TimothyRBilliarMD

PubMed

• 1 citations
  Patient, family caregiver, and economic outcomes of an integrated screening and novel stepped collaborative care intervention in the oncology setting in the USA (CARES...
  Jennifer L Steel, Charles J George, Lauren Terhorst, Jonathan G Yabes, Vincent Reyes, Dan P Zandberg, Marci Nilsen, Gauri Kiefer, Jonas Johnson, Christopher Marsh, Jas...> ;Lancet. 2024 Apr 6
• Mechanism matters: mortality and endothelial cell damage marker differences between blunt and penetrating traumatic injuries across three prehospital clinical trials.
  Donohue, J., Gruen, D., Iyanna, N., Lorence, J., Brown, J., Guyette, F., Daley, B., Eastridge, B., Miller, R., Nirula, R., Harbrecht, B., Claridge, J., Phelan, H., Ver...> ;Scientific Reports. 2024 Feb 2
• Transforming the Future of Surgeon-Scientists.
  Ladner, D., Goldstein, A., Billiar, T., Cameron, A., Carpizo, D., Chu, D., Coopersmith, C., DeMatteo, R., Feng, S., Gallagher, K., Gillanders, W., Lal, B., Lipshutz, G...> ;Annals of Surgery. 2024 Feb 1
• Fibroblastic reticular cell-derived exosomes are a promising therapeutic approach for septic acute kidney injury.
  Yiming Li, Chang Hu, Pan Zhai, Jing Zhang, Jun Jiang, Jinmeng Suo, Bo Hu, Jing Wang, Xiaocheng Weng, Xiang Zhou, Timothy R Billiar, John A Kellum, Meihong Deng, Zhiyon...> ;Kidney International. 2024 Mar 1
• NOS2 and COX2 Provide Key Spatial Targets that Determine Outcome in ER- Breast Cancer.
  Ridnour, L., Heinz, W., Cheng, R., Wink, A., Kedei, N., Pore, M., Imtiaz, F., Femino, E., Gonzalez, A., Coutinho, L., Butcher, D., Edmondson, E., Rangel, M., Kinders, ...> ;Biorxiv. 2023 Dec 23
• A common single nucleotide polymorphism is associated with inflammation and critical illness outcomes.
  Fayten El-Dehaibi, Ruben Zamora, Josiah Radder, Jinling Yin, Ashti M Shah, Rami A Namas, Michelle Situ, Yanwu Zhao, William Bain, Alison Morris, Bryan J McVerry, Derek...> ;Iscience. 2023 Dec 15
• Transcriptomic and Proteomic Characterization of the Immune Response to Elective Spinal Reconstructive Surgery: Impact of Aging and Comparison with Traumatic Injury Re...
  Reitz, K. M., Reitz, K. M., Jillian W Bonaroti, Mehves Ozel, Tianmeng Chen, Jennifer L Darby, Xuejing Sun, Hamed Moheimani, Katherine M Reitz, Upendra K Kar, Brian S Z...> ;Journal of the American College of Surgeons. 2024 May 1
• 1 citations
  Nuclear localization of STING1 competes with canonical signaling to activate AHR for commensal and intestinal homeostasis.
  Ruoxi Zhang, Chunhua Yu, Herbert J Zeh, Haichao Wang, Guido Kroemer, Daniel J Klionsky, Timothy R Billiar, Rui Kang, Daolin Tang> ;Immunity. 2023 Dec 12
• A Prospective Cohort Protocol for the Remnant Investigation in Sepsis Study.
  Seymour, C., Urbanek, K., Nakayama, A., Kennedy, J., Powell, R., Robinson, R., Kapp, K., Billiar, T., Vodovotz, Y., Gelhaus, S., Cooper, V., Tang, L., Mayr, F., Reitz,...> ;Critical Care Explorations. 2023 Nov 1
• Nitric oxide and thioredoxin modulate the activity of caspase 9 in HepG2 cells.
  Surupa Chakraborty, Ankita Choudhuri, Akansha Mishra, Camelia Bhattacharyya, Timothy R Billiar, Detcho A Stoyanovsky, Rajib Sengupta> ;Biochimica Et Biophysica Acta. General Subjects. 2023 Nov 1
• 1 citations
  Targeting inflammation in traumatic injury: entering a new era.
