ChristineHwayongChungMD

PubMed

• A cross-sectional study of the association of dental health factors with progression and all-cause mortality in men diagnosed with HPV-associated oropharyngeal cancer.
  Brittney L Dickey, L Robert Gore, Robbert Slebos, Bradley Sirak, Kimberly A Isaacs-Soriano, Kayoko Kennedy, Kristen Otto, J Trad Wadsworth, Anna R Giuliano, Christine ...> ;BMC Oral Health. 2024 Apr 9
• Psychosocial consequences of head and neck cancer symptom burden after chemoradiation: a mixed-method study.
  Carley Geiss, Aasha I Hoogland, Brandy Arredondo, Yvelise Rodriguez, Crystal Bryant, Krupal B Patel, Brian D Gonzalez, Heather S L Jim, Laura B Oswald, Christine H Chu...> ;Supportive Care in Cancer. 2024 Mar 27
• Spatial interactions modulate tumor growth and immune infiltration.
  Sadegh Marzban, Sonal Srivastava, Sharon Kartika, Rafael Bravo, Rachel Safriel, Aidan Zarski, Alexander Anderson, Christine H Chung, Antonio L Amelio, Jeffrey West> ;Biorxiv. 2024 Mar 13
• Identification of a Biomarker Panel from Genome-Wide Methylation to Detect Early HPV-Associated Oropharyngeal Cancer.
  Brittney L Dickey, Ryan M Putney, Michael J Schell, Anders E Berglund, Antonio L Amelio, Jimmy J Caudell, Christine H Chung, Anna R Giuliano> ;Cancer Prevention Research. 2024 Apr 2
• Characterization of the Thyroid Cancer Genomic Landscape by Plasma-Based Circulating Tumor DNA Next-Generation Sequencing.
  Valentina D Tarasova, Jill Tsai, Jude Masannat, Colleen Veloski, Sarimar Agosto Salgado, Bryan McIver, Christine H Chung, Hernandez Prera, J., Hallanger Johnson, J., D...> ;Thyroid. 2024 Feb 1
• An AI-Ready Multiplex Staining Dataset for Reproducible and Accurate Characterization of Tumor Immune Microenvironment.
  Parmida Ghahremani, Joseph Marino, Juan Hernandez-Prera, Janis V de la Iglesia, Robbert Jc Slebos, Christine H Chung, Saad Nadeem> ;Medical Image Computing and Computer-Assisted Intervention. 2023 Oct 1
• Radiotherapy Plus Cisplatin With or Without Lapatinib for Non-Human Papillomavirus Head and Neck Carcinoma: A Phase 2 Randomized Clinical Trial.
  Stuart J Wong, Pedro A Torres-Saavedra, Nabil F Saba, George Shenouda, Jeffrey M Bumpous, Robert E Wallace, Christine H Chung, Adel K El-Naggar, Clement K Gwede, Barba...> ;JAMA Oncology. 2023 Nov 1
• Immune landscape in molecular subtypes of human papillomavirus-negative head and neck cancer.
  Mengyu Xie, Ritu Chaudhary, Robbert J C Slebos, Kyubum Lee, Feifei Song, Maria I Poole, Dirk S Hoening, Leenil C Noel, Juan C Hernandez-Prera, Jose R Conejo-Garcia, Ch...> ;Molecular Carcinogenesis. 2024 Jan 1
• 1 citations
  Deciphering the Tumor-Immune-Microbe Interactions in HPV-Negative Head and Neck Cancer.
  Min Hu, Samuel Coleman, Muhammad Zaki Hidayatullah Fadlullah, Daniel Spakowicz, Christine H Chung, Aik Choon Tan> ;Genes. 2023 Aug 8
• 1 citations
  Randomized Phase II Trial of Ficlatuzumab With or Without Cetuximab in Pan-Refractory, Recurrent/Metastatic Head and Neck Cancer.
  Julie E Bauman, Nabil F Saba, Denise Roe, Jessica R Bauman, John Kaczmar, Aarti Bhatia, Jameel Muzaffar, Ricklie Julian, Steven Wang, Shethal Bearelly, Audrey Baker, C...> ;Journal of Clinical Oncology. 2023 Aug 1
• 4 citations
  Virtual alignment of pathology image series for multi-gigapixel whole slide images.
  Chandler D Gatenbee, Ann-Marie Baker, Sandhya Prabhakaran, Ottilie Swinyard, Robbert J C Slebos, Gunjan Mandal, Eoghan Mulholland, Noemi Andor, Andriy Marusyk, Simon L...> ;Nature Communications. 2023 Jul 26
• Unveiling targeted cell-free DNA methylation regions through paired methylome analysis of tumor and normal tissues.
