JenniferMarieSpechtMD

Breast Cancer

Jill D. Bennett Endowed Professor Clinical Research Director, Breast Oncology Professor, University of Washington, Division of Medical Oncology Professor, Clinical Research Division, Fred Hutchinson Cancer Center

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Office
1144 Eastlake Ave E.
Seattle, WA 98195
Phone+1 206-606-6889
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Education & Training

University of WashingtonFellowship, Hematology and Medical Oncology, 2002 - 2005
University of WashingtonResidency, Internal Medicine, 1999 - 2002
University of Washington School of MedicineClass of 1999

Certifications & Licensure

FL State Medical License 2022 - Present
WA State Medical License 2002 - 2025

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014

Clinical Trials

Sunitinib Malate, Paclitaxel, Doxorubicin Hydrochloride, and Cyclophosphamide Before Surgery in Treating Patients With Stage IIB-IIIC Breast Cancer Start of enrollment: 2007 Jun 01
Completed
Phase 2
FDG PET and DCE-MRI in Predicting Response to Treatment in Patients With Breast Cancer Start of enrollment: 2011 Nov 01
Terminated
Not Applicable
A Safety Study of SGN-LIV1A in Breast Cancer Patients Start of enrollment: 2013 Oct 22
Completed
Phase 1
Genetically Modified T-Cell Therapy in Treating Patients With Advanced ROR1+ Malignancies Start of enrollment: 2016 Mar 16
Terminated
Phase 1
Expanded Access With ABT-888 (Veliparib) to Treat Metastatic Breast Cancer
No longer available
Niraparib in Combination With Trastuzumab in Metastatic HER2+ Breast Cancer Start of enrollment: 2019 Sep 06
Recruiting
Phase 1, Phase 2
T-DM1 and Palbociclib for Metastatic HER2 Breast Cancer Start of enrollment: 2018 Dec 06
Completed
Phase 2
Autologous huMNC2-CAR44 or huMNC2-CAR22 T Cells for Breast Cancer Targeting Cleaved Form of MUC1 (MUC1*) Start of enrollment: 2020 Jan 15
Recruiting
Phase 1
Expanded Access Protocol for Subjects Previously Treated With Gedatolisib in B2151009
Available
Roles: Contact
Niraparib + Dostarlimab In BRCA Mutated Breast Cancer Start of enrollment: 2020 Dec 18
Recruiting
Phase 2
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Gedatolisib in combination with palbociclib and endocrine therapy in women with hormone receptor-positive, HER2-negative advanced breast cancer: results from the dose ...
E Claire Dees, Samuel Suzuki, Sarah C Mutka, Brian F Sullivan, Igor Gorbatchevsky, Rachel M Layman, Hyo S Han, Hope S Rugo, Erica M Stringer-Reasor, Jennifer M Specht,...> ;The Lancet. Oncology. 2024 Apr 1
The Current and Future Roles of Precision Oncology in Advanced Breast Cancer.
Heather Jacene, Eric Dietsche, Jennifer Specht> ;Journal of Nuclear Medicine. 2024 Mar 1
2 citations
Multimodal prediction of neoadjuvant treatment outcome by serial FDG PET and MRI in women with locally advanced breast cancer.
Anum S Kazerouni, Lanell M Peterson, Isaac Jenkins, Alena Novakova-Jiresova, Hannah M Linden, Julie R Gralow, David M Hockenbery, David A Mankoff, Peggy L Porter, Sava...> ;Breast Cancer Research. 2023 Nov 9
1 citations
Impact of Surveillance Mammography Intervals Less Than One Year on Performance Measures in Women With a Personal History of Breast Cancer.
Janie M Lee, Laura E Ichikawa, Karen J Wernli, Erin J A Bowles, Jennifer M Specht, Karla Kerlikowske, Diana L Miglioretti, Kathryn P Lowry, Anna N A Tosteson, Natasha ...> ;Korean Journal of Radiology. 2023 Aug 1
3 citations
Circulating tumor DNA association with residual cancer burden after neoadjuvant chemotherapy in triple-negative breast cancer in TBCRC 030.
Heather A Parsons, Timothy Blewett, Xiangying Chu, Sainetra Sridhar, Katheryn Santos, Kan Xiong, Vandana G Abramson, Ashka Patel, Ju Cheng, Adam Brufsky, Justin Rhoade...> ;Medrxiv. 2023 Mar 8
