Dolores B. Benedicta Njoku MD

PubMed

• 1 citations
  Elevated preoperative blood pressure and its relationship to intraoperative mean arterial pressure and blood loss in posterior spinal fusion for adolescent idiopathic ...
  Niyathi Prasad, Amit Jain, Rachel S Bronheim, Majd Marrache, Dolores B Njoku
  European Journal of Orthopaedic Surgery & Traumatology. 2024-01-01
• 2 citations
  Mitochondrial-triggered immune responses mechanistically connect drug-induced steatohepatitis and cardiomyopathy associated with nonalcoholic steatohepatitis
  Haoran Wang, Sananda Pai, Shun Ishiyama, Xin Guo, Wei Dong Gao
  Cellular & Molecular Immunology. 2021-07-12
• 3 citations
  The Role of Hypoxia-Induced Mitogenic Factor in Organ-Specific Inflammation in the Lung and Liver: Key Concepts and Gaps in Knowledge Regarding Molecular Mechanisms of...
  Sananda Pai, Dolores B. Njoku
  International Journal of Molecular Sciences. 2021-03-08

Journal Articles

• A prospective study of the incidence of drug-induced liver injury by the modern volatile anaesthetics sevoflurane and desflurane  
  Bishop B, Hannah N, Doyle A, Amico F, Hockey B, Moore D, Sood S, Gorelik A, Liew D, Njoku D and Nicoll A, Aliment Pharmacol Ther, 1/13/2019
• In Drug-induced, Immune-Mediated Hepatitis, Interleukin-33 Reduces Hepatitis and improves Survival independently and as a consequence of Activity of FoxP3+T Cells  
  Cottagiri M, Nwandjo M, Stephens M, Mantilla JJ, Saito H, Mackay I, Rose NR and Njoku DB, Cell Mol Immunol, 1/20/2018
• Detection of a novel epitope of CYP2E1 in drug-induced and viral hepatitis  
  McCarthy EK, Vakos A, Cottagiri M, Mantila JJ, Santhanam L, Thomas DL, Amzel LM, Rose NR and Njoku DB, mSphere, 1/1/2018
• Recurrence of deep surgical site infection in cerebral palsy after spinal fusion is rare  
  Jain A, Modhia UM, Njoku DB, Shah SA, Newton PO, Marks MC, Bastrom TP, Miyanji F, Sponseller PD, Spine Deformity, 1/1/2017
• Sub-classification of GMFCS Level-5 Cerebral Palsy as a Predictor of Complications and Health-Related Quality of Life After Spinal Arthrodesis  
  Jain A, Sponseller PD, Shah SA, Samdani A, Cahill PJ, Yaszay B, Njoku DB, Abel MF, Newton PO, Marks MC, Narayanan UG; Harms Study Group, J Bone Joint Surg Am, 1/1/2016
• Why No Signals? Cerebral Anatomy Predicts Success of Intraoperative Neuromonitoring During Correction of Scoliosis Secondary to Cerebral Palsy  
  Mo AZ, Asemota AO, Venkatesan A, Ritzl EK, Njoku DB, Sponseller PD, J Pediatr Orthop, 1/17/2015
• Intraoperative Cardiopulmonary Arrest in Children Undergoing Spinal Deformity Correction: Causes and Associated Factors  
  Menga EN, Hirschfield C, Jain A, Tran D, Caine H, Njoku DB, Karol L, Sponseller PD, Spine (Phila Pa 1976), 1/8/2015
• Smaller body size increases the percentage of blood volume loss during posterior spinal arthrodesis  
  Jain A, Sponseller PD, Newton PO, Shah SA, Cahill PJ, Njoku DB, Betz RR, Samdani AF, Bastrom, MA, Marks MA and the Harms Study Group, Journal of Bone and Joint Surgery, 1/1/2015
• Mu opioid receptor-triggered dorsal horn mTORC1 activation contributes to morphine tolerance and hyperalgesia  
  Xu J-T, Zhao J-Y, Zhao X, Ligons D, Tiwari V, Atianjoh F, Lee C-Y Liang L, Zang W, Njoku D, Raja S, Yaster M and Tao Y-X, J Clin Invest, 1/1/2014
• Drug-induced Hepatotoxicity: metabolic, genetic and immunological basis  
  Njoku D, Int J Mol Sci, 1/1/2014
• Assessment of Auto-antibodies and Their Relationship to Autoimmune Disease during Treatment for Hepatitis C in Children  