  Tingyi Li, Krupal B Patel, Xiaoqing Yu, Sijie Yao, Liang Wang, Christine H Chung, Xuefeng Wang> ;Biorxiv. 2023 Jun 29
• Patient-reported outcomes in immunotherapy for head and neck cancer.
  Kedar Kirtane, Aasha I Hoogland, Xiaoyin Li, Yvelise Rodriguez, Kelsey Scheel, Brent J Small, Laura B Oswald, Jameel Muzaffar, Julie A Kish, Marcelo Bonomi, Priyanka B...> ;Head & Neck. 2023 Jul 1
• 1 citations
  Management of Advanced Thyroid Cancer: Overview, Advances, and Opportunities.
  Sarimar Agosto Salgado, Erin Rachel Kaye, Zoukaa Sargi, Christine H Chung, Maria Papaleontiou> ;American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting. 2023 May 1
• 3 citations
  EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma.
  Ritu Chaudhary, Robbert J C Slebos, Leenil C Noel, Feifei Song, Maria I Poole, Dirk S Hoening, Juan C Hernandez-Prera, Jose R Conejo-Garcia, Jose A Guevara-Patino, Xue...> ;Cancer Research Communications. 2023 May 1
• 2 citations
  Phase 1 Dose Escalation of Stereotactic Body Radiation Therapy and Concurrent Cisplatin for Reirradiation of Unresectable, Recurrent Squamous Cell Carcinoma of the Hea...
  Michelle I Echevarria, George Q Yang, Dung-Tsa Chen, Kedar Kirtane, Jeffery Russell, Julie Kish, Jameel Muzaffar, Kristen Otto, Tapan Padhya, Caitlin McMullen, Krupal ...> ;International Journal of Radiation Oncology, Biology, Physics. 2023 Oct 1
• 16 citations
  Efficacy and Safety of Nivolumab Plus Ipilimumab vs Nivolumab Alone for Treatment of Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck: The Phase 2 ...
  Kevin J Harrington, Robert L Ferris, Maura Gillison, Makoto Tahara, Athanasios Argiris, Jérôme Fayette, Michael Schenker, Åse Bratland, John W T Walker, Peter Grell, C...> ;JAMA Oncology. 2023 Jun 1
• 11 citations
  Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial.
  Nabil F Saba, Conor E Steuer, Asari Ekpenyong, Ashley McCook-Veal, Kelly Magliocca, Mihir Patel, Nicole C Schmitt, William Stokes, James E Bates, Soumon Rudra, Jill Re...> ;Nature Medicine. 2023 Apr 1
• 2 citations
  NuKit: A deep learning platform for fast nucleus segmentation of histopathological images.
  Ching-Nung Lin, Christine H Chung, Aik Choon Tan> ;Journal of Bioinformatics and Computational Biology. 2023 Feb 1
• 1 citations
  F-FDG PET/CT Prediction of Treatment Outcomes in Human Papillomavirus-Positive, Locally Advanced Oropharyngeal Cancer Patients Receiving Deintensified Therapy: Results...
  Rathan M Subramaniam, Lyudmila DeMora, Min Yao, Sue S Yom, Maura Gillison, Jimmy J Caudell, John Waldron, Ping Xia, Christine H Chung, Minh Tam Truong, Michelle Echeva...> ;Journal of Nuclear Medicine. 2023 Mar 1
• 1 citations
  A subnetwork-based framework for prioritizing and evaluating prognostic gene modules from cancer transcriptome data.
  Biwei Cao, Krupal B Patel, Tingyi Li, Sijie Yao, Christine H Chung, Xuefeng Wang> ;Iscience. 2023 Feb 17
• 8 citations
  Radiotherapy and paclitaxel plus pazopanib or placebo in anaplastic thyroid cancer (NRG/RTOG 0912): a randomised, double-blind, placebo-controlled, multicentre, phase ...
  Eric J Sherman, Jonathan Harris, Keith C Bible, Ping Xia, Ronald A Ghossein, Christine H Chung, Nadeem Riaz, G Brandon Gunn, Robert L Foote, Sue S Yom, Stuart J Wong, ...> ;The Lancet. Oncology. 2023 Feb 1
• 3 citations
  Plasma cell-free DNA methylome profiling in pre- and post-surgery oral cavity squamous cell carcinoma.
