YousifHMatloubMD

Pediatric Hematology & Oncology • Cleveland, OH

Professor, Pediatrics, Case Western Reserve University School of Medicine

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Office
2065 Adelbert Rd
Cleveland, OH 44106
Phone+1 216-844-1000
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Education & Training

University of MinnesotaFellowship, Pediatric Hematology/Oncology, 1989 - 1992
University of Louisville School of MedicineResidency, Pediatrics, 1986 - 1989
University of Baghdad College of MedicineClass of 1977

Certifications & Licensure

OH State Medical License 1994 - 2026
WI State Medical License 2000 - 2015
MN State Medical License 1990 - 2012
CT State Medical License 2008 - 2010
American Board of Pediatrics Pediatric Hematology-Oncology

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014

Clinical Trials

Comparison of Different Combination Chemotherapy Regimens in Treating Children With Acute Lymphoblastic Leukemia Start of enrollment: 2000 Jun 01
Completed
Phase 3
Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients With Ewing's Sarcoma Start of enrollment: 2001 Feb 01
Unknown status
Phase 3
Isotretinoin With or Without Dinutuximab, Aldesleukin, and Sargramostim Following Stem Cell Transplant in Treating Patients With Neuroblastoma Start of enrollment: 2001 Oct 18
Active, not recruiting
Phase 3
Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors Start of enrollment: 2004 Mar 25
Recruiting
Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma/PNET Start of enrollment: 2007 Mar 26
Active, not recruiting
Phase 3
Long-Term Follow-Up of Patients Who Have Participated in Children's Oncology Group Studies Start of enrollment: 2008 Jul 17
Recruiting
Neuropsychological and Behavioral Testing in Younger Patients With Cancer Start of enrollment: 2009 Feb 27
Recruiting
Collecting and Storing Samples of Bone Marrow and Blood From Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma Start of enrollment: 2006 Sep 25
Completed
Collecting and Storing Malignant, Borderline Malignant Neoplasms, and Related Samples From Young Patients With Cancer Start of enrollment: 2003 Oct 13
Completed
Study of Kidney Tumors in Younger Patients Start of enrollment: 2006 Feb 27
Recruiting
Collecting and Storing Tissue From Young Patients With Cancer Start of enrollment: 2007 Mar 05
Recruiting
Collecting and Storing Samples of Blood and Tumor Tissue From Patients With Osteosarcoma Start of enrollment: 2008 Feb 04
Completed
Collecting and Storing Biological Samples From Patients With Ewing Sarcoma Start of enrollment: 2008 Feb 04
Completed
Collecting and Storing Biological Samples From Young Patients With Hodgkin?s Lymphoma Start of enrollment: 2006 Oct 23
Completed
Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma Start of enrollment: 2000 Nov 06
Recruiting
Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue Sarcoma Start of enrollment: 1999 Mar 15
Completed
Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors Start of enrollment: 2004 Feb 16
Completed
Combination Chemotherapy and Surgery in Treating Young Patients With Wilms Tumor Start of enrollment: 2009 Jul 13
Active, not recruiting
Phase 3
Study of Blood Samples From Newborns With Down Syndrome Start of enrollment: 2009 Feb 23
Completed
Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer Start of enrollment: 2009 Sep 14
Active, not recruiting
Phase 3
Collecting and Storing Tissue Samples From Patients With Rare or Cutaneous Non-Hodgkin Lymphoma Start of enrollment: 2005 May 30
Completed
Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Ependymoma Start of enrollment: 2010 May 07
Active, not recruiting
Phase 3
Risk-Based Classification System of Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Start of enrollment: 2010 Aug 09
Completed
Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma Start of enrollment: 2010 Aug 09
Active, not recruiting
Phase 3
Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors Start of enrollment: 2010 Nov 22
Completed
Phase 2
Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma Start of enrollment: 2010 Nov 22
Active, not recruiting
Phase 3
Caspofungin Versus Fluconazole in Preventing Invasive Fungal Infections (IFI) in Patients Undergoing Chemotherapy for Acute Myeloid Leukemia Start of enrollment: 2011 Apr 04
Completed
Phase 3
Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Start of enrollment: 2011 Jun 20
Active, not recruiting
Phase 3
Temsirolimus, Dexamethasone, Mitoxantrone Hydrochloride, Vincristine Sulfate, and Pegaspargase in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma Start of enrollment: 2011 Sep 01
Completed
Phase 1
A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia (ALL) Testing Clofarabine (IND# 73789, NSC# 606869) in the Very High Risk Stratum Start of enrollment: 2012 Feb 01
Caspofungin Acetate, Fluconazole, or Voriconazole in Preventing Fungal Infections in Patients Following Donor Stem Cell Transplant Start of enrollment: 2013 Mar 21
Completed
Phase 3
Assessing Compliance With Mercaptopurine Treatment in Younger Patients With Acute Lymphoblastic Leukemia in First Remission Start of enrollment: 2012 Feb 21
Active, not recruiting
Phase 3
Intergroup Trial for Children or Adolescents With B-Cell NHL or B-AL: Evaluation of Rituximab Efficacy and Safety in High Risk Patients Start of enrollment: 2012 Jun 01
Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors Start of enrollment: 2012 Jun 27
Active, not recruiting
Phase 2
MORAb-004 in Treating Young Patients With Recurrent or Refractory Solid Tumors or Lymphoma Start of enrollment: 2013 Nov 01
Completed
Phase 1
Irinotecan Hydrochloride and Temozolomide With Temsirolimus or Dinutuximab in Treating Younger Patients With Refractory or Relapsed Neuroblastoma Start of enrollment: 2013 Feb 12
Completed
Phase 2
Blood Sample Markers of Reproductive Hormones in Assessing Ovarian Reserve in Younger Patients With Newly Diagnosed Lymphomas Start of enrollment: 2013 Jun 17
Active, not recruiting
Busulfan, Cyclophosphamide, and Melphalan or Busulfan and Fludarabine Phosphate Before Donor Hematopoietic Cell Transplant in Treating Younger Patients With Juvenile Myelomonocytic Leukemia Start of enrollment: 2013 Jun 24
Completed
Phase 2
Open Label, Phase II Study to Evaluate Efficacy and Safety of Oral Nilotinib in Philadelphia Positive (Ph+) Chronic Myelogenous Leukemia (CML) Pediatric Patients. Start of enrollment: 2013 Aug 20
Completed
Phase 2
Brentuximab Vedotin or Crizotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II-IV Anaplastic Large Cell Lymphoma Start of enrollment: 2013 Nov 13
Active, not recruiting
Phase 2
Eribulin Mesylate in Treating Patients With Recurrent or Refractory Osteosarcoma Start of enrollment: 2014 Aug 01
Completed
Phase 2
Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Start of enrollment: 2014 Jul 11
Active, not recruiting
Phase 2, Phase 3
Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer Start of enrollment: 2009 Sep 01
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Publications & Presentations

