
David Charles Fajgenbaum MD MBA, MSc
Asst Prof of Medicine, Translational Medicine/Human Genetics, UPenn; Executive Director, Castleman Disease Collaborative Network
Join to View Full Profile
3535 Market Street, HUPFloor 7, Suite 700, Room 707Philadelphia, PA 19104
Dr. Fajgenbaum is on Doximity
As a Doximity member you'll join over two million verified healthcare professionals in a private, secure network.
- Gain access to free telehealth tools, such as our “call shielding” and one-way patient texting.
- Connect with colleagues in the same hospital or clinic.
- Read the latest clinical news, personalized to your specialty.
Education & Training
Wharton School - University of PennsylvaniaMBA, Health Care Management, 2013 - 2015
Perelman School of Medicine at the University of PennsylvaniaClass of 2013
University of OxfordM.S., Public Health, 2008
Georgetown UniversityBS, Human Sciences, 2003 - 2007
Certifications & Licensure
American Board of Orthopaedic Surgery Orthopaedic Surgery
Awards, Honors, & Recognition
- 30 under 30 in Healthcare Forbes, 2015
- RARE Champion of Hope - Science Gloabl Genes, 2015
- CMS Meaningful Use Stage Stage 1 Certification Allscripts Professional EHR, Allscripts, 2012, 2014
Clinical Trials
- Sirolimus in Previously Treated Idiopathic Multicentric Castleman Disease Start of enrollment: 2019 Sep 25
Publications & Presentations
PubMed
- 12 citationsDiagnostic challenges of the idiopathic plasmacytic lymphadenopathy (IPL) subtype of idiopathic multicentric Castleman disease (iMCD): Factors to differentiate from Ig...Asami Nishikori, Midori Filiz Nishimura, David C Fajgenbaum, Yoshito Nishimura, Kanna Maehama
Journal of Clinical Pathology. 2025-12-15 - 1 citationsInternational Consensus Histopathological Criteria for Subtyping Idiopathic Multicentric Castleman Disease Based on Machine Learning Analysis.Midori Filiz Nishimura, Tomoka Haratake, Yoshito Nishimura, Asami Nishikori, Remi Sumiyoshi
American Journal of Hematology. 2025-09-01 - 1 citationsThe Involvement of PI3K-Akt Signaling in the Clinical and Pathological Findings of Idiopathic Multicentric Castleman Disease-Thrombocytopenia, Anasarca, Fever, Reticul...Tomoka Haratake, Midori Filiz Nishimura, Asami Nishikori, Michael V Gonzalez, Daisuke Ennishi
Modern Pathology. 2025-08-01
Journal Articles
- Cytokine StormDavid Fajgenbaum, MD, The New England Journal of Medicine
- Predictors of Response to Anti‐IL6 Monoclonal Antibody Therapy (Siltuximab) in Idiopathic Multicentric Castleman Disease: Secondary Analyses of Phase II Clinical Trial...David C Fajgenbaum, Craig Tendler, British Journal of Haematology
- International, Evidence-Based Consensus Treatment Guidelines for Idiopathic Multicentric Castleman DiseaseAaron Goodman, Corey Casper, Sudipto Mukherjee, Peter Voorhees, Angela Dispenzieri, David C Fajgenbaum, Amy Chadburn, Razelle Kurzrock, Raj Jayanthan, Sunita Nasta, Th..., Blood
Books/Book Chapters
Abstracts/Posters
- Type I Interferon Response Identified through Phenotypic and Transcriptional Profiling of Circulating Immune Cells during Idiopathic Multicentric Castleman Disease FlareDavid C Fajgenbaum, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
- Quantitative Changes in Serum Proteins Including CXCL13 Are Early Indicators of Response to Anti-IL6 Therapy in Idiopathic Multicentric Castleman DiseaseDavid C Fajgenbaum, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
- Hypercytokine-Producing Cells and Oligoclonal T-Cell Populations in Lymph Nodes from Castleman Disease PatientsAnna Wiing, Wenzhao Meng, Gerald Wertheim, Dale Frank, Michele Paessler, Megan S. Lim, Eline T. Luning Prak, David C Fajgenbaum, Vinodh Pillai, Blood (ASH Annual Meeting Abstracts), 1/1/2018
Authored Content
- I Was Read My Last Rites as a Third-Year Medical StudentNovember 2019
- I Was Read My Last Rites as a Third-Year Medical StudentNovember 2019
- UpToDate - idiopathic multicentric Castleman disease10/17/2018
Press Mentions
Using Existing Drugs in New Ways to Treat & Cure Diseases of Brain & Body | Dr. David FajgenbaumNovember 3rd, 2025
The Next Big Think: Artificial Intelligence Arrives at Penn GastroenterologyOctober 7th, 2025
This Philadelphia Doctor's Story of Saving His Own Life Is Being Made Into a Movie: "I Almost Died Five Times"May 29th, 2025
Grant Support
- JAK1/2 as a Central Regulator of iMCD Pathogenesis and Novel Therapeutic TargetUNIVERSITY OF PENNSYLVANIA2018–2028
- ACCELERATE: An Efficient and Innovative Natural History Study Addressing Unmet Needs in Castleman DiseaseUNIVERSITY OF PENNSYLVANIA2022–2026
- ACCELERATE: An Efficient and Innovative Natural History Study Addressing Unmet Needs in Castleman DiseaseUNIVERSITY OF PENNSYLVANIA2022–2026
- mTOR as a Central Regulator of iMCD Pathogenesis and Novel Therapeutic TargetNational Institutes of Health - NHLBI2018–2023
Professional Memberships
- Member
Viewing the full profile is available to verified healthcare professionals only.
Find your profile and take control of your online presence:








