TimothyWalter SethClarkMD

PubMed

• Novel methods for integration and visualization of genomics and genetics data in Alzheimer's disease.
  Bihlmeyer, N. A.,Merrill, E.,Lambert, Y.,Srivastava, G. P.,Clark, T. W.,Hyman, B. T.,Das, S.> ;Alzheimers Dement. 2019 Apr 03
• 14 citations
  Neuronal calcineurin transcriptional targets parallel changes observed in Alzheimer disease brain.
  Sarah C. Hopp, Nathan A. Bihlmeyer, John P. Corradi, Charles R. Vanderburg, Angela Cacace, Sudeshna Das, Timothy Clark, Rebecca A. Betensky, Bradley T. Hyman, Eloise H...> ;Journal of Neurochemistry. 2018 Oct 1
• Identification of Two Distinct Sites for Antagonist and Biased Agonist Binding to the Human Chemokine Receptor CXCR3.
  Milanos L, Saleh N, Kling RC, Kaindl J, Tschammer N, Clark T> ;Angew. Chem. Int. Ed. Engl.. 2016-12-05
• DNA-Dye-Conjugates: Conformations and Spectra of Fluorescence Probes.
  Beierlein FR, Paradas Palomo M, Sharapa DI, Zozulia O, Mokhir A, Clark T> ;PLoS ONE. 2016-01-01
• In Silico Adoption of an Orphan Nuclear Receptor NR4A1.
  Lanig H, Reisen F, Whitley D, Schneider G, Banting L, Clark T> ;PLoS ONE. 2015-01-01
• Active-state model of a dopamine D2 receptor-Gαi complex stabilized by aripiprazole-type partial agonists.
  Kling RC, Tschammer N, Lanig H, Clark T, Gmeiner P> ;PLoS ONE. 2014-01-01
• Molecular dynamics simulations of liquid phase interfaces: understanding the structure of the glycerol/water-dodecane system.
  Beierlein FR, Krause AM, Jäger CM, Fita P, Vauthey E, Clark T> ;Langmuir. 2013-09-24
• 10 citations
  Genome-wide increase in histone H2A ubiquitylation in a mouse model of Huntington's disease.
  Karen N. McFarland, Sudeshna Das, Ting Ting Sun, Dmitri Leyfer, Mee-Ohk Kim, Eva Xia, Gavin R. Sangrey, Alexandre Kuhn, Ruth Luthi-Carter, Timothy Clark, Ghazaleh Sadr...> ;Journal of Huntington's Disease. 2013 Jan 1
• Active-state models of ternary GPCR complexes: determinants of selective receptor-G-protein coupling.
  Kling RC, Lanig H, Clark T, Gmeiner P> ;PLoS ONE. 2013-01-01
• A test of improved force field parameters for urea: molecular-dynamics simulations of urea crystals.
  Özpınar GA, Beierlein FR, Peukert W, Zahn D, Clark T> ;J Mol Model. 2012-08-01
• Genome-Wide Histone Acetylation Is Altered in a Transgenic Mouse Model of Huntington's Disease.
  McFarland, K. N., Das, S., Sun, T. T., Leyfer, D., Xia, E., Sangrey, G. R., Kuhn, A., Luthi-Carter, R., Clark, T. W., Sadri-Vakili, G., Cha, J. H.> ;PLoS ONE. 2012
• Molecular dynamics simulations of the effect of the G-protein and diffusible ligands on the β2-adrenergic receptor.
  Goetz A, Lanig H, Gmeiner P, Clark T> ;J. Mol. Biol.. 2011-12-09
• Predicting the effects of basepair mutations in DNA-protein complexes by thermodynamic integration.
  Beierlein FR, Kneale GG, Clark T> ;Biophys. J.. 2011-09-07
• Diarylpropane-1,3-dione derivatives as TetR-inducing tetracycline mimetics: Synthesis and biological investigations.
  Kormann C, Pimenta I, Löber S, Wimmer C, Lanig H, Clark T, Hillen W, Gmeiner P> ;Chembiochem. 2009-12-14
• Induction of the tetracycline repressor: characterization by molecular-dynamics simulations.
  Haberl F, Lanig H, Clark T> ;Proteins. 2009-12-01
• Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner.
  Benn CL, Sun T, Sadri-Vakili G, McFarland KN, DiRocco DP, Yohrling GJ, Clark TW, Bouzou B, Cha JJ> ;J. Neurosci.. 2008-10-15
• Molecular dynamics characterization of the structures and induction mechanisms of a reverse phenotype of the tetracycline receptor.
  Seidel U, Othersen OG, Haberl F, Lanig H, Beierlein FR, Clark T> ;J Phys Chem B. 2007-05-31
• SCRF-DFT and NMR comparison of tetracycline and 5a,6-anhydrotetracycline in solution.
  Othersen OG, Waibel R, Lanig H, Gmeiner P, Clark T> ;J Phys Chem B. 2006-12-07
• The structure of 5a,6-anhydrotetracycline and its Mg2+ complexes in aqueous solution.
  Othersen OG, Lanig H, Clark T> ;J Mol Model. 2006-09-01
• Molecular dynamics simulations of the tetracycline-repressor protein: the mechanism of induction.
  Lanig H, Othersen OG, Beierlein FR, Seidel U, Clark T> ;J. Mol. Biol.. 2006-06-16
• Structural changes and binding characteristics of the tetracycline-repressor binding site on induction.
  Lanig H, Othersen OG, Seidel U, Beierlein FR, Exner TE, Clark T> ;J. Med. Chem.. 2006-06-15
• Simulating FRET from tryptophan: is the rotamer model correct?
  Beierlein FR, Othersen OG, Lanig H, Schneider S, Clark T> ;J. Am. Chem. Soc.. 2006-04-19
• Aeromonas proteolytica aminopeptidase: an investigation of the mode of action using a quantum mechanical/molecular mechanical approach.
  Schürer G, Lanig H, Clark T> ;Biochemistry. 2004-05-11
• How does Mg(2+) affect the binding of anhydrotetracycline in the TetR protein?
  Leypold CF, Marian D, Roman C, Schneider S, Schubert P, Scholz O, Hillen W, Clark T, Lanig H> ;Photochem. Photobiol. Sci.. 2004-01-01
• Systematic surface scan of the most favorable interaction sites of magnesium ions with tetracycline.
  Othersen OG, Lanig H, Clark T> ;J. Med. Chem.. 2003-12-18
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