YaelPMosseMD

Pediatric Hematology & Oncology • Philadelphia, PA

Assistant Professor, Pediatrics, Perelman School of Medicine

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Office
3501 Civic Center Blvd, CTRB 3056
Children's Hospital Of Philadelphia - Hem/Onc
Philadelphia, PA 19104
Phone+1 215-590-0965

Fax+1 267-426-0685
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Education & Training

Children's Hospital of PhiladelphiaFellowship, Pediatric Hematology/Oncology, 2000 - 2003
Children's Hospital of PhiladelphiaResidency, Pediatrics, 1997 - 2000
Tel Aviv University SacklerClass of 1997

Certifications & Licensure

PA State Medical License 1998 - 2024
American Board of Pediatrics Pediatric Hematology-Oncology

Clinical Trials

N99-02: Melphalan and Buthionine Sulfoximine Start of enrollment: 2001 Aug 01
Completed
Phase 1
ABT-751 in Treating Children With Neuroblastoma That Has Relapsed or Not Responded to Previous Treatment Start of enrollment: 2007 Jan 01
Completed
Phase 2
A Phase I/II Study of MLN8237, an Oral Selective Small Molecule Inhibitor of Aurora A Kinase, in Children With Relapsed/Refractory Solid Tumors Start of enrollment: 2008 Sep 01
N2007-02:Bevacizumab,Cyclophosphamide,& Zoledronic Acid in Patients W/ Recurrent or Refractory High-Risk Neuroblastoma Start of enrollment: 2009 Dec 01
Completed
Phase 1
Studying Tumor Samples From Young Patients With Neuroblastoma Start of enrollment: 2008 Dec 01
Completed
Crizotinib in Treating Younger Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Start of enrollment: 2009 Sep 21
Completed
Phase 1, Phase 2
N2007-03: Vorinostat and 131-I MIBG in Treating Patients With Resistant or Relapsed Neuroblastoma Start of enrollment: 2010 Mar 01
Completed
Phase 1
Alisertib in Treating Young Patients With Recurrent or Refractory Solid Tumors or Leukemia Start of enrollment: 2011 Feb 01
Completed
Phase 2
131-I-MIBG Therapy for Refractory Neuroblastoma, Expanded Access Protocol
Available
Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With Isotretinoin Start of enrollment: 2010 Oct 04
Active, not recruiting
Phase 1
Vorinostat and Isotretinoin in Treating Patients With High-Risk Refractory or Recurrent Neuroblastoma Start of enrollment: 2010 Dec 01
Completed
Phase 1
Lenalidomide and Dinutuximab With or Without Isotretinoin in Treating Younger Patients With Refractory or Recurrent Neuroblastoma Start of enrollment: 2013 Feb 04
Active, not recruiting
Phase 1
N2012-01: Phase 1 Study of Difluoromethylornithine (DFMO) and Celecoxib With Cyclophosphamide/Topotecan Start of enrollment: 2014 Jan 16
Active, not recruiting
Phase 1
131I-MIBG Alone VS. 131I-MIBG With Vincristine and Irinotecan VS131I-MIBG With Vorinostat Start of enrollment: 2014 Jul 01
Completed
Phase 2
NANT 2015-02: A Phase 1 Study of Lorlatinib (PF-06463922) Start of enrollment: 2017 Sep 05
Active, not recruiting
Phase 1
A Study of LY3295668 Erbumine in Participants With Relapsed/Refractory Neuroblastoma Start of enrollment: 2020 Jun 11
Active, not recruiting
Phase 1
MIBG With Dinutuximab +/- Vorinostat Start of enrollment: 2018 Sep 12
Active, not recruiting
Phase 1
Roles: Contact
Neuroblastoma Biology Study Start of enrollment: 2011 Jul 01
Recruiting
Roles: Contact
GPC2 CAR T Cells for Relapsed or Refractory Neuroblastoma Start of enrollment: 2023 May 23
Recruiting
Phase 1
Roles: Contact
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Publications & Presentations