  Molleston JP, Melman W, Narkewicz MR, Balisteri WF, Gonzalez-Peralta RP, Jonas MM, Lobrito SJ, Parvathi M, Murray KF, Njoku D, Rosenthal P, Barton BA, Talor, MV Schwar..., J Pediatr Gastroenterol Nutr, 1/1/2013
• The Immortal Life of Henrietta Lacks: a book review  
  Njoku D, Anesth Analg, 1/1/2013
• Retrospective Identification of Gastro-esophageal Reflux Disease as a New Risk Factor for Surgical Site Infection in Cerebral Palsy Patients Following Spine Surgery  
  Chidambaran V, Gentry C, Ajuba-Iwuji C, Sponseller P, Ain M, Lin E, Zhang X, Klaus S and Njoku DB, Anesth Analg, 1/1/2013
• Repeated exposure to modern volatile anaesthetics may cause chronic hepatitis as well as acute liver injury  
  Nicoll A, More D, Njoku D and Hockey B, BMJ Case Rep, 1/1/2012
• Suppressive and Proinflammatory Roles for IL-4 in the Pathogenesis of Experimental Drug - Induced Liver Injury  
  Njoku D, Expert Opinion on Drug Metabolism and Toxicity, 1/1/2010
• In experimental drug-induced liver injury, IL-4 suppresses regulatory responses to autoantigens but induces pro-inflammatory responses to drug haptens  
  Njoku DB., Li Z, Washington ND, Mellerson JL, Talor MV, Sharma R and Rose NR, Eur J Immunol, 1/1/2009
• IP-10 protects while MIP-2 promotes experimental drug hapten hepatitis  
  Njoku DB, Li Z, Mellerson JL , Sharma R, Talor MV, Barat N and Rose NR, J Autoimmun, 1/1/2009
• Trifluoroacetylated IgG4 antibodies in a child with Idiosyncratic acute liver failure following first exposure to halothane  
  Nguyen C, Rose NR and Njoku DB, Journal of Pediatric Gastroenterology and Nutrition, 1/1/2008
• Desflurane hepatitis associated with hapten and autoantigen-specific IgG4 antibodies  
  Anderson JS, Rose NR, Martin JL, Eger EI and Njoku DB, Anesthesia and Analgesia, 1/1/2007
• Cutting Edge: T Cell Ig Mucin-3 reduces inflammatory heart disease by increasing CTLA-4 during innate immunity  
  Frisancho-Kiss S, Nyland JF, Davis SE, Barrett MA, Gatewood SJ, Njoku DB, Cihakova D, Silbergeld EK, Rose NR and Fairweather D, J Immunology, 1/1/2006
• Complement receptor 1 and 2 deficiency increases coxsackievirus B3-induced myocarditis, dilated cardiomyo-pathy and heart failure by increasing macrophages, IL-1beta a...  
  Fairweather D, Frisancho-Kiss S, Njoku DB, Nyland JF. Kaya Z, Yusung SA, Davis SE, Frisancho A, Barrett M and Rose NR, J Immunol, 1/1/2006
• Role of CYP2E1 IgG4 subclass antibodies and complement in the pathogenesis of idiosyncratic drug induced hepatitis  
  Njoku DB, Mellerson JL, Talor MV, Kerr DR, Faraday NR, Outschoorn I, and Rose NR, Clinical and Vaccine Immunology, 1/1/2006
• A Novel Model of Drug Hapten-Induced Hepatitis with Increased Mast Cells in the BALB/c Mouse  
  Njoku DB, Talor MV, Fairweather D, Frisancho-Kiss S, Odumade OA and Rose NR, Exp Mol Pathol, 1/1/2005
• Mast cells and innate cytokines are associated with susceptibility to autoimmune heart disease following Coxsackievirus B3 infection  
  Fairweather D, Frisancho-Kiss S, Gatewood S, Njoku D, Steele R, Barrett M and Rose NR, Autoimmunity, 1/1/2004
• Interferon-y protects against chronic viral myocarditis by reducing mast cell degranulation, fibrosis, and the profibrotic cytokines transforming growth factor-B1, Int...  
  Fairweather D, Frisancho-Kiss S, Yusung SA, Barrett MA, Davis SE, Gatewood SJ, Njoku DB and Rose NR, Am J Pathol, 1/1/2004
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Books/Book Chapters

