YuhchyauChenMD

Radiation Oncology • Rochester, NY

Physician

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Office
601 Elmwood Ave # 647
Rochester, NY 14642
Phone+1 585-275-2171

Fax+1 585-275-1531
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Education & Training

Brigham and Women's Hospital/Massachusetts General Hospital/Harvard Medical SchoolResidency, Radiation Oncology, 1991 - 1995
Virginia Mason Franciscan HealthInternship, Internal Medicine, 1990 - 1991
University of Washington School of MedicineClass of 1990

Certifications & Licensure

NY State Medical License 1995 - 2025
MA State Medical License 1994 - 2019
American Board of Radiology Radiation Oncology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012

Clinical Trials

Interstitial Brachytherapy With or Without External-Beam Radiation Therapy in Treating Patients With Prostate Cancer Start of enrollment: 2003 Jun 01
Completed
Phase 3
Radiation Therapy (WBI Versus PBI) in Treating Women Who Have Undergone Surgery For Ductal Carcinoma In Situ or Stage I or Stage II Breast Cancer Start of enrollment: 2005 Mar 01
Completed
Not Applicable
Trial of Chemotherapy Followed by Pulsed Docetaxel and Concurrent Radiation for Non-Small Cell Lung Cancer Start of enrollment: 2002 Feb 01
Completed
Phase 2
Genotoxicity Assessment for Patients Undergoing Radiation Treatment Start of enrollment: 2006 Apr 01
Completed
Low-Dose Taxotere® (Docetaxel) With Concurrent Radiotherapy For Localized, Inoperable Carcinoma Of The Uterine Cervix Start of enrollment: 2005 Jan 01
Completed
Phase 2
S0429: Docetaxel, Cetuximab, and Radiation Therapy in Treating Patients With Stage III Non-Small Cell Lung Cancer Start of enrollment: 2006 Apr 01
Terminated
Phase 1
Stereotactic Radiation Therapy With or Without Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases Start of enrollment: 2006 Jul 01
Completed
Phase 3
Prostate Radiation Therapy or Short-Term Androgen Deprivation Therapy and Pelvic Lymph Node Radiation Therapy With or Without Prostate Radiation Therapy in Treating Patients With a Rising Prostate Specific Antigen (PSA) After Surgery for Prostate Cancer Start of enrollment: 2008 Feb 01
Active, not recruiting
Phase 3
Radiation Therapy Regimens in Treating Patients With Limited-Stage Small Cell Lung Cancer Receiving Cisplatin and Etoposide Start of enrollment: 2008 Mar 01
Active, not recruiting
Phase 3
Stereotactic Body Radiation Therapy in Treating Patients With Stage I Non-Small Cell Lung Cancer Start of enrollment: 2009 Feb 01
Completed
Phase 1, Phase 2
Pelvic Radiation Therapy or Vaginal Implant Radiation Therapy, Paclitaxel, and Carboplatin in Treating Patients With High-Risk Stage I or Stage II Endometrial Cancer Start of enrollment: 2009 Mar 23
Active, not recruiting
Phase 3
Temozolomide and Radiation Therapy With or Without Bevacizumab in Treating Patients With Newly Diagnosed Glioblastoma Start of enrollment: 2009 Apr 15
Completed
Phase 3
Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma Start of enrollment: 2009 Sep 01
Recruiting
Phase 3
Observation or Radiation Therapy in Treating Patients With Grade I, Grade II, or Grade III Meningioma Start of enrollment: 2009 Jun 01
Completed
Phase 2
Phase I Study of Eltrombopag for Promoting Thrombopoiesis After Total Body Irradiation Start of enrollment: 2009 Dec 01
Completed
Phase 1
Abraxane and RT for Non-Small Cell Lung Cancer (NSCLC) Start of enrollment: 2008 Mar 01
Withdrawn
Phase 2
Radiation Therapy With or Without Androgen-Deprivation Therapy in Treating Patients With Prostate Cancer Start of enrollment: 2009 Sep 01
Active, not recruiting
Phase 3