  Krupal B Patel, Tapan A Padhya, Jinyong Huang, Juan C Hernandez-Prera, Tingyi Li, Christine H Chung, Liang Wang, Xuefeng Wang> ;Molecular Carcinogenesis. 2023 Apr 1
• 32 citations
  Combined nivolumab and ipilimumab with or without stereotactic body radiation therapy for advanced Merkel cell carcinoma: a randomised, open label, phase 2 trial.
  Sungjune Kim, Evan Wuthrick, Dukagjin Blakaj, Zeynep Eroglu, Claire Verschraegen, Ram Thapa, Matthew Mills, Khaled Dibs, Casey Liveringhouse, Jeffery Russell, Jimmy J ...> ;Lancet. 2022 Sep 24
• 4 citations
  Model-informed experimental design recommendations for distinguishing intrinsic and acquired targeted therapeutic resistance in head and neck cancer.
  Santiago D Cárdenas, Constance J Reznik, Ruchira Ranaweera, Feifei Song, Christine H Chung, Elana J Fertig, Jana L Gevertz> ;NPJ Systems Biology and Applications. 2022 Sep 8
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Journal Articles

• Integrated Time Course Omics Analysis Distinguishes Immediate Therapeutic Response from Acquired Resistance  
  Joseph A Califano, Christine H Chung, BioMed Central
• Cleaved NOTCH1 expression pattern in head and neck squamous cell carcinoma is associated with NOTCH1 mutation, HPV status and high-risk clinical features  
  Rettig EM, Chung CH, Bishop JA, Howard JD, Sharma RB, Li RJ, Douville C, Karchin R, Izumchenko E, Sidransky D, Koch W, Califano J, Agrawal N, Fakhry C, Cancer Prev Res, 1/1/2015
• A randomized phase II efficacy and correlative studies of cetuximab with or without sorafenib in recurrent and/or metastatic head and neck squamous cell carcinoma  
  Gilbert J, Schell MJ, Zhao X, Murphy B, Tanvetyanon T, Leon ME, Hayes DN, Haigentz M, Saba N, Nieva J, Bishop J, Sidransky D, Ravi R, Bedi A, Chung CH, Oral Oncol, 1/1/2015
• Novel targets in head and neck cancer: Should we be optimistic?  
  Krigsfeld G, Chung CH, Clin Can Res, 1/1/2015
• A retrospective analysis of cross-reacting cetuximab IgE antibody and its association with severe infusion reaction  
  Maier S, Chung CH, Morse M, Platts-Mills T, Townes L, Mukhopadhyay P, Bhagavatheeswaran P, Racenberg J, Trifan OC, Cancer Medicine, 1/1/2015
• Prognostic implication of persistent human papillomavirus type 16 DNA detection in oral rinses for human papillomavirus- related oropharyngeal carcinoma  
  Rettig EM, Wentz A, Posner MR, Gross ND, Haddad RI, Gillison M, Fakhry C, Quon H, Sikora AG, Stott WJ, Lorch JH, Gourin CG, Quo Y, Xiao W, Miles BA, Richmon JD, Anders..., JAMA Oncol, 1/1/2015
• Genomic alterations in head and neck squamous cell carcinoma determined by cancer gene-targeted sequencing  
  Chung CH, Guthrie VB, Masica DL, Tokheim C, Kang H, Richmon J, Agrawal, N, Fakhry C, Quon H, Subramaniam RM, Zuo Z, Seiwert T, Chalmers ZR, Frampton GM, Ali SM, Yelens..., Ann Oncol, 1/1/2015
• Surgical salvage improves overall survival for HPV-positive and HPV-negative recurrent locoregional and distant metastatic oropharyngeal cancer  
  Guo T, Qualliotine JR, Ha PK, Califano JA, Kim Y, Saunders JR, Blanco R, D'Souza G, Zhang Z, Chung CH, Kiess A, Gourin CG, Koch W, Richmon JD, Agrawal N, Eisele DW, Fa..., Cancer, 1/1/2015
• Detection of somatic mutations and HPV in the saliva and blood of patients with head and neck squamous cell carcinomas  
  Wang Y, Sidransky D, Papadopoulos N, Kiess A, Diaz L, Bettegowda C, Myers J, Westra W, Koch W, Califano J, Kinzler K, Sausen M, Pickering C, Fakhry C, Springer S, Mulv..., Sci Transl Med, 1/1/2015
• Predicting survival in head and neck squamous-cell carcinoma from TP53 mutation  
  Masica DL, Li S, Douville C, Manola J, Ferris RL, Burtness B, Forastiere AA, Koch WM, Chung CH, Karchin R, Hum Genet, 1/1/2015
• Diagnostic accuracy of follow-up FDG PET or PET/CT in patients with head and neck cancer after definitive treatment: A systematic review and meta-analysis  
  Sheikhbahaei S, Taghipour M, Ahmad R, Fakhry C, Kiess AP, Chung CH, Subramaniam RM, AJR Am J Roentgenol, 1/1/2015
• CHK it out! Blocking WEE kinase routs TP53 mutant cancer  
  Bauman JE, Chung CH, Clin Can Res, 1/1/2014
• p16 protein expression and human papillomavirus status as prognostic biomarkers of non-oropharyngeal head and neck squamous cell carcinoma  
  Chung CH, Zhang Q, Kong CS, Harris J, Fertig EJ, Harari PM, Wang D, Redmond KP, Shenouda G, Trotti A, Raben D, Gillison ML, Jordan RC, Le QT, J Clin Oncol, 1/1/2014
• A Randomized Phase III Trial to Test Accelerated versus Standard Fractionation in Combination with Concurrent Cisplatin for Head and Neck Carcinomas (RTOG0129): Long T...  
  Nguyen-Tan PF, Zhang Q, Ang KK, Weber RS, Rosenthal DI, Soulieres D, Kim H, Silverman C, Raben A, Galloway T, Fortin A, Gore E, Westra WH, Chung CH, Jordan RC, Gilliso..., J Clin Oncol, 1/1/2014
• NOTCH pathway activation in head and neck cancer  
  Sun W, Gaykalova DA, Ochs MF, Mambo E, Arnaoutakis D, Liu Y, Loyo M, Agrawal N, Howard J, Li R, Ahn S, Fertig E, Sidransky D, Houghton J, Buddavarapu K, Sanford T, Cho..., Cancer Res, 1/1/2014
• Evaluation of a novel rash scale and a serum proteomic predictor in a randomized phase II trial of sequential or concurrent cetuximab and pemetrexed in previously trea...  
  Maitland ML, Levine MR, Lacouture ME, Wroblewski KE, Chung CH, Gordon IO, Szeto L, Ratko G, Soltani K, Kozloff MF, Hoffman PC, Salgia R, Carbone DP, Karrison TG, Vokes EE, BMC Cancer, 1/1/2014
• RKIP and HMGA2 regulate breast tumor survival and metastasis through lysyl oxidase and syndecan-2  
  Sun M, Gomes S, Chen P, Frankenberger CA, Sankarashararma D, Chung CH, Chada KK, Rosner MR, Oncogene, 1/1/2014
• Clinical genomic and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke  
  Li R, Faden DL, Fakhry C, Langelier C, Jiao Y, Wang Y, Wilkerson MD, Pedamallu CS, Old M, Lang J, Loyo M, Ahn SM, Tan M, Gooi Z, Chan J, Richmon J, Wood LD, Hruban RH,..., Head Neck, 1/1/2014
• Using a question-prompt list as a communication aid in advanced cancer care  
  Yeh JC, Cheng MJ, Chung CH, Smith TJ, J Oncol Practice, 1/1/2014
• Loss of HNF6 expression correlates with human pancreatic cancer progression  
  Pekala K, Ma X, Kropp P, Petersen C, Hudgens C, Chung CH, Shi C, Merchant N, Maitra A, Means A, Gannon MA, Lab Invest, 1/1/2014
• A 3'UTR KRAS variant is associated with cisplatin resistance in patients with recurrent and/or metastatic head and neck squamous cell carcinoma  
  Chung CH, Lee JW, Slebos RJ, Howard JD, Perez J, Kang H, Fertig EJ, Considine M, Gilbert J, Murphy BA, Nallur S, Paranjape T, Jordan RC, Garcia J, Burtness B, Forastie..., Ann Oncol, 1/1/2014
• Prognostic value of FDG PET metabolic tumor volume in human papillomavirus- positive stage III and IV oropharyngeal squamous cell carcinoma  
  Alluri K, Tahari AK, Wahl RL, Koch W, Chung CH, Subramaniam RM, AJR Am J Roentgenol, 1/1/2014
• Loss of Trop2 causes ErbB3 activation through a neuregulin-1-dependent mechanism in the mesenchymal subtype of HNSCC  
  Zhang KH, Jones L, Lim S, Maher CA, Adkins D, Lewis J, Kimple RJ, Fertig EJ, Chung CH, Herrlich A, Ellis MJ, Van Tine B, Michel LS, Oncotarget, 1/1/2014
• Opportunities and challenges facing biomarker development for personalized head and neck cancer treatment  
  Lucs A, Saltman B, Chung CH, Steinberg B, Schwartz DL, Head Neck, 1/1/2013
• miRNA array analysis determines miR-205 is overexpressed in head and neck squamous cell carcinoma and enhances cellular proliferation  
  Howard J, Cheng H, Perez J, Ratner E, Fertig EJ, Considine M, Ochs MF, Slebos RJ, Weidhaas J, Chung CH, J Cancer Res Therapy, 1/1/2013
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Books/Book Chapters

• Molecular Targets of Head and Neck Cancer. Current Cancer Research 
  Chapter: Chapter 7-The PI3K signaling pathway in head and neck squamous cell carcinoma. 
