ZenaideQuezadoMD

Anesthesiology • Washington, DC

Cardiothoracic Anesthesiology, Pediatric Anesthesiology

Professor, Anesthesiology & Critical Care Medicine, George Washington University Sch of Med and Health Sciences

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Office
111 Michigan Ave Nw
Washington, DC 20010
Phone+1 202-884-2025
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Education & Training

Massachusetts General HospitalResidency, Anesthesiology, 1996 - 1999
Albert Einstein Healthcare NetworkResidency, Internal Medicine, 1987 - 1990
Federal University of Ceara Faculty of MedicineClass of 1983
Massachusetts General HospitalFellowship, Adult Cardiothoracic Anesthesiology

Certifications & Licensure

MD State Medical License 1991 - 2025
PA State Medical License 1988 - 2024
MA State Medical License 1998 - 2024
DC State Medical License 1995 - 2024
American Board of Anesthesiology Anesthesiology
American Board of Anesthesiology Pediatric Anesthesiology

Clinical Trials

SCD-PROMIS: A Software Platform to Enhance Self-efficacy and Patient-provider Engagement for Patients With Sickle Cell Pain Start of enrollment: 2016 Nov 01
Completed
Not Applicable

Publications & Presentations

PubMed

Syk inhibition suppresses NLRP3 inflammasome activation in platelets from sickle cell mice leading to decreased platelet secretion, aggregation, spreading, and in vitr...
Sebastian Vogel, Sayuri Kamimura, Meghann L Smith, Luis E F Almeida, Xizhong Cui, Christian A Combs, Zenaide M N Quezado> ;Thrombosis Research. 2024 Mar 22
Calcium flux alterations in erythrocytes from sickle cell mice: The relevance of mean corpuscular volume.
Luis E F Almeida, Meghann L Smith, Sayuri Kamimura, Sebastian Vogel, Zenaide M N Quezado> ;Blood Cells, Molecules & Diseases. 2024 Jan 1
2 citations
Mouse models of sickle cell disease: Imperfect and yet very informative.
Sayuri Kamimura, Meghann Smith, Sebastian Vogel, Luis E F Almeida, Swee Lay Thein, Zenaide M N Quezado> ;Blood Cells, Molecules & Diseases. 2024 Jan 1
1 citations
Nitrite decreases sickle hemoglobin polymerization in vitro independently of methemoglobin formation.
Luis E F Almeida, Meghann L Smith, Sayuri Kamimura, Sebastian Vogel, Celia M de Souza Batista, Zenaide M N Quezado> ;Toxicology and Applied Pharmacology. 2023 Aug 15
2 citations
Pain research and children and adolescents with severe intellectual disability: ethical challenges and imperatives.
Sarah Z Raskoff, Audrey Thurm, Helga O Miguel, Scott Y H Kim, Zenaide M N Quezado> ;The Lancet. Child & Adolescent Health. 2023 Apr 1
Subanesthetic ketamine: the way forward for pain management in sickle cell disease patients?
Raissa Nobrega, Veronica Carullo, Swee Lay Thein, Zenaide M N Quezado> ;Expert Review of Hematology. 2022 Oct 1
8 citations
Mitapivat increases ATP and decreases oxidative stress and erythrocyte mitochondria retention in a SCD mouse model.
Zenaide M N Quezado, Sayuri Kamimura, Meghann Smith, Xunde Wang, Michael R Heaven, Sirsendu Jana, Sebastian Vogel, Patricia Zerfas, Christian A Combs, Luis E F Almeida...> ;Blood Cells, Molecules & Diseases. 2022 Jul 1
Anesthetic Management of Children and Adolescents With Giant Axonal Neuropathy: A Large Case Series.
Muhammad Yousef, Diana Bharucha-Goebel, Dimah Saade, G. Averion, Carsten G. Bönnemann, Zenaide M.N. Quezado> ;A&A Practice. 2021 Oct 25
46 citations
Circulating mitochondrial DNA is a proinflammatory DAMP in sickle cell disease.
Laxminath Tumburu, Shohini Ghosh-Choudhary, Fayaz Seifuddin, Emilia Alina Barbu, Simon Yang, Maliha Maryam Ahmad, Lauren H. W. Wilkins, Ilker Tunc, Ishwarya Sivakumar,...> ;Blood. 2021 Jun 3
12 citations
NLRP3 inflammasome and bruton tyrosine kinase inhibition interferes with upregulated platelet aggregation and in vitro thrombus formation in sickle cell mice.
Sebastian Vogel, Sayuri Kamimura, Taruna Arora, Meghann L. Smith, Luis E.F. Almeida, Christian A. Combs, Swee Lay Thein, Zenaide M.N. Quezado> ;Biochemical and Biophysical Research Communications. 2021 May 28
2 citations
Nitric oxide and sickle cell disease-Is there a painful connection?
Lillian Hallmark, Luis E.F. Almeida, Sayuri Kamimura, Meghann L. Smith, Zenaide M.N. Quezado> ;Experimental Biology and Medicine. 2021 Feb 1
3 citations
Sickle cell disease mice have cerebral oxidative stress and vascular and white matter abnormalities.