Carboplatin and Paclitaxel With or Without Cisplatin and Radiation Therapy in Treating Patients With Stage I, Stage II, Stage III, or Stage IVA Endometrial Cancer Start of enrollment: 2009 Jun 29
Active, not recruiting
Phase 3
Radiation Therapy With or Without Cetuximab in Treating Patients Who Have Undergone Surgery for Locally Advanced Head and Neck Cancer Start of enrollment: 2009 Nov 01
Active, not recruiting
Phase 3
Chemotherapy and Radiation Therapy With or Without Panitumumab in Treating Patients With Stage IIIA Non-Small Cell Lung Cancer Start of enrollment: 2011 Feb 01
Completed
Phase 2
Chemotherapy and Pelvic Radiation Therapy With or Without Additional Chemotherapy in Treating Patients With High-Risk Early-Stage Cervical Cancer After Radical Hysterectomy Start of enrollment: 2009 Sep 01
Active, not recruiting
Phase 3
Gemcitabine Hydrochloride With or Without Erlotinib Hydrochloride Followed by the Same Chemotherapy Regimen With or Without Radiation Therapy and Capecitabine or Fluorouracil in Treating Patients With Pancreatic Cancer That Has Been Removed by Surgery Start of enrollment: 2010 Apr 05
Active, not recruiting
Phase 3
Radiation Therapy in Treating Patients With Extensive Stage Small Cell Lung Cancer Start of enrollment: 2010 Mar 01
Completed
Phase 2
Everolimus, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme Start of enrollment: 2010 Dec 01
Completed
Phase 1, Phase 2
Radiation Therapy in Treating Women With Locally Recurrent Breast Cancer Previously Treated With Repeat Breast-Preserving Surgery Start of enrollment: 2010 Jun 01
Completed
Phase 2
Radiation Therapy, Paclitaxel, and Carboplatin With or Without Trastuzumab in Treating Patients With Esophageal Cancer Start of enrollment: 2011 Feb 14
Completed
Phase 3
Radiation Therapy With or Without Chemotherapy in Treating Patients With High-Risk Malignant Salivary Gland Tumors That Have Been Removed By Surgery Start of enrollment: 2011 Jan 01
Active, not recruiting
Phase 2
Ganitumab and Gemcitabine Hydrochloride Followed by Radiation Therapy, Ganitumab, Capecitabine, and Maintenance Therapy in Treating Patients With Locally Advanced Cancer of the Pancreas Start of enrollment: 2012 Feb 01
Completed
Phase 1
Radiation Therapy With Cisplatin or Cetuximab in Treating Patients With Oropharyngeal Cancer Start of enrollment: 2011 Jun 01
Active, not recruiting
Phase 3
Rituximab, Methotrexate, Vincristine Sulfate, Procarbazine Hydrochloride, and Cytarabine With or Without Radiation Therapy in Treating Patients With Primary Central Nervous System Lymphoma Start of enrollment: 2011 Sep 01
Completed
Phase 2
Natural History of Brain Function, Quality of Life, and Seizure Control in Patients With Brain Tumor Who Have Undergone Surgery Start of enrollment: 2011 Oct 01
Completed
Whole-Brain Radiation Therapy or Stereotactic Radiosurgery With or Without Lapatinib Ditosylate in Treating Patients With Brain Metastasis From HER2-Positive Breast Cancer Start of enrollment: 2012 Dec 06
Completed
Phase 2
Bevacizumab With or Without Radiation Therapy in Treating Patients With Recurrent Glioblastoma Start of enrollment: 2012 Dec 20
Completed
Phase 2
A Phase 1 Dose Escalation Study of GC4419 in Combination With Chemoradiation for Squamous Cell Cancer of the Head & Neck Start of enrollment: 2013 Aug 01
Completed
Phase 1
Testing the Addition of a New Immunotherapy Drug, Atezolizumab (MPDL3280A), to the Usual Chemoradiation (CRT) Therapy Treatment for Limited Stage Small Cell Lung Cancer (LS-SCLC) Start of enrollment: 2019 Jul 26
Active, not recruiting
Phase 3
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Publications & Presentations

