GaryArthurSilvermanMDPhD

PubMed

• 7 citations
  Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins.
  Cliff J Luke, Stephanie Markovina, Misty Good, Ira E Wight, Brian J Thomas, John M Linneman, Wyatt E Lanik, Olga Koroleva, Maggie R Coffman, Mark T Miedel, Qingqing Go...> ;Communications Biology. 2022 Jan 12
• CemOrange2 fusions facilitate multifluorophore subcellular imaging in C. elegans.
  Thomas, B. J.,Wight, I. E.,Chou, WYY.,Moreno, M.,Dawson, Z.,Homayouni, A.,Huang, H.,Kim, H.,Jia, H.,Buland, J. R.,Wambach, J. A.,Cole, F. S.,Pak, S. C.,Silverman, G. A...> ;PLoS ONE. 2019 Mar 27
• 14 citations
  An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z
  Yan Wang, Murat Can Cobanoglu, Jie Li, Tunda Hidvegi, Pamela Hale, Andrew S. Chu, Zhenwei Gong, Radhika Muzumdar, Gary A. Silverman, Ivet Bahar, David H. Perlmutter, > ;Plos One. 2019 Jan 23
• Quantitative assessment of cell fate decision between autophagy and apoptosis.
  Liu, B.,Oltvai, Z. N.,Bayır, H.,Silverman, G. A.,Pak, S. C.,Perlmutter, D. H.,Bahar, I.> ;Sci Rep. 2017 Dec 16
• 9 citations
  Activation of the Caenorhabditis elegans Degenerin Channel by Shear Stress Requires the MEC-10 Subunit.
  Shujie Shi, Cliff J. Luke, Gary A. Silverman, Thomas R. Kleyman> ;The Journal of Biological Chemistry. 2016 Jul 1
• 673 citations
  Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
  Klionsky, D. J., Klionsky, D. J., Klionsky, D. J., Klionsky, D. J., Abdelmohsen, K., Abdelmohsen, K., Abdelmohsen, K., Abdelmohsen, K., Abe, A., Abe, A., Abe, A., Abe,...> ;Autophagy. 2016 Jan 23
• SERPINB12 Is a Slow-Binding Inhibitor of Granzyme A and Hepsin.
  Niehaus, J. Z.,Miedel, M. T.,Good, M.,Wyatt, A. N.,Pak, S. C.,Silverman, G. A.,Luke, C. J.> ;Biochemistry. 2015 Oct 27
• Enhancing autophagy with drugs or lung-directed gene therapy reverses the pathological effects of respiratory epithelial cell proteinopathy.
  Hidvegi T Stolz DB Alcorn JF Yousem SA Wang J Leme AS Houghton AM Hale P Ewing M Cai H Pastore N Annunziata P Kaminski N Pilewski J Shapiro SD Pak SC S...> ;J Biol Chem. 2015 Oct 22
• Human SERPINB12 Is an Abundant Intracellular Serpin Expressed in Most Surface and Glandular Epithelia.
  Niehaus JZ Good M Jackson LE Ozolek JA Silverman GA Luke CJ> ;J Histochem Cytochem. 2015 Jul 28
• 1 citations
  The Aggregation-Prone Intracellular Serpin SRP-2 Fails to Transit the ER in Caenorhabditis elegans
  Richard M. Silverman, Erin E. Cummings, Linda P. O’Reilly, Gary A. Silverman, Cliff J. Luke, David H. Perlmutter, Stephen C. Pak> ;Genetics. 2015 Jan 1
• Worming our way to novel drug discovery with the Caenorhabditis elegans proteostasis network, stress response and insulin-signaling pathways.
  O'Reilly, L. P.,Benson, J. A.,Cummings, E. E.,Perlmutter, D. H.,Silverman, G. A.,Pak, S. C.> ;Expert Opin Drug Discov. 2014 Jul 08
• Isolation of serpin-interacting proteins in C. elegans using protein affinity purification.
  Miedel, M. T.,Zeng, X.,Yates, N. A.,Silverman, G. A.,Luke, C. J.> ;Methods. 2014 May 07
• A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover.
  Long, O. S.,Benson, J. A.,Kwak, J. H.,Luke, C. J.,Gosai, S. J.,O'Reilly, L. P.,Wang, Y.,Li, J.,Vetica, A. C.,Miedel, M. T.,Stolz, D. B.,Watkins, S. C.,Züchner, S.,Perl...> ;Hum. Mol. Genet.. 2014 May 20
• A genome-wide RNAi screen identifies potential drug targets in a C. elegans model of α1-antitrypsin deficiency.
  O'Reilly, L. P.,Long, O. S.,Cobanoglu, M. C.,Benson, J. A.,Luke, C. J.,Miedel, M. T.,Hale, P.,Perlmutter, D. H.,Bahar, I.,Silverman, G. A.,Pak, S. C.> ;Hum. Mol. Genet.. 2014 May 20
• alpha1-Antitrypsin deficiency and the hepatocytes - An elegans solution to drug discovery.
  O'Reilly LP Perlmutter DH Silverman GA Pak SC> ;Int J Biochem Cell Biol. 2014 Feb
• Update of the human and mouse SERPIN gene superfamily.
  Heit C Jackson BC McAndrews M Wright MW Thompson DC Silverman GA Nebert DW Vasiliou V> ;Hum Genomics. 2013
• C. elegans in high-throughput drug discovery.
  O'Reilly LP Luke CJ Perlmutter DH Silverman GA Pak SC> ;Adv Drug Deliv Rev. 2013 Dec 12
• A small conductance calcium-activated K+ channel in C. elegans, KCNL-2, plays a role in the regulation of the rate of egg-laying.
  Chotoo CK Silverman GA Devor DC Luke CJ> ;PLoS One. 2013
• Disorders of protein misfolding: alpha-1-antitrypsin deficiency as prototype.
  Silverman GA Pak SC Perlmutter DH> ;J Pediatr. 2013 Aug
• A pro-cathepsin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C. elegans.
  Miedel MT Graf NJ Stephen KE Long OS Pak SC Perlmutter DH Silverman GA Luke CJ> ;PLoS One. 2012
• Using C. elegans to identify the protease targets of serpins in vivo.
  Bhatia SR Miedel MT Chotoo CK Graf NJ Hood BL Conrads TP Silverman GA Luke CJ> ;Methods Enzymol. 2011
• Using Caenorhabditis elegans to study serpinopathies.
  Long OS Gosai SJ Kwak JH King DE Perlmutter DH Silverman GA Pak SC> ;Methods Enzymol. 2011
• Differential effects of periopathogens on host protease inhibitors SLPI, elafin, SCCA1, and SCCA2.
  Yin L Swanson B An J Hacker BM Silverman GA Dale BA Chung WO> ;J Oral Microbiol. 2010
• Inhibition of Staphylococcus aureus cysteine proteases by human serpin potentially limits staphylococcal virulence.
  Kantyka T Plaza K Koziel J Florczyk D Stennicke HR Thogersen IB Enghild JJ Silverman GA Pak SC Potempa J> ;Biol Chem. 2011 May
• Hepatic fibrosis and carcinogenesis in alpha1-antitrypsin deficiency: a prototype for chronic tissue damage in gain-of-function disorders.
  Perlmutter DH Silverman GA> ;Cold Spring Harb Perspect Biol. 2011 Mar
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Journal Articles