1 citations
Variation in second breast cancer risk after primary invasive cancer by time since primary cancer diagnosis and estrogen receptor status.
Kathryn P Lowry, Laura Ichikawa, Rebecca A Hubbard, Diana S M Buist, Erin J A Bowles, Louise M Henderson, Karla Kerlikowske, Jennifer M Specht, Brian L Sprague, Karen ...> ;Cancer. 2023 Apr 15
Management of Brain Metastases from Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Breast Cancer.
Tresa M McGranahan, Alipi V Bonm, Jennifer M Specht, Vyshak Venur, Simon S Lo> ;Cancers. 2022 Oct 20
2 citations
Accuracy of tumor registry versus pharmacy dispensings for breast cancer adjuvant endocrine therapy.
Cameron B Haas, Erin J Aiello Bowles, Janie M Lee, Jennifer Specht, Diana S M Buist> ;Cancer Causes & Control. 2022 Sep 1
9 citations
First-In-Human, First-In-Class, Phase I Trial of the Fucosylation Inhibitor SGN-2FF in Patients with Advanced Solid Tumors.
Khanh T. Do, Laura Q.M. Chow, Karen L. Reckamp, Rachel E. Sanborn, Howard A. Burris, Francisco Robert, D. Ross Camidge, Conor E. Steuer, John H. Strickler, Amy Weise, ...> ;The Oncologist. 2021 Nov 1
10 citations
18F-fluorodeoxyglucose (FDG) PET or 18F-fluorothymidine (FLT) PET to assess early response to aromatase inhibitors (AI) in women with ER+ operable breast cancer in a w...
Perrin E. Romine, Lanell M. Peterson, Brenda F. Kurland, Darrin Byrd, Alena Novakova-Jiresova, Mark Muzi, Jennifer M. Specht, Robert K. Doot, Jeanne M. Link, Kenneth K...> ;Breast Cancer Research. 2021 Aug 23
5 citations
A Phase II Study Evaluating the Safety and Efficacy of Sunitinib Malate in Combination With Weekly Paclitaxel Followed by Doxorubicin and Daily Oral Cyclophosphamide P...
Lynn Symonds, Isaac C. Jenkins, Hannah M. Linden, Brenda F. Kurland, Julie Gralow, Vijayakrishna V K Gadi, Georgiana K. Ellis, Qian Wu, Eve T. Rodler, Pavani Chalasani...> ;Clinical Breast Cancer. 2021 May 24
9 citations
Digital Mammography and Breast Tomosynthesis Performance in Women with a Personal History of Breast Cancer, 2007–2016
Janie M. Lee, Laura Ichikawa, Karen J. Wernli, Erin J. Aiello Bowles, Jennifer M. Specht, Karla Kerlikowske, Diana L. Miglioretti, Kathryn P. Lowry, Anna N. A. Tosteso...> ;Radiology. 2021 May 18
21 citations
Updated Results of TBCRC026: Phase II Trial Correlating Standardized Uptake Value With Pathological Complete Response to Pertuzumab and Trastuzumab in Breast Cancer
Roisin M. Connolly, Jeffrey P. Leal, Lilja B. Solnes, Chiung-Yu Huang, Ashley Carpenter, Katy Gaffney, Vandana G Abramson, Lisa A. Carey, Minetta C. Liu, Mothaffar F. ...> ;Journal of Clinical Oncology. 2021 May 17
3 citations
Single arm, phase two study of low-dose metronomic eribulin in metastatic breast cancer
Pavani Chalasani, Kiah J. Farr, Vicky Wu, Isaac C. Jenkins, Alex Liu, Stephanie Parker, Vijayakrishna K. Gadi, Jennifer M. Specht, Hannah M. Linden> ;Breast Cancer Research and Treatment. 2021 Apr 2
13 citations
18F-Fluoroestradiol PET Imaging in a Phase II Trial of Vorinostat to Restore Endocrine Sensitivity in ER+/HER2- Metastatic Breast Cancer.
Lanell M. Peterson, Brenda F. Kurland, Fengting Yan, Alena Novakova Jiresova, Vijayakrishna K. Gadi, Jennifer M. Specht, Julie R. Gralow, Erin K. Schubert, Jeanne M. L...> ;Journal of Nuclear Medicine. 2021 Feb 1
140 citations
Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade.
Shivani Srivastava, Scott N. Furlan, Carla A. Jaeger-Ruckstuhl, Megha Sarvothama, Carolina Berger, Kimberly S. Smythe, Sarah M. Garrison, Jennifer M. Specht, Sylvia Le...> ;Cancer Cell. 2021 Feb 8
41 citations
TBCRC 030: a phase II study of preoperative cisplatin versus paclitaxel in triple-negative breast cancer: evaluating the homologous recombination deficiency (HRD) biom...
