ThomasDarmodyArnoldMD

PubMed

• Type-I-interferon-responsive microglia shape cortical development and behavior.
  Caroline C Escoubas, Leah C Dorman, Phi T Nguyen, Christian Lagares-Linares, Haruna Nakajo, Sarah R Anderson, Jerika J Barron, Sarah D Wade, Beatriz Cuevas, Ilia D Vai...> ;Cell. 2024 Mar 8
• PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the β5 integrin.
  Yang, C. D., Ritwik Datta, Dibyanti Mukherjee, Michael J Podolsky, Christopher D Yang, Diana L Alba, Sukhmani Singh, Thomas D Arnold, Suneil Koliwad, Carlos O Lizama, ...> ;The Journal of Biological Chemistry. 2024 Feb 1
• 15 citations
  APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints.
  Zhuoran Yin, Neta Rosenzweig, Kilian L Kleemann, Xiaoming Zhang, Wesley Brandão, Milica A Margeta, Caitlin Schroeder, Kisha N Sivanathan, Sebastian Silveira, Christian...> ;Nature Immunology. 2023 Nov 1
• Radial glia promote microglial development through integrin αβ-TGFβ1 signaling.
  Gabriel L McKinsey, Nicolas Santander, Xiaoming Zhang, Kilian Kleemann, Lauren Tran, Aditya Katewa, Kaylynn Conant, Matthew Barraza, Kian Waddell, Carlos Lizama, Marie...> ;Biorxiv. 2023 Sep 21
• 6 citations
  Finding the right tool: a comprehensive evaluation of microglial inducible cre mouse models.
  Alicia Bedolla, Gabriel Mckinsey, Kierra Ware, Nicolas Santander, Thomas Arnold, Yu Luo> ;Biorxiv. 2023 Apr 17
• 2 citations
  MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4γ-dependent transcription of CES enzymes.
  Ritwik Datta, Mohammad A Gholampour, Christopher D Yang, Regan Volk, Sinan Lin, Michael J Podolsky, Thomas Arnold, Florian Rieder, Balyn W Zaro, Michael Verzi, Richard...> ;Cell Reports. 2023 Mar 28
• 33 citations
  The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research.
  Lars Muhl, Liqun He, Ying Sun, Maarja Andaloussi Mäe, Riikka Pietilä, Jianping Liu, Guillem Genové, Lei Zhang, Yuan Xie, Stefanos Leptidis, Giuseppe Mocci, Simon Strit...> ;Stem Cell Reports. 2022 May 10
• 7 citations
  Microglia are involved in the protection of memories formed during sleep deprivation.
  Nicholas W Gentry, Thomas McMahon, Maya Yamazaki, John Webb, Thomas D Arnold, Susanna Rosi, Louis J Ptáček, Ying-Hui Fu> ;Neurobiology of Sleep and Circadian Rhythms. 2022 May 1
• 7 citations
  αVβ8 integrin targeting to prevent posterior capsular opacification
  Mahbubul H. Shihan, Samuel G Novo, Yan Wang, Dean Sheppard, Amha Atakilit, Thomas D. Arnold, Nicole M. Rossi, Adam Faranda, Melinda K. Duncan> ;JCI Insight. 2021 Nov 8
• 7 citations
  Bone Marrow-Derived Alk1 Mutant Endothelial Cells and Clonally Expanded Somatic Alk1 Mutant Endothelial Cells Contribute to the Development of Brain Arteriovenous Malf...
  Sonali Shaligram, Rui Zhang, Wan Zhu, Li Ma, Man Luo, Qiang Li, Miriam Weiss, Thomas D. Arnold, Nicolás Santander, Rich Liang, Leandro Barbosa Do Prado, Chaoliang Tang...> ;Translational Stroke Research. 2021 Oct 21
• Enrichment of Vascular Fragments from Mouse Embryonic Brains for Endothelial Cell Analysis
  Nicolás Santander, Thomas D. Arnold> ;Bio-Protocol. 2021 Jun 20
• 91 citations
  CNS fibroblasts form a fibrotic scar in response to immune cell infiltration
  Cayce E. Dorrier, Dvir Aran, Ezekiel A. Haenelt, Ryan N. Sheehy, Kimberly K. Hoi, Lucija Pintarić, Yanan Chen, Carlos Lizama, Kelly M. Cautivo, Geoffrey Weiner, Brian ...> ;Nature Neuroscience. 2021 Feb 1
• 10 citations
  Lack of Flvcr2 impairs brain angiogenesis without affecting the blood-brain barrier.