  Timothy R Billiar, Beverley J Hunt, Sebastien Bailly> ;Intensive Care Medicine. 2023 Aug 1
• 5 citations
  ADAR1 Zα domain P195A mutation activates the MDA5-dependent RNA-sensing signaling pathway in brain without decreasing overall RNA editing.
  Xinfeng Guo, Silvia Liu, Yi Sheng, Mazen Zenati, Timothy Billiar, Alan Herbert, Qingde Wang> ;Cell Reports. 2023 Jul 25
• 2 citations
  Interferon-gamma is quintessential for NOS2 and COX2 expression in ERbreast tumors that lead to poor outcome.
  Robert Y S Cheng, Lisa A Ridnour, Adelaide L Wink, Ana L Gonzalez, Elise L Femino, Helene Rittscher, Veena Somasundaram, William F Heinz, Leandro Coutinho, M Cristina ...> ;Cell Death & Disease. 2023 May 11
• 1 citations
  Central role for neurally dysregulated IL-17A in dynamic networks of systemic and local inflammation in combat casualties.
  Ruben Zamora, Jonathan A Forsberg, Ashti M Shah, Desiree Unselt, Scott Grey, Felipe A Lisboa, Timothy R Billiar, Seth A Schobel, Benjamin K Potter, Eric A Elster, Yora...> ;Scientific Reports. 2023 Apr 24
• 12 citations
  Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression.
  Fei Pei, Ren-Qi Yao, Chao Ren, Soheyl Bahrami, Timothy R Billiar, Irshad H Chaudry, De-Chang Chen, Xu-Lin Chen, Na Cui, Xiang-Ming Fang, Yan Kang, Wei-Qin Li, Wen-Xion...> ;Military Medical Research. 2022 Dec 26
• 5 citations
  Targeting Nitric Oxide: Say NO to Metastasis.
  Tejaswini P Reddy, Sharon A Glynn, Timothy R Billiar, David A Wink, Jenny C Chang> ;Clinical Cancer Research. 2023 May 15
• 2 citations
  Intraperitoneal injection of class A TLR9 agonist enhances anti-PD-1 immunotherapy in colorectal peritoneal metastases.
  Ting Jiang, Hongji Zhang, Yiming Li, Preethi Jayakumar, Hong Liao, Hai Huang, Timothy R Billiar, Meihong Deng> ;JCI Insight. 2022 Oct 24
• Short-Term Administration of HIV Protease Inhibitor Saquinavir Improves Skull Bone Healing with Enhanced Osteoclastogenesis.
  Haixia Liu, Yun Shen, Bingkun Zhao, Enoch H Poon, Shengcai Qi, Dai Fei Elmer Ker, Timothy R Billiar, Gregory M Cooper, Yuanzhi Xu, Dan Wang> ;Plastic and Reconstructive Surgery. 2022 Dec 1
• 17 citations
  Aconitate decarboxylase 1 is a mediator of polymicrobial sepsis.
  Runliu Wu, Jiao Liu, Nian Wang, Ling Zeng, Chunhua Yu, Feng Chen, Haichao Wang, Timothy R Billiar, Jianxin Jiang, Daolin Tang, Rui Kang> ;Science Translational Medicine. 2022 Aug 24
• 3 citations
  Multi-Omic Admission-Based Prognostic Biomarkers Identified by Machine Learning Algorithms Predict Patient Recovery and 30-Day Survival in Trauma Patients.
  Sultan S Abdelhamid, Jacob Scioscia, Yoram Vodovotz, Junru Wu, Anna Rosengart, Eunseo Sung, Syed Rahman, Robert Voinchet, Jillian Bonaroti, Shimena Li, Jennifer L Darb...> ;Metabolites. 2022 Aug 23
• 9 citations
  High Dimensional Multiomics Reveals Unique Characteristics of Early Plasma Administration in Polytrauma Patients With TBI.