Alfia Khaibullina, Luis E.F. Almeida, Sayuri Kamimura, Patricia M. Zerfas, Meghann L. Smith, Sebastian Vogel, Paul Wakim, Olavo M. Vasconcelos, Martha Quezado, Iren Ho...> ;Blood Cells, Molecules & Diseases. 2021 Feb 1
10 citations
Regional rates of brain protein synthesis are unaltered in dexmedetomidine sedated young men with fragile X syndrome: A L-[1-11C]leucine PET study
Kathleen C Schmidt, Inna Loutaev, Zenaide M.N. Quezado, Carrie Sheeler, Carolyn Beebe Smith> ;Neurobiology of Disease. 2020 Sep 1
4 citations
Locomotor mal-performance and gait adaptability deficits in sickle cell mice are associated with vascular and white matter abnormalities and oxidative stress in cerebe...
Luis E.F. Almeida, Li Wang, Sayuri Kamimura, Patricia M. Zerfas, Meghann L. Smith, Osorio Abath Neto, Ticiana Vale, Martha Quezado, Iren Horkayne-Szakaly, Paul Wakim, ...> ;Brain Research. 2020 Jun 10
22 citations
Kcnn2 blockade reverses learning deficits in a mouse model of fetal alcohol spectrum disorders.
Shahid Mohammad, Stephen J. Page, Li Wang, Seiji Ishii, Peijun Li, Toru Sasaki, Aiesha Basha, Anna C. Salzberg, Zenaide Quezado, Fumiaki Imamura, Hirotaka Nishi, Keiic...> ;Nature Neuroscience. 2020 Mar 16
13 citations
Sickle cell disease subjects and mouse models have elevated nitrite and cGMP levels in blood compartments
Luis E.F. Almeida, Sayuri Kamimura, Celia M. de Souza Batista, Nicholas Spornick, Margaret Y. Nettleton, Elizabeth Walek, Meghann L. Smith, Julia C. Finkel, Deepika S....> ;Nitric Oxide. 2020 Jan 1
2 citations
Analgesic Requirements in Adolescents Undergoing Bariatric Surgery-an Observational Study.
Janelle D Vaughns, Elaine F Williams, Eleanor R. Mackey, Jane Muret, John N. van den Anker, Evan P. Nadler, Zenaide M.N. Quezado> ;Obesity Surgery. 2019 May 1
7 citations
The role of nitrite in muscle function, susceptibility to contraction injury, and fatigability in sickle cell mice.
Li Wang, Luis E.F. Almeida, Sayuri Kamimura, Jack H. Van der Meulen, Kanneboyina Nagaraju, Martha Quezado, Paul Wakim, Zenaide M.N. Quezado> ;Nitric Oxide. 2018 Nov 1
50 citations
The platelet NLRP3 inflammasome is upregulated in sickle cell disease via HMGB1/TLR4 and Bruton tyrosine kinase.
Sebastian Vogel, Taruna Arora, Xunde Wang, Laurel Mendelsohn, James S. Nichols, Darlene Allen, Arun S. Shet, Christian A. Combs, Zenaide M.N. Quezado, Swee Lay Thein> ;Blood Advances. 2018 Oct 23
12 citations
RON kinase inhibition reduces renal endothelial injury in sickle cell disease mice.
Alfia Khaibullina, Elena Afia Adjei, Nowah Afangbedji, Andrey Ivanov, Namita Kumari, Luis E.F. Almeida, Zenaide M.N. Quezado, Sergei Nekhai, Marina Jerebtsova> ;Haematologica. 2018 May 1
12 citations
The corticosteroid compounds prednisolone and vamorolone do not alter the nociception phenotype and exacerbate liver injury in sickle cell mice
Luis E.F. Almeida, Jesse M. Damsker, Sarah Albani, Nina Afsar, Sayuri Kamimura, Drew Pratt, David E. Kleiner, Martha Quezado, Heather Gordish-Dressman, Zenaide M.N. Qu...> ;Scientific Reports. 2018 Apr 17
23 citations
Patient characteristics affect the response to ketamine and opioids during the treatment of vaso-occlusive episode-related pain in sickle cell disease.
Raissa Nobrega, Kathy A Sheehy, Caroline Lippold, Amy L Rice, Julia C. Finkel, Zenaide M.N. Quezado> ;Pediatric Research. 2018 Feb 1
21 citations
Dexmedetomidine as an adjuvant for perioperative pain management in adolescents undergoing bariatric surgery: An observational cohort study.
Janelle D. Vaughns, Celeste Martin, Jonathon Nelson, Evan P. Nadler, Zenaide M.N. Quezado> ;Journal of Pediatric Surgery. 2017 Nov 1
1 citations
Data on the effect of sex on the size, cellular content, and neuronal density of the developing brain in mice exposed to isoflurane and carbon monoxide.
Li Wang, Aili Wang, William W. Supplee, Kayla Koffler, Ying Cheng, Zenaide M.N. Quezado, Richard J. Levy> ;Data in Brief. 2017 Aug 1
8 citations
Blood collection vials and clinically used intravenous fluids contain significant amounts of nitrite
Luis E.F. Almeida, Sayuri Kamimura, Margaret Y. Nettleton, Celia M. de Souza Batista, Elizabeth Walek, Alfia Khaibullina, Li Wang, Zenaide M.N. Quezado> ;Free Radical Biology & Medicine. 2017 Jul 1
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Grant Support

