
Daniel S. Chen MD PhD
Melanoma
Founder and CEO, Synthetic Design Lab, Inc Founding Partner, Genesis BioCapital
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Synthetic Design LabSan Carlos, CA 94070
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Summary
- Dr. Daniel Chen is Physician Scientist, Medical Oncologist and Immunologist based in San Carlos, CA, specializing in melanoma and the development of novel treatments for Cancer and other human diseases. He completed his medical education at the Keck School of Medicine at the University of Southern California, followed by a residency, fellowship and post-doctorate at Stanford University. He holds a BS in Biology from MIT. Dr. Chen is the Founder and CEO of Synthetic Design Lab and a founding partner at Genesis BioCapital, LLC, and previously served as an Attending Physician at Stanford Health Care. His other previous roles include Chief Medical Officer at IGM Biosciences and Vice President, Global Head of Cancer Immunotherapy at Genentech/Roche. Dr. Chen's expertise encompasses cancer immunotherapy, novel engineered therapeutics, oncology, virology, and immunology. He has been published in leading journals, including Nature and Immunity, and his work, including "Oncology meets Immunology: The Cancer-Immunity Cycle", has received numerous citations. Additionally, Dr. Chen has contributed to many clinical trials focused on immunotherapy and led the development of TECENTRIQ (anti-PD-L1) from first in human studies to multiple global approvals.
Education & Training
UCLA David Geffen School of Medicine/UCLA Medical CenterResidency, Gastroenterology, 2017 - 2023
Stanford Health Care-Sponsored Stanford UniversityFellowship, Medical Oncology, 2000 - 2003
Stanford Health Care-Sponsored Stanford UniversityResidency, Internal Medicine, 1998 - 2000
Keck School of Medicine of the University of Southern CaliforniaClass of 1998
Massachusetts Institute of TechnologyBS, Biology, 1986 - 1990
Certifications & Licensure
CA State Medical License 1999 - 2024
Awards, Honors, & Recognition
- https://www.pinterest.com/dschen5/dsc/
Clinical Trials
- Carboplatin Plus Etoposide With or Without MPDL3280A in Untreated Extensive Stage Small Cell Lung Cancer
- Atezolizumab and Bevacizumab in Treating Patients With Rare Solid Tumors Start of enrollment: 2017 Mar 03
- A Study of Imvotamab Monotherapy and in Combination in Subjects With Relapsed/Refractory Non-Hodgkin Lymphoma Start of enrollment: 2019 Sep 30
Publications & Presentations
PubMed
- 1 citationsHuman cancer-targeted immunity via transgenic hematopoietic stem cell progeny.Theodore S Nowicki, Nataly Naser Al Deen, Cole W Peters, Begoña Comin-Anduix, Egmidio Medina
Nature Communications. 2025-07-01 - Immunity as biophysics at the surface of a T cell.Daniel S Chen
Immunity. 2024-02-13 - 648 citationsThe cancer-immunity cycle: Indication, genotype, and immunotype.Ira Mellman, Daniel S Chen, Thomas Powles, Shannon J Turley
Immunity. 2023-10-10
Journal Articles
- Differential Regulation of PD-L1 Expression by Immune and Tumor Cells in NSCLC and the Response to Treatment with Atezolizumab (Anti–PD-L1)Alan Sandler, David S Shames, Hartmut Koeppen, Jamie Chaft, Scott N Gettinger, Alexander Spira, Daniel S Chen, Naiyer A Rizvi, David R Spigel, Proceedings of the National Academy of Sciences
- Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trialFehrenbacher, L, Spira, A, Ballinger, M, Kowanetz, M, Vansteenkiste, J, Mazieres, J, Park, K, Smith, D, Artal-Cortes, A, Lewanski, C, Braiteh, F, Waterkamp, D, He, P, ..., Lancet, 1/1/2016
Press Mentions
Too Many Trials, Not Enough PatientsNovember 18th, 2019
Drug Giant Tries New Tactic to Fight CancerMay 27th, 2019
A Cure for Cancer: How to Kill a KillerNovember 4th, 2018
Committees
- Co-Organizer, SITC Immuno Engineering Initiative 2022 - Present
- co-organizer, SITC Deep Dive Series 2020 - Present
- Board of Directors, SITC (Society of Immunotherapy for Cancer) 2018 - 2022
- Co-Chair, CRI Cancer Immunotherapy Consortium 2016 - 2020
- Committee Chair, Society for Immunotherapy of Cancer 2012 - 2018
Professional Memberships
- Member
- Member
- Member
Other Languages
- Chinese (Mandarin)
Industry Relationships
- Founder, Bionic Cell Medicines2022 - Present
- Founder and CEO, Synthetic Design Lab2022 - Present
- Founder, Engenuity Life Sciences2022 - Present
- Chief Medical Officer, IGM Biosciences2018 - Present
- Vice President, Global Head for Cancer Immunotherapy, Genentech/Roche2006 - 2018
External Links
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