PashtoonMurtazaKasiMD

Cancer Genetics/Cancer Risk Assessment, Gastrointestinal Cancer, Hematologic Oncology

Oncology, Gastrointestinal Malignancies (Colon & Rectal Cancer; Hereditary GI Cancers, BRCA 1/2)

Overview of Dr. Kasi

Assistant Professor Oncology,
Assistant Professor (Interim) College of Medicine, Weill Cornell Medicine
Post-Doctoral Master’s in Basic and Biomedical Sciences.

Office
1305 York Avenue
12th Floor
New York, NY 10021
Book by Phone+1(323) 458-5590
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Clinical Expertise

Immunotherapy, Biological Therapy, Medical oncology, Hematology, Toll-Like Receptor 4, Tumor Cell Line, Combined modality therapy, Adjuvant chemotherapy, Gastrointestinal / Hepatic pathology, Colonic neoplasms, Cholangiocarcinoma, Pancreatic Neoplasms, BRCA2 Genes, BRCA1 Genes, Gastrointestinal oncology, Hematologic oncology, Colon cancer, Liver metastases, Metastatic diseases, Hepatic metastases, Metastatic colon cancer, Colorectal cancer, Hereditary nonpolyposis colorectal cancer, General medical oncology, Pancreatic cancer, Hepatic cancer

Education & Training

Mayo School of Graduate Medical EducationM.S., Basic and Biomedical Sciences , 2015 - 2018
Mayo Clinic College of Medicine and Science (Rochester)Fellowship, Hematology and Medical Oncology, 2013 - 2016
UPMC Medical EducationResidency, Internal Medicine, 2010 - 2013
University of Texas Health Science Center San Antonio Joe and Teresa Lozano Long School of MedicineInternship, Transitional Year, 2009 - 2010
Aga Khan Medical CollegeClass of 2006

Certifications & Licensure

FL State Medical License 2016 - 2026
NY State Medical License 2021 - 2025
MN State Medical License 2013 - 2024
IA State Medical License 2019 - 2023
PA State Medical License 2010 - 2013
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

Teamwork - Above and Beyond Recognition Program Mayo Clinic, 2017
Excellence - Above and Beyond Recognition Program Mayo Clinic, 2017
Tow Tan Humanism in Medicine Mayo Clinic, 2016
Outstanding Hematology-Oncology Fellowship Trainee Mayo Clinic, 2016
Excellence in Patient Care and Professionalism - Nominee Mayo Clinic, 2015-2016
Humanism and Excellence in Teaching Arnold P. Gold Foundation, 2012
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Clinical Trials

R-ICE and Lenalidomide in Treating Patients With First-Relapse/Primary Refractory Diffuse Large B-Cell Lymphoma Start of enrollment: 2016 May 20
Active, not recruiting
Phase 1, Phase 2
EAP 177Lu-DOTA0-Tyr3-Octreotate for Inoperable, SSR+, NETs, Progressive Under SSA Tx
Approved for marketing
FOLFIRI or Modified FOLFIRI and Veliparib as Second Line Therapy in Treating Patients With Metastatic Pancreatic Cancer Start of enrollment: 2016 Sep 01
Active, not recruiting
Phase 2
Veliparib, Pembrolizumab, and Combination Chemotherapy in Treating Patient With Locally Advanced Rectal Cancer Start of enrollment: 2017 Jan 11
Completed
Phase 2
Study of Encorafenib + Cetuximab Plus or Minus Binimetinib vs. Irinotecan/Cetuximab or Infusional 5-Fluorouracil (5-FU)/Folinic Acid (FA)/Irinotecan (FOLFIRI)/Cetuximab With a Safety Lead-in of Encorafenib + Binimetinib + Cetuximab in Patients With BRAF V600E-mutant Metastatic Colorectal Cancer Start of enrollment: 2016 Oct 13
Completed
Phase 3
A Study to Test Combination Treatments in Participants With Advanced Gastric Cancer Start of enrollment: 2016 Nov 29
Completed
Phase 2
DS-8201a in Human Epidermal Growth Factor Receptor2 (HER2)-Expressing Colorectal Cancer (DESTINY-CRC01) Start of enrollment: 2018 Feb 23
Completed
Phase 2
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Publications & Presentations

PubMed

Abscopal downstaging of intermediate stage hepatocellular via combination cryoablation and immunotherapy with complete pathologic response.
Lewis, A. R., Lewis, A. R., Ana P Lucas, Andrew R Lewis, Pashtoon M Kasi, Beau B Toskich, Ricardo Paz-Fumagalli> ;Radiology Case Reports. 2024 Mar 1
3 citations
Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial.
Devoe, C. E., Shubham Pant, Zev A Wainberg, Colin D Weekes, Muhammad Furqan, Pashtoon M Kasi, Craig E Devoe, Alexis D Leal, Vincent Chung, Olca Basturk, Haley VanWyk, ...> ;Nature Medicine. 2024 Feb 1
1 citations
Circulating Tumor DNA Enables Sensitive Detection of Actionable Gene Fusions and Rearrangements Across Cancer Types.
Pashtoon M Kasi, Jessica K Lee, Lincoln W Pasquina, Brennan Decker, Pierre Vanden Borre, Dean C Pavlick, Justin M Allen, Christine Parachoniak, Julia C F Quintanilha, ...> ;Clinical Cancer Research. 2024 Feb 16
False-Positive Liquid Biopsy Assays Secondary to Overlapping Aberrant Methylation from Non-Cancer Disease States.
Lutfi, A., Afghan, M., Swed, B., Kasi, P.> ;Case Reports in Oncology. 2023 Dec 5
Author Correction: Genetic features and therapeutic relevance of emergent circulating tumor DNA alterations in refractory non-colorectal gastrointestinal cancers.
David Hsiehchen, Leslie Bucheit, Dong Yang, Muhammad Shaalan Beg, Mir Lim, Sunyoung S Lee, Pashtoon Murtaza Kasi, Ahmed O Kaseb, Hao Zhu> ;Nature Communications. 2023 Nov 22
1 citations
Anti-EGFR Antibodies in the Management of Advanced Colorectal Cancer.
Pashtoon Murtaza Kasi, Manuel Geroy Afable, Cameron Herting, Mariusz Lukanowski, Zhaohui Jin> ;The Oncologist. 2023 Dec 11
3 citations
Neoadjuvant botensilimab plus balstilimab response pattern in locally advanced mismatch repair proficient colorectal cancer.
Pashtoon Murtaza Kasi, Manuel Hidalgo, Mehraneh D Jafari, Heather Yeo, Lea Lowenfeld, Uqba Khan, Alana T H Nguyen, Despina Siolas, Brandon Swed, Jini Hyun, Sahrish Kha...> ;Oncogene. 2023 Oct 1
Pan-Cancer Prevalence of Microsatellite Instability-High (MSI-H) Identified by Circulating Tumor DNA and Associated Real-World Clinical Outcomes.
Pashtoon Murtaza Kasi, Leslie A Bucheit, Jiemin Liao, Jason Starr, Pedro Barata, Samuel J Klempner, David Gandara, Ardaman Shergill, Luciana Madeira da Silva, Caroline...> ;JCO Precision Oncology. 2023 Sep 1
Evaluation of Intratumoral Response Heterogeneity in Metastatic Colorectal Cancer and Its Impact on Patient Overall Survival: Findings from 10,551 Patients in the ARCA...
Fang-Shu Ou, Daniel H Ahn, Jesse G Dixon, Axel Grothey, Yiyue Lou, Pashtoon M Kasi, Joleen M Hubbard, Eric Van Cutsem, Leonard B Saltz, Hans-Joachim Schmoll, Richard M...> ;Cancers. 2023 Aug 15
Circulating Tumor DNA Response and Minimal Residual Disease Assessment in DNA Polymerase Epsilon-Mutated Colorectal Cancer Undergoing Immunotherapy.
Areeb Lutfi, Maaz K Afghan, Pashtoon M Kasi> ;Cureus. 2023 Aug 1
25 citations
Tucatinib plus trastuzumab for chemotherapy-refractory, HER2-positive, RAS wild-type unresectable or metastatic colorectal cancer (MOUNTAINEER): a multicentre, open-la...
John H Strickler, Andrea Cercek, Salvatore Siena, Thierry André, Kimmie Ng, Eric Van Cutsem, Christina Wu, Andrew S Paulson, Joleen M Hubbard, Andrew L Coveler, Christ...> ;The Lancet. Oncology. 2023 May 1
Types of Liquid Biopsies: Understanding the Different Lenses Through Which They Can Detect Cancer.
Pashtoon Murtaza Kasi> ;The Oncologist. 2023 Apr 6
7 citations
Testing: Time to Put Patient Safety First.
Sharyn D Baker, Susan E Bates, Gabriel A Brooks, William L Dahut, Robert B Diasio, Wafik S El-Deiry, William E Evans, William D Figg, Dan L Hertz, J Kevin Hicks, Sunee...> ;Journal of Clinical Oncology. 2023 May 20
Circulating tumour cell enumeration, biomarker analyses, and kinetics in patients with colorectal cancer and other GI malignancies.
Walla Malkawi, Areeb Lutfi, Maaz Khan Afghan, Lamisha Mashiyat Shah, Lillian Costandy, Arturo B Ramirez, Thaddeus C George, Fatima Toor, Aliasger K Salem, Pashtoon Mur...> ;Frontiers in Oncology. 2023 Jan 1
Editorial: Case reports in gastrointestinal cancers : 2022.
Kasi, P.> ;Frontiers in Oncology. 2023 Jan 1
3 citations
Using Tumor-Informed Circulating Tumor DNA (ctDNA)-Based Testing for Patients with Anal Squamous Cell Carcinoma.
Georges Azzi, Mehrad Tavallai, Vasily N Aushev, Allyson Koyen Malashevich, Gregory P Botta, Mohamedtaki A Tejani, Diana Hanna, Shifra Krinshpun, Meenakshi Malhotra, Ad...> ;The Oncologist. 2023 Mar 17
Genetic features and therapeutic relevance of emergent circulating tumor DNA alterations in refractory non-colorectal gastrointestinal cancers.
David Hsiehchen, Leslie Bucheit, Dong Yang, Muhammad Shaalan Beg, Mir Lim, Sunyoung S Lee, Pashtoon Murtaza Kasi, Ahmed O Kaseb, Hao Zhu> ;Nature Communications. 2022 Dec 3
16 citations
Analysis of Circulating Tumor DNA to Predict Risk of Recurrence in Patients With Esophageal and Gastric Cancers.
Brandon M Huffman, Vasily N Aushev, Griffin L Budde, Joseph Chao, Farshid Dayyani, Diana Hanna, Gregory P Botta, Daniel V T Catenacci, Steven B Maron, Shifra Krinshpun...> ;JCO Precision Oncology. 2022 Dec 1
7 citations
Peptide Receptor Radionuclide Therapy in Merkel Cell Carcinoma: A Comprehensive Review.
Emran Askari, Soroush Zarehparvar Moghadam, Damian Wild, Ebrahim Delpassand, Sergio Baldari, Bernhard Nilica, Philipp E Hartrampf, Grace Kong, Chiara Maria Grana, Mart...> ;Journal of Nuclear Medicine Technology. 2023 Mar 1
1 citations
Liquid biopsies and tumor mutational burden: the cutoff conundrum.
Pashtoon Murtaza Kasi> ;Nature Medicine. 2022 Sep 1
Reply to F. Dayyani et al.
Pashtoon M Kasi, Gordon Fehringer, Alexey Aleshin, Scott Kopetz> ;JCO Precision Oncology. 2022 Jul 1
13 citations
Detection of microsatellite instability-high (MSI-H) by liquid biopsy predicts robust and durable response to immunotherapy in patients with pancreatic cancer.
Sakti Chakrabarti, Leslie Bucheit, Jason Scott Starr, Racquel Innis-Shelton, Ardaman Shergill, Hiba Dada, Regina Resta, Stephanie Wagner, Naomi Fei, Pashtoon Murtaza Kasi> ;Journal for Immunotherapy of Cancer. 2022 Jun 1
Call for Adoption of Synchronized Biweekly Dosing of Anti-EGFR Agent Cetuximab: Implications for Patients with Metastatic Colorectal Cancer, and Squamous Cell Carcinom...
Pashtoon Murtaza Kasi> ;The Oncologist. 2022 May 6
15 citations
Circulating tumor DNA (ctDNA) serial analysis during progression on PD-1 blockade and later CTLA-4 rescue in patients with mismatch repair deficient metastatic colorec...
Pashtoon Murtaza Kasi, Griffin Budde, Michael Krainock, Vasily N Aushev, Allyson Koyen Malashevich, Meenakshi Malhotra, Perry Olshan, Paul R Billings, Alexey Aleshin> ;Journal for Immunotherapy of Cancer. 2022 Jan 1
5 citations
Tumor-Informed Versus Plasma-Only Liquid Biopsy Assay in a Patient With Multiple Primary Malignancies.
Pashtoon Murtaza Kasi> ;JCO Precision Oncology. 2022 Jan 1
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Journal Articles

Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer
Pashtoon M Kasi, Robert R McWilliams, JAMA

Lectures

A phase II trial of pharmacological ascorbate, gemcitabine, and nabpaclitaxel for metastatic pancreatic cancer.
ASCO Gastrointestinal Cancers Symposium - San Francisco, CA - 1/24/2020
and microsatellite instability prediction through CA-19-9/CEA ratio in patients with colorectal cancer.
ASCO Annual Meeting 2019 - Chicago, IL - 5/31/2019
Circulating tumor DNA dynamics, serial testing and evolution on treatment in 322 colorectal cancer patients.
ASCO Annual Meeting 2019 - Chicago, IL - 6/3/2019
Incidence of pathogenic variants in individuals with a personal or family history of pancreatic cancer.
2018 ASCO Annual Meeting - Chicago, Illinois - 06/2/2018
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Press Mentions

Active Surveillance or Maintenance After Chemo Induction in Metastatic CRC?March 8th, 2022
Detecting Cancer with a Simple Blood Draw Could Soon Be a RealityNovember 24th, 2021
Is the Pandemic-Era Telehealth Boom Coming to an End?September 8th, 2021
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Grant Support

Colon Cancer - Career Development AwardNorma Lee and Morton Funger Clinician Career 2017 Development Fund Award in Colon Cancer Research ($150,000) for establishment and molecular characterization of a patient-derived colorectal cancer tissue2017–2020
BRCA-Related Pancreatic Cancer: Outcomes and PD-L1 expressionMayo Clinic Cancer Center2017–2019