ValerieIBrownMDPhD

Pediatric Hematology & Oncology • Hershey, PA

Pediatric Hematologic Oncology

Associate Professor of Pediatrics and Director of Experimental Therapeutics for the Division of Pediatric Hematology/Oncology

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Office
500 University Dr
MC H085, P.O. Box 850
Hershey, PA 17033
Phone+1 717-531-6012

Fax+1 717-531-4789
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Education & Training

Children's Hospital of PhiladelphiaFellowship, Pediatric Hematology/Oncology, 1999 - 2002
Children's Hospital of PhiladelphiaResidency, Pediatrics, 1996 - 1999
Perelman School of Medicine at the University of PennsylvaniaClass of 1996
Perelman School of Medicine at the University of Pennsylvania (formerly known as the University of Pennsylvania School of Medicine)PhD, 1987 - 1992

Certifications & Licensure

PA State Medical License 1997 - 2024
TN State Medical License 2011 - 2014
American Board of Pediatrics Pediatric Hematology-Oncology

Clinical Trials

Molecular-Guided Therapy for Childhood Cancer Start of enrollment: 2014 Jul 08
Completed
Not Applicable
Pediatric Precision Laboratory Advanced Neuroblastoma Therapy Start of enrollment: 2015 Sep 01
Recruiting
Phase 2
Trial of Tolcapone With Oxaliplatin for Neuroblastoma Start of enrollment: 2015 Dec 01
Terminated
Phase 1
Neuroblastoma Maintenance Therapy Trial Start of enrollment: 2016 Feb 01
Recruiting
Phase 2
A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations Start of enrollment: 2020 Mar 12
Recruiting
Phase 1, Phase 2
Carfilzomib in Combination With Cyclophosphamide and Etoposide for Children Start of enrollment: 2016 Feb 16
Completed
Phase 1
Roles: Contact, Principal Investigator
Study of Talazoparib in Combination With Chemotherapy in Relapsed Pediatric AML to Determine Safety and Efficacy Start of enrollment: 2023 Feb 23
Recruiting
Phase 1
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