PubMed

16 citations
Favorable Trisomies and ETV6-RUNX1 Predict Cure in Low-Risk B-Cell Acute Lymphoblastic Leukemia: Results From Children's Oncology Group Trial AALL0331
Leonard A. Mattano, Meenakshi Devidas, Kelly W. Maloney, Cindy Wang, Alison M. Friedmann, Patrick J. Buckley, Michael J. Borowitz, Andrew J. Carroll, Julie M. Gastier-...> ;Journal of Clinical Oncology. 2021 Mar 19
4 citations
Increased Toxicity Among Adolescents and Young Adults Compared with Children Hospitalized with Acute Lymphoblastic Leukemia at Children's Hospitals in the United States
Ajay Gupta, Rahul C Damania, Ravi Talati, Mary Ann O'Riordan, Yousif Matloub, Sanjay P Ahuja> ;Journal of Adolescent and Young Adult Oncology. 2021 Jan 28
88 citations
Outcome in Children With Standard-Risk B-Cell Acute Lymphoblastic Leukemia: Results of Children’s Oncology Group Trial AALL0331
Kelly W. Maloney, Meenakshi Devidas, Cindy Wang, Leonard A. Mattano, Alison M. Friedmann, Patrick J. Buckley, Michael J. Borowitz, Andrew J. Carroll, Julie M. Gastier-...> ;Journal of Clinical Oncology. 2020 Feb 20
13 citations
Excellent long-term survival of children with Down syndrome and standard-risk ALL: a report from the Children’s Oncology Group
Yousif Matloub, Karen R. Rabin, Lingyun Ji, Meenakshi Devidas, Johann Hitzler, Xinxin Xu, Bruce Bostrom, Linda C. Stork, Naomi J. Winick, Julie M. Gastier-Foster, Nyla...> ;Blood Advances. 2019 Jun 11
1 citations
Trilineage hematopoiesis induced by low-dose eltrombopag in a patient with Fanconi anemia can be used as a bridge to hematopoietic stem cell transplant
Ashish Gupta, Rasmi Palassery, Howard J. Meyerson, Sanjay P Ahuja, Yousif Matloub> ;Journal of Pediatric Hematology/oncology. 2019 Apr 1
80 citations
Outcome of children with multiply relapsed B-cell acute lymphoblastic leukemia: a therapeutic advances in childhood leukemia & lymphoma study.
Weili Sun, Jemily Malvar, Richard Sposto, Anupam Verma, Jennifer J. Wilkes, Robyn M. Dennis, Kenneth Heym, Theodore W. Laetsch, Melissa Widener, Susan R. Rheingold, Ja...> ;Leukemia. 2018 Mar 15
185 citations
Adolescent and Young Adult Oncology, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology.
Peter F. Coccia, Alberto S. Pappo, Lynda K. Beaupin, Virginia F. Borges, Scott C. Borinstein, Rashmi Chugh, Shira Dinner, Jeanelle Folbrecht, A. Lindsay Frazier, Rober...> ;Journal of the National Comprehensive Cancer Network. 2018 Jan 1
9 citations
Epstein-Barr Virus-associated Mucocutaneous Ulcer in a Patient With T-Cell Acute Lymphoblastic Leukemia: Importance of Accurate Diagnosis and Conservative Management.
Anant Vatsayan, Ashish Gupta, Sanjay P Ahuja, Rachel A. Egler, Rose Beck, Yousif Matloub> ;Journal of Pediatric Hematology/oncology. 2017 Aug 1
147 citations
L-asparaginase in the treatment of patients with acute lymphoblastic leukemia.
Rachel A. Egler, Sanjay P Ahuja, Yousif Matloub> ;Journal of Pharmacology & Pharmacotherapeutics. 2016 Apr 1
17 citations
Outcome of Children with Standard-Risk T-Lineage Acute Lymphoblastic Leukemia—Comparison among Different Treatment Strategies
Yousif Matloub, Linda C. Stork, Barbara L. Asselin, Stephen P. Hunger, Michael J. Borowitz, Tamekia L. Jones, Bruce Bostrom, Julie M. Gastier-Foster, Nyla A. Heerema, ...> ;Pediatric Blood & Cancer. 2016 Feb 1
22 citations
Comparative Toxicity by Sex Among Children Treated for Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group
Kathleen Meeske, Lingyun Ji, David R. Freyer, Paul S. Gaynon, Kathleen S. Ruccione, Anna Butturini, Vassilios I. Avramis, Stuart E. Siegel, Yousif Matloub, Nita L. Sei...> ;Pediatric Blood & Cancer. 2015 Dec 1
101 citations
Escalating intravenous methotrexate improves event-free survival in children with standard-risk acute lymphoblastic leukemia: a report from the Children's Oncology Group
Yousif Matloub, Bruce Bostrom, Stephen P. Hunger, Linda C. Stork, Anne L. Angiolillo, Harland N. Sather, Mei La, Julie M. Gastier-Foster, Nyla A. Heerema, Scott L. Sai...> ;Blood. 2011 Jul 14
64 citations
Oral 6-mercaptopurine versus oral 6-thioguanine and veno-occlusive disease in children with standard-risk acute lymphoblastic leukemia: report of the Children's Oncolo...