  Junru Wu, Hamed Moheimani, Shimena Li, Upendra K Kar, Jillian Bonaroti, Richard S Miller, Brian J Daley, Brian G Harbrecht, Jeffrey A Claridge, Herbert A Phelan, Franc...> ;Annals of Surgery. 2022 Oct 1
• 2 citations
  Impaired interferon-γ signaling promotes the development of silicosis.
  Zhouyangfan Peng, Mingwu Duan, Yiting Tang, Jianfeng Wu, Kai Zhao, Yanjun Zhong, Zhihui He, Jie Meng, Fangping Chen, Xianzhong Xiao, Haichao Wang, Timothy R Billiar, B...> ;Iscience. 2022 Jul 15
• LONGITUDINAL ANALYSIS OF TRANSCRIPTOMIC SUBTYPES IN TRAUMA PATIENTS.
  Tianmeng Chen, Yue Wei, Yoram Vodovotz, Wei Chen, Timothy R Billiar> ;Shock. 2022 Jul 1
• 29 citations
  Z-DNA binding protein 1 promotes heatstroke-induced cell death.
  Fangfang Yuan, Jizhen Cai, Jianfeng Wu, Yiting Tang, Kai Zhao, Fang Liang, Fanglin Li, Xinyu Yang, Zhihui He, Timothy R Billiar, Haichao Wang, Lei Su, Ben Lu> ;Science. 2022 May 6
• 19 citations
  Prehospital low titer group O whole blood is feasible and safe: Results of a prospective randomized pilot trial.
  Frank X Guyette, Mazen Zenati, Darrell J Triulzi, Mark H Yazer, Hunter Skroczky, Barbara J Early, Peter W Adams, Joshua B Brown, Louis Alarcon, Matthew D Neal, Raquel ...> ;The Journal of Trauma and Acute Care Surgery. 2022 May 1
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Journal Articles

• Tranexamic Acid During Prehospital Transport in Patients at Risk for Hemorrhage After Injury  
  Francis X Guyette, Brian J Eastridge, Raminder Nirula, Gary A Vercruysse, Louis H Alarcon, Clifton W Callaway, Brian S Zuckerbraun, Matthew D Neal, Raquel M Forsythe, ..., JAMA Surgery
• Association Between Preoperative Metformin Exposure and Postoperative Outcomes in Adults with Type 2 Diabetes  
  Katherine M Reitz, Edith Tzeng, Timothy R Billiar, Brian S Zuckerbraun, Richard L Simmons, Matthew R Rosengart, Matthew D Neal, JAMA Surgery
• PKM2-Dependent Glycolysis Promotes NLRP3 and AIM2 Inflammasome Activation  
  Timothy Billiar, MD, Nature
• Hepatic Dysfunction after Shock: Clinical Parameters and Biological Pathways for Therapeutic Intervention  
  Gill R., Billiar TR, J Organ Dysfunction, 1/1/2009
• Endothelial Specificity of ICAM2, Flt-1, and Tie2 Promoters In Vitro and In Vivo  
  Lei J, Vodovotz Y, Billiar TR, Int J Biolog Biomed Med Sci, 1/1/2008
• Invited Critique: Etomidate use in the critically injured patient is associated with increased risk of adrenal insufficiency  
  Billiar TR, Arch Surg, 1/1/2008
• Session IV: Arginine and pathophysiology II – discussion summary  
  Billiar TR, J Nutr, 1/1/2004
• Carbon monoxide paradoxically protects against hypoxia  
  Zuckerbraun BS, Billiar TR, J Surg Res, 1/1/2003
• Inhaled carbon monoxide abrogates pulmonary hypertension  
  Nadler EP, Zuckerbraun BS, Otterbein LE, Billiar TR, Kanno S, J Surg Res, 1/1/2003
• Signaling events triggered by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL): caspase-8 is required for TRAIL-induced apoptosis  
  Seol DW, Li J, Seol MH, Park S, Talanian RV, Billiar TR, Cancer Res, 1/1/2001
• Nitric Oxide – Biology and Pathobiology  
  Kibbe MR, Lee PC, Billiar TR, Tzeng E, 1/1/2001
• Nitric oxide from the inducible nitric oxide synthase (iNOS) increases the expression of cytochrome P450 2E1 in iNOS-null hepatocytes in the absence of inflammatory st...  