Molecular-guided therapy for the treatment of patients with relapsed and refractory childhood cancers: a Beat Childhood Cancer Research Consortium trial.
Giselle L Saulnier Sholler, Genevieve Bergendahl, Elizabeth C Lewis, Jacqueline Kraveka, William Ferguson, Abhinav B Nagulapally, Karl Dykema, Valerie I Brown, Michael...> ;Genome Medicine. 2024 Feb 12
Allogeneic hematopoietic cell transplantation for blastic plasmacytoid dendritic cell neoplasm: a CIBMTR analysis.
Abid, M. B., Hemant S Murthy, Mei-Jie Zhang, Karen Chen, Sairah Ahmed, Uday Deotare, Siddhartha Ganguly, Ankit Kansagra, Fotios V Michelis, Taiga Nishihori, Mrinal Pat...> ;Blood Advances. 2023 Nov 28
3 citations
Chronic pain in children and adolescents diagnosed with cancer: the challenge of mitigating the pain and the potential of integrating exercise into pain management.
Maxime Caru, Nicole M Alberts, Michelle C Freeman, Smita C Dandekar, Pooja Rao, Daniel J McKeone, Valerie I Brown, Lisa M McGregor, Kathryn H Schmitz> ;Supportive Care in Cancer. 2023 Mar 23
Correction to: Impact of pre-transplant induction and consolidation cycles on AML allogeneic transplant outcomes: a CIBMTR analysis in 3113AML patients.
Michael Boyiadzis, Mei-Jie Zhang, Karen Chen, Hisham Abdel-Azim, Muhammad Bilal Abid, Mahmoud Aljurf, Ulrike Bacher, Talha Badar, Sherif M Badawy, Minoo Battiwalla, Ne...> ;Leukemia. 2023 May 1
Donor HLA mismatch promotes full donor T-cell chimerism in the allogeneic stem cell transplant with reduced-intensity conditioning and post-transplant cyclophosphamide...
Joseph Cioccio, Kevin Rakszawski, Hong Zheng, Myles Nickolich, Seema Naik, Baldeep Wirk, Witold Rybka, Christopher Ehmann, Brooke Silar, Caitlin Vajdic, Neal Shah, Leo...> ;Annals of Hematology. 2023 Mar 1
3 citations
A pilot study of genomic-guided induction therapy followed by immunotherapy with difluoromethylornithine maintenance for high-risk neuroblastoma.
Jacqueline M Kraveka, Elizabeth C Lewis, Genevieve Bergendahl, William Ferguson, Javier Oesterheld, Elizabeth Kim, Abhinav B Nagulapally, Karl J Dykema, Valerie I Brow...> ;Cancer Reports. 2022 Nov 1
3 citations
Impact of pre-transplant induction and consolidation cycles on AML allogeneic transplant outcomes: a CIBMTR analysis in 3113 AML patients.
Michael Boyiadzis, Mei-Jie Zhang, Karen Chen, Hisham Abdel-Azim, Muhammad Bilal Abid, Mahmoud Aljurf, Ulrike Bacher, Talha Badar, Sherif M Badawy, Minoo Battiwalla, Ne...> ;Leukemia. 2023 May 1
1 citations
Natural Killer Cell Alloreactivity Predicted By Killer Cell Immunoglobulin-Like Receptor Ligand Mismatch Does Not Impact Engraftment in Umbilical Cord Blood and Haploi...
Folashade Otegbeye, Marcelo A Fernandez Vina, Tao Wang, Yung-Tsi Bolon, Aleksandr Lazaryan, Amer Beitinjaneh, Vijaya Raj Bhatt, Paul Castillo, Steven G E Marsh, Gerhar...> ;Transplantation and Cellular Therapy. 2022 Aug 1
13 citations
A scoping review to map the evidence of physical activity interventions in post-treatment adolescent and young adult cancer survivors.
Maxime Caru, Ariane Levesque, Pooja Rao, Smita Dandekar, Christopher Terry, Valerie Brown, Lisa McGregor, Kathryn Schmitz> ;Critical Reviews in Oncology/hematology. 2022 Mar 1
8 citations
Genomic and Transcriptomic Analysis of Relapsed and Refractory Childhood Solid Tumors Reveals a Diverse Molecular Landscape and Mechanisms of Immune Evasion
Sara A. Byron, William P.D. Hendricks, Abhinav Nagulapally, Jacqueline M. Kraveka, William S. Ferguson, Valerie I. Brown, Don E Eslin, Deanna Mitchell, Albert Corneliu...> ;Cancer Research. 2021 Oct 5
1 citations
Improved outcome in AML relapse after allogeneic transplant with high-intensity chemotherapy followed by 2nd allogeneic stem cell transplant or donor lymphocyte infusion.
Neal Shah, Kevin Rakszawski, Myles Nickolich, Christopher Ehmann, Baldeep Wirk, Seema Naik, Witold B. Rybka, Hong Zheng, Joseph Mierski, Brooke Silar, Gina Mackey, Rob...> ;Annals of Hematology. 2021 Jul 29
3 citations
Genetics of HLA Peptide Presentation and Impact on Outcomes in HLA-Matched Allogeneic Hematopoietic Cell Transplantation.
Charlotte McIlwaine Story, Tao Wang, Vijaya Raj Bhatt, Minoo Battiwalla, Sherif M. Badawy, Malek Kamoun, Loren Gragert, Valerie I. Brown, Lee Ann Baxter-Lowe, Steven G...> ;Transplantation and Cellular Therapy. 2021 Jul 1
2 citations
A new record for a massive Porites colony at Ta'u Island, American Samoa.
Georgia Coward, Alice Lawrence, Natasha Ripley, Valerie I. Brown, Mareike Sudek, Eric W. Brown, Ian Moffitt, Bert Fuiava, Bernardo Vargas-Ángel> ;Scientific Reports. 2020 Dec 7
