David Gutmann, MD, Neurology, Saint Louis, MO, St. Louis Children's Hospital

DavidHGutmannMDPhD

Neurology Saint Louis, MO

Neurooncology, Child Neurology

Donald O. Schnuck Family Professor, Neurology, Washington University School of Medicine; Director, Washington University Neurofibromatosis Center

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Summary

  • David H. Gutmann received his undergraduate, graduate (PhD) and medical (MD) degrees from the University of Michigan, where he trained as an immunologist in the laboratory of Dr. John Niederhuber. During his residency in Neurology at the University of Pennsylvania, he had the good fortune of working with Dr. Kenneth Fischbeck who sparked his interest in neurogenetics. He then returned to the University of Michigan for research fellowship training in Human Genetics with Dr. Francis Collins. During this time, he identified the neurofibromatosis type 1 (NF1) protein and began to elucidate its function as a RAS regulator. In late 1993, he was recruited to Washington University, becoming a full professor in 2001 and the Donald O. Schnuck Family Professor in 2002. He established the St. Louis Children’s Hospital Neurofibromatosis Clinical Program in 1994 and the Washington University Neurofibromatosis Center in 2004. His laboratory is currently focused on understanding the genomic, molecular and cellular basis for nervous system problems affecting children and adults with NF1. Over the past 15 years, his team has developed numerous mouse models of NF1-associated optic glioma, somatic growth defects, attention deficit, autism, plexiform neurofibroma, and spatial learning impairments as well as NF2-associated meningioma. They have used these preclinical models to define the cellular origins of tumors, the contribution of the tumor microenvironment, and the major growth control pathways that dictate brain development in NF. He has published over 360 peer-reviewed manuscripts, and has been recognized for his achievements with the 2012 Children’s Tumor Foundation Frederich von Recklinghausen awards, the 2013 Washington University Distinguished Faculty Research Award, and the 2014 Riley Church Lectureship.

Education & Training

  • University of Pennsylvania Health System
    University of Pennsylvania Health SystemResidency, Neurology, 1987 - 1990
  • University of Pennsylvania Health System
    University of Pennsylvania Health SystemInternship, Internal Medicine, 1986 - 1987
  • University of Michigan Medical School
    University of Michigan Medical SchoolClass of 1986

Certifications & Licensure

  • IL State Medical License
    IL State Medical License 2020 - 2023
  • MO State Medical License
    MO State Medical License 1993 - 2022
  • MI State Medical License
    MI State Medical License 1990 - 2012
  • PA State Medical License
    PA State Medical License 1987 - 2006
  • American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

  • Riley-Church Lectureship Stanford University, 2014
  • Distinguished Faculty Research Award Washington University, 2013
  • Frederich Von Recklinghausen Award Children's Tumor Foundation, 2012
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Clinical Trials

Publications & Presentations

PubMed

Press Mentions

  • Genetic and Genomic Alterations Differentially Dictate Low-Grade Glioma Growth Through Cancer Stem Cell-Specific Chemokine Recruitment of T Cells and Microglia
    Genetic and Genomic Alterations Differentially Dictate Low-Grade Glioma Growth Through Cancer Stem Cell-Specific Chemokine Recruitment of T Cells and MicrogliaOctober 9th, 2019
  • Immune Cells Determine How Fast Certain Tumours Grow
    Immune Cells Determine How Fast Certain Tumours GrowJune 4th, 2019
  • MRI Reveals Brain Tumors Are 3 Times More Likely to Appear in Children with Neurofibromatosis
    MRI Reveals Brain Tumors Are 3 Times More Likely to Appear in Children with NeurofibromatosisAugust 9th, 2018
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Grant Support

  • Neurofibromin Regulation Of Neural Stem Cell Function In Vitro And In VivoNational Institute Of Neurological Disorders And Stroke2010–2012
  • Stromal Contributions To NF1 Glioma Formation And GrowthNational Cancer Institute2009–2012
  • Targeting Stoma-Tumor Co-Dependency For Glioma TherapyNational Cancer Institute2009–2011
  • Regulation And Role Of Mtor In Neurofibromin Growth ControlNational Cancer Institute2008–2011
  • Integrative Approaches To Stroma-Directed Glioma TherapyNational Institute Of Neurological Disorders And Stroke2010
  • Molecular Determinants Of Neural Stem Cell FunctionNational Institute Of Neurological Disorders And Stroke2007–2008
  • Identification And Preclinical Evaluation Of New Brain Tumor TherapiesNational Institute Of Neurological Disorders And Stroke2006–2007
  • Preclinical Models For Human AstrocytomasNational Institute Of Neurological Disorders And Stroke2001–2004
  • Neurofibromatosis Foundation International ConsortiumNational Institute Of Neurological Disorders And Stroke2003
  • Protein 4.1 Tumor Suppressors In Meningioma PathogenesisNational Institute Of Neurological Disorders And Stroke2001–2003
  • Functional Analysis Of NF2 Gene MutationsNational Institute Of Neurological Disorders And Stroke1997–2003
  • Neurofibromin As A Negative Regulator For AstrocytesNational Institute Of Neurological Disorders And Stroke1999–2002
  • Regulation Of NF1 Gene Expression During DifferentiationNational Institute Of Neurological Disorders And Stroke1995–1999
  • Characteriza. Of Neurofibromatosis Type 1 Gene ProductNational Institute Of Neurological Disorders And Stroke1995–1996
  • Neurofibromatosis 1 Gene ProductNational Institute Of Neurological Disorders And Stroke1994
  • Characterization Of The Neurofibromatosis 1 Gene ProductNational Institute Of Neurological Disorders And Stroke1993
  • Characterization Of The Neurofibromatosis 1 Gene ProductNational Institute Of Neurological Disorders And Stroke1992–1993

Professional Memberships

Hospital Affiliations