WilliamEGillandersMD

General Surgery • Saint Louis, MO

Breast, Endocrine, Surgical Oncology (Other than Breast)

Professor, Surgery, Washington University School of Medicine

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Office
4921 Parkview Pl
Ste 7C
Saint Louis, MO 63110
Phone+1 314-747-0072

Fax+1 314-454-5509
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Education & Training

Washington University/B-JH/SLCH ConsortiumResidency, Surgery, 1991 - 1999
Duke University School of MedicineClass of 1991

Certifications & Licensure

MO State Medical License 2005 - 2025
SC State Medical License 1999 - 2005
American Board of Surgery Surgery

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification Allscripts Enterprise EHR, Allscripts, 2012
Fellow (FACS) American College of Surgeons

Clinical Trials

Effect of Neoadjuvant or Adjuvant Systemic Therapy on Breast Cancers, Bone Marrow Cancer Cells, and Circulating Cancer Cells Start of enrollment: 2005 Sep 14
Recruiting
A Study to Determine the Clinical Significance of Molecular Detection of Breast Cancer in the Blood of Stage IV Breast Cancer Patients Start of enrollment: 2005 Nov 01
Completed
Not Applicable
LDE225 in Treating Patients With Stage II-III Estrogen Receptor- and HER2-Negative Breast Cancer Start of enrollment: 2014 Apr 01
Withdrawn
Phase 2
Effect of Trastuzumab on Disease Free Survival in Early Stage HER2-Negative Breast Cancer Patients With ERBB2 Expressing Disseminated Tumor Cells Start of enrollment: 2013 Dec 19
Terminated
Phase 2
Axillary Ultrasound With or Without Sentinel Lymph Node Biopsy in Detecting the Spread of Breast Cancer in Patients Receiving Breast Conservation Therapy Start of enrollment: 2013 Apr 04
Terminated
Not Applicable
Paclitaxel and BKM120 Before Surgery in Treating Patients With Stage II or III Estrogen Receptor-Positive and HER2-Negative Breast Cancer Start of enrollment: 2014 Aug 01
Withdrawn
Phase 2
Neoadjuvant Treatment of Triple Negative Breast Cancer Patients With Docetaxel and Carboplatin to Assess Anti-tumor Activity Start of enrollment: 2014 Jul 07
Terminated
Phase 2
Safety and Immune Response to a Mammaglobin-A DNA Vaccine In Breast Cancer Patients Undergoing Neoadjuvant Endocrine Therapy Start of enrollment: 2015 Jan 07
Active, not recruiting
Phase 1
Safety and Immunogenicity of a Personalized Synthetic Long Peptide Breast Cancer Vaccine Strategy in Patients With Persistent Triple-Negative Breast Cancer Following Neoadjuvant Chemotherapy Start of enrollment: 2015 Sep 29
Withdrawn
Phase 1
Testing the Addition of an Individualized Vaccine to Nab-Paclitaxel, Durvalumab and Tremelimumab and Chemotherapy in Patients With Metastatic Triple Negative Breast Cancer Start of enrollment: 2021 Apr 13
Recruiting
Phase 2
Expanded Access Neoantigen Vaccine in Solid Tumors
No longer available
Neoantigen Peptide Vaccine Strategy in Pancreatic Cancer Patients Following Surgical Resection and Adjuvant Chemotherapy Start of enrollment: 2020 Feb 13
Terminated
Phase 1
Neoantigen Vaccines in Pancreatic Cancer in the Window Prior to Surgery Start of enrollment: 2022 Dec 15
Active, not recruiting
Phase 1
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

