TimothyJNelsonMDPhD

Research • Rochester, MN

Clinical Pharmacology

Associate Professor, Internal Medicine, Molecular Pharmacology, Mayo Medical School

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Office
200 1st Street SW
Rochester, MN 55905
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Education & Training

Mayo Clinic College of Medicine and Science (Rochester)Fellowship, Cardiovascular Disease, 2008 - 2010
Mayo Clinic College of Medicine and Science (Rochester)Residency, Internal Medicine, 2005 - 2008
Medical College of WisconsinClass of 2005

Certifications & Licensure

MN State Medical License 2006 - 2024

Clinical Trials

A Prospective Study of Patients With Hypoplastic Left Heart Syndrome (HLHS) Following Stage II Surgical Palliation Start of enrollment: 2012 Oct 01
Completed
Umbilical Cord Blood Collection and Processing for Hypoplastic Left Heart Syndrome Patients Start of enrollment: 2012 May 01
Recruiting
Not Applicable
Safety Study of Autologous Umbilical Cord Blood Cells for Treatment of Hypoplastic Left Heart Syndrome Start of enrollment: 2013 May 15
Completed
Phase 1
Study of Autologous Bone Marrow Derived Mononuclear Cells for Treatment of Ebstein Anomaly Start of enrollment: 2016 Sep 01
Completed
Phase 1
Modifiable Predictors of Neural Vulnerabilities for Obesity Start of enrollment: 2020 Oct 30
Enrolling by invitation
Not Applicable
National Collaborative to Improve Care of Children With Complex Congenital Heart Disease Start of enrollment: 2016 May 01
Recruiting
Roles: Contact
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Publications & Presentations