• Essentials of Pediatric Anesthesiology. 
  Chapter: Orthopedic Surgery 
  Kattail D, Lo C, Njoku DCambridge University Press2015
• Pathophysiologic States and Adverse Effects in Essentials of Pediatric Anesthesiology. 
  Chapter: Pharmacology: Physiologic States 
  Njoku D, Lyon CCambridge University Press2015
• Essentials of Neuroanesthesia and Critical Care Handbook. 
  Chapter: Challenges During Surgery for Traumatic Brain Injury. 
  Ajuba-Iwuji C and Njoku DBEditors: J Kirsch and A Brambrink.Springer2012
• Pocket ICU Medicine. 
  Chapter: Rashes. 
  Ajuba-Iwuji C and Njoku DBEditors: M Wall.Pocketmedicine.com, New York, NY2009
• Anesthesia for Strategies in Pediatric Anesthesia for the Palm Pilot. 
  Chapter: Branchial Cleft Cyst. 
  Njoku DEditors: RS Litman.Pocketmedicine.com, New York, NYEdition 2nd,2007
• Anesthesia for Strategies in Pediatric Anesthesia for the Palm Pilot. 
  Chapter: Craniotomy for CNS Tumor Excision. 
  Kaufman S and Njoku DEditors: RS Litman.Pocketmedicine.com, New York, NYEdition 2nd,2007
• Decision Making in Anesthesiology 
  Chapter: Latex Allergy. 
  Brady KM, Njoku DBMosby Year BookEdition 4th,2007
• Anesthesiology 
  Chapter: Understanding the Metabolism and Toxicity of Modern Fluorinated Anesthetics. 
  Martin J and Njoku DBEditors: R. Miller.Edition 5th,2004
• Essence of Anesthesia Practice 
  Chapter: Subclavian Steal Syndrome. 
  Martin JL, Njoku DEditors: M. Roizen and L. Fleisher.W. B. Saunders Company, New York, NY2002
• Problems in Anesthesia 
  Chapter: Effects of Halogenated Inhalational Anesthetics on the Liver and Kidney. 
  Page 478 - 487Njoku DEditors: M. Yaster, L. Fleisher, and D. Prough.Lippncott Williams & Wilkins, Philadelphia, PA1998
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Abstracts/Posters

• IL-10 modulates IL-33 and Treg responses in a mouse model of drug-hapten, immune-mediated hepatitis.
  Cottagiri M, Mallory B, Chen G, Thomas D, Mantila J, Rose N, Njoku D, Eur J Immunol; International Congress of Immunology, Melbourne, Australia, 1/1/2016
• M ST2/IL-33 signaling worsens immune-mediated hepatitis from drug haptens.
  Njoku D, Goodman S, Cho J, Kim L, Haham, Front Immunol Conference; 15th International Congress of Immunology, 1/1/2013
• Sex Bias in experimental immune-mediated drug-induced liver injury in BALB/c mice: roles for estrogen and estrogen receptor alpha
  Li Z and Njoku DB, IARS Best of Section Liver/Transplantation, Vancouver, Canada, 1/21/2011
• Sex bias in drug-induced immune mediated hepatitisin
  Njoku DB, Li Z, Talor MV, Rose NR, and Njoku DB, 6th International Congress on Autoimmunity, Oporto, Portugal, 1/1/2008
• Sex bias in drug-induced immune mediated hepatitis
  Li Z, Talor MV, Rose NR, and Njoku DB, FASEB J, 1/1/2008
• IL-4 promotes experimental drug-induced hepatitis and modulates IP-10. Hepatobiliary Pathobiology II: Liver Injury and Regeneration.
  Njoku DB, Mellerson J, Sharma R, Talor MV, Ligons D, Li Z and Rose NR, FASEB Journal; Experimental Biology Meeting, 1/1/2007
• Identification of a High Risk Subset of POCA Registrants: Potential Impact on Practice Recommendations for Successful Resuscitation.
  Singh D, Gross RM, Monitto C, Heitmiller E and Njoku DB, Society of Pediatric Anesthesia Winter Meeting, Santa Fe, NM, 1/1/2007
• Etiological Differences in Blood Loss in Scoliosis Patients Undergoing Posterior Spinal Fusion Surgery.
  Bhatnager R, Njoku DB, Miller N, Sponseller PD, American Academy of Pediatrics National Conference and Exhibition, Washington, DC, 1/9/2005
• Immune-mediated drug-induced, idiosyncratic hepatitis in mice requires IL-4 as well as IL-4-dependent, MIP-2.
  Njoku DB, Mellerson JL, Rose NR, Hepatology, 1/1/2005
• Complement Receptor 1 Protects Against Coxsackievirus B3-Induced Myocarditis by Decreasing Interleukin-1B and Crry Levels on Macrophages.
  Frisancho-Kiss S, Njoku DB, Davis S, Barrett MA, Steele RA, Gatewood SL, Rose NR and Fairweather D, 12th International Congress of Immunology and the 4th Annual Conference of FOCIS, Montreal, Canada, 1/6/2004
• Role of Kupffer cells and mast cells in drug-induced hepatitis in mice.
  Njoku DB, Odumade O, Talor M, Fairweather D, Frisancho-Kiss S, Rose NR, FASEB Journal; AAI Block Symposium, Experimental Biology meeting abstracts, 1/1/2004
• IFN-gamma protects against chronic viral myocarditis by reducing mast cell degranulation, fibrosis, and the profibroticcytokines TGF-beta 1 and IL-4.
  Fairweather D, Frisancho-Kiss S, Yusung S, Barrett M, Gatewood S, Njoku D and Rose N, FASEB Journal; AAI Block Symposium, Experimental Biology meeting abstracts, 1/1/2004
• Blood Loss in Pediatric Spinal Fusion Surgery: Factors outside of the Curve
  Njoku DB, Little KJ, Schwengel DA, Sponseller PD, Anesthesiology, 1/1/2003
• Autoantibodies Associated with Inhalational Anesthetic Hepatitis Found in the Sera of a Large Cohort of Pediatric Anesthesiologists.
  Njoku DB, Bourdi M, Martin JL, Greenberg RS, and Pohl LR, IARS Annual Meeting, Los Angeles, CA, 1/1/1999
• Immunochemical evidence against the role of renal cysteine conjugate b-lyase in the nephrotoxicity of Compound A.
  Njoku DB, Pohl LR, Martin JL, Society of Toxicology 37th Annual Meeting, 1/1/1998
• Autoantibodies Associated with Inhalational Anesthetic Hepatitis Found in the Sera of Anesthesiologists.
  Njoku DB, Greeenberg RS, Bourdi M, Martin JL, Pohl LR, Society of Pediatric Anesthesiology, 1/1/1998
• Compound A Toxicity in Wistar Rats: Role of Thiols.
  Njoku DB, Pohl LR, Martin JL, International Anesthesia Research Society Annual Meeting, San Francisco, CA, 1/18/1997
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Lectures

