ZhenFanMD

PubMed

• 1 citations
  Redirecting host preexisting influenza A virus immunity for cancer immunotherapy
  Bharat Kumar Reddy Chaganty, Songbo Qiu, Yang Lu, Gabriel Lopez-Berestein, Bulent Ozpolat, Zhen Fan> ;Cancer Immunology, Immunotherapy. 2021 Nov 3
• 20 citations
  ASCT2 overexpression is associated with poor survival of OSCC patients and ASCT2 knockdown inhibited growth of glutamine-addicted OSCC cells.
  Yijun Luo, Wei Li, Zihang Ling, Qinchao Hu, Zhen Fan, Bin Cheng, Xiaoan Tao> ;Cancer Medicine. 2020 Mar 12
• 22 citations
  Rational combination with PDK1 inhibition overcomes cetuximab resistance in head and neck squamous cell carcinoma.
  Haiquan Lu, Yang Lu, Yangyiran Xie, Songbo Qiu, Xinqun Li, Zhen Fan> ;JCI Insight. 2019 Oct 4
• 107 citations
  Trastuzumab upregulates PD-L1 as a potential mechanism of trastuzumab resistance through engagement of immune effector cells and stimulation of IFNγ secretion.
  Bharat Kumar Reddy Chaganty, Songbo Qiu, Anneliese Gest, Yang Lu, Cristina Ivan, George A. Calin, Louis M. Weiner, Zhen Fan> ;Cancer Letters. 2018 Aug 28
• 22 citations
  Functional cooperation between HIF-1α and c-Jun in mediating primary and acquired resistance to gefitinib in NSCLC cells with activating mutation of EGFR.
  Shuyan Meng, Guorui Wang, Yang Lu, Zhen Fan> ;Lung Cancer. 2018 Jul 1
• 28 citations
  AP1G1 is involved in cetuximab-mediated downregulation of ASCT2-EGFR complex and sensitization of human head and neck squamous cell carcinoma cells to ROS-induced apop...
  Xiaoan Tao, Yang Lu, Songbo Qiu, Yi Wang, Jun Qin, Zhen Fan> ;Cancer Letters. 2017 Nov 1
• 58 citations
  Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab.
  Jingtao Luo, Yun Hong, Yang Lu, Songbo Qiu, Bharat Kumar Reddy Chaganty, Lun Zhang, Xudong Wang, Qiang Li, Zhen Fan> ;Cancer Letters. 2017 Jan 1
• 42 citations
  ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis
  Haiquan Lu, Xinqun Li, Yang Lu, Songbo Qiu, Zhen Fan> ;Cancer Letters. 2016 Oct 10
• 21 citations
  Identification and validation of COX-2 as a co-target for overcoming cetuximab resistance in colorectal cancer cells
  Yang Lu, Chunmei Shi, Songbo Qiu, Zhen Fan> ;Oncotarget. 2016 Apr 8
• 34 citations
  Trastuzumab upregulates expression of HLA-ABC and T cell costimulatory molecules through engagement of natural killer cells and stimulation of IFNγ secretion.
  Bharat Kumar Reddy Chaganty, Yang Lu, Songbo Qiu, Srinivas S. Somanchi, Dean A. Lee, Zhen Fan> ;Oncoimmunology. 2016 Apr 2
• 117 citations
  Overcoming cisplatin resistance of ovarian cancer cells by targeting HIF-1-regulated cancer metabolism.
  Zhihong Ai, Yang Lu, Songbo Qiu, Zhen Fan> ;Cancer Letters. 2016 Apr 1
• 20 citations
  Acquired resistance to anti-EGFR mAb ICR62 in cancer cells is accompanied by an increased EGFR expression, HER-2/HER-3 signalling and sensitivity to pan HER blockers.
  Said Abdullah Khelwatty, Sharadah Essapen, Alan M. Seddon, Zhen Fan, Helmout Modjtahedi> ;British Journal of Cancer. 2015 Sep 29
• 28 citations
  AMPK-mediated energy homeostasis and associated metabolic effects on cancer cell response and resistance to cetuximab
  Xinqun Li, Yang Lu, Haiquan Lu, Jingtao Luo, Yun Hong, Zhen Fan> ;Oncotarget. 2015 Mar 23
• 13 citations
  Autocrine/paracrine erythropoietin regulates migration and invasion potential and the stemness of human breast cancer cells.
  Ke Liang, Songbo Qiu, Yang Lu, Zhen Fan> ;Cancer Biology & Therapy. 2014 Jan 1
• 60 citations
  Cetuximab reverses the warburg effect by inhibiting HIF-1-regulated LDH - A
  Haiquan Lu, Xinqun Li, Zhongguang Luo, Jie Liu, Zhen Fan> ;Molecular Cancer Therapeutics. 2013 Oct 1
• 14 citations
  HER2 regulates Brk/PTK6 stability via upregulating calpastatin, an inhibitor of calpain.
  Midan Ai, Songbo Qiu, Yang Lu, Zhen Fan> ;Cellular Signalling. 2013 Sep 1
• 30 citations
  A novel role of EMMPRIN/CD147 in transformation of quiescent fibroblasts to cancer-associated fibroblasts by breast cancer cells.
  Jing Xu, Yang Lu, Songbo Qiu, Zhi Nan Chen, Zhen Fan> ;Cancer Letters. 2013 Jul 28
• 28 citations
  Brk/PTK6 cooperates with HER2 and Src in regulating breast cancer cell survival and epithelial-to-mesenchymal transition.
  Midan Ai, Ke Liang, Yang Lu, Songbo Qiu, Zhen Fan> ;Cancer Biology & Therapy. 2013 Jan 4
• 46 citations
  Brk/PTK6 Sustains Activated EGFR Signaling through Inhibiting EGFR Degradation and Transactivating EGFR
  Xinqun Li, Yiling Lu, Ke Liang, J. M. Hsu, Constance Albarracin, Gordon B. Mills, Mien Chie Hung, Zhen Fan> ;Oncogene. 2012 Oct 4
• 40 citations
  The anti-EGFR antibody cetuximab sensitizes human head and neck squamous cell carcinoma cells to radiation in part through inhibiting radiation-induced upregulation of...
  Haiquan Lu, Ke Liang, Yang Lu, Zhen Fan> ;Cancer Letters. 2012 Sep 1
• 7 citations
  Constitutively active Harvey Ras confers resistance to epidermal growth factor receptor–targeted therapy with cetuximab and gefitinib
  Rodney B. Luwor, Yang Lu, Xinqun Li, Ke Liang, Zhen Fan> ;Cancer Letters. 2011 Jul 1
• 14 citations
  1, 9-Pyrazoloanthrones downregulate HIF-1α and sensitize cancer cells to cetuximab-mediated anti-EGFR therapy.
  Yang Lu, Xinqun Li, Haiquan Lu, Zhen Fan> ;Plos One. 2010 Dec 29
• 111 citations
  Recombinant Human Erythropoietin Antagonizes Trastuzumab Treatment of Breast Cancer Cells via Jak2-Mediated Src Activation and PTEN Inactivation
  Ke Liang, Francisco J. Esteva, Constance Albarracin, Katherine Stemke-Hale, Yang Lu, Giampaolo Bianchini, Ching Yi Yang, Yong Li, Xinqun Li, Chun Te Chen, Gordon B. Mi...> ;Cancer Cell. 2010 Nov 16
• 41 citations
  From combinatorial peptide selection to drug prototype (II): Targeting the epidermal growth factor receptor pathway
  Marina Cardó-Vila, Ricardo J. Giordano, Richard L. Sidman, Lawrence Bronk, Zhen Fan, John Mendelsohn, Wadih Arap, Renata Pasqualini> ;Proceedings of the National Academy of Sciences of the United States of America. 2010 Mar 16
• 54 citations
  Requirement of hypoxia-inducible factor-1α down-regulation in mediating the antitumor activity of the anti–epidermal growth factor receptor monoclonal antibody cetuximab
  Xinqun Li, Yang Lu, Ke Liang, Tianhong Pan, John Mendelsohn, Zhen Fan> ;Molecular Cancer Therapeutics. 2008 May 1
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