WilliamLBrownMD

Psychiatry • Spokane, WA

Physician

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Office
906 W 2nd Ave Ste 600
Spokane, WA 99201
Phone+1 509-458-5889
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Summary

Dr. William Brown, MD is a board certified psychiatrist in Spokane, Washington. He is currently licensed to practice medicine in Washington and Oregon. He is affiliated with Mann-Grandstaff Veterans Affairs Medical Center.

Education & Training

Oregon Health & Science UniversityResidency, Psychiatry, 1991 - 1995
Oregon Health and Science University School of MedicineClass of 1991

Certifications & Licensure

OR State Medical License 1992 - Present
WA State Medical License 2004 - 2023
American Board of Psychiatry and Neurology Psychiatry

Publications & Presentations

PubMed

A lentivirus-based system for Cas9/gRNA expression and subsequent removal by Cre-mediated recombination.
Carpenter, M. A.,Law, E. K.,Serebrenik, A.,Brown, W. L.,Harris, R. S.> ;Methods. 2018 Dec 24
Natural APOBEC3C variants can elicit differential HIV-1 restriction activity.
Anderson, B. D.,Ikeda, T.,Moghadasi, S. A.,Martin, A. S.,Brown, W. L.,Harris, R. S.> ;Retrovirology. 2018 Dec 19
Epstein-Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity.
Cheng, A. Z.,Yockteng-Melgar, J.,Jarvis, M. C.,Malik-Soni, N.,Borozan, I.,Carpenter, M. A.,McCann, J. L.,Ebrahimi, D.,Shaban, N. M.,Marcon, E.,Greenblatt, J.,Brown, W....> ;Nat Microbiol. 2018 Nov 14
Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease.
Ebrahimi, D.,Richards, C. M.,Carpenter, M. A.,Wang, J.,Ikeda, T.,Becker, J. T.,Cheng, A. Z.,McCann, J. L.,Shaban, N. M.,Salamango, D. J.,Starrett, G. J.,Lingappa, J. R...> ;Nat Commun. 2018 Oct 10
APOBEC3H Subcellular Localization Determinants Define Zipcode for Targeting HIV-1 for Restriction.
Salamango, D. J.,Becker, J. T.,McCann, J. L.,Cheng, A. Z.,Demir, Ö. Ö.,Amaro, R. E.,Brown, W. L.,Shaban, N. M.,Harris, R. S.> ;Mol. Cell. Biol.. 2018 Sep 19
APOBEC3B Nuclear Localization Requires Two Distinct N-Terminal Domain Surfaces.
Salamango, D. J.,McCann, J. L.,Demir, Ö. Ö.,Brown, W. L.,Amaro, R. E.,Harris, R. S.> ;J. Mol. Biol.. 2018 May 23
Simian Immunodeficiency Virus Vif and Human APOBEC3B Interactions Resemble Those between HIV-1 Vif and Human APOBEC3G.
Wang, J.,Shaban, N. M.,Land, A. M.,Brown, W. L.,Harris, R. S.> ;J. Virol.. 2018 Apr 06
9 citations
Prevalence and Associations of Central-Peripheral Rivalry-Type Diplopia in Patients With Epiretinal Membrane.
Kevin K. Veverka, Sarah R. Hatt, David A. Leske, William L. Brown, Andrew J. Barkmeier, Raymond Iezzi, Jonathan M. Holmes> ;JAMA Ophthalmology. 2017 Dec 1
The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism.
Shaban, N. M.,Shi, K.,Lauer, K. V.,Carpenter, M. A.,Richards, C. M.,Salamango, D.,Wang, J.,Lopresti, M. W.,Banerjee, S.,Levin-Klein, R.,Brown, W. L.,Aihara, H.,Harris,...> ;Mol. Cell. 2018 Jan 02
20 citations
Causes of Diplopia in Patients With Epiretinal Membranes.
Kevin K. Veverka, Sarah R. Hatt, David A. Leske, William L. Brown, Raymond Iezzi, Jonathan M. Holmes> ;American Journal of Ophthalmology. 2017 Jul 1
40 citations
APOBEC3G expression correlates with T cell infiltration and improved clinical outcomes in high-grade serous ovarian carcinoma
Brandon Leonard, Gabriel J. Starrett, Matthew J. Maurer, Ann L. Oberg, Mieke Van Bockstal, Jo Van Dorpe, Olivier De Wever, Jozien Helleman, Anieta M. Sieuwerts, Els M....> ;Clinical Cancer Research. 2016 Sep 15