PubMed

10 citations
Chronic cortisol differentially impacts stem cell-derived astrocytes from major depressive disorder patients.
Kelly J. Heard, Maxim N. Shokhirev, Caroline Becronis, Callie Fredlender, Nadia Zahid, Amy T. Le, Yuan Ji, Michelle K. Skime, Timothy J. Nelson, Daniel K. Hall-Flavin,...> ;Translational Psychiatry. 2021 Nov 30
8 citations
Clinical Impact of Autologous Cell Therapy on Hypoplastic Left Heart Syndrome After Bidirectional Cavopulmonary Anastomosis
Marie Vincenti, Patrick W. O'Leary, M. Yasir Qureshi, Drew K. Seisler, Harold M. Burkhart, Frank Cetta, Timothy J. Nelson> ;Seminars in Thoracic and Cardiovascular Surgery. 2021 Sep 1
4 citations
Cone Reconstruction for Ebstein Anomaly: Ventricular Remodeling and Preliminary Impact of Stem Cell Therapy.
Patrick W. O'Leary, M. Yasir Qureshi, Frank Cetta, Timothy J. Nelson, Kimberly A. Holst, Joseph A. Dearani, Timothy Nelson, Amanda Breuer, Sara Martineau, Angela R. Mi...> ;Mayo Clinic Proceedings. 2021 Aug 31
Author Correction: Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs.
Jay W. Schneider, Saji Oommen, Muhammad Yasir Qureshi, Sean C. Goetsch, David R. Pease, Rhianna S. Sundsbak, Wei Guo, Mingming Sun, Han Sun, Hidehito Kuroyanagi, Denni...> ;Nature Medicine. 2021 Jun 2
2 citations
Identifying gaps in parental support for families of children with hypoplastic left heart syndrome.
Meghan Landry, Meghan Katers, Erica Olson, Lynn Cern, Timothy J. Nelson, Katherine Campbell> ;Cardiology in the Young. 2021 May 10
2 citations
From Safety to Benefit in Cell Delivery During Surgical Repair of Ebstein Anomaly: Initial Results.
Kimberly A. Holst, Joseph A. Dearani, M. Yasir Qureshi, Philip L. Wackel, Bryan C. Cannon, Patrick W. O'Leary, Timothy M. Olson, Drew K. Seisler, Timothy J. Nelson, Ka...> ;The Annals of Thoracic Surgery. 2021 Feb 1
3 citations
Activation of P53 Via Nutlin-3a Reveals Role for P53 In ROS Signaling During Cardiac Differentiation of hiPSCs.
Emma B. Brandt, Xing Li, Timothy J. Nelson> ;Journal of Stem Cell Reports. 2021 Jan 1
47 citations
Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs.
Jay W. Schneider, Saji Oommen, Muhammad Yasir Qureshi, Sean C. Goetsch, David R. Pease, Rhianna S. Sundsbak, Wei Guo, Mingming Sun, Han Sun, Hidehito Kuroyanagi, Denni...> ;Nature Medicine. 2020 Nov 13
22 citations
Patient-Specific Induced Pluripotent Stem Cells Implicate Intrinsic Impaired Contractility in Hypoplastic Left Heart Syndrome.
Sharon L. Paige, Francisco X Galdos, Soah Lee, Elizabeth T Chin, Sara Ranjbarvaziri, Dries A.M. Feyen, Adrija K. Darsha, Sidra Xu, Julia Ryan, Aimee Beck, M. Yasir Qur...> ;Circulation. 2020 Oct 20
27 citations
Patient-specific genomics and cross-species functional analysis implicate LRP2 in hypoplastic left heart syndrome
Jeanne L. Theis, Georg Vogler, Maria A. Missinato, Xing Li, Tanja Nielsen, Zeng Xi, Almudena Martinez-Fernandez, Stanley M. Walls, Anaïs Kervadec, James N. Kezos, Katj...> ;Elife. 2020 Oct 2
70 citations
Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome.
Yifei Miao, Lei Tian, Marcy Martin, Sharon L. Paige, Francisco X Galdos, Jibiao Li, Alyssa Klein, Hao Zhang, Ning Ma, Yuning Wei, Maria Stewart, Soah Lee, Jan-Renier A...> ;Cell Stem Cell. 2020 Oct 1
5 citations
Loss of Ventricular Function After Bidirectional Cavopulmonary Connection: Who Is at Risk?
Marie Vincenti, M. Yasir Qureshi, Talha Niaz, Drew K. Seisler, Timothy J. Nelson, Frank Cetta> ;Pediatric Cardiology. 2020 Aug 11
8 citations
Mitochondrial DNA: Hotspot for Potential Gene Modifiers Regulating Hypertrophic Cardiomyopathy
Parisa K Kargaran, Jared M. Evans, Sara E Bodbin, James G W Smith, Timothy J. Nelson, Chris Denning, Diogo Mosqueira> ;Journal of Clinical Medicine. 2020 Jul 23
43 citations
m.3243A > G-Induced Mitochondrial Dysfunction Impairs Human Neuronal Development and Reduces Neuronal Network Activity and Synchronicity.
