WilliamHenrySt. ClairMD

Radiation Oncology • Lexington, KY

Physician

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Office
800 Rose St
c114-b
Lexington, KY 40536
Phone+1 859-323-6486

Fax+1 859-257-6114
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Education & Training

Brigham and Women's Hospital/Massachusetts General Hospital/Harvard Medical SchoolResidency, Radiation Oncology, 1996 - 2000
Christ HospitalInternship, Internal Medicine, 1995 - 1996
University of Kentucky College of MedicineClass of 1995
University of IowaPhD, Radiation Biology, 1985

Certifications & Licensure

KY State Medical License 2000 - 2025

Publications & Presentations

PubMed

Gamma Knife Radiosurgery to Four Brainstem Lesions After Whole Brain Radiation Therapy.
Mark E. Bernard, William H. St. Clair, Damodar Pokhrel> ;Cureus. 2021 Aug 16
2 citations
Changes in Angioarchitecture After Stereotactic Radiosurgery for Dural Arteriovenous Fistula
Benton Maglinger, M. Maher Hulou, Christopher J. McLouth, Madison Sands, Damodar Pokhrel, William H. St. Clair, Stephen Grupke, Justin F. Fraser> ;Journal of Stroke and Cerebrovascular Diseases. 2021 Feb 25
15 citations
Comprehensive evaluation of treatment and outcomes of low-grade diffuse gliomas.
Catherine R. Garcia, Stacey A. Slone, Thomas Pittman, William H. St. Clair, Donita Lightner, John L. Villano> ;Plos One. 2018 Sep 20
3 citations
Bilateral Radiation Optic Neuropathy Following Concurrent Chemotherapy and Radiation in Glioblastoma.
Jigisha P. Thakkar, John T. Slevin, Charles D. Smith, Padmaja Sudhakar, William H. St. Clair, John L. Villano> ;Neuro-Ophthalmology. 2017 May 30
28 citations
RelB expression determines the differential effects of ascorbic acid in normal and cancer cells.
Xiaowei Wei, Yong Xu, Fang Fang Xu, Luksana Chaiswing, David M. Schnell, Teresa Noel, Chi Wang, Jinfei Chen, Daret K. St. Clair, William H. St. Clair> ;Cancer Research. 2017 Mar 15
4 citations
Prostate brachytherapy seed migration to the heart seen on cardiovascular computed tomographic angiography.
Shilpa Sachdeva, Nneka S. Udechukwu, Hossam Elbelasi, Kevin P. Landwehr, William H. St. Clair, Michael A. Winkler> ;Radiology Case Reports. 2017 Mar 1
17 citations
Salvage Brachytherapy for Biochemically Recurrent Prostate Cancer following Primary Brachytherapy
John M Lacy, William A. Wilson, Raevti Bole, Li Chen, Ali S. Meigooni, Randall G. Rowland, William H. St. Clair> ;Prostate Cancer. 2016 Mar 22
27 citations
Redox-Mediated and Ionizing-Radiation-Induced Inflammatory Mediators in Prostate Cancer Development and Treatment
Lu Miao, Aaron K. Holley, Yanming Zhao, William H. St. Clair, Daret K. St. Clair> ;Antioxidants & Redox Signaling. 2014 Feb 27
51 citations
Long-term outcome of high-dose γ knife surgery in treatment of trigeminal neuralgia.
Byron Young, Armin Shivazad, Richard J. Kryscio, William H. St. Clair, Heather M. Bush> ;Journal of Neurosurgery. 2013 Nov 1
50 citations
KEAP1 Is a Redox Sensitive Target That Arbitrates the Opposing Radiosensitive Effects of Parthenolide in Normal and Cancer Cells
Yong Xu, Fang Fang, Sumitra Miriyala, Peter A. Crooks, Terry D. Oberley, Luksana Chaiswing, Teresa Noel, Aaron K. Holley, Yanming Zhao, Kelley K. Kiningham, Daret K. S...> ;Cancer Research. 2013 Jul 15
36 citations
Roles of mitochondria-generated reactive oxygen species on X-ray-induced apoptosis in a human hepatocellular carcinoma cell line, HLE
Hiroko P. Indo, Osamu Inanami, Tomoko Koumura, Shigeaki Suenaga, Hsiu-Chuan Yen, Shizuko Kakinuma, Ken-ichiro Matsumoto, Ikuo Nakanishi, William H. St. Clair, Daret K....> ;Free Radical Research. 2012 Jun 1
10 citations
Inverse relationship between PSA and IL-8 in prostate cancer: an insight into a NF-κB-mediated mechanism.