Linda C. Stork, Yousif Matloub, Emmett Broxson, Mei La, Rochelle Yanofsky, Harland Sather, Ray Hutchinson, Nyla A. Heerema, April D. Sorrell, Margaret Masterson, Archi...> ;Blood. 2010 Apr 8
189 citations
Potent, transient inhibition of BCR-ABL with dasatinib 100 mg daily achieves rapid and durable cytogenetic responses and high transformation-free survival rates in chr...
Neil P. Shah, Dong-Wook Kim, Hagop M. Kantarjian, Philippe Rousselot, Pedro Enrique Dorlhiac Llacer, Alicia Enrico, Jorge Vela-Ojeda, Richard T. Silver, Hanna Jean Kho...> ;Haematologica. 2010 Feb 1
106 citations
Dasatinib 100 mg once daily minimizes the occurrence of pleural effusion in patients with chronic myeloid leukemia in chronic phase and efficacy is unaffected in patie...
Kimmo Porkka, H. Jean Khoury, Ronald Paquette, Yousif Matloub, Ritwik Sinha, Jorge E. Cortes> ;Cancer. 2010 Jan 15
88 citations
Intrathecal triple therapy decreases central nervous system relapse but fails to improve event-free survival when compared with intrathecal methotrexate: Results of th...
Yousif Matloub, Susan Lindemulder, Paul S. Gaynon, Harland N. Sather, Mei La, Emmett Broxson, Rochelle Yanofsky, Raymond J. Hutchinson, Nyla A. Heerema, James B. Nachm...> ;Blood. 2006 Aug 15
20 citations
Detection of central nervous system leukemia in children with acute lymphoblastic leukemia by real-time polymerase chain reaction.
Sharon R. Pine, Changhong Yin, Yousif Matloub, Hatem E. Sabaawy, Claudio Sandoval, Oya Levendoglu-Tugal, M. Fevzi Ozkaynak, Somasundaram Jayabose> ;The Journal of Molecular Diagnostics. 2005 Feb 1
35 citations
Staged informed consent for a randomized clinical trial in childhood leukemia: impact on the consent process.
Anne L. Angiolillo, Christian Simon, Eric Kodish, Beverly J. Lange, Robert B. Noll, Kathy Ruccione, Yousif Matloub> ;Pediatric Blood & Cancer. 2004 May 1
25 citations
Is there a potential role for serum cardiac troponin I as a marker for myocardial dysfunction in pediatric patients receiving anthracycline-based therapy? A pilot study.
Prasad Mathew, William Suarez, Katrinka Kip, Emel A. Bayar, Rama Jasty, Yousif H. Matloub, Dennis Raisch> ;Cancer Investigation. 2001 Apr 30
2 citations
Anterior mediastinal mass in childhood non-Hodgkin lymphoma: dilemma of post-therapy imaging.
Emel Bayar, Prasad Mathew, Rama Jasty, Yousif H. Matloub, Margaret G. Robinson> ;Medical and Pediatric Oncology. 2000 Feb 1
4 citations
Pediatric case of the day. Ewing sarcoma of the rib with intraspinal extension.
Robert J. Coombs, Emel A. Bayar, Yousif H. Matloub, Manuel E. Velasco> ;Radiographics. 1999 Jan 1
12 citations
One course versus two courses of antithymocyte globulin for the treatment of severe aplastic anemia in children
Yousif H. Matloub, C. Smith, Bruce Bostrom, Marion A. Koerper, M. O'Leary, S. Khuder, William A. Smithson, H. J. Nickerson, Teresa Silberman, Joanne M. Hilden, Christo...> ;Journal of Pediatric Hematology/oncology. 1997 Mar 1
4 citations
Massive intra-atrial Wilms' tumor : A treatment dilemma
Giulio J. D'Angio, Yousif H. Matloub, Marc D. Le Gras, Herschel C. Rosenberg, A. Rashid Dar, David Girvan, Alan H. Menkis, Timothy J. Brown, R. Morrison Hurley> ;Medical and Pediatric Oncology. 1997 Feb 1
17 citations
Antithymocyte globulin, cyclosporine, and prednisone for the treatment of severe aplastic anemia in children : a pilot study
Yousif Matloub, Bruce Bostrom, B. Golembe, John R. Priest, Norma K.C. Ramsay> ;The American Journal of Pediatric Hematology/oncology. 1994 May 1
31 citations
In utero engraftment of fully h-2-incompatible versus congenic adult bone marrow transferred into nonanemic or anemic murine fetal recipients
Kang Howson-Jan, Yousif H. Matloub, Daniel A. Vallera, Bruce R. Blazar> ;Transplantation. 1993 Sep 1
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Professional Memberships

American Society of Clinical Oncology - ASCO
Member

Hospital Affiliations

University Hospitals Cleveland Medical CenterCleveland, Ohio

YousifHMatloubMD

Dr. Matloub is on Doximity

Education & Training

Certifications & Licensure

Awards, Honors, & Recognition

Clinical Trials

Publications & Presentations

Professional Memberships

Hospital Affiliations

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