PubMed

Impact of Apolipoprotein E Genotype on Neurocognitive Function in Patients With Brain Metastases: An Analysis of NRG Oncology's RTOG 0614.
Wefel, J., Deshmukh, S., Brown, P., Grosshans, D., Sulman, E., Cerhan, J., Mehta, M., Khuntia, D., Shi, W., Mishra, M., Suh, J., Laack, N., Chen, Y., Curtis, A., Laba,...> ;International Journal of Radiation Oncology, Biology, Physics. 2023 Dec 13
KDM3B Single-Nucleotide Polymorphisms Impact Radiation Therapy Toxicity Through Circular RNA-Mediated KDM3B Expression and Inflammatory Responses.
Yin Sun, Ying Tsai, Ronald Wood, Binghui Shen, Jinbo Chen, Zhen Zhou, Guohua Zeng, Brian Marples, Sarah Kerns, Yuhchyau Chen> ;International Journal of Radiation Oncology, Biology, Physics. 2023 Nov 25
1 citations
Assessment of Differences in Academic Rank and Compensation by Gender and Race/Ethnicity Among Academic Radiation Oncologists in the United States.
Ann C Raldow, Malika L Siker, James A Bonner, Yuhchyau Chen, Fei-Fei Liu, James M Metz, Benjamin Movsas, Louis Potters, Christopher J Schultz, Emily Wilson, Xiaoyan Wa...> ;Advances in Radiation Oncology. 2023 Mar 10
2 citations
Lack of hydroxyurea-associated mutagenesis in pediatric sickle cell disease patients.
Dorothea K Torous, Svetlana Avlasevich, Jeffrey C Bemis, Thad Howard, Russell E Ware, Chunkit Fung, Yuhchyau Chen, Deepak Sahsrabudhe, James T MacGregor, Stephen D Der...> ;Environmental and Molecular Mutagenesis. 2023 Mar 1
Stroke death in patients receiving radiation for head and neck cancer in the modern era.
Sara J Hardy, Sanjukta Bandyopadhyay, Hongmei Yang, Annalynn Williams, Abdi Gudina, Michael A Cummings, Hong Zhang, Deepinder P Singh, Yuhchyau Chen, Nimish A Mohile, ...> ;Frontiers in Oncology. 2023 Jan 1
3 citations
Body composition and mortality in men receiving prostate radiotherapy: A pooled analysis of NRG/RTOG 9406 and NRG/RTOG 0126.
Andrew M McDonald, Lyudmila DeMora, Eddy S Yang, John M Hoyle, Andrew Lenzie, Grant R Williams, Jeff M Michalski, Don Yee, Jean-Paul Bahary, Robert B Den, Mack Roach 3...> ;Cancer. 2023 Mar 1
6 citations
Targeting the radiation-induced ARv7-mediated circNHS/miR-512-5p/XRCC5 signaling with Quercetin increases prostate cancer radiosensitivity.
Dong Chen, Fu-Ju Chou, Yuhchyau Chen, Chi-Ping Huang, Hao Tian, Yaqin Wang, Yuanjie Niu, Bosen You, Shuyuan Yeh, Nianzeng Xing, Chawnshang Chang> ;Journal of Experimental & Clinical Cancer Research. 2022 Aug 3
Methodological Comparison of Mapping the Expanded Prostate Cancer Index Composite to EuroQoL-5D-3L Using Cross-Sectional and Longitudinal Data: Secondary Analysis of N...
Rahul Khairnar, Lyudmila DeMora, Howard M Sandler, W Robert Lee, Ester Villalonga-Olives, C Daniel Mullins, Francis B Palumbo, Deborah W Bruner, Fadia T Shaya, Soren M...> ;JCO Clinical Cancer Informatics. 2022 Jun 1
Retraction Note to: IL-6 signaling promotes DNA repair and prevents apoptosis in CD133+ stem-like cells of lung cancer after radiation.
