DavidHGutmannMDPhD
Neurology • Saint Louis, MODonald O. Schnuck Family Professor, Neurology, Washington University School of Medicine; Director, Washington University Neurofibromatosis Center
Dr. Gutmann is on Doximity
As a Doximity member you'll join over two million verified healthcare professionals in a private, secure network.
- Connect with other colleagues in the same hospital or clinic
- Search all U.S. specialist profiles and refer a patient
- Read the latest clinical news and earn CME/CEU credits
Office
1 Childrens Place
Saint Louis, MO 63110Phone+1 314-454-6120Fax+1 314-454-2523- Is this information wrong?
Summary
- David H. Gutmann received his undergraduate, graduate (PhD) and medical (MD) degrees from the University of Michigan. Following his residency training in Neurology at the University of Pennsylvania, he returned to the University of Michigan for research fellowship training with Dr. Francis Collins. During that time, he identified the neurofibromatosis type 1 (NF1) protein and began to elucidate its function as a negative RAS regulator. In late 1993, Dr. Gutmann was recruited to Washington University, becoming a full professor in 2001 and the Donald O. Schnuck Family Professor in 2002. He established the St. Louis Children’s Hospital Neurofibromatosis Clinical Program in 1994 and the Washington University Neurofibromatosis Center in 2004.
For the past 30 years, his laboratory has focused on understanding the genomic, molecular and cellular basis for nervous system problems affecting children and adults with NF1 using both human induced pluripotent stem cells and novel genetically engineered mouse strains. Dr. Gutmann has published over 500 peer-reviewed manuscripts, and his research laboratory has been continuous funded by the NIH since 1993, including a NINDS R35 Research Program Award.
Gutmann has been recognized for his achievements with numerous awards, including the 2012 Children’s Tumor Foundation Frederich von Recklinghausen Lifetime Achievement Award, a 2017 Alexander von Humboldt Award, the 2019 Society for Neuro-Oncology Abhijit Guha Award, the 2020 American Academy of Neurology Neuro-Oncology Scientific Award, and the 2020 American Association of Neurology triennial George W. Jacoby Award. He is an elected Fellow of the American Academy of Neurology, the American Neurological Association, the Association of American Physicians, the American Association for the Advancement of Science, and the National Academy of Medicine, as well as a former member of the National Institute of Neurological Disorders and Stroke Advisory Council.
Education & Training
University of Pennsylvania Health SystemResidency, Neurology, 1987 - 1990- University of Pennsylvania Health SystemInternship, Internal Medicine, 1986 - 1987
University of Michigan Medical SchoolClass of 1986
Certifications & Licensure
IL State Medical License 2020 - 2026
MO State Medical License 1993 - 2025
MI State Medical License 1990 - 2012
PA State Medical License 1987 - 2006- American Board of Psychiatry and Neurology Neurology
Awards, Honors, & Recognition
- Elected Fellow Association of American Physicians, 2022
- Elected Member National Academy of Medicine, 2022
- Elected Fellow American Association for the Advancement of Science, 2020
- Join now to see all
Clinical Trials
- A Randomized Placebo-Controlled Study of Lovastatin in Children With Neurofibromatosis Type 1 Start of enrollment: 2009 Jul 01
- Everolimus for Children With NF1 Chemotherapy-Refractory Radiographic Progressive Low Grade Gliomas Start of enrollment: 2010 Jul 10
- Phase 2 Study of Bevacizumab in Children and Young Adults With NF 2 and Progressive Vestibular Schwannomas Start of enrollment: 2013 May 15
- Join now to see all
Publications & Presentations
PubMed