T. M. Klein Gunnewiek, Eline J.H. van Hugte, Monica Frega, Gemma Solé Guardia, Katharina Foreman, Daan M. Panneman, Britt Mossink, Katrin Linda, Jason M. Keller, Dirk ...> ;Cell Reports. 2020 Apr 21
15 citations
Challenging misinformation and engaging patients: characterizing a regenerative medicine consult service.
Cambray Smith, Charlene Martin-Lillie, Jennifer Dens Higano, Leigh Turner, Sydney Phu, Jennifer R. Arthurs, Timothy J. Nelson, Shane A. Shapiro, Zubin Master> ;Regenerative Medicine. 2020 Mar 1
17 citations
Human Induced Pluripotent Stem Cell-Derived Non-Cardiomyocytes Modulate Cardiac Electrophysiological Maturation Through Connexin 43-Mediated Cell-Cell Interactions
Sherri M. Biendarra-Tiegs, Daniel J. Clemens, Frank J. Secreto, Timothy J. Nelson> ;Stem Cells and Development. 2020 Jan 10
13 citations
Model system identification of novel congenital heart disease gene candidates: focus on RPL13.
Analyne Manzano Schroeder, Massoud Allahyari, Georg Vogler, Maria A. Missinato, Tanja Nielsen, Michael S. Yu, Jeanne L. Theis, Lars Allan Larsen, Preeya Goyal, Jill A....> ;Human Molecular Genetics. 2019 Dec 1
37 citations
Autologous stem cell therapy for hypoplastic left heart syndrome: Safety and feasibility of intraoperative intramyocardial injections.
Harold M. Burkhart, Muhammad Yasir Qureshi, Joseph W. Rossano, Susana Cantero Peral, Patrick W. O'Leary, Matthew A. Hathcock, Walter K. Kremers, Timothy J. Nelson, Ama...> ;The Journal of Thoracic and Cardiovascular Surgery. 2019 Dec 1
22 citations
Hypoplastic left heart syndrome: From bedside to bench and back
Anita Saraf, Wendy Book, Timothy J. Nelson, Chunhui Xu> ;Journal of Molecular and Cellular Cardiology. 2019 Oct 1
Studying treatment resistance in depression using patient derived neurons in vitro.
Vadodaria, K. C.,Ji, Y.,Skime, M.,Paquola, A.,Nelson, T.,Hall-Flavin, D.,Fredlender, C.,Heard, K. J.,Deng, Y.,Le, A. T.,Dave, S.,Fung, L.,Li, X.,Marchetto, M. C.,Weins...> ;Mol. Psychiatry. 2019 May 24
26 citations
Single-Cell RNA-Sequencing and Optical Electrophysiology of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveal Discordance Between Cardiac Subtype-Assoc...
Sherri M. Biendarra-Tiegs, Xing Li, Dan Ye, Emma B. Brandt, Michael J. Ackerman, Timothy J. Nelson> ;Stem Cells and Development. 2019 May 15
51 citations
Altered serotonergic circuitry in SSRI-resistant major depressive disorder patient-derived neurons.
Krishna C. Vadodaria, Yuan Ji, Michelle K. Skime, Apuã C. M. Paquola, Timothy J. Nelson, Daniel K. Hall-Flavin, Kelly J. Heard, Callie Fredlender, Yalin Deng, James El...> ;Molecular Psychiatry. 2019 Mar 22
Towards Understanding the Origin of Cosmic-Ray Electrons.
Aguilar, M.,Ali Cavasonza, L.,Alpat, B.,Ambrosi, G.,Arruda, L.,Attig, N.,Azzarello, P.,Bachlechner, A.,Barao, F.,Barrau, A.,Barrin, L.,Bartoloni, A.,Basara, L.,Başeğme...> ;Phys. Rev. Lett.. 2019 Apr 02
Towards Understanding the Origin of Cosmic-Ray Positrons.
Aguilar, M.,Ali Cavasonza, L.,Ambrosi, G.,Arruda, L.,Attig, N.,Azzarello, P.,Bachlechner, A.,Barao, F.,Barrau, A.,Barrin, L.,Bartoloni, A.,Basara, L.,Başeğmez-du Pree,...> ;Phys. Rev. Lett.. 2019 Feb 16
20 citations
Addressing Variability and Heterogeneity of Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Sherri M. Biendarra-Tiegs, Frank J. Secreto, Timothy J. Nelson> ;Advances in Experimental Medicine and Biology. 2020 Jan 1
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Lectures

Addressing Variability and Heterogeneity of Induced Pluripotent Stem Cell-Derived Cardiomyocytes
10/11/2014

Press Mentions

Model for Rare Cancer Results Instead in ObesityJanuary 11th, 2021
Science Saturday: Across Time, Place to Find Cures for Inherited Heart DiseasesDecember 22nd, 2020
Undergraduate Students Participate in Mayo Research, Develop Careers, CollaborationsJuly 25th, 2019
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