Brandon C.McKinneyMDPhD

Psychiatry • Pittsburgh, PA

Psychopharmacology, Integrative Psychiatry

Brandon C. McKinney, MD, PhD

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Office
3811 O'Hara Street
Pittsburgh, PA 15213
Fax+1 888-948-8425
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Summary

Dr. Brandon C. McKinney is a psychiatrist in Pittsburgh, PA specializing in psychopharmacology with nine years of experience.

He received his MD and PhD in Neuroscience from University of Michigan Medical School, and did his residency training in general adult psychiatry at UPMC Western Psychiatric Hospital.

He joined the faculty in University of Pittsburgh Medical School's Department of Psychiatry after completing his psychiatry residency. As a faculty member, he directed an NIH-funded laboratory investigating the role of epigenetic mechanisms in schizophrenia and brain aging. He also practiced psychiatry in multiple settings including the psychiatric emergency room, outpatient psychiatric clinics, and primary care clinic.

In 2022, he left his faculty position to pursue a career in the private sector. He remains a volunteer faculty member at the University of Pittsburgh Medical School and maintains a small private practice.

Education & Training

University of Pittsburgh School of MedicinePost-Doctoral Fellowship, Translational Neuroscience, 2014
UPMC Medical EducationChief Residency, Psychiatry, 2013 - 2014
UPMC Medical EducationResidency, Psychiatry, 2010 - 2014
University of Michigan Medical SchoolClass of 2010
University of Michigan Medical SchoolPhD, Neuroscience, 2010
University of Illinois at Urbana-ChampaignMS, Biology, 2001 - 2002
University of Illinois at Urbana-ChampaignMSc, Biology, 2002
University of Illinois at Urbana-ChampaignBS, Biology, Honors, 1997 - 2001
University of Illinois at Urbana-ChampaignB.S., Honors Biology, 1996 - 2001

Certifications & Licensure

MT License, PA 2010 - 2024
American Board of Psychiatry and Neurology Psychiatry

Awards, Honors, & Recognition

Outstanding Poster Presentation WPIC Research Day, 2014
Scholar American Association of Geriatric Psychiatry, 2012
Outstanding Resident Award NIMH, 2012
Horace H. Rackham Distinguished Dissertation Award, Nominated 2008
Montford Piercey Award Michigan Society for Neuroscience, 2006
James Scholar University of Illinois, 2001
Instructor Ranked Outstanding by Students (Chemistry 102) University of Illinois, 2001
Jonathan Baldwin Turner Scholar University of Illinois, 1997
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Publications & Presentations

