ThomasGerardBurkeMD

PubMed

• Plasma and tissue disposition of non-liposomal DB-67 and liposomal DB-67 in C.B-17 SCID mice.
  Zamboni, W.C., Jung, L.L., Strychor, S., Joseph, E., Zamboni, B.A., Fetterman, S.A., Sidone, B.J., Burke, T.G., Curran, D.P., Eiseman, J.L.> ;Invest New Drugs. 2008 Oct
• The novel highly lipophilic topoisomerase I inhibitor DB67 is effective in the treatment of liver metastases of murine CT-26 colon carcinoma.
  Lopez-Barcons, L.A., Zhang, J., Siriwitayawan, G., Burke, T.G., Perez-Soler, R.> ;Neoplasia. 2004-09-01
• Determination of 9-nitrocamptothecin by precolumn derivatization and its metabolite 9-aminocamptothecin in a biological fluid using reversed-phase high-performance liq...
  Zhang, J., Burke, T.G., Latus, L.J.> ;J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Oct 5
• A versatile prodrug approach for liposomal core-loading of water-insoluble camptothecin anticancer drugs.
  Liu, X., Lynn, B.C., Zhang, J., Song, L., Bom, D., Du, W., Curran, D.P., Burke, T.G.> ;J Am Chem Soc. 2002 Jul 3
• Characterization of the aqueous decomposition products of (+)1,2-bis(3,5-dioxopiperazinyl-1-yl)-propane (ICRF-187) by liquid chromatographic and mass spectral analysis.
  Burke, T. G., Lee, T. D., van Balgooy, J., Doroshow, J. H.> ;J Pharm Sci. 1991 Apr
• Chemistry of the camptothecins in the bloodstream. Drug stabilization and optimization of activity.
  Burke, T. G.> ;Ann N Y Acad Sci. 1996 Dec 13
• Phase I and pharmacokinetic study of GI147211, a water-soluble camptothecin analogue, administered for five consecutive days every three weeks.
  Eckhardt, S. G., Baker, S. D., Eckardt, J. R., Burke, T. G., Warner, D. L., Kuhn, J. G., Rodriguez, G., Fields, S., Thurman, A., Smith, L., Rothenberg, M. L., White, L...> ;Clin Cancer Res. 1998 Mar
• Preferential binding of the carboxylate form of camptothecin by human serum albumin.
  Burke, T. G., Mi, Z.> ;Anal Biochem. 1993 Jul
• A fluorescence study examining how 14-valerate side chain substitution modulates anthracycline binding to small unilamellar phospholipid vesicles.
  Burke, T. G., Israel, M., Seshadri, R., Doroshow, J. H.> ;Biochim Biophys Acta. 1989 Jun 26
• Abrogation of the selectivity of adriamycin for negatively-charged phospholipids by 14-valerate side chain substitution.
  Burke, T. G., Israel, M., Seshadri, R., Doroshow, J. H.> ;Cancer Biochem Biophys. 1990 Apr
• The important role of albumin in determining the relative human blood stabilities of the camptothecin anticancer drugs.
  Burke, T. G., Munshi, C. B., Mi, Z., Jiang, Y.> ;J Pharm Sci. 1995 Apr
• Ethyl substitution at the 7 position extends the half-life of 10-hydroxycamptothecin in the presence of human serum albumin.
  Burke, T. G., Mi, Z.> ;J Med Chem. 1993 Aug 20
• Differential interactions of camptothecin lactone and carboxylate forms with human blood components.
  Mi, Z., Burke, T. G.> ;Biochemistry. 1994 Aug 30
• Stabilization of topotecan in low pH liposomes composed of distearoylphosphatidylcholine.
  Burke, T. G., Gao, X.> ;J Pharm Sci. 1994 Jul
• Removal of the basic center from doxorubicin partially overcomes multidrug resistance and decreases cardiotoxicity.
  Priebe, W., Van, N. T., Burke, T. G., Perez-Soler, R.> ;Anticancer Drugs. 1993 Feb
• In vitro cytotoxicity, cellular pharmacology, and DNA lesions induced by annamycin, an anthracycline derivative with high affinity for lipid membranes.
  Ling, Y. H., Priebe, W., Yang, L. Y., Burke, T. G., Pommier, Y., Perez-Soler, R.> ;Cancer Res. 1993 Apr 1
• Marked interspecies variations concerning the interactions of camptothecin with serum albumins: a frequency-domain fluorescence spectroscopic study.
  Mi, Z., Burke, T. G.> ;Biochemistry. 1994 Oct 25
• The structural basis of camptothecin interactions with human serum albumin: impact on drug stability.
  Burke, T. G., Mi, Z.> ;J Med Chem. 1994 Jan 7
• Stabilization of 10-hydroxycamptothecin in poly(lactide-co-glycolide) microsphere delivery vehicles.
  Shenderova, A., Burke, T. G., Schwendeman, S. P.> ;Pharm Res. 1997 Oct
• Reduced albumin binding promotes the stability and activity of topotecan in human blood.
  Mi, Z., Malak, H., Burke, T. G.> ;Biochemistry. 1995 Oct 24
• The acidic microclimate in poly(lactide-co-glycolide) microspheres stabilizes camptothecins.
  Shenderova, A., Burke, T. G., Schwendeman, S. P.> ;Pharm Res. 1999 Feb
• Lipid bilayer partitioning and stability of camptothecin drugs.
  Burke, T. G., Mishra, A. K., Wani, M. C., Wall, M. E.> ;Biochemistry. 1993 May 25
• Fluorescence detection of the anticancer drug topotecan in plasma and whole blood by two-photon excitation.
  Burke, T. G., Malak, H., Gryczynski, I., Mi, Z., Lakowicz, J. R.> ;Anal Biochem. 1996 Nov 15
• Simple and versatile high-performance liquid chromatographic method for the simultaneous quantitation of the lactone and carboxylate forms of camptothecin anticancer d...
  Warner, D. L., Burke, T. G.> ;J Chromatogr B Biomed Sci Appl. 1997 Mar 28
• The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity.
  Bom, D., Curran, D. P., Kruszewski, S., Zimmer, S. G., Thompson Strode, J., Kohlhagen, G., Du, W., Chavan, A. J., Fraley, K. A., Bingcang, A. L., Latus, L. J., Pommier...> ;J Med Chem. 2000 Oct 19
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