WilliamEHughesMD

PubMed

• A Critical Role for β-Catenin in Modulating Levels of Insulin Secretion from β-Cells by Regulating Actin Cytoskeleton and Insulin Vesicle Localization.
  Sorrenson B, Cognard E, Lee KL, Dissanayake WC, Fu Y, Han W, Hughes WE, Shepherd PR> ;J. Biol. Chem.. 2016-12-09
• An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake.
  Kee AJ, Yang L, Lucas CA, Greenberg MJ, Martel N, Leong GM, Hughes WE, Cooney GJ, James DE, Ostap EM, Han W, Gunning PW, Hardeman EC> ;Traffic. 2016-01-01
• An actin filament population defined by the tropomyosin Tpm3.1 regulates glucose uptake.
  Kee AJ, Yang L, Lucas CA, Greenberg MJ, Martel N, Leong GM, Hughes WE, Cooney GJ, James DE, Ostap EM, Han W, Gunning PW, Hardeman EC> ;Traffic. 2015-07-01
• PI4KIIα phosphorylation by GSK3 directs vesicular trafficking to lysosomes.
  Robinson JW, Leshchyns'ka I, Farghaian H, Hughes WE, Sytnyk V, Neely GG, Cole AR> ;Biochem. J.. 2014-11-15
• Annexin A6 is a scaffold for PKCα to promote EGFR inactivation.
  Koese M, Rentero C, Kota BP, Hoque M, Cairns R, Wood P, Vilà de Muga S, Reverter M, Alvarez-Guaita A, Monastyrskaya K, Hughes WE, Swarbrick A, Tebar F, Daly RJ, Enrich...> ;Oncogene. 2013-06-06
• Novel systems for dynamically assessing insulin action in live cells reveals heterogeneity in the insulin response.
  Burchfield JG, Lu J, Fazakerley DJ, Tan S, Ng Y, Mele K, Buckley MJ, Han W, Hughes WE, James DE> ;Traffic. 2013-03-01
• Mutations in the Saccharomyces cerevisiae gene SAC1 cause multiple drug sensitivity.
  Hughes, W. E., Pocklington, M. J., Orr, E., Paddon, C. J.> ;Yeast. 1999 Aug
• The Sac phosphatase domain.
  Hughes, W. E.> ;Curr Biol. 2001 Apr 3
• Sac phosphatase domain proteins.
  Hughes, W. E., Cooke, F. T., Parker, P. J.> ;Biochem J. 2000 Sep 1
• Endosomal localization of phospholipase D 1a and 1b is defined by the C-termini of the proteins, and is independent of activity.
  Hughes, W. E., Parker, P. J.> ;Biochem J. 2001 Jun 15
• SAC1 encodes a regulated lipid phosphoinositide phosphatase, defects in which can be suppressed by the homologous Inp52p and Inp53p phosphatases.
  Hughes, W. E., Woscholski, R., Cooke, F. T., Patrick, R. S., Dove, S. K., McDonald, N. Q., Parker, P. J.> ;J Biol Chem. 2000 Jan 14
• Redox control of β2-glycoprotein I-von Willebrand factor interaction by thioredoxin-1.
  Passam, F. H., Rahgozar, S., Qi, M., Raftery, M. J., Wong, J. W., Tanaka, K., Ioannou, Y., Zhang, J. Y., Gemmell, R., Qi, J. C., Giannakopoulos, B., Hughes, W. E., Hog...> ;J Thromb Haemost. 2010 Aug
• Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility.
  Ng, T., Parsons, M., Hughes, W. E., Monypenny, J., Zicha, D., Gautreau, A., Arpin, M., Gschmeissner, S., Verveer, P. J., Bastiaens, P. I., Parker, P. J.> ;EMBO J. 2001 Jun 1
• Identification of RhoGAP22 as an Akt-dependent regulator of cell motility in response to insulin.
  Rowland, A. F., Larance, M., Hughes, W. E., James, D. E.> ;Mol Cell Biol. 2011 Dec
• A subset of interleukin-21+ chemokine receptor CCR9+ T helper cells target accessory organs of the digestive system in autoimmunity.
  McGuire, H. M., Vogelzang, A., Ma, C. S., Hughes, W. E., Silveira, P. A., Tangye, S. G., Christ, D., Fulcher, D., Falcone, M., King, C.> ;Immunity. 2011 Apr 22
• Gab2 regulates cytoskeletal organization and migration of mammary epithelial cells by modulating RhoA activation.
  Herrera Abreu, M. T., Hughes, W. E., Mele, K., Lyons, R. J., Rickwood, D., Browne, B. C., Bennett, H. L., Vallotton, P., Brummer, T., Daly, R. J.> ;Mol Biol Cell. 2011 Jan 1
• Beta 2 glycoprotein I is a substrate of thiol oxidoreductases.
  Passam, F. H., Rahgozar, S., Qi, M., Raftery, M. J., Wong, J. W., Tanaka, K., Ioannou, Y., Zhang, J. Y., Gemmell, R., Qi, J. C., Giannakopoulos, B., Hughes, W. E., Hog...> ;Blood. 2010 Sep 16
• The myotubularin phosphatase MTMR4 regulates sorting from early endosomes.
  Naughtin, M. J., Sheffield, D. A., Rahman, P., Hughes, W. E., Gurung, R., Stow, J. L., Nandurkar, H. H., Dyson, J. M., Mitchell, C. A.> ;J Cell Sci. 2010 Sep 15
• Exocytotic vesicle behaviour assessed by total internal reflection fluorescence microscopy.
  Burchfield, J. G., Lopez, J. A., Mele, K., Vallotton, P., Hughes, W. E.> ;Traffic. 2010 Apr
• Identification of a distal GLUT4 trafficking event controlled by actin polymerization.
  Lopez, J. A., Burchfield, J. G., Blair, D. H., Mele, K., Ng, Y., Vallotton, P., James, D. E., Hughes, W. E.> ;Mol Biol Cell. 2009 Sep 01
• Measuring phospholipase D activity in insulin-secreting pancreatic beta-cells and insulin-responsive muscle cells and adipocytes.
  Cazzolli, R., Huang, P., Teng, S., Hughes, W. E.> ;Methods Mol Biol. 2009 Jan 01
• The Diacylglycerol-dependent translocation of ras guanine nucleotide-releasing protein 4 inside a human mast cell line results in substantial phenotypic changes, inclu...
  Katsoulotos, G. P., Qi, M., Qi, J. C., Tanaka, K., Hughes, W. E., Molloy, T. J., Adachi, R., Stevens, R. L., Krilis, S. A.> ;J Biol Chem. 2008 Jan 18
• Canine erythrocytes express the P2X7 receptor: greatly increased function compared with human erythrocytes.
  Sluyter, R., Shemon, A. N., Hughes, W. E., Stevenson, R. O., Georgiou, J. G., Eslick, G. D., Taylor, R. M., Wiley, J. S.> ;Am J Physiol Regul Integr Comp Physiol. 2007 Nov
• The role of phosphoinositide 3-kinase C2alpha in insulin signaling.
  Falasca, M., Hughes, W. E., Dominguez, V., Sala, G., Fostira, F., Fang, M. Q., Cazzolli, R., Shepherd, P. R., James, D. E., Maffucci, T.> ;J Biol Chem. 2007 Sep 21
• Phospholipid signalling through phospholipase D and phosphatidic acid.
  Cazzolli, R., Shemon, A. N., Fang, M. Q., Hughes, W. E.> ;IUBMB Life. 2006 Aug
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