PubMed

Percutaneous biopsy for the diagnosis, risk stratification, and molecular profiling of neuroblastoma: A single-center retrospective study.
Schoeman, S., Maris, J., Mattei, P., Bagatell, R., Cahill, A., Mosse, Y., Pogoriler, J., Srinivasan, A., Acord, M.> ;Pediatric Blood & Cancer. 2024 Apr 1
12 citations
Serial Profiling of Circulating Tumor DNA Identifies Dynamic Evolution of Clinically Actionable Genomic Alterations in High-Risk Neuroblastoma.
Kristopher R Bosse, Anna Maria Giudice, Maria V Lane, Brendan McIntyre, Patrick M Schürch, Guillem Pascual-Pasto, Samantha N Buongervino, Sriyaa Suresh, Alana Fitzsimm...> ;Cancer Discovery. 2022 Dec 2
32 citations
Second Paediatric Strategy Forum for anaplastic lymphoma kinase (ALK) inhibition in paediatric malignancies: ACCELERATE in collaboration with the European Medicines Ag...
Andrew D.J. Pearson, Elly Barry, Yael P. Mosse, Franca Ligas, Nick Bird, Teresa de Rojas, Zachary Franklin Zimmerman, Keith D. Wilner, Willi Woessmann, Susan L. Weiner...> ;European Journal of Cancer. 2021 Sep 15
25 citations
Randomized Phase II Trial of MIBG Versus MIBG, Vincristine, and Irinotecan Versus MIBG and Vorinostat for Patients With Relapsed or Refractory Neuroblastoma: A Report ...
Steven G. DuBois, M. Meaghan Granger, Susan Groshen, Denice D. Tsao-Wei, Lingyun Ji, Anasheh Shamirian, Scarlett Czarnecki, Fariba Goodarzian, Rachel Berkovich, Hiroyu...> ;Journal of Clinical Oncology. 2021 Jul 16
8 citations
Venetoclax-based rational combinations are effective in models of MYCN-amplified neuroblastoma.
, , , , , , , , , , , , , , , , , > ;Molecular Cancer Therapeutics. 2021 Jun 4
8 citations
A safety and feasibility trial of 131 I-MIBG in newly diagnosed high-risk neuroblastoma: A Children's Oncology Group study.
Brian Weiss, Gregory A. Yanik, Arlene Naranjo, Fan F Zhang, Wendy Fitzgerald, Barry L. Shulkin, Marguerite T. Parisi, Heidi V. Russell, Stephan A. Grupp, Luke Pater, P...> ;Pediatric Blood & Cancer. 2021 May 24
3 citations
Computational studies of anaplastic lymphoma kinase mutations reveal common mechanisms of oncogenic activation.
Keshav Patil, Earl Joseph Jordan, Jin H. Park, Krishna Suresh, Courtney M. Smith, Abigail A Lemmon, Yael P. Mosse, Mark A. Lemmon, Ravi Radhakrishnan> ;Proceedings of the National Academy of Sciences of the United States of America. 2021 Mar 9
11 citations
Myeloablative Busulfan/Melphalan Consolidation following Induction Chemotherapy for Patients with Newly Diagnosed High-Risk Neuroblastoma: Children's Oncology Group Tr...
M. Meaghan Granger, Arlene Naranjo, Rochelle Bagatell, Steven G. DuBois, Jeannine S. McCune, Sheena C. Tenney, Brian Weiss, Yael P. Mosse, Shahab Asgharzadeh, S. Grupp...> ;Transplantation and Cellular Therapy. 2021 Jun 1
52 citations
The B7-H3-Targeting Antibody-Drug Conjugate m276-SL-PBD Is Potently Effective Against Pediatric Cancer Preclinical Solid Tumor Models.
Nathan M. Kendsersky, Jarrett M. Lindsay, E. Anders Kolb, Malcolm A. Smith, Beverly A. Teicher, Stephen W. Erickson, Eric J. Earley, Yael P. Mosse, Daniel Martinez, Je...> ;Clinical Cancer Research. 2021 Feb 22
49 citations
Activity of Crizotinib in Patients with ALK-Aberrant Relapsed/Refractory Neuroblastoma: A Children's Oncology Group Study (ADVL0912)
Jennifer Foster, Stephan D. Voss, David Hall, Charles G. Minard, Frank M. Balis, Keith D. Wilner, Stacey L. Berg, Elizabeth Fox, Peter C. Adamson, Susan M. Blaney, Bre...> ;Clinical Cancer Research. 2021 Feb 10
3 citations
Image-Guided Biopsy for Relapsed Neuroblastoma: Focus on Safety, Adequacy for Genetic Sequencing, and Correlation of Tumor Cell Percent With Quantitative Lesion MIBG U...
Andrew Samoyedny, Abhay Srinivasan, Lisa J. States, Yael P. Mosse, Emma Alai, Bruce R. Pawel, Jennifer Pogoriler, Sphoorti Shellikeri, Seth Vatsky, Michael Acord, Fern...> ;JCO Precision Oncology. 2021 Jan 28
19 citations
Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers
Adam J. Wolpaw, Richard Bayliss, Gabriele Büchel, Chi V. Dang, Martin Eilers, W. Clay Gustafson, Gwenn H. Hansen, Natalia Jura, Stefan Knapp, Mark A. Lemmon, David Lev...> ;Cancer Research. 2021 Jan 28
20 citations
Safety, tolerability and pharmacokinetics of crizotinib in combination with cytotoxic chemotherapy for pediatric patients with refractory solid tumors or anaplastic la...