• A pro-cathespin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C elegans  
  Miedel MT, Graf NJ, Stephen KE, Long, OS, Pak SC, Perlmutter DH, Silverman GA, Luke, CJ, PLoS One, 1/1/2012
• Editorial Serpin Identification, Production and Characterization  
  Silverman GA, Lomas DA, Methods, 1/1/2004
• Translocations and amplification of the BCL2 gene are detected in interphase nuclei of non-Hodgkin’s lymphoma by in situ hybridization with yeast artificial chromosome...  
  Taniwaki M, Silverman GA, Nishida K, Horrike S, Misawa S, Shimazaki C, Miura I, Nagai M, Abe M, Fukuhara S, Kashima K, Blood, 1/1/1995
• Report of the first international workshop on human chromosome 18 mapping  
  LeBeau MM, Overhauser J, Straub RE, Silverman G, Gilliam TC, Ott J, O'Connell P, Francke U, Geurts van Kessel A, Cytogenet Cell Genet, 1/1/1993
• Meiotic recombination between yeast artificial chromosomes yields a single clone containing the entire BCL2 proto-oncogene  
  Silverman GA, Green ED, Young RL, Jockel JI, Domer PH, Korsmeyer SJ, Proc Natl Acad Sci USA, 12/1/1990
• Effects of enteric antigenic exposure on humoral and cell-mediated immune responses, Doctoral dissertation  
  Silverman GA, University of Chicago, Department of Pathology, 1/1/1982
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