Yuhchyau Chen, Fuquan Zhang, Ying Tsai, Xiadong Yang, Li Yang, Shanzhou Duan, Xin Wang, Peter Keng, Soo Ok Lee> ;Radiation Oncology. 2022 May 16
7 citations
Use of angiotensin converting enzyme inhibitors is associated with reduced risk of late bladder toxicity following radiotherapy for prostate cancer.
Sarah L Kerns, Ashley Amidon Morlang, Sharon M Lee, Derick R Peterson, Brian Marples, Hong Zhang, Kevin Bylund, Doug Rosenzweig, William Hall, Kim De Ruyck, Barry S Ro...> ;Radiotherapy and Oncology. 2022 Mar 1
Retraction Note: Radiation-induced glucocorticoid receptor promotes CD44 + prostate cancer stem cell growth through activation of SGK1-Wnt/β-catenin signaling.
Feng Chen, Xiaodong Chen, Yu Ren, Guobin Weng, Peter C Keng, Yuhchyau Chen, Soo Ok Lee> ;Journal of Molecular Medicine. 2022 Jan 1
Increased risk of high-grade prostate cancer among testicular cancer survivors.
Hong Zhang, Hongmei Yang, Sanjukta Bandyopadhyay, Michael T Milano, Chunkit Fung, Edward M Messing, Yuhchyau Chen> ;Plos One. 2022 Jan 1
1 citations
New dosimetric guidelines for linear Boltzmann transport equations through comparative evaluation of stereotactic body radiation therapy for lung treatment planning
Matthew Webster, Sean Tanny, Neil Joyce, Amy Herman, Yuhchyau Chen, Michael T. Milano, Kenneth Y. Usuki, Louis S. Constine, Deepinder P. Singh, Inhwan Yeo> ;Journal of Applied Clinical Medical Physics. 2021 Nov 16
3 citations
Risk stratification after recurrence of human papillomavirus (HPV)-related and non-HPV-related oropharyngeal cancer: A secondary analysis of NRG Oncology RTOG 0129 and...
Elaine Bigelow, Jonathan Harris, Carole Fakhry, Maura L. Gillison, Phuc Felix Nguyen-Tân, David I. Rosenthal, Steven J. Frank, Suresh G. Nair Md, Houda Bahig, John A. ...> ;Head & Neck. 2021 Nov 3
Retraction notice to "Neuroendocrine differentiation contributes to radioresistance development and metastatic potential increase in non-small cell lung cancer" [Bioch...
Rongying Zhu, Xiaodong Yang, Xiang Xue, Mingjing Shen, Feng Chen, Xiaodong Chen, Ying Tsai, Peter C Keng, Yongbing Chen, Soo Ok Lee, Yuhchyau Chen> ;Biochimica Et Biophysica Acta. Molecular Cell Research. 2021 Oct 1
Risk of adverse pathological features for intermediate risk prostate cancer: Clinical implications for definitive radiation therapy.
Hong Zhang, C.W. Doucette, Hongmei Yang, Sanjukta Bandyopadhyay, Craig E Grossman, Edward M. Messing, Yuhchyau Chen> ;Plos One. 2021 Jul 15
2 citations
Retraction notice to "FASN-TGF-β1-PD-L1 axis contributes to the development of resistance to NK cell cytotoxicity of cisplatin-resistant lung cancer cells" [BBA - Mole...
Mingjing Shen, Ying Tsai, Rongying Zhu, Peter C. Keng, Yongbing Chen, Yuhchyau Chen, Soo Ok Lee> ;Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. 2021 Apr 28
4 citations
Impact of Diabetes and Insulin Use on Prognosis in Patients With Resected Pancreatic Cancer: An Ancillary Analysis of NRG Oncology RTOG 9704.
