TomaszSablinskiMDPh.D.

General Surgery • Short Hills, NJ

Transplantation

Founder & CEO of Transparency Life Sciences, a drug dev company

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Office
25
Short Hills, NJ 07078
Phone+1 973-921-9115
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Summary

I am a board certified general surgeon, who left practice some 15 years ago to became a drug developer. I have over thirty years of experience in healthcare ranging from basic research through clinical practice to drug and biologics development, in a broad international setting of Europe, Japan, and US.
I believe that the current model of clinical development is fundamentally broken, and I became passionate about changing it by:
- converging modern information technology with drug development "know-how" to increase the speed and quality of advancement of pharmaceuticals and biologics pipelines
- exploiting an unlimited potential of "knowledge networking" to revolutionize drug development and therapeutic decisions
Currently I am a managing drug development at Celtic Therapeutics, and I recently co-founded Transparency Life Sciences, the first drug development company based on open innovation crowd sourcing and cyber medicine.
www.transparencyls.com

Education & Training

Brigham and Women's HospitalPost-Doctoral Fellowship, transplant immunology, 1988 - 1992
Medical University of WarsawClass of 1981

Certifications & Licensure

MA State Medical License 1996 - Present

Clinical Trials

Efficacy and Safety Study of KIACTA in Preventing Renal Function Decline in AA Amyloidosis Start of enrollment: 2010 Nov 01
Completed
Phase 3
Phase 3 Study of OTX-101 in the Treatment of Keratoconjunctivitis Sicca Start of enrollment: 2016 Feb 01
Completed
Phase 3