Erica L. Mayer, Vandana G. Abramson, Rachel C. Jankowitz, Carla I. Falkson, Paul K. Marcom, Tiffany A. Traina, Lisa A. Carey, Mothaffar F. Rimawi, Jennifer M. Specht, ...> ;Annals of Oncology. 2020 Nov 1
8 citations
Surveillance for second breast cancer events in women with a personal history of breast cancer using breast MRI: a systematic review and meta-analysis.
Cameron B. Haas, Larissa Nekhlyudov, Janie M. Lee, Sara H. Javid, Mary Bush, Dianne Johnson, Timothy Gleason, Cary Kaufman, Jennifer M. Specht, Sean Stitham, Karen J. ...> ;Breast Cancer Research and Treatment. 2020 Apr 17
8 citations
Facility Variability in Examination Indication Among Women With Prior Breast Cancer: Implications and the Need for Standardization.
Diana S. M. Buist, Laura Ichikawa, Karen J. Wernli, Christoph I. Lee, Louise M. Henderson, Karla Kerlikowske, Erin J. Aiello Bowles, Diana L. Miglioretti, Jennifer M. ...> ;Journal of the American College of Radiology. 2020 Jan 28
4 citations
Patterns of Surveillance Advanced Imaging and Serum Tumor Biomarker Testing Following Launch of the Choosing Wisely Initiative.
Randy C. Miles, Christoph I Lee, Qin Sun, Aasthaa Bansal, Gary H. Lyman, Jennifer M Specht, Catherine R. Fedorenko, Mikael Anne Greenwood-Hickman, Scott D. Ramsey, Jan...> ;Journal of the National Comprehensive Cancer Network. 2019 Jul 1
20 citations
Test–Retest Reproducibility of 18F-FDG PET/CT Uptake in Cancer Patients Within a Qualified and Calibrated Local Network
Brenda F. Kurland, Lanell M. Peterson, Andrew Shields, Jean H. Lee, Darrin Byrd, Alena Novakova-Jiresova, Mark Muzi, Jennifer M. Specht, David A. Mankoff, Hannah M. Li...> ;Journal of Nuclear Medicine. 2019 May 1
20 citations
Combined Targeted Therapies for First-line Treatment of Metastatic Triple Negative Breast Cancer-A Phase II Trial of Weekly Nab-Paclitaxel and Bevacizumab Followed by ...
Lynn Symonds, Hannah M. Linden, Vijayakrishna K. Gadi, Larissa A. Korde, Eve T. Rodler, Julie R. Gralow, Mary W. Redman, Kelsey Baker, Quan Vicky Wu, Isaac C. Jenkins,...> ;Clinical Breast Cancer. 2019 Apr 1
30 citations
TBCRC026: Phase II Trial Correlating Standardized Uptake Value With Pathologic Complete Response to Pertuzumab and Trastuzumab in Breast Cancer
Roisin M. Connolly, Jeffrey P. Leal, Lilja Solnes, Chiung Yu Huang, Ashley Carpenter, Katy Gaffney, Vandana G. Abramson, Lisa A. Carey, Minetta C. Liu, Mothaffar F. Ri...> ;Journal of Clinical Oncology. 2019 Feb 5
30 citations
Prospective Study of Serial 18F-FDG PET and 18F-Fluoride PET to Predict Time to Skeletal-Related Events, Time to Progression, and Survival in Patients with Bone-Domina...
Lanell M. Peterson, Janet O'Sullivan, Qian Vicky Wu, Alena Novakova-Jiresova, Isaac C. Jenkins, Jean H. Lee, Andrew Shields, Susan Montgomery, Hannah M. Linden, Julie ...> ;Journal of Nuclear Medicine. 2018 Dec 1
1 citations
Adjuvant continuous metronomic adriamycin + cyclophosphamide followed by weekly nab-paclitaxel for high-risk early-stage breast cancer.
Eunpi Cho, Qian Wu, Lena Rubinstein, Hannah M. Linden, Julie R. Gralow, Jennifer M. Specht, Vijayakrishna K. Gadi, Georgiana K. Ellis> ;The Breast Journal. 2018 Mar 13
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Journal Articles

Test-Retest Reproducibility of FDG-PET/CT Uptake in Cancer Patients Within a Qualified and Calibrated Local Network
Jennifer M Specht, Jean H Lee, Hannah M Linden, Andrew T Shields, David A Mankoff, Paul E Kinahan, Journal of Nuclear Medicine

Grant Support

Role of ctDNA change as a response measure in the EA1183 patient population and how ctDNA changes correlate with metabolic response by serial FDG PET/CTNCI2021–2026