Danielle S. Bitterman, Kathryn Winter, Theodore S. Hong, Charles S. Fuchs, William F. Regine, Ross A. Abrams, Howard Safran, John P. Hoffman, Al B. Benson, Timothy Kas...> ;International Journal of Radiation Oncology, Biology, Physics. 2021 Jan 1
3 citations
Mapping expanded prostate cancer index composite to EQ5D utilities to inform economic evaluations in prostate cancer: Secondary analysis of NRG/RTOG 0415.
Rahul Khairnar, Stephanie L. Pugh, Howard M. Sandler, W. Robert Lee, Ester Villalonga Olives, C. Daniel Mullins, Francis B. Palumbo, Deborah Watkins Bruner, Fadia T. S...> ;Plos One. 2021 Apr 14
[Corrigendum] Increased infiltration of macrophages to radioresistant lung cancer cells contributes to the development of the additional resistance of tumor cells to t...
Mingjing Shen, Yongbing Chen, Lijun Xu, Rongying Zhu, Xiang Xue, Ying Tsai, Peter C Keng, Soo Ok Lee, Yuhchyau Chen> ;International Journal of Oncology. 2020 Oct 1
16 citations
Targeting the radiation-induced TR4 nuclear receptor-mediated QKI/circZEB1/miR-141-3p/ZEB1 signaling increases prostate cancer radiosensitivity
Dong Chen, Fu-Ju Chou, Yuhchyau Chen, Hao Tian, Yaqin Wang, Bosen You, Yuanjie Niu, Chi-Ping Huang, Shuyuan Yeh, Nianzeng Xing, Chawnshang Chang> ;Cancer Letters. 2020 Aug 6
13 citations
Human blood PIG-A mutation and micronucleated reticulocyte flow cytometric assays: Method optimization and evaluation of intra- and inter-subject variation.
Dorothea K. Torous, Svetlana L. Avlasevich, Mona Khattab, Ayesha Baig, Lawrence J. Saubermann, Yuhchyau Chen, Jeffrey C. Bemis, David P. Lovell, Vernon E. Walker, Jame...> ;Environmental and Molecular Mutagenesis. 2020 Jun 22
6 citations
Glucocorticoid receptor upregulation increases radioresistance and triggers androgen independence of prostate cancer.
Xiaodong Chen, Feng Chen, Yu Ren, Guobin Weng, Peter C Keng, Yunchyau Chen, Soo Ok Lee> ;The Prostate. 2020 Jun 1
Corrigendum to “In vitro-induced M2 type macrophages induces the resistance of prostate cancer cells to cytotoxic action of NK cells”[Exp Cell Res 364 (2018) 113–123]
Lijun Xu, Mingjing Shen, Xiaodong Chen, Dong-Rong Yang, Ying Tsai, Peter C. Keng, Soo Ok Lee, Yuhchyau Chen> ;Experimental Cell Research. 2020 Jun 1
Marital Status and Overall Survival in Patients with Resectable Pancreatic Cancer: Results of an Ancillary Analysis of NRG Oncology/RTOG 9704.
Marsha Reyngold, Kathryn A Winter, William F Regine, Ross A Abrams, Howard Safran, John P Hoffman, Rex B Mowat, John P Hayes, Ivan L Kessel, Thomas DiPetrillo, Samir N...> ;The Oncologist. 2020 Mar 1
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Journal Articles

Comparison of Single- and Five-Fraction Regimens of Stereotactic Body Radiation Therapy for Peripheral Early Stage Non-Small Cell Lung Cancer: A Two-Institution Propen...
Yusef Syed, Harish K Malhotra, Yuhchyau Chen, Deepinder P Singh, Anurag K Singh, Clinical Lung Cancer

Authored Content

Comparison of Single- and Five-Fraction Regimens of Stereotactic Body Radiation Therapy for Peripheral Early Stage Non-Small Cell Lung Cancer: A Two-Institution Propensity Matched AnalysisJuly 2018