Emily Greengard, Yael P. Mosse, Xiaowei Liu, Charles G. Minard, Joel M. Reid, Stephan D. Voss, Keith D. Wilner, Elizabeth Fox, Frank M. Balis, Susan M. Blaney, Peter C...> ;Cancer Chemotherapy and Pharmacology. 2020 Dec 1
Advances and Challenges in Pediatric and Childhood Cancers
Cynthia Hawkins, Stefan M. Pfister, David T.W. Jones, Nirali N. Shah, Richard J. Gilbertson, E. Alejandro Sweet-Cordero, Michael A. Dyer, Yael P. Mosse, Michelle Haber...> ;Cancer Cell. 2020 Oct 12
239 citations
The Human Tumor Atlas Network: Charting Tumor Transitions Across Space and Time at Single-Cell Resolution
Lim, K., Orit Rozenblatt-Rosen, Aviv Regev, Philipp Oberdoerffer, Tal Nawy, Anna Hupalowska, Jennifer Rood, Orr Ashenberg, Ethan Cerami, Robert J. Coffey, Emek Demir, ...> ;Cell. 2020 Apr 16
12 citations
Preclinical evaluation of the combination of AZD1775 and irinotecan against selected pediatric solid tumors: A Pediatric Preclinical Testing Consortium report
E. Anders Kolb, Peter J. Houghton, Raushan T. Kurmasheva, Yael P. Mosse, John M. Maris, Stephen W. Erickson, Yuelong Guo, Beverly A. Teicher, Malcolm A. Smith, Richard...> ;Pediatric Blood & Cancer. 2020 Jan 23
88 citations
Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design.
Jo Lynne Rokita, Komal S. Rathi, Maria F. Cardenas, Kristen A. Upton, Joy Jayaseelan, Katherine L. Cross, Jacob Pfeil, Laura E. Egolf, Gregory P. Way, Alvin Farrel, Na...> ;Cell Reports. 2019 Nov 5
21 citations
Differences in Genomic Profiles and Outcomes Between Thoracic and Adrenal Neuroblastoma.
Derek A. Oldridge, Bao C. Q. Truong, Douglas Russ, Steven G. DuBois, Zalman Vaksman, Yael P. Mosse, Sharon J. Diskin, John M. Maris, Katherine K. Matthay> ;Journal of the National Cancer Institute. 2019 Nov 1
2 citations
Thrown for a Loop: Awakening BORIS to Evade ALK Inhibition Therapy.
Esther R. Berko, Yael P. Mosse> ;Cancer Cell. 2019 Oct 14
53 citations
A Phase II Study of Alisertib in Children with Recurrent/Refractory Solid Tumors or Leukemia: Children's Oncology Group Phase I and Pilot Consortium (ADVL0921)
Yael P. Mosse, Elizabeth Fox, David T. Teachey, Joel M. Reid, Stephanie L. Safgren, Hernan Carol, Richard B. Lock, Peter J. Houghton, Malcolm A. Smith, David Hall, Don...> ;Clinical Cancer Research. 2019 Jun 1
13 citations
Outcomes After Proton Therapy for Treatment of Pediatric High-Risk Neuroblastoma.
Christine E. Hill-Kayser, Zelig Tochner, Yimei Li, G. Kurtz, Robert A. Lustig, Paul A. James, Naomi Balamuth, Richard B. Womer, Peter Mattei, S A Grupp, Yael P. Mosse,...> ;International Journal of Radiation Oncology, Biology, Physics. 2019 Jun 1
74 citations
Clinical utility of custom-designed NGS panel testing in pediatric tumors
Lea F. Surrey, Suzanne P. MacFarland, Fengqi Chang, Kajia Cao, Komal S. Rathi, Gozde T. Akgumus, Daniel Gallo, Fumin Lin, Adam Gleason, Pichai Raman, Richard Aplenc, R...> ;Genome Medicine. 2019 May 28
3 citations
Heterozygosity mapping for human dominant trait variants.
Atsuko Imai-Okazaki, Yi Li, Sukanya Horpaopan, Yasser Riazalhosseini, Masoud Garshasbi, Yael P. Mosse, Di Zhang, Isabelle Schrauwen, Aarushi Sharma, Cathy S.J. Fann, S...> ;Human Mutation. 2019 Jul 1
9 citations
Computational algorithms for in silico profiling of activating mutations in cancer
E. Joseph Jordan, Keshav Patil, Krishna Suresh, Jin H. Park, Yael P. Mosse, Mark A. Lemmon, Ravi Radhakrishnan> ;Cellular and Molecular Life Sciences. 2019 Apr 13
37 citations
An antibody-drug conjugate directed to the ALK receptor demonstrates efficacy in preclinical models of neuroblastoma
Renata Sano, Kateryna Krytska, Colleen Larmour, Pichai Raman, Daniel Martinez, Gwenda F. Ligon, Jay S. Lillquist, Ulisse Cucchi, Paolo Orsini, Simona Rizzi, Bruce R. P...> ;Science Translational Medicine. 2019 Mar 13
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Press Mentions

Women’s History Month: CHOP Doctor Leading Team That Has Developed Revolutionary Treatment for Childhood CancerMarch 28th, 2022
American Cancer Society and St. Baldrick's Foundation Award Millions in Research Grants to Fight Childhood CancerMay 14th, 2021
‘He Has His Life Back’: Young Boy Thriving Because of Discovery That Happened with Help from Alex’s Lemonade Stand FoundationJune 12th, 2019
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