3 citations
Epigenetic regulation during cancer transitions across 11 tumour types.
Nadezhda V Terekhanova, Alla Karpova, Wen-Wei Liang, Alexander Strzalkowski, Siqi Chen, Yize Li, Austin N Southard-Smith, Michael D Iglesia, Michael C Wendl, Reyka G J...> ;Nature. 2023 Nov 1
Molecular characteristics of isthmus papillary thyroid cancers: Supporting evidence for unfavorable clinical behavior.
Eileen R Smith, C Corbin Frye, T K Pandian, William E Gillanders, John A Olson, Taylor C Brown, Sina Jasim> ;American Journal of Surgery. 2024 Feb 1
5 citations
Complete Remission of Widely Metastatic Human Epidermal Growth Factor Receptor 2-Amplified Pancreatic Adenocarcinoma After Precision Immune and Targeted Therapy With D...
Daniel A King, Amber R Smith, Gino Pineda, Michitaka Nakano, Flavia Michelini, S Peter Goedegebuure, Sheeno Thyparambil, Wei-Li Liao, Aaron McCormick, Jihang Ju, Miche...> ;JCO Precision Oncology. 2023 Apr 1
Analysis of Preoperative Predictors of Single and Multigland Primary Hyperparathyroidism.
C Corbin Frye, Sai Anusha Sanka, Janessa Sullivan, L Michael Brunt, William E Gillanders, T K Pandian, Taylor C Brown> ;The Journal of Surgical Research. 2023 Aug 1
1 citations
Magnitude of parathyroid hormone elevation in primary hyperparathyroidism: Does time of day matter?
C Corbin Frye, Janessa Sullivan, Sai Anusha Sanka, Jingxia Liu, L Michael Brunt, William Gillanders, Taylor C Brown, T K Pandian> ;Surgery. 2023 Mar 1
5 citations
A randomized phase 2 study of neoadjuvant carboplatin and paclitaxel with or without atezolizumab in triple negative breast cancer (TNBC) - NCI 10013.
Foluso O Ademuyiwa, Feng Gao, Cherease R Street, Ina Chen, Donald W Northfelt, Robert Wesolowski, Mili Arora, Adam Brufsky, E Claire Dees, Cesar A Santa-Maria, Roisin ...> ;NPJ Breast Cancer. 2022 Dec 30
50 citations
Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer.
Daniel Cui Zhou, Reyka G Jayasinghe, Siqi Chen, John M Herndon, Michael D Iglesia, Pooja Navale, Michael C Wendl, Wagma Caravan, Kazuhito Sato, Erik Storrs, Chia-Kuei ...> ;Nature Genetics. 2022 Sep 1
13 citations
Use of acidic nanoparticles to rescue macrophage lysosomal dysfunction in atherosclerosis.
Xiangyu Zhang, Santosh Kumar Misra, Parikshit Moitra, Xiuli Zhang, Se-Jin Jeong, Jeremiah Stitham, Astrid Rodriguez-Velez, Arick Park, Yu-Sheng Yeh, William E Gillande...> ;Autophagy. 2023 Mar 1
Pollock: fishing for cell states.
Erik P Storrs, Daniel Cui Zhou, Michael C Wendl, Matthew A Wyczalkowski, Alla Karpova, Liang-Bo Wang, Yize Li, Austin Southard-Smith, Reyka G Jayasinghe, Lijun Yao, Ru...> ;Bioinformatics Advances. 2022 Jan 1
4 citations
Combination TIGIT/PD-1 blockade enhances the efficacy of neoantigen vaccines in a model of pancreatic cancer.
Hui Peng, Lijin Li, Chong Zuo, Michael Y Chen, Xiuli Zhang, Nancy B Myers, Graham D Hogg, David G DeNardo, S Peter Goedegebuure, William G Hawkins, William E Gillanders> ;Frontiers in Immunology. 2022 Jan 1
1 citations
epitope prediction analyses highlight the potential for distracting antigen immunodominance with allogeneic cancer vaccines.
C Alston James, Peter Ronning, Darren Cullinan, Kelsy C Cotto, Erica K Barnell, Katie M Campbell, Zachary L Skidmore, Dominic E Sanford, S Peter Goedegebuure, William ...> ;Cancer Research Communications. 2021 Nov 1
24 citations
Neoadjuvant FOLFIRINOX Therapy Is Associated with Increased Effector T Cells and Reduced Suppressor Cells in Patients with Pancreatic Cancer.
Hui Peng, C. Alston James, Darren R. Cullinan, Graham D. Hogg, Jacqueline Mudd, Chong Zuo, Rony Takchi, Katharine E. Caldwell, Jingxia Liu, David G. DeNardo, Ryan C. F...> ;Clinical Cancer Research. 2021 Sep 30
2 citations
Impact of consensus guidelines for breast-conserving surgery in patients with ductal carcinoma in situ
Abigail Tremelling, Rebecca Aft, Amy E. Cyr, William E. Gillanders, Katherine Glover-Collins, Virginia Herrmann, Julie A. Margenthaler> ;Cancer Reports. 2021 Jul 10
28 citations