  Zamora R, Vodovotz Y, Alarcon L, Betten B, Loughran PA, Aulak KS, Stuehr DG, Gibson KF, Billiar TR, Arch Biochem Biophys, 1/1/2001
• Induction of Reperfusion-Independent Early Events in the Inflammatory Cascade of Hemorrhagic Shock  
  Hierholzer C, Harbrecht BG, Billiar TR, Tweardy DJ, Surg Forum, 1/1/2000
• Mice Deficient in eNOS Have Normal Blood Pressure Response to Resuscitation but Increased Early Mortality following Hemorrhagic Shock  
  Schuchert VD, Baust JJ, Gallo DJ, Zenati MS, Peitzman AB, Billiar TR, Harbrecht BG, Surg Forum, 1/1/2000
• Activation of C-JUN N-Terminal Kinase in Mouse Liver during Hemorrhagic Shock  
  McCloskey CA, Billiar TR, Surg Forum, 1/1/2000
• The Role of Serine/Threonine and Tyrosine Phosphatases in Mediating Inhibition of Vascular Smooth Muscle Cell Proliferation  
  Kibbe MR, Nie S, Billiar TR, Tzeng E, Surg Forum, 1/1/2000
• Increased Expression of Vascular Endothelial Growth Factor in Steroid-Treated Murine Wounds  
  Schwentker A, Salyapongse AN, Billiar TR, Surg Forum, 1/1/2000
• Inducible Nitric Oxide Synthase Attenuates Acute Cardiac Rejection  
  Lee PC, Wang ZL, Mahidhara R, Qian S, Watkins SC, Griffith BP, Billiar TR, Shears LL, Surg Forum, 1/1/2000
• The nitric oxide scavenger NOX reduces intestinal inflammation and organ damage following hemorrhagic shock  
  Hierholzer C, Kalff JC, Menezes JM, Siewert JR, Billiar TR, Bauer AJ, Tweardy DJ, Harbrecht BG, Surg Forum, 1/1/1999
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  Bombeck CA, Ganster RW, Green A, Ou J, Billiar TR, Surg Forum, 1/1/1999
• Nitric oxide mediates growth factor-stimulated angiogenesis  
  Lee PC, Kibbe MR, Stolz DB, Gleixner SL, Watkins SC, Griffith BP, Billiar TR, Shears LL, Surg Forum, 1/1/1999
• p53 is protective against nitric oxide-induced apoptosis in vascular smooth muscle cells  
  Kibbe MR, Li J, Nie S, Billiar TR, Tzeng E, Surg Forum, 1/1/1999
• Improved transfection efficiency of excisional wounds using poloxamer 407 or targeting adenoviral vectors  
  Salyapongse AN, Bragdon GA, Edington HDJ, Lizonova A, Kovesdi I, Billiar TR, Surg Forum, 1/1/1999
• Introduction, from the Guest Editor  
  Billiar TR, Sepsis, 1/1/1998
• The involvement of apoptosis in inflammatory liver failure  
  Bombeck CA, Billiar TR, Sepsis, 1/1/1998
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Books/Book Chapters

• Schwartz's Principles of Surgery 
  Brunicardi FC, Andersen DK, Billiar TR, Dunn DL, Hunter JG, Matthews JB, Pollock REMcGraw-Hill Companies, New YorkEdition 10th,2014
• Schwartz's Principles of Surgery 
  Brunicardi FC, Brandt ML, Andersen DK, Billiar TR, Dunn DL, Hunter JG, Matthews JB, Pollock REMcGraw-Hill Companies, New YorkEdition 9th,2009
• Radicals for Life: The Various Forms of Nitric Oxide 
  Chapter: Cellular non-heme iron modulates apoptosis and caspase 3 activity 
  Page 253 - 268Stoyanovsky DA, Billiar TREditors: van Faassen E, Vanin AF.Elsevier Publishers, Oxford, UK2007
• Schwartz’s Manual of Surgery 
  T Billiar (editor)Editors: Brunicardi FC, Andersen DK, Billiar TR, Dunn DL, Hunter JG, Pollock, RE.McGraw-Hill Companies, New YorkEdition 8th,2006
• Schwartz’s Manual of Surgery Self-Assessment and Board Review 
  T Billiar (editor)Editors: Brunicardi FC, Brandt ML, Andersen DK, Billiar TR, Dunn DL, Hunter JG, Pollock, RE.McGraw-Hill Companies, New YorkEdition 8th,2006
• Greenfield’s Surgery Scientific Principles & Practice 
  Chapter: Inflammation 
  Page 124 - 163Rosengart MR, Billiar TREditors: Mulholland MW, Lillemoe KD, Doherty GM, Maier RV, Upchurch GR.Lippincott Williams & Wilkins, Philadelphia, PAEdition 4th,2006
• Modern Surgical Care: Physiologic Foundations and Clinical Applications 
  Chapter: Hepatic Physiology 
  Page 427 - 441Prince JM, Billiar TREditors: Miller TA.Informa Healthcare USA, Inc, New York, NYEdition 3rd,2006
• Schwartz's Principles of Surgery 
  T Billiar (editor)Editors: Brunicardi FC, Andersen DK, Billiar TR, Dunn DL, Hunter JG, Pollock, RE.McGraw-Hill Companies, New YorkEdition 8th,2005
• Schwartz’s Principles of Surgery 
  Chapter: Shock 
  Page 85 - 108Peitzman AB, Harbrecht BG, Billiar TREditors: Bruncardi FC, Anderson DK, Billiar TR, Dunn DL, Hunter JG, Pollock RE.McGraw-Hill Companies, New York, NYEdition 8th,2005
• Proceedings of the 11th Congress of the European Shock Society 
  Chapter: Initiation of inflammation pathways in hemorrhagic shock 
  Page 1 - 6Prince J, Levy R, Billiar TREditors: Redl H.Medimod, Bologna2005
• Immunobiology of Organ Transplantation 
  Chapter: Nitric oxide, oxygen radicals 
  Page 477 - 487Kanno S, Shears LL, and Billiar TREditors: Wilkes DS, Burlingham WJ.Kluwer2004
• The Trauma Manual 
  Chapter: Shock 
  Page 23 - 27Harbrecht BG, Billiar TREditors: Peitzman AB, Rhodes M, Schwab CW, Yealy DM, Fabian TC.Lippincott Williams & Wilkins, Philadelphia, PA2002
• Nitric Oxide and Inflammation 
  T Billiar (editor)Editors: Salvimini D, Billiar TR, Vodovotz Y.Birkhäuser Verlag Basel, Switzerland2001
• Surgical Research 
  Chapter: Biology of Nitric Oxide: Measurement, Modulation, and Models 
  Collins JL, Vodovotz Y, Billiar TREditors: Souba WW, Wilmore DW.Academic Press, San Diego, CAEdition 949,2001
• Nitric oxide-mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes 
  Jaiswal M, LaRusso N, Shapiro R, Billiar TR, Gores G2001
• Nitric Oxide and Inflammation 
  Chapter: Nitric oxide in shock: sepsis and hemorrhage 
  McCloskey CA, Billiar TREditors: Sakvemini D, Billiar TR, Vodovotz Y.Birkhauser Verlag Basel, Switzerland2001
• Multiple Organ Failure Pathophysiology, Prevention and Therapy 
  Chapter: Nitric oxide as a modulator of sepsis: therapeutic possibilities 
  Page 176 - 187Salyapongse AN, Billiar TRSpringer-Verlag, New York, NY2000
• Handbook of Experimental Pharmacology 
  Chapter: Nitric Oxide: A True Inflammatory Mediator 
  Page 493 - 523Zamora R. and Billiar TRMayer-Springer2000
• Recent Advances in Nitric Oxide Research 
  Chapter: Regulation and Function of Nitric Oxide in the Liver 
  Page 109 - 137Taylor BS, Billiar TR, Geller DASpringer-Verlag, Tokyo, Japan1999
• Encyclopedia of Molecular Biology 
  Chapter: Nitric Oxide 
  Page 1607 - 1615Li J, Billiar TRJohn Wiley & Sons, Inc1999
• Free Radicals & Inflammation 
  Chapter: Reactive oxygen species, nitric oxide and apoptosis 
