., Tripathi, A., Ely, J., Kelley, E., Mead, H., Hsu, J., Dizman, N., Salgia, N., Chawla, N., Ch...> ;The Oncologist. 2023 Sep 7
Biomarker-Directed Therapy in Black and White Men With Metastatic Castration-Resistant Prostate Cancer.
Park, J., Holland, B., Jang, A., Clara Hwang, Nicholas C Henderson, Shih-Chun Chu, Brandon Holland, Frank C Cackowski, Amanda Pilling, Albert Jang, Shoshana Rothstein,...> ;JAMA Network Open. 2023 Sep 5
Clinical implications of AR alterations in advanced prostate cancer: A multi-institutional collaboration.
Tanya Dorff, Zeynep Zengin, Nicholas Henderson, Alicia Ali, Charles Nguyen, Clara Hwang, Pedro C Barata, Mehmet Bilen, Laura Graham, George Mo, Deepak Kilari, Abhishek...> ;Research Square. 2023 Aug 10
2 citations
Unique Spectrum of Activating BRAF Alterations in Prostate Cancer.
Alex Chehrazi-Raffle, Hanna Tukachinsky, Eamon Toye, Smruthy Sivakumar, Alexa B Schrock, Hannah E Bergom, Hedyeh Ebrahimi, Sumanta Pal, Tanya Dorff, Neeraj Agarwal, Br...> ;Clinical Cancer Research. 2023 Oct 2
The diagnosis and treatment of castrate-sensitive oligometastatic prostate cancer: A review.
Rand N Wilcox Vanden Berg, Thomas Zilli, Vérane Achard, Tanya Dorff, Michael Abern> ;Prostate Cancer and Prostatic Diseases. 2023 Dec 1
Changes in Perception of Cure Among Patients With Genitourinary Cancers Initiating Immune Checkpoint Inhibitors: A Longitudinal Study.
Cristiane Decat Bergerot, Errol J Philip, Ameish Govindarajan, Daniela Castro, Jasnoor Malhotra, Paulo Bergerot, Sabrina Salgia, Meghan Salgia, Nicholas Salgia, JoAnn ...> ;Clinical Genitourinary Cancer. 2023 Dec 1
Incorporating Prognostic Models Into Clinical Practice for Patients With Castration-Resistant Prostate Cancer.
Tanya Dorff, Abhishek Tripathi> ;Journal of Clinical Oncology. 2023 May 20
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Lectures

Closing the Gap: Knowledge Gaps and Interpreting Current Data in the Era of Novel Imaging — Medical...
ASCO Annual Meeting 2019 - Chicago, IL - 5/31/2019
A randomized phase II clinical trial of a fasting-mimic diet prior to chemotherapy to evaluate the impact on toxicity and efficacy.
2018 ASCO Annual Meeting - Chicago, Illinois - 06/4/2018

Press Mentions

Overview of Efficacy and Safety Data of Combination Therapy with PARPi and NHAsMarch 27th, 2023
Treatment Options for Advanced HCC Patients Who Are Not Eligible for IO First LineMarch 14th, 2023
Clinical Implementation of PARPi Monotherapy for Prostate Cancer Patients – a US and EU PerspectiveFebruary 15th, 2023
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