Functional Implications of the Dynamic Regulation of EpCAM during Epithelial-to-Mesenchymal Transition.
Taylor C. Brown, Narendra V. Sankpal, William E. Gillanders> ;Biomolecules. 2021 Jun 29
21 citations
Immunogenomic profiling and pathological response results from a clinical trial of docetaxel and carboplatin in triple-negative breast cancer
Foluso O. Ademuyiwa, Ina Chen, Jingqin Luo, Mothaffar F. Rimawi, Ian S. Hagemann, Bryan Fisk, Gejae Jeffers, Zachary L. Skidmore, Anamika Basu, Megan Richters, Cynthia...> ;Breast Cancer Research and Treatment. 2021 Jun 26
5 citations
Challenges targeting cancer neoantigens in 2021: a systematic literature review.
Ina Chen, Michael Y. Chen, S. Peter Goedegebuure, William E. Gillanders> ;Expert Review of Vaccines. 2021 Jun 9
5 citations
Staging of the Axilla in Breast Cancer and the Evolving Role of Axillary Ultrasound
Michael Y. Chen, William E Gillanders> ;Breast Cancer. 2021 May 17
1 citations
Cancer-associated mutations reveal a novel role for EpCAM as an inhibitor of cathepsin-L and tumor cell invasion
Narendra V. Sankpal, Taylor C. Brown, Timothy P. Fleming, John M. Herndon, Anusha A. Amaravati, Allison N. Loynd, William E. Gillanders> ;BMC Cancer. 2021 May 12
27 citations
Optimized polyepitope neoantigen DNA vaccines elicit neoantigen-specific immune responses in preclinical models and in clinical translation.
Lijin Li, Xiuli Zhang, Xiaoli Wang, Samuel W. Kim, John M. Herndon, Michelle Becker-Hapak, Beatriz M. Carreno, Nancy B. Myers, Mark A. Sturmoski, Michael D. McLellan, ...> ;Genome Medicine. 2021 Apr 21
18 citations
Neoantigen vaccine platforms in clinical development: understanding the future of personalized immunotherapy.
Suangson Supabphol, Lijin Li, S. Peter Goedegebuure, William E. Gillanders> ;Expert Opinion on Investigational Drugs. 2021 Mar 31
18 citations
Cancer vaccines: shared tumor antigens return to the spotlight.
Lijin Li, S. Peter Goedegebuure, William E. Gillanders> ;Signal Transduction and Targeted Therapy. 2020 Oct 30
244 citations
cDC1 prime and are licensed by CD4+ T cells to induce anti-tumour immunity
Stephen T. Ferris, Vivek Durai, Renee Wu, Derek J. Theisen, Jeffrey P. Ward, Michael D. Bern, Jesse T. Davidson, Prachi Bagadia, Tiantian Liu, Carlos G. Briseño, Lijin...> ;Nature. 2020 Aug 12
6 citations
Cost-effectiveness analyses demonstrate that observation is superior to sentinel lymph node biopsy for postmenopausal women with HR + breast cancer and negative axilla...
Aubriana M. McEvoy, Steven P. Poplack, Katelin B. Nickel, Margaret A. Olsen, Foluso O. Ademuyiwa, Imran Zoberi, Elizabeth B. Odom, Jennifer Yu, Su-Hsin Chang, William ...> ;Breast Cancer Research and Treatment. 2020 Jul 10
239 citations
The Human Tumor Atlas Network: Charting Tumor Transitions Across Space and Time at Single-Cell Resolution
Lim, K., Orit Rozenblatt-Rosen, Aviv Regev, Philipp Oberdoerffer, Tal Nawy, Anna Hupalowska, Jennifer Rood, Orr Ashenberg, Ethan Cerami, Robert J. Coffey, Emek Demir, ...> ;Cell. 2020 Apr 16
92 citations
pVACtools: A Computational Toolkit to Identify and Visualize Cancer Neoantigens.
Jasreet Hundal, Susanna Kiwala, Joshua F. McMichael, Christopher A. Miller, Huiming Xia, Alexander T. Wollam, Connor J. Liu, Sidi Zhao, Yang-Yang Feng, Aaron P. Graube...> ;Cancer Immunology Research. 2020 Jan 6
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Journal Articles

WDFY4 Is Required for Cross-Presentation in Response to Viral and Tumor Antigens
Herbert W Virgin, Kenneth M Murphy, William E Gillanders, Wayne Yokoyama, Science Magazine

Press Mentions

$10.4 Million Awarded for Pancreatic Cancer ResearchAugust 15th, 2016

Grant Support

Peripheral Blood Molecular Staging Of Breast CancerNational Cancer Institute2006–2010
Molecular Detection Of Breast Cancer In Peripheral BloodNational Cancer Institute2004–2006
Molecular Detection Of Breast Cancer In Peripheral BloodNational Cancer Institute2002–2004
Peptide Mediated Immunotherapy In TransplantationNational Institute Of Allergy And Infectious Diseases1994–1995