PubMed

8 citations
Schizophrenia-associated differential DNA methylation in brain is distributed across the genome and annotated to MAD1L1, a locus at which DNA methylation and transcrip...
Brandon C McKinney, Lora L McClain, Christopher M Hensler, Yue Wei, Lambertus Klei, David A Lewis, Bernie Devlin, Jiebiao Wang, Ying Ding, Robert A Sweet> ;Translational Psychiatry. 2022 Aug 20
22 citations
More than a marker: potential pathogenic functions of MAP2.
Rebecca A DeGiosio, Melanie J Grubisha, Matthew L MacDonald, Brandon C McKinney, Carlos J Camacho, Robert A Sweet> ;Frontiers in Molecular Neuroscience. 2022 Jan 1
24 citations
Density of small dendritic spines and microtubule-associated-protein-2 immunoreactivity in the primary auditory cortex of subjects with schizophrenia
Brandon C. McKinney, Matthew L. MacDonald, Jason T. Newman, Micah A. Shelton, RA DeGiosio, Ryan M. Kelly, Kenneth N. Fish, Allan R. Sampson, David A. Lewis, Robert A. ...> ;Neuropsychopharmacology. 2019 Feb 22
14 citations
DNA methylation in the human frontal cortex reveals a putative mechanism for age-by-disease interactions.
Brandon C. McKinney, Chien-Wei Lin, Tanbin Rahman, Hyunjung Oh, David A. Lewis, George C. Tseng, Etienne Sibille> ;Translational Psychiatry. 2019 Jan 29
3 citations
Epigenetic Programming: A Putative Neurobiological Mechanism Linking Childhood Maltreatment and Risk for Adult Psychopathology.
Brandon C. McKinney> ;The American Journal of Psychiatry. 2017 Dec 1
36 citations
DNA methylation age is not accelerated in brain or blood of subjects with schizophrenia.
Brandon C. McKinney, Huang Lin, Ying Ding, David A. Lewis, Robert A. Sweet> ;Schizophrenia Research. 2018 Jun 1
12 citations
A novel mouse model of the aged brain: Over-expression of the L-type voltage-gated calcium channel CaV1.3.
Jamie N. Krueger, Shannon J. Moore, Rachel Parent, Brandon C. McKinney, Amy S. Lee, Geoffrey G. Murphy> ;Behavioural Brain Research. 2017 Mar 30
32 citations
DNA methylation evidence against the accelerated aging hypothesis of schizophrenia
Brandon C. McKinney, Huang Lin, Ying Ding, David A. Lewis, Robert A. Sweet> ;NPJ Schizophrenia. 2017 Mar 23
21 citations
DNA methylation as a putative mechanism for reduced dendritic spine density in the superior temporal gyrus of subjects with schizophrenia.
Brandon C. McKinney, Ying Ding, David A. Lewis, Robert A. Sweet> ;Translational Psychiatry. 2017 Feb 14
20 citations
Hypermethylation of BDNF and SST Genes in the Orbital Frontal Cortex of Older Individuals: A Putative Mechanism for Declining Gene Expression with Age
Brandon C. McKinney, Chien-Wei Lin, Hyunjung Oh, George C. Tseng, David A. Lewis, Etienne Sibille> ;Neuropsychopharmacology. 2015 Apr 16
17 citations
Age-by-disease biological interactions: implications for late-life depression.
Brandon C. McKinney, Hyunjung Oh, Etienne Sibille> ;Frontiers in Genetics. 2012 Nov 16
50 citations
The age-by-disease interaction hypothesis of late-life depression.
Brandon C. McKinney, Etienne Sibille> ;The American Journal of Geriatric Psychiatry. 2012 Oct 1
39 citations
Deletion of the L-type Calcium Channel CaV1.3 but not CaV1.2 Results in a Diminished sAHP in Mouse CA1 Pyramidal Neurons
Amy E. Gamelli, Brandon C. McKinney, Jessica A. White, Geoffrey G. Murphy> ;Hippocampus. 2011 Feb 1
43 citations
Impaired long-term potentiation and enhanced neuronal excitability in the amygdala of CaV1.3 knockout mice
Brandon C. McKinney, Wilson Sze, Benjamin Lee, Geoffrey G. Murphy> ;Neurobiology of Learning and Memory. 2009 Nov 1
42 citations
Exaggerated emotional behavior in mice heterozygous null for the sodium channel Scn8a (Nav1.6).
Brandon C. McKinney, Clement Y. Chow, Miriam H. Meisler, Geoffrey G. Murphy> ;Genes, Brain, and Behavior. 2008 Aug 1
36 citations
L-type voltage-gated calcium channels in conditioned fear: a genetic and pharmacological analysis
Brandon C. McKinney, Wilson Sze, Jessica A. White, Geoffrey G. Murphy> ;Learning & Memory. 2008 May 1
22 citations
Decreased locomotor activity in mice expressing tTA under control of the CaMKIIα promoter
Brandon C. McKinney, J. S. Schneider, G. L. Schafer, J. L. Lowing, S. Mohan, M. X. Zhao, M. Y. Heng, Roger L. Albin, Audrey F. Seasholtz, Huda Akil, Geoffrey G. Murphy> ;Genes, Brain, and Behavior. 2008 Mar 1
94 citations
Conditional forebrain deletion of the L-type calcium channel CaV1.2 disrupts remote spatial memories in mice
Jessica A. White, Brandon C. McKinney, Manorama C. John, Patricia A. Powers, Timothy J. Kamp, Geoffrey G. Murphy> ;Learning & Memory. 2008 Jan 1
75 citations
The L-Type voltage-gated calcium channel Cav1.3 mediates consolidation, but not extinction, of contextually conditioned fear in mice.
Brandon C. McKinney, Geoffrey G. Murphy> ;Learning & Memory. 2006 Sep 1
145 citations
Hippocampal pyramidal cells in adult Fmr1 knockout mice exhibit an immature-appearing profile of dendritic spines.
Aaron W. Grossman, Nicholas M. Elisseou, Brandon C. McKinney, William T. Greenough> ;Brain Research. 2006 Apr 21
136 citations
Dendritic spine abnormalities in the occipital cortex of C57BL/6 Fmr1 knockout mice
Brandon C. McKinney, Aaron W. Grossman, Nicholas M. Elisseou, William T. Greenough> ;American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 2005 Jul 5
90 citations
Experience effects on brain development: possible contributions to psychopathology.
Aaron W. Grossman, James D. Churchill, Brandon C. McKinney, Ian M. Kodish, Stephani Otte, William T. Greenough> ;Journal of Child Psychology and Psychiatry, and Allied Disciplines. 2003 Jan 1
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Abstracts/Posters

