GregoryBarnesMDPhD

Director, University of Louisville Autism Center, Professor of Neurology and Pediatrics, University of Louisville School of Medicine

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Office
411 E Chestnut St
Louisville, KY 40202
Phone+1 502-588-3650

Fax+1 502-588-7852
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Education & Training

Duke University HospitalFellowship, Epilepsy Research Fellowship, 1997 - 2000
Children's Hospital/Beth Israel Deaconess Medical Center/Harvard Medical SchoolResidency, Child Neurology, 1994 - 1997
Washington University/B-JH/SLCH ConsortiumResidency, Pediatrics, 1992 - 1994
University of Kentucky College of MedicineClass of 1992

Certifications & Licensure

KY State Medical License 2000 - 2025
TN State Medical License 2004 - 2023
NC State Medical License 1997 - 2004
American Board of Psychiatry and Neurology Neurology with Special Qualification in Child Neurology
American Board of Psychiatry and Neurology Epilepsy

Clinical Trials

A Trial of Levodopa in Angelman Syndrome Start of enrollment: 2011 Jan 01
Completed
Phase 2, Phase 3

Publications & Presentations

PubMed

A personalized classification of behavioral severity of autism spectrum disorder using a comprehensive machine learning framework.
Mohamed T Ali, Ahmad Gebreil, Yaser ElNakieb, Ahmed Elnakib, Ahmed Shalaby, Ali Mahmoud, Ahmed Sleman, Guruprasad A Giridharan, Gregory Barnes, Ayman S Elbaz> ;Scientific Reports. 2023 Oct 9
2 citations
Role of Artificial Intelligence for Autism Diagnosis Using DTI and fMRI: A Survey.
Eman Helmy, Ahmed Elnakib, Yaser ElNakieb, Mohamed Khudri, Mostafa Abdelrahim, Jawad Yousaf, Mohammed Ghazal, Sohail Contractor, Gregory Neal Barnes, Ayman El-Baz> ;Biomedicines. 2023 Jun 29
8 citations
Understanding the Role of Connectivity Dynamics of Resting-State Functional MRI in the Diagnosis of Autism Spectrum Disorder: A Comprehensive Study.
Yaser ElNakieb, Mohamed T Ali, Ahmed Elnakib, Ahmed Shalaby, Ali Mahmoud, Ahmed Soliman, Gregory Neal Barnes, Ayman El-Baz> ;Bioengineering. 2023 Jan 2
7 citations
Potential Cross Talk between Autism Risk Genes and Neurovascular Molecules: A Pilot Study on Impact of Blood Brain Barrier Integrity.
Rekha Jagadapillai, Xiaolu Qiu, Kshama Ojha, Zhu Li, Ayman El-Baz, Shipu Zou, Evelyne Gozal, Gregory N Barnes> ;Cells. 2022 Jul 15
7 citations
The Role of Structure MRI in Diagnosing Autism.
Mohamed T Ali, Yaser ElNakieb, Ahmed Elnakib, Ahmed Shalaby, Ali Mahmoud, Mohammed Ghazal, Jawad Yousaf, Hadil Abu Khalifeh, Manuel Casanova, Gregory Barnes, Ayman El-Baz> ;Diagnostics. 2022 Jan 11
9 citations
The Role of Diffusion Tensor MR Imaging (DTI) of the Brain in Diagnosing Autism Spectrum Disorder: Promising Results.
Yaser ElNakieb, Mohamed T Ali, Ahmed Elnakib, Ahmed Shalaby, Ahmed Soliman, Ali Mahmoud, Mohammed Ghazal, Gregory Neal Barnes, Ayman El-Baz> ;Sensors. 2021 Dec 7
2 citations
A Personalized Computer-Aided Diagnosis System for Mild Cognitive Impairment (MCI) Using Structural MRI (sMRI)
Fatma El-Zahraa A. El-Gamal, Mohammed Elmogy, Ali Mahmoud, Ahmed Shalaby, Andrew E. Switala, Mohammed Ghazal, Hassan Soliman, Ahmed Atwan, Norah Saleh Alghamdi, Gregor...> ;Sensors. 2021 Aug 11
8 citations
Dynamic glial response and crosstalk in demyelination-remyelination and neurodegeneration processes.
Tianci Chu, Lisa B E Shields, Wenxin Zeng, Yi Ping Zhang, Yuanyi Wang, Gregory N. Barnes, Christopher B. Shields, Jun Cai> ;Neural Regeneration Research. 2021 Jul 1
13 citations
Potential crosstalk between sonic hedgehog-WNT signaling and neurovascular molecules: Implications for blood-brain barrier integrity in autism spectrum disorder.
Evelyne Gozal, Rekha Jagadapillai, Jun Cai, Gregory N. Barnes> ;Journal of Neurochemistry. 2021 Jun 25
12 citations
A Robust DWT-CNN Based CAD System for Early Diagnosis of Autism Using Task-based fMRI
Reem Haweel, Ahmed Shalaby, Ali Mahmoud, Noha A. Seada, Said Ghoniemy, Mohammed Ghazal, Manuel F. Casanova, Gregory N. Barnes, Ayman El-Baz> ;Medical Physics. 2021 May 1
5 citations
Identifying brain areas correlated with ADOS raw scores by studying altered dynamic functional connectivity patterns
Omar Dekhil, Ahmed Shalaby, Ahmed Soliman, Ali Mahmoud, Maiying Kong, Gregory N. Barnes, Adel Elmaghraby, Ayman El-Baz> ;Medical Image Analysis. 2021 Feb 1
