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725 Welch RdPalo Alto, CA 94304
Phone+1 650-497-8000
Fax+1 650-497-8959
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Summary
- Dr. Crystal Mackall is a Pediatric Hematology and Oncology specialist based in Palo Alto, CA. She completed her fellowship in Pediatric Hematology/Oncology at the National Capital Consortium from 1989 to 1992 and her residency in Internal Medicine at Akron General Medical Center/NEOMED prior to that. Dr. Mackall has co-authored several publications, notably in prominent journals such as Cancer Discovery, Nature, Cancer Immunology Research, and Blood, focusing on CAR T-cell therapies and immunosuppression in tumors. She is actively involved in clinical trials related to innovative cancer therapies, including studies on chimeric antigen receptor (CAR) T-cell therapy. Dr. Mackall has been recognized by Marquis Who's Who in Medicine and Healthcare and is an elected member of The American Society for Clinical Investigation.
Education & Training
National Capital ConsortiumFellowship, Pediatric Hematology/Oncology, 1989 - 1992
Cleveland Clinic Foundation/Akron GeneralResidency, Internal Medicine, 1984 - 1988
Northeast Ohio Medical UniversityClass of 1984
Certifications & Licensure
CA State Medical License 2016 - 2027
OH State Medical License 1984 - 2018
MD State Medical License 1994 - 2017
DC State Medical License 1994 - 1998
American Board of Internal Medicine Internal Medicine
Awards, Honors, & Recognition
- Whos Who in Medicine and Healthcare Marquis Whos Who
- Elected Member The American Society for Clinical Investigation, 2005
Clinical Trials
- A Pilot Study of Tumor-Specific Peptide Vaccination and IL-2 With or Without Autologous T Cell Transplantation in Recurrent Pediatric Sarcomas Start of enrollment: 1996 Dec 23
- A Pilot Study of Autologous T-Cell Transplantation With Vaccine Driven Expansion of Anti-Tumor Effectors After Cytoreductive Therapy in Metastatic Pediatric Sarcomas Start of enrollment: 1996 Dec 01
- Evaluation, Treatment, and Natural History of Children and Young Adults With Cancer or Rare Diseases Start of enrollment: 1998 Mar 19
Publications & Presentations
PubMed
- c-JUN enhances CRISPR knockin anti-B7-H3 CAR T cell function in small cell lung cancer and thoracic SMARCA4-deficient undifferentiated tumors.Hyatt Balke-Want, Vimal Keerthi, Maria Del Carmen Arenas, Yiyun Chen, Meena Malipatlolla
Cell Reports. Medicine. 2026-01-20 - Liberalizing hospital proximity requirements for children/young adults with low-burden B-ALL receiving tisagenlecleucel.Lauren E Appell, Christina Baggott, Khanh Nguyen, Snehit Prabhu, Holly Pacenta
Blood Advances. 2026-01-13 - Clinical and Cytokine Features of Immune Effector Cell-Associated Hemophagocytic Lymphohistiocytosis-Like Syndrome.Hrishikesh K Srinagesh, Anne Marijn Kramer, John H Baird, Agnes Reschke, Bita Sahaf
Blood Cancer Discovery. 2025-12-18
Journal Articles
- Fludarabine and Neurotoxicity in Engineered T-cell TherapyElliot Norry, Crystal L Mackall, Nature
- Tumor Antigen Escape from CAR T-cell TherapyCrystal L Mackall, Robbie G Majzner, Clinical Cancer Research
Abstracts/Posters
- Identification of Dual Positive CD19+/CD3+ T Cells in an Apheresis Product Undergoing Chimeric Antigen Receptor (CAR) TransductionCrystal L. Mackall, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
- Detectable Circulating Tumor DNA 28 Days after the CD19 CAR T-Cell Therapy, Axicabtagene Ciloleucel, Is Associated with Poor Outcomes in Patients with Diffuse Large B-...Crystal L. Mackall, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
- Allogeneic Chimeric Antigen Receptor-Invariant Natural Killer T Cells Exert Both Direct and Indirect Antitumor Effects through Host CD8 T Cell Cross-PrimingCrystal L. Mackall, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Press Mentions
Gale and Ira Drukier Prize in Children’s Health Research Awarded to Pediatric Rheumatologist at Boston Children’s HospitalOctober 16th, 2025
Pediatric Rheumatologist at Boston Children’s Hospital Receives Gale and Ira Drukier Prize in Children’s Health ResearchOctober 16th, 2025
Stanford, UCSF Launch Cancer Research and Care CollaborationJuly 24th, 2025
Grant Support
- Immunobiology And Immunotherapy Of Pediatric TumorsNational Cancer Institute2011
- Biology And Therapy Of LymphopeniaNational Cancer Institute2011
- Clinical Program In Pediatric SarcomasNational Cancer Institute2010–2011
- Immunobiology Of Pediatric TumorsNational Cancer Institute2010
- Developing Immune Based TherapiesNational Cancer Institute2010
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