  Page 131 - 161Howard J, Chung CHSpringer, New York, NY2014
• Head and Neck Cancer: A Multidisciplinary Approach 
  Chapter: Chapter 16: Cancer of the Oral Cavity: General Principles and Management. 
  Koch WM, Stafford E, Chung CH, Quon HWolters Kluwer Health--Lippincott Williams & Wilkins2014
• Textbook of Uncommon Cancer 
  Chapter: Chapter 9: Esthesioneuroblastoma. 
  Page 133 - 142Murphy BA, Aulino JM, Chung CH, Ely K, Sinard R, Cmelak AJohn Wiley & Sons, Ltd.Edition 3rd,2006

Lectures

• Ready for a Molecular Signature as a Prognostic/Predictive Biomarker? 
  Milan, Italy - 1/24/2014
• What is the current and future role of systemic therapy in the TOS-treated patients? 
  Baltimore, MD - 1/24/2014
• Benefits of genomic medicine: what to tell the patient. 
  Boston, MA - 1/14/2014
• Integrating anti-PD1/PDL1 inhibitors into the management of head and neck cancer. 
  Mount Laurel, NJ - 1/10/2014
• Are we ready for biomarker-driven clinical trials in head and neck cancer? 
  Bethesda, MD - 1/3/2014
• HPV-positive head and neck cancer and its genomic profile. 
  Baltimore, MD - 1/1/2014
• Ethical considerations for genomics in cancer care and research: science, technology, and research perspective. 
  Chicago, IL - 1/31/2013
• Do EGFR inhibitors work in patients with HPV-positive HNSCC? 
  National Harbor, MD - 1/25/2013
• Reaping the benefits from the genomic data in head and neck cancer. 
  Johns Hopkins University, Baltimore, MD - 1/23/2013
• Personalized therapy for head and neck cancer: present and future. 
  Medical University of South Carolina, Charleston, SC - 1/18/2013
• Genomics and proteomics technology in biomarker discovery: Matching the phenotype and -omics data. 
  Atlanta, GA - 1/18/2013
• Biology of HPV-related head and neck cancer. 
  Johns Hopkins University, Baltimore, MD - 1/15/2013
• p16 expression as a human papillomavirus (HPV)-independent prognostic biomarker of non-oropharyngeal squamous cell carcinoma (non-OPSCC). 
  Philadelphia, PA - 1/15/2013
• Recent updates in the Management of Head and Neck Cancer 
  Johns Hopkins University - 1/14/2013
• Phase II randomized trial of the combination of cetuximab and sorafenib or single agent cetuximab in patients with refractory, recurrent and/or metastatic squamous cel... 
  Bethesda, MD - 1/9/2013
• Targetable genetic alterations in head and neck cancer. 
  Atlanta, GA - 1/7/2013
• Advancing the therapeutic ratio in head and neck cancer: Benchtop to clinical advances. 
  Greater Baltimore Medical Center, Baltimore, MD - 1/6/2013
• Reaping the benefits of the genomic report: What to tell the patient. 
  Chicago, IL - 1/3/2013
• Targetable Genetic Alterations in SCCHN 
  Phoenix, AZ - 1/27/2012
• Chemotherapy in HNSCC 
  Johns Hopkins University - 1/21/2012
• The Management of Head and Neck Cancer 
  Johns Hopkins University - 1/19/2012
• EGFR inhibitor therapies in head and neck cancer. 
  Johns Hopkins University, Baltimore, MD - 1/14/2012
• Novel treatment approaches to HPV-related head and neck cancer. 
  Baltimore, MD - 1/13/2012
• New treatment options for head and neck cancer. 
  New York, NY - 1/11/2012
• Personalized Therapy for Head and Neck Cancer: Present and Future 
  Feinstein Institute for Medical Research, Manhasset, NY - 1/7/2012
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Other

• Supportive care for patients with head and neck cancer. Medscape Hematology-Oncology. 
  Murphy BA, Chung CH, Medscape, LLC
  1/1/2006