  Nicolás Santander, Carlos Lizama, Eman Meky, Gabriel L. McKinsey, Bongnam Jung, Dean Sheppard, Christer Betsholtz, Thomas D. Arnold> ;The Journal of Clinical Investigation. 2020 Aug 3
• 80 citations
  A new genetic strategy for targeting microglia in development and disease.
  Gabriel L. McKinsey, Carlos Lizama, Amber E Keown-Lang, Abraham Niu, Nicolás Santander, Amara Larpthaveesarp, Elin Chee, Fernando F. Gonzalez, Thomas D. Arnold> ;Elife. 2020 Jun 23
• 12 citations
  Disruption of the Extracellular Matrix Progressively Impairs Central Nervous System Vascular Maturation Downstream of β-Catenin Signaling
  Lasse Jensen, Belma Hot, Daniel Ramsköld, Raoul Freitas Vale Germano, Chika Yokota, Sarantis Giatrellis, Volker M. Lauschke, Dirk Hubmacher, Minerva Xueting Li, Mike H...> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2019 May 9
• 28 citations
  Impaired αVβ8 and TGFβ signaling lead to microglial dysmaturation and neuromotor dysfunction
  Thomas D. Arnold, Carlos Lizama, Kelly M. Cautivo, Nicolás Santander, Lucia C. Lin, Haiyan Qiu, Eric J. Huang, Chang Liu, Yoh-suke Mukouyama, Louis F. Reichardt, Ann C...> ;The Journal of Experimental Medicine. 2019 Apr 1
• 81 citations
  Tissue Myeloid Progenitors Differentiate into Pericytes through TGF-β Signaling in Developing Skin Vasculature
  Tomoko Yamazaki, Ani Nalbandian, Yutaka Uchida, Wenling Li, Thomas D. Arnold, Yoshiaki Kubota, Seiji Yamamoto, Masatsugu Ema, Yoh Suke Mukouyama> ;Cell Reports. 2017 Mar 21
• 43 citations
  Visualization of vascular mural cells in developing brain using genetically labeled transgenic reporter mice
  Bongnam Jung, Thomas D. Arnold, Elisabeth Raschperger, Konstantin Gaengel, Christer Betsholtz> ;Journal of Cerebral Blood Flow and Metabolism. 2017 Mar 9
• 195 citations
  The αvβ1 integrin plays a critical in vivo role in tissue fibrosis
  Nilgun Isik Reed, Hyunil Jo, Chun Chen, Kazuyuki Tsujino, Thomas D. Arnold, William F. DeGrado, Dean Sheppard> ;Science Translational Medicine. 2015 May 20
• 87 citations
  LSR/angulin-1 is a tricellular tight junction protein involved in blood–brain barrier formation
  Fabien Sohet, Christina Lin, Roeben N. Munji, Seo Yeon Lee, Nadine Ruderisch, Allison Soung, Thomas D. Arnold, Nikita Derugin, Zinaida S. Vexler, Frances T. Yen, Richa...> ;The Journal of Cell Biology. 2015 Mar 16
• 77 citations
  Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain
  Thomas D. Arnold, Colin Niaudet, Mei-Fong Pang, Julie A. Siegenthaler, Konstantin Gaengel, Bongnam Jung, Gina M. Ferrero, Yoh-suke Mukouyama, Jonas Fuxe, Rosemary J. A...> ;Development. 2014 Dec 1
• 11 citations
  Mesangial cell αvβ8-integrin regulates glomerular capillary integrity and repair
  Sujata Lakhe-Reddy, Vincent Li, Thomas D. Arnold, Shenaz Khan, Jeffrey R. Schelling> ;American Journal of Physiology. Renal Physiology. 2014 Jun 15
• 63 citations
  De Novo Cerebrovascular Malformation in the Adult Mouse After Endothelial Alk1 Deletion and Angiogenic Stimulation
  Wanqiu Chen, Zhengda Sun, Zhenying Han, Kristine Jun, Marine Camus, Mamta Wankhede, Lei Mao, Thomas D. Arnold, William L. Young, Hua Su> ;Stroke. 2014 Mar 1
• 553 citations
  Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs
  Neil C. Henderson, Thomas D. Arnold, Yoshio Katamura, Marilyn M. Giacomini, Juan D Rodriguez, Joseph H. McCarty, Antonella Pellicoro, Elisabeth Raschperger, Christer B...> ;Nature Medicine. 2013 Dec 1
• 11 citations
  Deletion of integrin-linked kinase from neural crest cells in mice results in aortic aneurysms and embryonic lethality.
  Thomas D. Arnold, Keling Zang, Ainara Vallejo-Illarramendi> ;Disease Models & Mechanisms. 2013 Sep 1
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