11 citations
Disruption of essential metal homeostasis in the brain by cadmium and high-fat diet.
John C. Mazzocco, Rekha Jagadapillai, Evelyne Gozal, Maiying Kong, Qian Xu, Gregory N. Barnes, Jonathan H. Freedman> ;Toxicology Reports. 2020 Aug 23
5 citations
Platelet-Activating Factor Deteriorates Lysophosphatidylcholine-Induced Demyelination Via Its Receptor-Dependent and -Independent Effects
Zhisen Tian, Tianci Chu, Lisa B E Shields, Qingsan Zhu, Yi Ping Zhang, Maiying Kong, Gregory N. Barnes, Yuanyi Wang, Christopher B. Shields, Jun Cai> ;Molecular Neurobiology. 2020 Jul 13
15 citations
Neuroprotective Effects of Adenosine A1 Receptor Signaling on Cognitive Impairment Induced by Chronic Intermittent Hypoxia in Mice.
Yi-Chun Zhang, Hongchao Cao, Xuehao Qiu, Danfen Xu, Yifeng Chen, Gregory N. Barnes, Yun-Jia Tu, Adwoa Takyiwaa Gyabaah, Abdulla Husain Abdulla Ahmed Gharbal, Chenlei P...> ;Frontiers in Cellular Neuroscience. 2020 Jul 9
5 citations
Factors Associated With Seizure Onset in Children With Autism Spectrum Disorder.
Jamie K. Capal, Eric A. Macklin, Frances Lu, Gregory N. Barnes> ;Pediatrics. 2020 Apr 1
18 citations
A Comprehensive Framework for Differentiating Autism Spectrum Disorder From Neurotypicals by Fusing Structural MRI and Resting State Functional MRI.
Omar Dekhil, Mohamed T. Ali, Reem Haweel, Yaser Elnakib, Mohammed Ghazal, Hassan Hajjdiab, Luay Fraiwan, Ahmed Shalaby, Ahmed Soliman, Ali Mahmoud, Robert S. Keynton, ...> ;Seminars in Pediatric Neurology. 2020 Mar 6
1 citations
Publisher Correction: Cadmium and High-Fat Diet Disrupt Renal, Cardiac and Hepatic Essential Metals.
Jamie L. Young, Xiaofang Yan, Jianxiang Xu, Xinmin Yin, Xiang Zhang, Gavin E. Arteel, Gregory N. Barnes, J. Christopher States, Walter H. Watson, Maiying Kong, Lu Cai,...> ;Scientific Reports. 2020 Feb 10
32 citations
Dynamic response of microglia/macrophage polarization following demyelination in mice.
Tianci Chu, Yi Ping Zhang, Zhisen Tian, Chu-Yuan Ye, Mingming Zhu, Lisa B E Shields, Maiying Kong, Gregory N. Barnes, Christopher B. Shields, Jun Cai> ;Journal of Neuroinflammation. 2019 Oct 17
25 citations
Cadmium and High-Fat Diet Disrupt Renal, Cardiac and Hepatic Essential Metals.
Jamie L. Young, Xiaofang Yan, Jianxiang Xu, Xinmin Yin, Xiang Zhang, Gavin E. Arteel, Gregory N. Barnes, J. Christopher States, Walter H. Watson, Maiying Kong, Lu Cai,...> ;Scientific Reports. 2019 Oct 11
24 citations
A Personalized Autism Diagnosis CAD System Using a Fusion of Structural MRI and Resting-State Functional MRI Data.
Omar Dekhil, Mohamed T. Ali, Yaser ElNakieb, Ahmed Shalaby, Ahmed Soliman, Andrew E. Switala, Ali Mahmoud, Mohammed Ghazal, Hassan Hajjdiab, Manuel F. Casanova, Adel E...> ;Frontiers in Psychiatry. 2019 Jul 4
22 citations
Deletion of Semaphorin 3F in Interneurons Is Associated with Decreased GABAergic Neurons, Autism-like Behavior, and Increased Oxidative Stress Cascades.
Zhu Li, Rekha Jagadapillai, Evelyne Gozal, Gregory N. Barnes> ;Molecular Neurobiology. 2019 Jan 11
30 citations
Using resting state functional MRI to build a personalized autism diagnosis system
Omar Dekhil, Hassan Hajjdiab, Babajide O. Ayinde, Ahmed Shalaby, A. Switala, Dawn Sosnin, Aliaa Elshamekh, Mohamed Ghazal, Robert S. Keynton, Gregory N. Barnes, Ayman ...> ;Plos One. 2018 Oct 31
18 citations
A randomized controlled trial of levodopa in patients with Angelman syndrome
Wen-Hann Tan, Lynne M. Bird, Anjali Sadhwani, Rene Barbieri-Welge, Steven A. Skinner, Lucia T. Horowitz, Carlos A. Bacino, Lisa M. Noll, Cary Fu, Rachel J. Hundley, Lo...> ;American Journal of Medical Genetics. Part A. 2018 May 1
39 citations
Neuroimmunologic and Neurotrophic Interactions in Autism Spectrum Disorders: Relationship to Neuroinflammation.
Kshama Ohja, Evelyne Gozal, Margaret Fahnestock, Lu Cai, Jun Cai, Jonathan H. Freedman, A. Switala, Ayman El-Baz, Gregory N. Barnes> ;Neuromolecular Medicine. 2018 Apr 24
2 citations
A Novel Early Diagnosis System for Mild Cognitive Impairment Based on Local Region Analysis: A Pilot Study.
Fatma El-Zahraa A. El-Gamal, Mohammed Elmogy, Mohammed Ghazal, Ahmed Atwan, Manuel F. Casanova, Gregory N. Barnes, Robert S. Keynton, Ayman El-Baz, Ashraf Khalil> ;Frontiers in Human Neuroscience. 2018 Jan 9
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