3 citations
Specific Class I HLA Supertypes but Not HLA Zygosity or Expression Are Associated with Outcomes following HLA-Matched Allogeneic Hematopoietic Cell Transplant: HLA Sup...
Christine Camacho-Bydume, Tao Wang, Jennifer A. Sees, Marcelo Fernandez-Vina, Muhammad Bilal Abid, Medhat Askar, Amer Beitinjaneh, Valerie I. Brown, Paul Castillo, Sau...> ;Transplantation and Cellular Therapy. 2021 Feb 1
31 citations
A subset analysis of a phase II trial evaluating the use of DFMO as maintenance therapy for high-risk neuroblastoma
Elizabeth C. Lewis, Jacqueline M. Kraveka, William S. Ferguson, Don Eslin, Valerie I. Brown, Genevieve Bergendahl, William Roberts, Randal K. Wada, Javier Oesterheld, ...> ;International Journal of Cancer. 2020 Dec 1
34 citations
Incidence, Risk Factors, and Outcomes of Patients Who Develop Mucosal Barrier Injury-Laboratory Confirmed Bloodstream Infections in the First 100 Days After Allogeneic...
Christopher E. Dandoy, Soyoung Kim, Min Chen, Kwang Woo Ahn, Monica I. Ardura, Valerie I. Brown, Saurabh Chhabra, Miguel Angel Diaz, Christopher C. Dvorak, Nosha Farha...> ;JAMA Network Open. 2020 Jan 3
29 citations
Bloodstream Infection Due to Vancomycin-resistant Enterococcus Is Associated With Increased Mortality After Hematopoietic Cell Transplantation for Acute Leukemia and M...
Genovefa A. Papanicolaou, Celalettin Ustun, Jo Anne H. Young, Min Chen, Soyoung Kim, Kwang Woo Ahn, Krishna V. Komanduri, Caroline A. Lindemans, Jeffery J. Auletta, Ma...> ;Clinical Infectious Diseases. 2019 Oct 30
17 citations
Survival outcomes of allogeneic hematopoietic cell transplants with EBV-positive or EBV-negative post-transplant lymphoproliferative disorder, A CIBMTR study.
Seema Naik, Marcie L. Riches, Parameswaran Hari, Soyoung Kim, Min Chen, Carlos Bachier, Paul J. Shaughnessy, Joshua A. Hill, Per Ljungman, Minoo Battiwalla, Saurabh Ch...> ;Transplant Infectious Disease. 2019 Oct 1
9 citations
Increased overall and bacterial infections following myeloablative allogeneic HCT for patients with AML in CR1
Celalettin Ustun, Soyoung Kim, Min Chen, Amer Beitinjaneh, Valerie I. Brown, Parastoo B. Dahi, Andrew Daly, Miguel Angel Diaz, Cesar O. Freytes, Siddhartha Ganguly, Sh...> ;Blood Advances. 2019 Sep 10
45 citations
Bacterial blood stream infections (BSIs), particularly post-engraftment BSIs, are associated with increased mortality after allogeneic hematopoietic cell transplantation
Celalettin Ustun, Jo Anne H. Young, Genovefa A. Papanicolaou, Soyoung Kim, Kwang Woo Ahn, Min Chen, Hisham Abdel-Azim, Mahmoud Aljurf, Amer Beitinjaneh, Valerie I. Bro...> ;Bone Marrow Transplantation. 2019 Aug 1
24 citations
Outcomes after Second Hematopoietic Cell Transplantation in Children and Young Adults with Relapsed Acute Leukemia.
Troy C. Lund, Kwang Woo Ahn, Heather R. Tecca, Megan V. Hilgers, Hisham Abdel-Azim, Allistair Abraham, Miguel Angel Diaz, Sherif M. Badawy, Larisa Broglie, Valerie I. ...> ;Biology of Blood and Marrow Transplantation. 2019 Feb 1
58 citations
Maintenance DFMO Increases Survival in High Risk Neuroblastoma
Giselle Saulnier Sholler, William S. Ferguson, Genevieve Bergendahl, Jeffrey P. Bond, Kathleen A. Neville, Don Eslin, Valerie I. Brown, William Roberts, Randal K. Wada...> ;Scientific Reports. 2018 Sep 27
145 citations
Dasatinib plus intensive chemotherapy in children, adolescents, and young adults with philadelphia chromosome–positive acute lymphoblastic leukemia: Results of childre...
William B. Slayton, Kirk R. Schultz, John A. Kairalla, Meenakshi Devidas, Xinlei Mi, Michael A. Pulsipher, Bill H. Chang, Charles G. Mullighan, Ilaria Iacobucci, Lewis...> ;Journal of Clinical Oncology. 2018 May 29
12 citations
Personalized Prognostic Risk Score for Long-Term Survival for Children with Acute Leukemia after Allogeneic Transplantation.
Menachem Bitan, Kwang Woo Ahn, Heather R. Millard, Michael A. Pulsipher, Hisham Abdel-Azim, Jeffery J. Auletta, Valerie I. Brown, Ka Wah Chan, Miguel Angel Diaz, Andre...> ;Biology of Blood and Marrow Transplantation. 2017 Sep 1
40 citations
Hematopoietic Stem Cell Transplantation Activity in Pediatric Cancer between 2008 and 2014 in the United States: A Center for International Blood and Marrow Transplant...
Pooja Khandelwal, Heather R. Millard, Elizabeth Thiel, Hisham Abdel-Azim, Allistair Abraham, Jeffery J. Auletta, Farid Boulad, Valerie I. Brown, Bruce M. Camitta, Ka W...> ;Biology of Blood and Marrow Transplantation. 2017 Aug 1
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