JoshuaRFriedmanMDPhD

PubMed

• 1 citations
  Deep Learning Models Capture Histological Disease Activity in Crohn's Disease and Ulcerative Colitis with High Fidelity.
  Dawid Rymarczyk, Weiwei Schultz, Adriana Borowa, Tomasz Danel, Patrick Branigan, Michał Chałupczak, Anna Bracha, Tomasz Krawiec, Michał Warchoł, Katherine Li, Gert De ...> ;Journal of Crohn's & Colitis. 2024 Apr 23
• 19 citations
  Biopsy and blood-based molecular biomarker of inflammation in IBD.
  Friedman, J. R., Carmen Argmann, Ruixue Hou, Ryan C Ungaro, Haritz Irizar, Zainab Al-Taie, Ruiqi Huang, Roman Kosoy, Swati Venkat, Won-Min Song, Antonio F Di'Narzo, Bo...> ;Gut. 2023 Jul 1
• 2 citations
  A temporal classifier predicts histopathology state and parses acute-chronic phasing in inflammatory bowel disease patients.
  Friedman, J. R., Lauren A Peters, Joshua R Friedman, Aleksandar Stojmirovic, Jacob Hagen, Sander Houten, Tetyana Dodatko, Mariana P Amaro, Paula Restrepo, Zhi Chai, J ...> ;Communications Biology. 2023 Jan 24
• 33 citations
  Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy.
  Friedman, J. R., Polychronis Pavlidis, Anastasia Tsakmaki, Eirini Pantazi, Katherine Li, Domenico Cozzetto, Jonathan Digby-Bell, Feifei Yang, Jonathan W Lo, Elena Albe...> ;Nature Communications. 2022 Oct 3
• 6 citations
  Cytokine responsive networks in human colonic epithelial organoids unveil a molecular classification of inflammatory bowel disease.
  Polychronis Pavlidis, Anastasia Tsakmaki, Agatha Treveil, Katherine Li, Domenico Cozzetto, Feifei Yang, Umar Niazi, Bu Hussain Hayee, Mansoor Saqi, Tamas Korcsmaros, G...> ;Cell Reports. 2022 Sep 27
• 10 citations
  Molecular Characterization of Limited Ulcerative Colitis Reveals Novel Biology and Predictors of Disease Extension.
  Friedman, J. R., Carmen Argmann, Minami Tokuyama, Ryan C. Ungaro, Ruiqi Huang, Ruixue Hou, Sakteesh Gurunathan, Roman Kosoy, Antonio Di’Narzo, Wenhui Wang, Bojan Losic...> ;Gastroenterology. 2021 Dec 1
• 93 citations
  Intestinal Inflammation Modulates the Expression of ACE2 and TMPRSS2 and Potentially Overlaps With the Pathogenesis of SARS-CoV-2-related Disease.
  Friedman, J. R., Mayte Suárez-Fariñas, Minami Tokuyama, Gabrielle Wei, Ruiqi Huang, Alexandra E. Livanos, Divya Jha, Anais Levescot, Haritz Irizar, Roman Kosoy, Sascha...> ;Gastroenterology. 2021 Jan 1
• 14 citations
  Deep Analysis of the Peripheral Immune System in IBD Reveals New Insight in Disease Subtyping and Response to Monotherapy or Combination Therapy.
  Friedman, J. R., Roman Kosoy, Seunghee Kim-Schulze, Adeeb Rahman, Joshua R. Friedman, Ruiqi Huang, Lauren A. Peters, El-ad David Amir, Jacqueline Perrigoue, Aleksandar...> ;Cellular and Molecular Gastroenterology and Hepatology. 2021 Jan 1
• 40 citations
  Relationship Between Combined Histologic and Endoscopic Endpoints and Efficacy of Ustekinumab Treatment in Patients With Ulcerative Colitis.
  Katherine Li, Colleen Marano, Hongyan Zhang, Feifei Yang, William J. Sandborn, Bruce E. Sands, Brian G. Feagan, David T. Rubin, Laurent Peyrin-Biroulet, Gert De Hertog...> ;Gastroenterology. 2020 Dec 1
• 43 citations
  Effects of Ustekinumab on Histologic Disease Activity in Patients With Crohn's Disease.
  Katherine Li, Daphne Chan, Paul F. Pollack, Feifei Yang, Douglas Jacobstein, Carrie Brodmerkel, Christopher Gasink, Brian G. Feagan, William J. Sandborn, Paul Rutgeert...> ;Gastroenterology. 2019 Oct 1
• 388 citations
  Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy.
  Friedman, J. R., Jerome Martin, Christie Chang, Gilles Boschetti, Ryan C. Ungaro, Mamta Giri, John A. Grout, Kyle Gettler, Ling-Shiang Chuang, Shikha Nayar, Alexander ...> ;Cell. 2019 Sep 5
• 14 citations
  A negative role for the interleukin-2-inducible T-cell kinase (ITK) in human Foxp3+ TREG differentiation.
