DouglasLytleMayersMD

PubMed

• 15 citations
  ATI-2173, a Novel Liver-Targeted Non-Chain-Terminating Nucleotide for Hepatitis B Virus Cure Regimens.
  Katherine E. Squires, Douglas L. Mayers, Gregory R. Bluemling, Alexander A. Kolykhalov, David B. Guthrie, Prabhakar Reddy, Debbie G. Mitchell, Manohar Saindane, Zachar...> ;Antimicrobial Agents and Chemotherapy. 2020 Aug 20
• 17 citations
  A randomized, double-blind, multiple-dose study of the pan-genotypic NS5A inhibitor samatasvir in patients infected with hepatitis C virus genotype 1, 2, 3 or 4
  Bradley D. Vince, J. Hill, Eric Lawitz, William O'Riordan, Lynn R. Webster, D. Gruener, Ricky S. Mofsen, Abel Murillo, Eileen Donovan, Jie Chen, Joseph F. McCarville, ...> ;Journal of Hepatology. 2014 May 1
• 8 citations
  IDX184 in combination with pegylated interferon-α2a and ribavirin for 2 weeks in treatment-naive patients with chronic hepatitis C.
  Jacob Lalezari, Terry Box, William O'Riordan, Purvi Mehra, Tuan V. Nguyen, Fred Poordad, Edwin DeJesus, Paul Y. Kwo, Eliot Godofsky, Shannon Lawrence, Gloria Dubuc-Pat...> ;Antiviral Therapy. 2013 Aug 1
• 10 citations
  Short-Term Monotherapy with IDX184, a Liver-Targeted Nucleotide Polymerase Inhibitor, in Patients with Chronic Hepatitis C Virus Infection
  Jacob Lalezari, David M. Asmuth, Arnaldo Casiró, Hugo E. Vargas, Shannon Lawrence, Gloria Dubuc-Patrick, Jie Chen, Joseph F. McCarville, Keith Pietropaolo, Xiao-Jian Z...> ;Antimicrobial Agents and Chemotherapy. 2012 Dec 1
• 8 citations
  Recombination between variants from genital tract and plasma : evolution of multidrug-resistant HIV type 1
  Kimdar Sherefa Kemal, Christina M. Ramirez, Harold Burger, Brian T. Foley, Douglas L. Mayers, Thomas Klimkait, François Hamy, Kathryn Anastos, Katarina Petrovic, Vladi...> ;AIDS Research and Human Retroviruses. 2012 Nov 21
• 10 citations
  First-in-Human Study of the Pharmacokinetics and Antiviral Activity of IDX375, a Novel Nonnucleoside Hepatitis C Virus Polymerase Inhibitor
  J. de Bruijne, J. van de Wetering de Rooij, A. Van Vliet, Xiao-Jian Zhou, M. F. Temam, J. Molles, Jie Chen, Keith Pietropaolo, John Sullivan-Bólyai, Douglas L. Mayers,...> ;Antimicrobial Agents and Chemotherapy. 2012 Aug 1
• 9 citations
  Drug interaction profile for GSK2248761, a next generation non-nucleoside reverse transcriptase inhibitor.
  Steve Piscitelli, J. Kim, Elizabeth Gould, Yu Lou, Scott White, Mark de Serres, Mark Johnson, Xiao-Jian Zhou, Keith Pietropaolo, Douglas L. Mayers> ;British Journal of Clinical Pharmacology. 2012 Aug 1
• 8 citations
  Safety and Efficacy of GSK2248761, a Next-Generation Nonnucleoside Reverse Transcriptase Inhibitor, in Treatment-Naive HIV-1-Infected Subjects
  Carlos Zala, Marty St. Clair, Kathleen Dudas, J. Kim, Yu Lou, Scott R. White, Steve Piscitelli, Etienne Dumont, Keith Pietropaolo, Xiao-Jian Zhou, Douglas L. Mayers> ;Antimicrobial Agents and Chemotherapy. 2012 May 1
• 3 citations
  Rapid decline of viral RNA in chronic hepatitis C patients treated once daily with IDX320: a novel macrocyclic HCV protease inhibitor.
  Joep de Bruijne, Andre van Vliet, Christine J. Weegink, Włodzimierz Mazur, Alicja Wiercińska-Drapało, Krzysztof Simon, Grażyna Cholewińska-Szymańska, Judit Kapocsi, Is...> ;Antiviral Therapy. 2012 May 1
• 7 citations
  Short-course Combivir after single-dose nevirapine reduces but does not eliminate the emergence of nevirapine resistance in women.
  Sarah Palmer, Valerie F. Boltz, Jeremy Y. Chow, Neil A. Martinson, James McIntyre, Glenda Gray, Mark J. Hopley, Douglas L. Mayers, Patrick A. Robinson, David B. Hall, ...> ;Antiviral Therapy. 2011 Jan 1
• 49 citations
  Safety and Pharmacokinetics of IDX184, a Liver-Targeted Nucleotide Polymerase Inhibitor of Hepatitis C Virus, in Healthy Subjects
  Xiao-Jian Zhou, Keith Pietropaolo, Jie Chen, Samina Khan, John Sullivan-Bólyai, Douglas L. Mayers> ;Antimicrobial Agents and Chemotherapy. 2011 Jan 1
• 27 citations
  Evolution and recombination of genes encoding HIV-1 drug resistance and tropism during antiretroviral therapy.
  Binshan Shi, Christina M. R. Kitchen, Barbara Weiser, Douglas L. Mayers, Brian T. Foley, Kimdar Sherefa Kemal, Kathryn Anastos, Marc A. Suchard, Monica M. Parker, Cher...> ;Virology. 2010 Aug 15
• 15 citations
  Optimization of allele-specific PCR using patient-specific HIV consensus sequences for primer design.
  Valerie F. Boltz, Frank Maldarelli, Neil A. Martinson, Lynn Morris, James McIntyre, Glenda Gray, Mark J. Hopley, Toshio Kimura, Douglas L. Mayers, Patrick A. Robinson,...> ;Journal of Virological Methods. 2010 Mar 1
• 34 citations
  Microdose pharmacokinetics of IDX899 and IDX989, candidate HIV-1 non-nucleoside reverse transcriptase inhibitors, following oral and intravenous administration in heal...
  Xiao-Jian Zhou, R. Colin Garner, Sheila Nicholson, C. James Kissling, Douglas L. Mayers> ;Journal of Clinical Pharmacology. 2009 Dec 1
• 7 citations
  Absence of effect of telbivudine on cardiac repolarization: results of a thorough QT/QTc study in healthy participants.
  Fred Poordad, Gillian Zeldin, Stuart I. Harris, June Ke, Limin Xu, Douglas L. Mayers, X.-J. Zhou> ;Journal of Clinical Pharmacology. 2009 Dec 1
• 70 citations
  Efficacy of short-course AZT plus 3TC to reduce nevirapine resistance in the prevention of mother-to-child HIV transmission: a randomized clinical trial.
  James McIntyre, Mark J. Hopley, Daya Moodley, Marie Eklund, Glenda E. Gray, David B. Hall, Patrick A. Robinson, Douglas L. Mayers, Neil A. Martinson> ;Plos Medicine. 2009 Oct 27
• 5 citations
  Population pharmacokinetics of telbivudine and determination of dose adjustment for patients with renal impairment.
  Xiao-Jian Zhou, June Ke, William M. Sallas, Colm Farrell, Douglas L. Mayers, Helen S. Pentikis> ;Journal of Clinical Pharmacology. 2009 Jun 1
• 21 citations
  Single-Dose Escalation and Multiple-Dose Safety, Tolerability, and Pharmacokinetics of IDX899, a Candidate Human Immunodeficiency Virus Type 1 Nonnucleoside Reverse Tr...
  Xiao-Jian Zhou, Keith Pietropaolo, David Damphousse, Bruce Belanger, Jie Chen, John Sullivan-Bólyai, Douglas L. Mayers> ;Antimicrobial Agents and Chemotherapy. 2009 May 1
• 16 citations
  Long-term efficacy and safety of tipranavir boosted with ritonavir in HIV-1-infected patients failing multiple protease inhibitor regimens: 80-week data from a phase 2...
  Martin Markowitz, Leonard N. Slater, Robert S. Schwartz, Powel Kazanjian, Bruce Hathaway, David Wheeler, Mitchell Goldman, Dietmar Neubacher, Douglas L. Mayers, Hernan...> ;Journal of Acquired Immune Deficiency Syndromes. 2007 Aug 1
• 10 citations
  Antiviral activity of low-dose alovudine in antiretroviral-experienced patients: results from a 4-week randomized, double-blind, placebo-controlled dose-ranging trial.
  Jade Ghosn, A-M Quinson, ND Sabo, Laurent Cotte, C Piketty, N Dorléacq, M-L Bravo, Douglas L. Mayers, J Harmenberg, G Mårdh, Hernan Valdez, Christine Katlama> ;HIV Medicine. 2007 Apr 1
• 21 citations
  Efficacy And Safety of Three Doses of Tipranavir Boosted with Ritonavir in Treatment-Experienced HIV Type 1-Infected Patients
  Joseph Gathe, Gerald Pierone, Peter J. Piliero, Keikawus Arastéh, Rafael Rubio, Richard G. Lalonde, David A. Cooper, Adriano Lazzarin, Veronika Kohlbrenner, Catherine ...> ;AIDS Research and Human Retroviruses. 2007 Feb 27
• 27 citations
  HIV-1 drug resistance in variants from the female genital tract and plasma
  Kimdar Sherefa Kemal, Harold Burger, Douglas L. Mayers, Kathryn Anastos, Brian T. Foley, Christina M. R. Kitchen, Penelope Huggins, Tamara L. Schroeder, Gaston Picchio...> ;The Journal of Infectious Diseases. 2007 Feb 15
• 1 citations
  Seeking ethical designs for HIV clinical trials in treatment-experienced patients: an industry perspective.
  Douglas L. Mayers, Jain Chung, Veronika Kohlbrenner, David B. Hall, Ralph DeMasi, Dietmar Neubacher, Neil Buss, Miklos Salgo> ;AIDS Research and Human Retroviruses. 2006 Dec 5
• 71 citations
  Ritonavir-Boosted Tipranavir Demonstrates Superior Efficacy to Ritonavir-Boosted Protease Inhibitors in Treatment-Experienced HIV-Infected Patients: 24-Week Results of...
  Pedro Cahn, Jorge Villacian, Adriano Lazzarin, Christine Katlama, Beatriz Grinsztejn, Keikawus Arastéh, Paulo López, Nathan Clumeck, Jan Gerstoft, Nikolas Stavrianeas,...> ;Clinical Infectious Diseases. 2006 Nov 15
• 69 citations
  Efficacy of the Protease Inhibitors Tipranavir plus Ritonavir in Treatment-Experienced Patients: 24-Week Analysis from the RESIST-1 Trial
  Joseph Gathe, David A. Cooper, Charles Farthing, Dushyantha Jayaweera, Dorece Norris, Gerald Pierone, Corklin R. Steinhart, Benoit Trottier, Sharon Walmsley, Cassy Wor...> ;Clinical Infectious Diseases. 2006 Nov 15
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