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Tuan Tran, MD, Infectious Disease, Indianapolis, IN, Indiana University Health University Hospital

TuanManhTranMDPhD

Infectious Disease • Indianapolis, IN

International Health, Travel & Tropical

Associate Professor of Medicine, Pediatrics, and Microbiology & Immunology

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Summary

  • Malaria is a significant public health burden caused by parasites of the genus Plasmodium, afflicting ~200 million people globally per annum. Our laboratory is focused on defining mechanisms of host immunity to malaria in endemic settings. By investigating naturally acquired immunity to malaria, we can gain a better understanding as to why malaria vaccines that perform well in naïve donors have performed less effectively in the field. To this end, we apply systems biology approaches such as transcriptomics, multi-parameter immunological analyses, and proteomics to elucidate the complex immune responses to P. falciparum during both asymptomatic and symptomatic infections. To conduct these studies, we collaborate with investigators in Mali and Kenya to collect clinical data and biospecimens from well-characterized cohorts of children and adults living in areas highly endemic for malaria. This unbiased, systems biology approach allows us to generate new hypotheses related to immunity to human malaria, which we further validate and test at both the population and mechanistic level.

Education & Training

  • National Institutes of Health Clinical Center
    National Institutes of Health Clinical CenterFellowship, Infectious Disease, 2010 - 2015
  • Johns Hopkins University
    Johns Hopkins UniversityResidency, Internal Medicine, 2007 - 2010
  • Emory University School of Medicine
    Emory University School of MedicineClass of 2007
  • Emory University
    Emory UniversityPhD, Immunology and Molecular Pathogenesis, 2001 - 2005
  • University of Florida
    University of FloridaB.S., Zoology, 1999
  • Universiteit Utrecht
    Universiteit UtrechtBachelor's

Certifications & Licensure

  • IN State Medical License
    IN State Medical License 2015 - 2025
  • MD State Medical License
    MD State Medical License 2010 - 2015
  • American Board of Internal Medicine Internal Medicine
  • American Board of Internal Medicine Infectious Disease

Awards, Honors, & Recognition

  • Fellow Infectious Diseases Society of America, 2022
  • Doris Duke Clinical Scientist Development Award Doris Duke Charitable Foundation, 2018
  • Showalter Young Investigator Award Showalter Research Trust, 2018

Publications & Presentations

PubMed

Journal Articles

  • Whole-Blood Transcriptional Signatures Composed of Erythropoietic and Nrf2-Regulated Genes Differ Between Cerebral Malaria and Severe Malarial Anemia  
    Tuan M Tran, Chandy C John, Gregory S Park, The Journal of Infectious Diseases
  • Oa Extent and Dynamics of Polymorphism in the Malaria Vaccine Candidate Plasmodium Falciparum Reticulocyte–Binding Protein Homologue-5 in Kalifabougou, Mali  
    Christopher V Plowe, Tuan M Tran, The American Journal of Tropical Medicine and Hygiene
  • Synergistic Malaria Vaccine Combinations Identified by Systematic Antigen Screening  
    Tuan Tran, MD, Proceedings of the National Academy of Sciences

Abstracts/Posters

  • A whole-blood transcriptional signature predicts parasite control and protection from malaria fever during natural Plasmodium falciparum infection.
    Tran TM, Ongoiba A, Jones M, Skinner J, Shanping L, Doumbo S, Kone, Y, Bathily A, Sangala J, Doumbo O, Venepally P, Kayentao K, Traore B, Kirkness E, Crompton PD, ID Week 2014, Philadelphia, PA, 1/9/2014
  • RNA-seq analysis of whole blood from malaria-susceptible and immune children reveals an early pro-inflammatory response to P. falciparum infection that correlates with...
    Tran TM, Ongoiba A, Jones M, Skinner J, Li S, Doumbo S, Doumtabe D, Kone Y, Bathily A, Dia S, Niangaly M, Traore A, Dara C, Sangala J, Doumbo OK, Venepally P, Kayentao..., 63st AnnualMeeting of the American Society of Tropical Medicine and Hygiene, New Orleans, LA, 1/2/2014
  • A prospective analysis of Plasmodium falciparum infection risk from infancy to adulthood in an area of intense, seasonal transmission in Mali.
    Tran TM, Portugal S, Li S, Doumtabe D, Doumbo S, Dia S, Aboudramane B, Anye J, Traore A, Huang CY, Diakate S, Fairhurst RM, Valenzuela J, Kayentao K, Ongoiba A, Doumbo..., 61st AnnualMeeting of the American Society of Tropical Medicine and Hygiene, Atlanta, GA, 1/11/2012
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Lectures

  • "Insights into Malaria Immunity from the Kalifabougou Cohort using Systems Biology Approaches" 
    Emory Vaccine Center, Emory University, Atlanta, GA - 1/18/2014
  • "Naturally acquired Plasmodium falciparum RH5-specific IgG antibodies correlate with protection from malaria" (Co-chair and speaker, American Committee of Molecular, C... 
    Washington, DC - 1/14/2013
  • "A novel method for assessing malaria risk reveals a correlation between Plasmodium falciparum RH5-specific IgG and protection from malaria" 
    National Institutes of Health, Bethesda, MD - 1/7/2013
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Other

  • Evaluation of the Plasmodium vivax reticulocyte binding protein 1 as a vaccine candidate. 
    Tran, TM, Emory University, 174 pages (UMI No. 3176069)
    Atlanta, GA - 1/1/2005

Authored Content

  • Confirmed COVID-19 (SARS-CoV-2) cases in the United States 2020 Data Visualization AppMarch 2020
  • Kalifabougou malaria systems study data visualization dashboardSeptember 2019

Press Mentions

  • Biomarker Predicts if Someone Infected with Malaria Will Get Sick
    Biomarker Predicts if Someone Infected with Malaria Will Get SickSeptember 3rd, 2019
  • Five New Malaria Targets That Could Lead to an Effective Vaccine
    Five New Malaria Targets That Could Lead to an Effective VaccineOctober 23rd, 2017
  • Mosquito Control Starts Now as Temperatures Warm Up
    Mosquito Control Starts Now as Temperatures Warm UpMay 18th, 2016
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Grant Support

  • Evaluating the role of P53 pathways in malariaNational Institute of Allergy and Infectious Diseases2021–2026
  • Validation and characterization of antibody responses to Plasmodium falciparum antigens identified by protein array screeningNational Institute of Allergy and Infectious Diseases2021–2023
  • Investigating gene regulatory networks in immune cells of children who differ in susceptibility to malaria infection using single-cell approachesNational Institute of Allergy and Infectious Diseases2021–2023
  • Defining clinical and sterile immunity to Plasmodium falciparum infection using systems biology approachesNational Institute of Allergy and Infectious Diseases2017–2022
  • Systems analysis to understand protective immunity induced by an attenuated sporozoite malaria vaccine in African infantsDoris Duke Charitable Foundation2018–2021

Other Languages

  • Vietnamese

Hospital Affiliations

External Links

Dr. Tuan Tran, Dr. Tuan Tran, MD, Dr. T Tran, Dr. Tuan Manh Tran