  Polina Mamontov, Ryan A. Eberwine, Jackie Perrigoue, Anuk Das, J. Rodrigo Mora, Friedman, J. R., Joshua R. Friedman> ;Plos One. 2019 Apr 25
• 87 citations
  Gut microbiota density influences host physiology and is shaped by host and microbial factors
  Friedman, J. R., Eduardo J. Contijoch, Graham J. Britton, Chao Yang, Ilaria Mogno, Zhihua Li, Ruby Ng, Sean R. Llewellyn, Sheela Hira, Crystal H Johnson, Keren M. Rabi...> ;Elife. 2019 Jan 22
• 57 citations
  Abnormal Small Intestinal Epithelial Microvilli in Patients With Crohn’s Disease
  Kelli L. VanDussen, Aleksandar Stojmirović, Katherine Li, Ta-Chiang Liu, Patrick K. Kimes, Brian D. Muegge, Katherine F. Simpson, Matthew A. Ciorba, Jacqueline Perrigo...> ;Gastroenterology. 2018 Sep 1
• 40 citations
  Molecular Comparison of Adult and Pediatric Ulcerative Colitis Indicates Broad Similarity of Molecular Pathways in Disease Tissue.
  Katherine Li, Richard Strauss, Jodie Ouahed, Daphne Chan, Shannon Telesco, Dror S. Shouval, James B. Canavan, Carrie Brodmerkel, Scott B. Snapper, Friedman, J. R., Jos...> ;Journal of Pediatric Gastroenterology and Nutrition. 2018 Jul 1
• 85 citations
  Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression.
  Friedman, J. R., Yanxia Guo, Alice M. Walsh, Mary Canavan, Mihir D. Wechalekar, Suzanne Cole, Xuefeng Yin, Brittney Scott, Mathew J. Loza, Carl Orr, Trudy McGarry, Mic...> ;Plos One. 2018 Feb 28
• 143 citations
  A functional genomics predictive network model identifies regulators of inflammatory bowel disease.
  Friedman, J. R., Lauren A. Peters, Jacqueline Perrigoue, Arthur Mortha, Alina Iuga, Won-Min Song, Eric M. Neiman, Sean R. Llewellyn, Antonio Fabio Di Narzo, Brian A. K...> ;Nature Genetics. 2017 Sep 11
• 1 citations
  GI Research Path: From Academia to the Pharmaceutical Industry.
  Friedman, J. R., Joshua R. Friedman> ;Cellular and Molecular Gastroenterology and Hepatology. 2017 Jan 1
• 1000 citations
  Ustekinumab as Induction and Maintenance Therapy for Crohn's Disease.
  Friedman, J. R., Brian G Feagan, William J Sandborn, Christopher Gasink, Douglas Jacobstein, Yinghua Lang, Joshua R Friedman, Marion A Blank, Jewel Johanns, Long-Long ...> ;The New England Journal of Medicine. 2016 Nov 17
• 63 citations
  MicroRNA-122 regulates polyploidization in the murine liver.
  Shu-Hao Hsu, Evan R. Delgado, P. Anthony Otero, Kun-Yu Teng, Huban Kutay, Kolin M. Meehan, Justin B. Moroney, Jappmann K. Monga, Nicholas J. Hand, Joshua R. Friedman, ...> ;Hepatology. 2016 Aug 1
• 14 citations
  Pediatric eosinophilic esophagitis is associated with changes in esophageal microRNAs
  Adam M. Zahm, Calies Menard-Katcher, Alain Benitez, Daphne Tsoucas, Nicholas J. Hand, Friedman, J. R., Joshua R. Friedman, Claire L. Le Guen> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2014 Oct 15
• 48 citations
  Rectal microRNAs are perturbed in pediatric inflammatory bowel disease of the colon
  Adam M. Zahm, Nicholas J. Hand, Daphne Tsoucas, Robert N. Baldassano, Friedman, J. R., Joshua R. Friedman, Claire L. Le Guen> ;Journal of Crohn's & Colitis. 2014 Sep 1
• 247 citations
  Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets.
  Vasumathi Kameswaran, Nuria C. Bramswig, Lindsay B. McKenna, Melinda Penn, Jonathan Schug, Nicholas J. Hand, Ying Chen, Inchan Choi, Anastassios Vourekas, Kyoung-Jae W...> ;Cell Metabolism. 2014 Jan 7
• 6 citations
  Novel targets of miR-30, a microRNA required for biliary development.
  Joshua R. Friedman, Nicholas J. Hand, Friedman, J. R., Claire L. Le Guen> ;F1000research. 2013 Sep 24
• 22 citations
  Extrahepatic cholangiocyte cilia are abnormal in biliary atresia.
  Sara Karjoo, Nicholas J. Hand, Lorena Loarca, Pierre Russo, Rebecca G. Wells, Friedman, J. R., Joshua R. Friedman> ;Journal of Pediatric Gastroenterology and Nutrition. 2013 Jul 1
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