  Page 207 - 219Bombeck CA, Li J, Billiar TREditors: Winyard P.G..Birkhauser Publishing Ltd1999
• The Trauma Manual 
  Chapter: Patterns of blunt injury 
  Page 6 - 11Billiar TR, Peitzman ABEditors: Peitzman AB, Rhodes M, Schwab CW, Yealy DM.Lippincott-Raven Inc, Philadelphia, PA1998
• Molecular Biology of Free Radicals in Human Diseases 
  Chapter: Nitric oxide, altered DNA, and mammalian disease 
  Page 287 - 325Felley-Bosco E, Buzard GS, Billiar TR, Keefer LKEditors: Aruoma OI, Halliwell B.OICA International1998
• Applied Cardiovascular Physiology, #28 Update in Intensive Care and Emergency Medicine 
  Chapter: Hemorrhagic shock: from physiology to molecular biology 
  Page 209 - 216Omert LA, Billiar TREditors: Pinsky MR.Springer-Verlag, Berlin, Germany1997
• Endothelial Modulation of Cardiac Function 
  Chapter: Nitric oxide, sepsis and the heart 
  Page 71 - 90Alarcon LH, Billiar TR, Simmons RLEditors: Lewis MJ, Shah AM.Harwood Academic Publishers, The Netherlands1997
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Lectures

• The Role of HMGB1 in driving hypoxia-induced inflammasome activation and mitophagy 
  Stockholm, Sweden - 1/30/2014
• Of Men and Mice: An Iterative Strategy to Dissect the Immune Response To Trauma 
  Multiple Locations - 1/20/2014
• Perspective: The Role of Surgeon Scientist 
  Pittsburgh, PA, 2013; Providence, RI, 2014 - 1/18/2014
• Management of Ambulatory Surgery 
  Changsha, China - 1/17/2014
• Circulating Biomarkers Predict Nosocomial Infection After Trauma in Humans 
  Newport, RI - 1/15/2014
• The Tolls of Trauma 
  Multiple Locations - 1/10/2014
• Characterization of the Inflammatory Response to Severe Injury 
  Shanghai, China - 1/10/2014
• Biology and Metabolism of Sepsis 
  Baltimore, MD - 1/1/2014
• An Iterative Strategy to Sudy Complex Human Diseases 
  Shanghai, China - 1/29/2013
• Drivers of the Inflammatory Response following Injury 
  Wuhan, China - 1/28/2013
• Cell-type Selective Roles of HMGB1 in liver 
  Honolulu, HI - 1/25/2013
• The Role of Toll-like Receptors in Sensing Tissue Ischemia 
  Xi’an, China - 1/19/2013
• Sensing tissue damage and ischemia through toll like receptors 
  Seattle, WA - 1/18/2013
• Innate Immune Mechanisms of Sensing Ischemia and Tissue Trauma 
  Taipei, Taiwan - 1/16/2013
• General Surgery Training in the United States 
  Wuhan, China - 1/12/2013
• Regulation of the Immuno-inflammatory Response to Injury 
  Guangzhou, China - 1/2/2013
• Cell Type Specific Roles for TLR4 in Sepsis and Trauma 
  Chicago, IL - 1/30/2012
• Molecular Biology of Hemorrhagic Shock 
  San Francisco, CA - 1/21/2012
• The Role of the Surgeon Scientist 
  Changsha, China - 1/21/2012
• The Role of Danger Associated Molecular Pattern Molecules Toll-Like Receptors 
  Guangzhou, China - 1/15/2012
• DAMPs in Trauma and Sepsis 
  Heidelberg, Germany - 1/10/2012
• Cell Specific TLR4 Response to Injury 
  Miami, FL - 1/9/2012
• Perspectives 
  1/30/2011
• Injury Induced Inflammation 
  Wuhan, China - 1/29/2011
• The Tolls of Trauma: Trauma and Regenerative Medicine Symposium 
  Shanghai, China - 1/27/2011
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