The Role Of Neuronal Nitric Oxide Synthase In A Model Of Peritonitis And SepsisClinical Center2007–2008
The Role Of Neuronal Nitric Oxide On Current Vocalization ThresholdsClinical Center2007–2008
A Non-Injurious Assay To Study Mechanisms Of Transmission Of Noxious StimulusClinical Center2007–2008
The Effect Of Aging And Sex In NociceptionClinical Center2005–2008
The Role Of Neuronal Nitric Oxide Synthase In A Model OfClinical Center2006
A Non-Injurious Assay To Study Mechanisms Of TransmissioClinical Center2006
The Role Of Neuronal Nitric Oxide On Pain ThresholdsClinical Center2005
Non-Injurious Murine Assay To Study Nociception TransmisClinical Center2005
Neuronal Nitric Oxide Synthase In A Model Of PeritonitisClinical Center2005
Non-Injurious Murine Assay Study Mechanisms NociceptionClinical Center2004
Neuronal Nitric Oxide Synthase: Model Peritonitis/SepsisClinical Center2004
The Role Of Nitric Oxide Synthase 1 (NOS1) In A Rodent MClinical Center2003
Development Of SAFE Neuro-Specific Nociceptive AssayClinical Center2003
The Role Of Nitric Oxide Synthase 1 (NOS1) In SepsisClinical Center2002

Other Languages

Portuguese, Spanish

Hospital Affiliations

Children's National HospitalWashington, District of Columbia