Lineage-Specific Viral Hijacking of Non-canonical E3 Ubiquitin Ligase Cofactors in the Evolution of Vif Anti-APOBEC3 Activity.
Kane JR, Stanley DJ, Hultquist JF, Johnson JR, Mietrach N, Binning JM, Jónsson SR, Barelier S, Newton BW, Johnson TL, Franks-Skiba KE, Li M, Brown WL, Gunnarsson HI, A...> ;Cell Rep. 2015-05-26
6 citations
Retinal and pontine striations: neurodiagnostic signs of autosomal recessive spastic ataxia of Charlevoix-Saguenay.
Jacqueline A. Leavitt, Wolfgang Singer, William L. Brown, Jose S. Pulido, Michael C. Brodsky> ;Journal of Neuro-Ophthalmology. 2014 Dec 1
25 citations
Comprehensive assessment of genetic variants within TCF4 in Fuchs' endothelial corneal dystrophy.
Eric D. Wieben, Ross A. Aleff, Bruce W. Eckloff, Elizabeth J. Atkinson, Saurabh Baheti, Sumit Middha, William L. Brown, Sanjay V. Patel, Jean Pierre A. Kocher, Keith H...> ;Investigative Ophthalmology & Visual Science. 2014 Aug 28
20 citations
Catalytic activity of APOBEC3F is required for efficient restriction of Vif-deficient human immunodeficiency virus.
John S. Albin, William L. Brown, Reuben S. Harris> ;Virology. 2014 Feb 1
124 citations
APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma
Brandon Leonard, Steven N. Hart, Michael B. Burns, Michael A. Carpenter, Nuri A. Temiz, Anurag Rathore, Rachel Isaksson Vogel, Jason B. Nikas, Emily K. Law, William L....> ;Cancer Research. 2013 Dec 15
The local dinucleotide preference of APOBEC3G can be altered from 5'-CC to 5'-TC by a single amino acid substitution.
Rathore A, Carpenter MA, Demir Ö, Ikeda T, Li M, Shaban NM, Law EK, Anokhin D, Brown WL, Amaro RE, Harris RS> ;J. Mol. Biol.. 2013-11-15
Endogenous APOBEC3A DNA cytosine deaminase is cytoplasmic and nongenotoxic.
Land AM, Law EK, Carpenter MA, Lackey L, Brown WL, Harris RS> ;J. Biol. Chem.. 2013-06-14
APOBEC3B and AID have similar nuclear import mechanisms.
Lackey L, Demorest ZL, Land AM, Hultquist JF, Brown WL, Harris RS> ;J. Mol. Biol.. 2012-06-22
First-In-Class Small Molecule Inhibitors of the Single-Strand DNA Cytosine Deaminase APOBEC3G.
Li, M., Shandilya, S., Carpenter, M., Rathore, A., Brown, W., Perkins, A., Harki, D.A., Solberg, J., Hook, D., Pandey, K.K., Parniak, M.A., Johnson, J., Krogan, N.J., ...> ;ACS Chem Biol. 2012 Mar 16
Human and Rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H Demonstrate a Conserved Capacity to Restrict Vif-deficient HIV-1.
Hultquist, J.F., Lengyel, J.A., Refsland, E.W., Larue, R.S., Lackey, L., Brown, W.L., Harris, R.S.> ;J Virol. 2011 Nov
2 citations
Vision rehabilitation of persons with age related macular degeneration.
Dennis W. Siemsen, William L. Brown> ;Seminars in Ophthalmology. 2011 May 24
Copy number variation in the complement factor H-related genes and age-related macular degeneration.
Kubista, K.E., Tosakulwong, N., Wu, Y., Ryu, E., Roeder, J.L., Hecker, L.A., Baratz, K.H., Brown, W.L., Edwards, A.O.> ;Mol Vis. 2011
Use of dissimilar trifocals to equalize fields of view for asymmetric orbital positions secondary to progressive facial hemiatrophy.
Brown, W.L., Bite, U.> ;Ophthal Plast Reconstr Surg. 2011-01-01
A single amino acid in human APOBEC3F alters susceptibility to HIV-1 Vif.
Albin, J.S., LaRue, R.S., Weaver, J.A., Brown, W.L., Shindo, K., Harjes, E., Matsuo, H., Harris, R.S.> ;J Biol Chem. 2010 Dec 24
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Press Mentions

Glasgow Skeptics: “What Phrenology Teaches Us About Ourselves”March 18th, 2019

Hospital Affiliations

Mann-Grandstaff Veterans Affairs Medical CenterSpokane, Washington