- SRF-deficient astrocytes provide neuroprotection in mouse models of excitotoxicity and neurodegeneration.Thumu, S., Jain, M., Soman, S., Das, S., Verma, V., Nandi, A., Jayaprakash, B., Nair, D., Clement, J., Marathe, S., Ramanan, N., Gutmann, D.> ;Elife. 2024 Feb 9
- Pediatric low-grade glioma: State-of-the-art and ongoing challenges.Jason Fangusaro, David T Jones, Roger J Packer, Till Milde, Olaf Witt, Sabine Mueller, Jordan R Hansford, Uri Tabori, Darren Hargrave, Pratiti Bandopadhayay, Gutmann, ...> ;Neuro-Oncology. 2024 Jan 5
- A common single nucleotide variant in the cytokine receptor-like factor-3 (CRLF3) gene causes neuronal deficits in human and mouse cells.Anna F Wilson, Rasha Barakat, Rui Mu, Leah L Karush, Yunqing Gao, Kelly A Hartigan, Ji-Kang Chen, Hongjin Shu, Tychele N Turner, Susan E Maloney, Steven J Mennerick, C...> ;Human Molecular Genetics. 2023 Dec 1
- Join now to see all
Press Mentions
Jazz, Genetics, and Neurofibromatosis September 9th, 2023
Epilepsy drug stops nervous system tumor growth in miceMay 19th, 2022
Asthma may reduce risk of brain tumors — but how?December 23rd, 2021- Join now to see all
Grant Support
- T cell regulation of low-grade gliomaNational Cancer Institute2022–2027
- Neuronal regulation of low-grade gliomagenesisNational Cancer Institute2022–2027
- Defining the Mechanistic Basis for Neurofibromatosis-1 Nervous System Disease HeterogeneityNational Institutes of Health2016–2024
- Neurofibromin Regulation Of Neural Stem Cell Function In Vitro And In VivoNational Institute Of Neurological Disorders And Stroke2010–2012
- Stromal Contributions To NF1 Glioma Formation And GrowthNational Cancer Institute2009–2012
- Targeting Stoma-Tumor Co-Dependency For Glioma TherapyNational Cancer Institute2009–2011
- Regulation And Role Of Mtor In Neurofibromin Growth ControlNational Cancer Institute2008–2011
- Integrative Approaches To Stroma-Directed Glioma TherapyNational Institute Of Neurological Disorders And Stroke2010
- Molecular Determinants Of Neural Stem Cell FunctionNational Institute Of Neurological Disorders And Stroke2007–2008
- Identification And Preclinical Evaluation Of New Brain Tumor TherapiesNational Institute Of Neurological Disorders And Stroke2006–2007
- Preclinical Models For Human AstrocytomasNational Institute Of Neurological Disorders And Stroke2001–2004
- Neurofibromatosis Foundation International ConsortiumNational Institute Of Neurological Disorders And Stroke2003
- Protein 4.1 Tumor Suppressors In Meningioma PathogenesisNational Institute Of Neurological Disorders And Stroke2001–2003
- Functional Analysis Of NF2 Gene MutationsNational Institute Of Neurological Disorders And Stroke1997–2003
- Neurofibromin As A Negative Regulator For AstrocytesNational Institute Of Neurological Disorders And Stroke1999–2002
- Regulation Of NF1 Gene Expression During DifferentiationNational Institute Of Neurological Disorders And Stroke1995–1999
- Characteriza. Of Neurofibromatosis Type 1 Gene ProductNational Institute Of Neurological Disorders And Stroke1995–1996
- Neurofibromatosis 1 Gene ProductNational Institute Of Neurological Disorders And Stroke1994
- Characterization Of The Neurofibromatosis 1 Gene ProductNational Institute Of Neurological Disorders And Stroke1993
- Characterization Of The Neurofibromatosis 1 Gene ProductNational Institute Of Neurological Disorders And Stroke1992–1993
Professional Memberships
- Member
- Member
Hospital Affiliations
St. Louis Children's HospitalSaint Louis, Missouri
Barnes-Jewish HospitalSaint Louis, Missouri
Siteman Cancer CenterSaint Louis, Missouri
External Links
- NF Centerhttp://nfcenter.wustl.edu
- Gutmann Labhttps://gutmannlab.wustl.edu
Viewing the full profile is available to verified healthcare professionals only.
Find your profile and take control of your online presence:
