ThomasHughesMD

Pediatrics • Austin, TX

Capital Pediatric Group

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Office
1100 west 39 1/2 St
Austin, TX 78756
Phone+1 512-454-4545

Fax+1 512-454-2164
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Education & Training

University of Southern California/LAC+USC Medical CenterResidency, Pediatrics, 1970 - 1973
University of Southern California/LACUSC Medical CenterInternship, Transitional Year, 1967 - 1968
University of Pittsburgh School of MedicineClass of 1967

Certifications & Licensure

CA State Medical License 1971 - Present
TX State Medical License 1973 - 2022
American Board of Pediatrics Pediatrics

Awards, Honors, & Recognition

Super Doctor SuperDoctors.com

Publications & Presentations

PubMed

2 citations
Optically activated, customizable, excitable cells.
Merrilee Thomas, Thomas E. Hughes> ;Plos One. 2020 Dec 30
23 citations
Analyzing kinetic signaling data for G-protein-coupled receptors.
Sam R. J. Hoare, Paul Tewson, Anne Marie Quinn, Thomas E. Hughes, Lloyd J. Bridge> ;Scientific Reports. 2020 Jul 23
6 citations
Live-Cell Assays for Cell Stress Responses Reveal New Patterns of Cell Signaling Caused by Mutations in Rhodopsin, α-Synuclein and TDP-43.
Kevin M. Harlen, Elizabeth C. Roush, Joseph E. Clayton, Scott Martinka, Thomas E. Hughes> ;Frontiers in Cellular Neuroscience. 2019 Dec 18
2 citations
Correction to: A genetically encoded Ca2+ indicator based on circularly permutated sea anemone red fluorescent protein eqFP578.
Yi Shen, Hod Dana, Ahmed S. Abdelfattah, Ronak Patel, Jamien Shea, Rosana S. Molina, Bijal Rawal, Vladimir Rancic, Yu-Fen Chang, Lanshi Wu, Yingche Chen, Yong Qian, Ma...> ;BMC Biology. 2019 Oct 30
Live-cell biosensors reveal novel insight into neurotoxic and cardiotoxic compound mediated cellular stress response.
Kevin M. Harlen, Thomas Hughes, Chris Fleming, Greg Luerman> ;Journal of Pharmacological and Toxicological Methods. 2019 Jan 1
A genetically encoded near-infrared fluorescent calcium ion indicator.
Qian, Y.,Piatkevich, K. D.,Mc Larney, B.,Abdelfattah, A. S.,Mehta, S.,Murdock, M. H.,Gottschalk, S.,Molina, R. S.,Zhang, W.,Chen, Y.,Wu, J.,Drobizhev, M.,Hughes, T. E....> ;Nat. Methods. 2019 Jan 22
8 citations
Assay for Detecting Gαi-Mediated Decreases in cAMP in Living Cells:
Paul Tewson, Scott Martinka, Nathan C. Shaner, Catherine H. Berlot, Anne Marie Quinn, Thomas E. Hughes> ;SLAS Discovery. 2018 Jul 10
Preclinical Efficacy and Safety of the Novel Antidiabetic, Antiobesity MetAP2 Inhibitor ZGN-1061.
Burkey, B. F.,Hoglen, N. C.,Inskeep, P.,Wyman, M.,Hughes, T. E.,Vath, J. E.> ;J. Pharmacol. Exp. Ther.. 2018 Mar 02
5 citations
Publisher Correction: A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters
Kiryl D. Piatkevich, Erica E. Jung, Christoph Straub, Changyang Linghu, Demian Park, Ho-Jun Suk, Daniel Hochbaum, Daniel Goodwin, Eftychios A. Pnevmatikakis, Nikita Pa...> ;Nature Chemical Biology. 2018 Mar 8
Physiological mechanisms of sustained fumagillin-induced weight loss.
An, J.,Wang, L.,Patnode, M. L.,Ridaura, V. K.,Haldeman, J. M.,Stevens, R. D.,Ilkayeva, O.,Bain, J. R.,Muehlbauer, M. J.,Glynn, E. L.,Thomas, S.,Muoio, D.,Summers, S. A...> ;JCI Insight. 2018 Mar 09
194 citations
A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters.
Kiryl D. Piatkevich, Erica E. Jung, Christoph Straub, Changyang Linghu, Demian Park, Ho-Jun Suk, Daniel Hochbaum, Daniel Goodwin, Eftychios A. Pnevmatikakis, Nikita Pa...> ;Nature Chemical Biology. 2018 Feb 26
A genetically encoded Ca2+ indicator based on circularly permutated sea anemone red fluorescent protein eqFP578.
Shen, Y.,Dana, H.,Abdelfattah, A. S.,Patel, R.,Shea, J.,Molina, R. S.,Rawal, B.,Rancic, V.,Chang, Y. F.,Wu, L.,Chen, Y.,Qian, Y.,Wiens, M. D.,Hambleton, N.,Ballanyi, K...> ;BMC Biol.. 2018 Jan 18
Effects of MetAP2 inhibition on hyperphagia and body weight in Prader-Willi syndrome: A randomized, double-blind, placebo-controlled trial.
McCandless, S. E.,Yanovski, J. A.,Miller, J.,Fu, C.,Bird, L. M.,Salehi, P.,Chan, C. L.,Stafford, D.,Abuzzahab, M. J.,Viskochil, D.,Barlow, S. E.,Angulo, M.,Myers, S. E...> ;Diabetes Obes Metab. 2017 May 31
37 citations
Near-Infrared Fluorescent Proteins Engineered from Bacterial Phytochromes in Neuroimaging.
Kiryl D. Piatkevich, Ho-Jun Suk, Suhasa B. Kodandaramaiah, Fumiaki Yoshida, Ellen M DeGennaro, Mikhail Drobizhev, Thomas E. Hughes, Robert Desimone, Edward S. Boyden, ...> ;Biophysical Journal. 2017 Nov 21
71 citations
Deciphering the molecular mechanism responsible for GCaMP6m's Ca2+-dependent change in fluorescence
Lauren M. Barnett, Thomas E. Hughes, Mikhail Drobizhev> ;Plos One. 2017 Feb 9
84 citations
Cilia have high cAMP levels that are inhibited by Sonic Hedgehog-regulated calcium dynamics.
Bryn S. Moore, Ann Stepanchick, Paul Tewson, Cassandra M. Hartle, Jin Zhang, Anne Marie Quinn, Thomas E. Hughes, Tooraj Mirshahi> ;Proceedings of the National Academy of Sciences of the United States of America. 2016 Nov 15
59 citations
Toward Better Genetically Encoded Sensors of Membrane Potential
Douglas A. Storace, Masoud Sepehri Rad, BokEum Kang, Lawrence B. Cohen, Thomas E. Hughes, Bradley J. Baker> ;Trends in Neurosciences. 2016 May 1
74 citations
New DAG and cAMP Sensors Optimized for Live-Cell Assays in Automated Laboratories
Paul Tewson, Scott Martinka, Nathan C. Shaner, Thomas E. Hughes, Anne Marie Quinn> ;Journal of Biomolecular Screening. 2016 Mar 1
29 citations
Long- and Short-Range Electrostatic Fields in GFP Mutants: Implications for Spectral Tuning.
Mikhail Drobizhev, Patrik R. Callis, R. Nifosì, Geoffrey Wicks, Caleb R. Stoltzfus, Lauren M. Barnett, Thomas E. Hughes, P. Sullivan, A. Rebane> ;Scientific Reports. 2015 Aug 19
36 citations
Green Fluorescent Protein with Anionic Tryptophan-Based Chromophore and Long Fluorescence Lifetime
Karen S. Sarkisyan, Alexander S. Goryashchenko, Peter V. Lidsky, Dmitry A. Gorbachev, Nina G. Bozhanova, Andrey Yu. Gorokhovatsky, Alina Pereverzeva, Alina P. Ryumina,...> ;Biophysical Journal. 2015 Jul 21
15 citations
Two-photon directed evolution of green fluorescent proteins
Caleb R. Stoltzfus, Lauren M. Barnett, Mikhail Drobizhev, Geoffrey Wicks, Alexander Mikhaylov, Thomas E. Hughes, Aleksander Rebane> ;Scientific Reports. 2015 Jul 6
14 citations
Live-cell multiphoton fluorescence correlation spectroscopy with an improved large Stokes shift fluorescent protein
Yinghua Guan, Matthias Meurer, Sarada Raghavan, Aleksander Rebane, Jake R. Lindquist, Sofia A. Santos, Ilia Kats, Michael W. Davidson, Ralph Mazitschek, Thomas E. Hugh...> ;Molecular Biology of the Cell. 2015 Jun 1
107 citations
Ratiometric biosensors based on dimerization-dependent fluorescent protein exchange
Yidan Ding, Jiao Li, Jhon R. Enterina, Yi Shen, Issan Zhang, Paul Tewson, Gary C. H. Mo, Jin Zhang, Anne Marie Quinn, Thomas E. Hughes, Dusica Maysinger, Spencer C. Al...> ;Nature Methods. 2015 Mar 1
15 citations
Genetically Encoded Protein Sensors of Membrane Potential
Douglas A. Storace, Masoud Sepehri Rad, Zhou Han, Lei Jin, Lawrence B. Cohen, Thomas E. Hughes, Bradley J. Baker, Uhna Sung> ;Advances in Experimental Medicine and Biology. 2015 Jan 1
Down-Regulation of miR-92 in Breast Epithelial Cells and in Normal but Not Tumour Fibroblasts Contributes to Breast Carcinogenesis.
Smith L, Baxter EW, Chambers PA, Green CA, Hanby AM, Hughes TA, Nash CE, Millican-Slater RA, Stead LF, Verghese ET, Speirs V> ;PLoS ONE. 2015-01-01
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ThomasHughesMD

Dr. Hughes is on Doximity

Education & Training

Certifications & Licensure

Awards, Honors, & Recognition

Publications & Presentations

Viewing the full profile is available to verified healthcare professionals only.