• Malignant Hyperthermia: The Essentials 
  Phoenix, AZ - 1/9/2019
• The Broad Impact of Robotic Surgery: The Importance of Anesthesiology Training 
  Phoenix, AZ - 1/9/2019
• Sevoflurane and Desflurane Hepatotoxicity 
  Phoenix, AZ, 2018, 2019 - 1/9/2019
• Regulatory cells in immune-mediated hepatitis: A story of the Capulets and the Montagues 
  University of Rochester, Rochester, NY, 2017; Boston Children�s Hospital, Boston, MA, 2017 - 1/25/2017
• Understanding Outcomes in Pediatric Spine Fusion 
  Vanderbilt University, Nashville, TN - 1/18/2017
• Grant Writing and Study Section for the Uninitiated 
  New Orleans, LA - 1/13/2014
• FSA 2013 Annual Meeting 
  Florida Society of Anesthesiologists, Palm Beach, Florida - 6/7/2013
• General Perioperative Concerns 
  Dallas, TX - 1/17/2013
• Pharmacology 
  Dallas, TX - 1/17/2013
• Fluid resuscitation in pediatric trauma 
  1/7/2013
• The impact of pediatric obesity in the ambulatory setting 
  1/7/2013
• The Broad Impact of Robotic Surgery: Complications and Cost, Training and Practice 
  Washington, DC - 1/14/2012
• Preventing Liver Injury From Commonly Used Drugs 
  Johns Hopkins University, Baltimore, MD - 1/26/2011
• Liver Injury followingcommonly used drugs. 
  Johns Hopkins University, Baltimore, MD - 1/18/2011
• Update on Robotics. 
  Chicago, IL - 1/16/2011
• Liver Failure After Anesthetics 
  Children's National Medical Center, Washington, DC - 1/6/2011
• Pediatric Trauma. 
  San Diego, CA - 1/17/2010
• Pediatric Obesity 
  Baltimore, MD - 1/2/2010
• Peri-operative Implications of Anesthesia � Induced Inflammation 
  New Orleans, LA - 1/18/2009
• The Changing "Face" of Anesthesia. The Impact of Robotics on Anesthesia Practice 
  New Orleans, LA - 1/17/2009
• From Anesthetic Hepatitis to DILI: Lessons Learned from Ben, Jo and Rey 
  Vanderbilt University - 1/21/2008
• Role of Gender in Autoimmunity 
  Children�s National Medical Center - 1/20/2007
• Anesthetic Implications of Noonan�s Syndrome 
  Multiple Locations, 2000, 2002, 2004, 2007 - 1/18/2007
• Pre-operative Screening for the Obese Adolescent. 
  Johns Hopkins University - 1/1/2007
• Role of Gender, Cytokines and Cells in Drug-Induced Immune-Mediated Hepatitis 
  Johns Hopkins University - 1/1/2007
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Other

• Scientific Advisory Report: Role of IL-4 in Facilitating Translational Therapies for Drug-Induced Liver Injury. 
  Njoku D, Association of University Anesthesiologists Newsletter Spring
  1/1/2012
• Pediatric Anesthesiologists Risk Halothane-Related Liver Injury 
  Njoku D, Science Daily
  www.sciencedaily.com/releases/1998/06/980625144459
  1/25/1998
• Anesthesiologists May be Exposed to Too Much Gas. 
  Njoku D, Anesthesiology News
  1/1/1998
• Anesthesiologists May Be Exposed to Too Much Gas. (Interview by National Public Radio) 
  Njoku D
  1/1/1998
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