DNA methylation of Somatostatin in Aging and Major Depressive Disorder.
McKinney B.C. and Sibille E., Society for Biological Psychiatry Annual Meeting, 1/1/2014
The Somatostatin Promoter is Hypermethylated in the Aged Human Prefrontal Cortex.
McKinney B. C. and Sibille. E., Western Psychiatric Institute & Clinic Research Day, Society for Neuroscience Program, American College of Neuropsychopharmacology Program, 1/1/2014
Mice heterozygous for a null mutation in sodium channel Scn8a (Nav1.6) exhibit enhanced innate and conditioned fear.
McKinney B.C., Chow C.Y., Meisler M.H., and Murphy G.G., FENS Forum, 1/1/2006
Voltage-gated L-type calcium channel subtype Cav 1.3 contributes significantly to the generations of the AHP in CA1 pyramidal neurons.
Kuo A.G., McKinney B.C., Chow C.Y., White J.A., and Murphy G.G., Society for Neuroscience Program, 1/1/2006
Expression of the tetracycline transactivator gene underregulation of the CaMKII promoter causes anxiety-like phenotype in mice.
Schneider J.S., Schafer G., McKinney B.C., Mohan S., Murphy G, Seasholtz A., and Akil H, Society for Neuroscience Program, 1/1/2006
Decreased exploratory behavior observed in C57BL/6 CaMKII alpha-tTA mice persists in F1 C57BL/6:129 Sve hybrid background
Murphy G.G., Lowing J.L., Heng M.Y., Albin R.L., and McKinney B.C., Society for Neuroscience Program, 1/1/2006
The L-type voltage-gated calcium channel Cav 1.3 mediates acquisition, but not extinction, of contextually conditioned fear.
McKinney B.C. and Murphy G.G., Society for Neuroscience Program, 1/1/2006
Dendritic spines along apical shafts of hippocampal pyramidal cells exhibit immature-appearing morphological distribution in Fmr1 knockout mice.
Grossman A.W., Elisseou N.M., McKinney B.C., and Greenough W.T., Society for Neuroscience Program, 1/1/2005
Cognitive and behavioral abnormalities in mice heterozygous null for the sodium channel Scn8a.
McKinney B.C., Meisler M.H., and Murphy G.G., Society for Neuroscience Program, 1/1/2005
Dendritic Spine Abnormalities in Fragile X (FMR-1) Knockout Mice with a C57BL/6 Background.
McKinney B.C., Elisseou N.M., and Greenough W.T., Society for Neuroscience Program, 1/1/2002
Synapse Development in Fragile X Knockout Mice.
McKinney B.C., Grossman A.W., deVries F.E., Lambers F.A.E., Elisseou N.M., Aballea A.F., Henson C., Bertaina-Anglade V.S., Klintsova A.Y., Greenough W.T., International Fragile X Conference, 1/1/2002
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Lectures

Graduate and Medical Training in the Neurosciences.
1/3/2013

Press Mentions

Department of Psychiatry Welcomes Talented New Researchers to Its FacultyFebruary 1st, 2017
14th Annual Department of Psychiatry Research Day Celebrates Outstanding Science, Mentorship, and Academic ServiceJune 16th, 2014

Grant Support

DNA methylation as a mechanism for reduced dendritic spine density in schizophreniaNIMH2017–2021

Professional Memberships

American Psychiatric Association - APA
Member