Yong Xu, Fang Fang, Daret K. St. Clair, William H. St. Clair> ;Plos One. 2012 Mar 5
19 citations
Unilateral parotid electron beam radiotherapy as palliative treatment for sialorrhea in amyotrophic lateral sclerosis.
Edward J. Kasarskis, Jacob Hodskins, William H. St. Clair> ;Journal of the Neurological Sciences. 2011 Sep 15
76 citations
miR-17* suppresses tumorigenicity of prostate cancer by inhibiting mitochondrial antioxidant enzymes.
Yong Xu, Fang Fang, Jiayou Zhang, Sajni Josson, William H. St. Clair, Daret K. St. Clair> ;Plos One. 2010 Dec 22
49 citations
RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells.
Aaron K. Holley, Yong Xu, Daret K. St. Clair, William H. St. Clair> ;Annals of the New York Academy of Sciences. 2010 Jul 1
20 citations
RelB-dependent differential radiosensitization effect of STI571 on prostate cancer cells.
Yong Xu, Fang Fang, Yulan Sun, Daret K. St. Clair, William H. St. Clair> ;Molecular Cancer Therapeutics. 2010 Apr 1
106 citations
A NADPH Oxidase–Dependent Redox Signaling Pathway Mediates the Selective Radiosensitization Effect of Parthenolide in Prostate Cancer Cells
Yulan Sun, Daret K. St. Clair, Yong Xu, Peter A. Crooks, William H. St. Clair> ;Cancer Research. 2010 Apr 1
13 citations
p53 is an important factor for the radiosensitization effect of 2-deoxy-D-glucose
Chompunoot Sinthupibulyakit, Kristopher R. Grimes, Frederick E. Domann, Yong Xu, Fang Fang, Wanida Ittarat, Daret K. St. Clair, William H. St. Clair> ;International Journal of Oncology. 2009 Sep 1
40 citations
Integration of irradiation with cytoplasmic incompatibility to facilitate a lymphatic filariasis vector elimination approach
Corey L. Brelsfoard, William H. St. Clair, Stephen L. Dobson> ;Parasites & Vectors. 2009 Aug 14
59 citations
RelB Enhances Prostate Cancer Growth: Implications for the Role of the Nuclear Factor-κB Alternative Pathway in Tumorigenicity
Yong Xu, Sajni Josson, Fang Fang, Terry D. Oberley, Daret K. St. Clair, X. Steven Wan, Yulan Sun, Vasudevan Bakthavatchalu, Anantharaman Muthuswamy, William H. St. Clair> ;Cancer Research. 2009 Apr 15
21 citations
Mutations in the SOD2 promoter reveal a molecular basis for an activating protein 2-dependent dysregulation of manganese superoxide dismutase expression in cancer cells.
Yong Xu, Fang Fang, Sanjit K. Dhar, Antonio Bosch, William H. St. Clair, Edward J. Kasarskis, Daret K. St. Clair> ;Molecular Cancer Research. 2008 Dec 1
46 citations
SN52, a novel nuclear factor-κB inhibitor, blocks nuclear import of RelB:p52 dimer and sensitizes prostate cancer cells to ionizing radiation
Yong Xu, Fang Fang, Daret K. St. Clair, Pradoldej Sompol, Sajni Josson, William H. St. Clair> ;Molecular Cancer Therapeutics. 2008 Aug 1
2 citations
Adjuvant Radiation of Bilateral Postauricular Keloids: An Illustration of Technique
J.L. Huhn, E. Lee Johnson, William H. St. Clair> ;Medical Dosimetry. 2007 Dec 1
65 citations
The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-κB inhibition and enhanced by the presence of PTEN
Yulan Sun, Daret K. St. Clair, Fang Fang, Graham W. Warren, Vivek M. Rangnekar, Peter A. Crooks, William H. St. Clair> ;Molecular Cancer Therapeutics. 2007 Sep 1
48 citations
Suppression of RelB-mediated manganese superoxide dismutase expression reveals a primary mechanism for radiosensitization effect of 1α,25-dihydroxyvitamin D3 in prosta...
Yong Xu, Fang Fang, Daret K. St. Clair, Sajni Josson, Pradoldej Sompol, Ivan Spasojevic, William H. St. Clair> ;Molecular Cancer Therapeutics. 2007 Jul 1
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Hospital Affiliations

University of Kentucky Albert B. Chandler HospitalLexington, Kentucky