Publications & Presentations

PubMed

3 citations
Opening up clinical study design to the long tail.
Tomasz Sablinski> ;Science Translational Medicine. 2014 Oct 1
73 citations
Acute Humoral Xenograft Rejection: Destruction of the Microvascular Capillary Endothelium in Pig-to-Nonhuman Primate Renal Grafts
Akira Shimizu, Shane Meehan, Tomasz Kozlowski, T. Sablinski, Francesco L. Ierino, David K. C. Cooper, David H. Sachs, Robert B. Colvin> ;Laboratory Investigation; a Journal of Technical Methods and Pathology. 2000 Jun 1
10 citations
Decreased graft-versus-host disease after haplotype mismatched bone marrow allografts in miniature swine following interleukin-2 treatment
Tomasz Kozlowski, T. Sablinski, M. Basker, Hiroshi Kitamura, Thomas R. Spitzer, Jay A. Fishman, Megan Sykes, David K. C. Cooper, David H. Sachs> ;Bone Marrow Transplantation. 2000 Jan 1
42 citations
Long-term discordant xenogeneic (porcine-to-primate) bone marrow engraftment in a monkey treated with porcine-specific growth factors.
T. Sablinski, David W. Emery, Rodney L. Monroy, Robert J. Hawley, Y. Xu, Pierre Gianello, Thomas Lorf, Tomasz Kozlowski, M. Bailin, David K. C. Cooper, Cosimi Ab, Davi...> ;Transplantation. 1999 Apr 15
Tolerance to solid organ transplants through transfer of MHC class II genes.
Sonntag, K. C., Emery, D. W., Yasumoto, A., Haller, G., Germana, S., Sablinski, T., Shimizu, A., Yamada, K., Shimada, H., Arn, S., Sachs, D. H., LeGuern, C.> ;J Clin Invest. 2001 Jan
Tolerance in a concordant nonhuman primate model.
Bartholomew, A. M., Powelson, J., Sachs, D. H., Bailin, M., Boskovic, S., Colvin, R., Hong, H. Z., Johnson, M., Kimikawa, M., LeGuern, A., Meehan, S., Sablinski, T., W...> ;Transplantation. 1999 Dec 15
Removal of anti-porcine natural antibodies from human and nonhuman primate plasma in vitro and in vivo by a Galalpha1-3Galbeta1-4betaGlc-X immunoaffinity column.
Xu, Y., Lorf, T., Sablinski, T., Gianello, P., Bailin, M., Monroy, R., Kozlowski, T., Awwad, M., Cooper, D. K., Sachs, D. H.> ;Transplantation. 1998 Jan 27
Expression of an allogeneic MHC DRB transgene, through retroviral transduction of bone marrow, induces specific reduction of alloreactivity.
Emery, D. W., Sablinski, T., Shimada, H., Germana, S., Gianello, P., Foley, A., Shulman, S., Arn, S., Fishman, J., Lorf, T., Nickeleit, V., Colvin, R. B., Sachs, D. H....> ;Transplantation. 1997 Nov 27
Apheresis and column absorption for specific removal of Gal-alpha-1,3 Gal natural antibodies in a pig-to-baboon model.
Kozlowski, T., Fuchimoto, Y., Monroy, R., Bailin, M., Martinez-Ruiz, R., Foley, A., Xu, Y., Awwad, M., Fishman, J., Andrews, D., Ritzenthaler, J., Sablinski, T., Ierin...> ;Transplant Proc. 1997 Feb 01
A study of tolerance in a concordant xenograft model.
Bartholomew, A. M., Cosimi, A. B., Sachs, D. H., Bailin, M., Boskovic, S., Colvin, R., Hong, H., Johnson, M., Kimikawa, M., Leguern, A., Meehan, S., Sablinski, T., Wee...> ;Transplant Proc. 1997 Feb 01
Mechanism of tolerance following class II gene transduction of autologous swine bone marrow.
Yasumoto, A., Yamada, K., Sablinski, T., LeGuern, C., Sykes, M., Sachs, D. H.> ;Transplant Proc. 1997 Feb 01
Pig to monkey bone marrow and kidney xenotransplantation.
Sablinski, T., Gianello, P. R., Bailin, M., Bergen, K. S., Emery, D. W., Fishman, J. A., Foley, A., Hatch, T., Hawley, R. J., Kozlowski, T., Lorf, T., Meehan, S., Monr...> ;Surgery. 1997 Apr
A mixed chimerism approach to renal transplantation between concordant nonhuman primate species.
Powelson, J., Bailin, M., Bartholomew, A., Boskebick, S., Colvin, R., Hong, H. Z., Johnson, M., Kimikawa, M., Sablinski, T., Wee, S. L., Sachs, D., Cosimi, A. B.> ;Transplant Proc. 1996 Apr
Retrovirus-mediated transfer and expression of swine MHC class II genes in CD34+ monkey stem cells.
Banerjee, P. T., Ierino, F., Kaynor, G. C., Giovino, M., Sablinski, T., Emery, D. W., Rosa, M. D., LeGuern, C., Sachs, D. H., Monroy, R. L.> ;Transplant Proc. 1996 Apr
Rapamycin treatment prevents and/or erases sensitization and abrogates accelerated rejection of vascularized organ allografts.
Schmidbauer, G., Hancock, W. W., Wasowska, B. A., Sablinski, T., Kupiec-Weglinski, J. W.> ;Transplant Proc. 1993 Feb
Modulation of acute and hyperacute rejection of xenografts in concordant hamster-to-rat combination.
Sablinski, T., Hancock, W. W., Wasowska, B. A., Schmidbauer, G., Baldwin, W. M., Kut, J. P., Milford, E. L., Kupiec-Weglinski, J. W.> ;Transplant Proc. 1993 Feb
Porcine-to-primate orthotopic liver transplantation.
Powelson, J., Cosimi, A. B., Austen, W., Bailen, M., Colvin, R., Gianello, P., Sablinski, T., Lorf, T., Kawai, T., Tanaka, M.> ;Transplant Proc. 1994 Jun
Xenotransplantation from pig to cynomolgus monkey: the potential for overcoming xenograft rejection through induction of chimerism.
Tanaka, M., Latinne, D., Gianello, P., Sablinski, T., Lorf, T., Bailin, M., Nickeleit, V., Colvin, R., Lebowitz, E., Sykes, M.> ;Transplant Proc. 1994 Jun
Induction of tolerance to pig antigens in mice grafted with fetal pig thymus/liver grafts.
Lee, L. A., Gritsch, H. A., Arn, J. S., Emery, D. W., Glaser, R. M., Sablinski, T., Sachs, D. H., Sykes, M.> ;Transplant Proc. 1994 Jun
Specific tolerance across a discordant xenogeneic transplantation barrier.
Lee, L. A., Gritsch, H. A., Sergio, J. J., Arn, J. S., Glaser, R. M., Sablinski, T., Sachs, D. H., Sykes, M.> ;Proc Natl Acad Sci U S A. 1994 Nov 8
The importance of nonimmune factors in reconstitution by discordant xenogeneic hematopoietic cells.
Gritsch, H. A., Glaser, R. M., Emery, D. W., Lee, L. A., Smith, C. V., Sablinski, T., Arn, J. S., Sachs, D. H., Sykes, M.> ;Transplantation. 1994 Mar 27
In vivo treatment with monoclonal antibodies directed against CD4 and CD8 antigens in miniature swine.
Smith, C. V., Sablinski, T., Arn, J. S., Myers, D. E., Rosengard, B. R., Uckun, F. M., Sachs, D. H.> ;J Immunother Emphasis Tumor Immunol. 1994 Aug
Bone marrow culture and transduction of stem cells in a miniature swine model.
Emery, D. W., Sablinski, T., Arn, J. S., LeGuern, C., Sachs, D. H.> ;Blood Cells. 1994
[Some words on transplantation science].
Sabli?ski, T.> ;Pieleg Polozna. 1987
[Kidney transplantation].
Sabli?ski, T.> ;Pieleg Polozna. 1987
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