KennethRHallowsMDPhD, FASN

PubMed

• Activation of AMP-activated protein kinase during sepsis/inflammation improves survival by preserving cellular metabolic fitness.
  Jin, K., Ma, Y., Manrique-Caballero, C. L., Li, H., Emlet, D. R., Li, S., Baty, C. J., Wen, X., Kim-Campbell, N., Frank, A., Menchikova, E. V., Pastor-Soler, N. M., Ha...> ;FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 Apr 5
• AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.
  Jia, J., Bissa, B., Brecht, L., Allers, L., Choi, S. W., Gu, Y., Zbinden, M., Burge, M. R., Timmins, G., Hallows, K., Behrends, C., Deretic, V.> ;Molecular cell. 2020 Jan 30
• Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.
  Cárdenas C, Miller RA, Smith I, Bui T, Molgó J, Müller M, Vais H, Cheung KH, Yang J, Parker I, Thompson CB, Birnbaum MJ, Hallows KR, Foskett JK> ;Cell.
• AMPK phosphorylation of the β₁Pix exchange factor regulates the assembly and function of an ENaC inhibitory complex in kidney epithelial cells.
  Ho, P., Li, H., Cheng, L., Bhalla, V., Fenton, R. A., Hallows, K. R.> ;American journal of physiology. Renal physiology. 2019 Oct 1
• Ex vivo kidney slice preparations as a model system to study signaling cascades in kidney epithelial cells.
  Saitta, B., Jalili, M. F., Zohoorkari, H., Rao, R., Hallows, K. R., Baty, C. J., Pastor-Soler, N. M.> ;Methods in cell biology. 2019 Aug 10
• MIF Matters: The Macrophage Migration Inhibitory Factor and Kidney Injury.
  Unruh, M., Wagner, B., Hallows, K. R.> ;American journal of kidney diseases : the official journal of the National Kidney Foundation. 2018 Sep 23
• β
  Ho, P. Y., Ho, P. Y., Ho, P. Y., Ho, P. Y., Ho, P. Y., Li, H., Li, H., Li, H., Li, H., Li, H., Pavlov, T. S., Pavlov, T. S., Pavlov, T. S., Pavlov, T. S., Pavlov, T. S...> ;The Journal of biological chemistry. 2018 Jun 3
• "First do no harm": kidney drug targeting to avoid toxicity in ADPKD.
  Chung, E. J., Hallows, K. R.> ;American journal of physiology. Renal physiology. 2018 May 31
• A Randomized Clinical Trial of Metformin to Treat Autosomal Dominant Polycystic Kidney Disease.
  Seliger SL, Abebe KZ, Hallows KR, Miskulin DC, Perrone RD, Watnick T, Bae KT> ;American journal of nephrology. 2018-05-18
• 1 citation
  Role of AMP-activated protein kinase in kidney tubular transport, metabolism, and disease.
  Rajani, R., Pastor-Soler, N. M., Hallows, K. R.> ;Current opinion in nephrology and hypertension. 2017 Jun 15
• 1 citation
  Lack of Effects of Metformin and AICAR Chronic Infusion on the Development of Hypertension in Dahl Salt-Sensitive Rats.
  Pavlov, T. S., Levchenko, V., Ilatovskaya, D. V., Li, H., Palygin, O., Pastor-Soler, N. M., Hallows, K. R., Staruschenko, A.> ;Frontiers in physiology. 2017 May 6
• 6 citations
  Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 &2 and AMP-activated Protein Kinase in the Kidney.
  Christensen, M., Jensen, J. B., Jakobsen, S., Jessen, N., Frøkiær, J., Kemp, B. E., Marciszyn, A. L., Li, H., Pastor-Soler, N. M., Hallows, K. R., Nørregaard, R.> ;Scientific reports. 2016 Oct 27
• Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells.
  Al-Bataineh MM, Li H, Ohmi K, Gong F, Marciszyn AL, Naveed S, Zhu X, Neumann D, Wu Q, Cheng L, Fenton RA, Pastor-Soler NM, Hallows KR> ;American journal of physiology. Renal physiology. 2016-08-17
• 1 citation
  Aurora kinase A activates the vacuolar H+-ATPase (V-ATPase) in kidney carcinoma cells.
  Al-Bataineh, M. M., Alzamora, R., Ohmi, K., Ho, P., Marciszyn, A. L., Gong, F., Li, H., Hallows, K. R., Pastor-Soler, N. M.> ;American journal of physiology. Renal physiology. 2016 Feb 26
• Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action.
  Roy A, Al-Qusairi L, Donnelly BF, Ronzaud C, Marciszyn AL, Gong F, Chang YP, Butterworth MB, Pastor-Soler NM, Hallows KR, Staub O, Subramanya AR> ;The Journal of clinical investigation. 2015-08-04
• Epithelial morphological reversion drives Profilin-1-induced elevation of p27(kip1) in mesenchymal triple-negative human breast cancer cells through AMP-activated prot...
  Jiang, C., Veon, W., Li, H., Hallows, K. R., Roy, P.> ;Cell cycle (Georgetown, Tex.). 2015 Jul 16
• 3 citations
  Interactions between HIF-1α and AMPK in the regulation of cellular hypoxia adaptation in chronic kidney disease.
  Li, H., Satriano, J., Thomas, J. L., Miyamoto, S., Sharma, K., Pastor-Soler, N. M., Hallows, K. R., Singh, P.> ;American journal of physiology. Renal physiology. 2015 Jul 3
• Muc1 is protective during kidney ischemia-reperfusion injury.
  Pastor-Soler NM, Sutton TA, Mang HE, Kinlough CL, Gendler SJ, Madsen CS, Bastacky SI, Ho J, Al-Bataineh MM, Hallows KR, Singh S, Monga SP, Kobayashi H, Haase VH, Hughe...> ;American journal of physiology. Renal physiology. 2015-04-29
• 6 citations
  Septic acute kidney injury: molecular mechanisms and the importance of stratification and targeting therapy.
  Morrell, E. D., Kellum, J. A., Pastor-Soler, N. M., Hallows, K. R.> ;Critical care (London, England). 2015 Jan 13
• 6 citations
  Akt recruits Dab2 to albumin endocytosis in the proximal tubule.
  Koral, K., Li, H., Ganesh, N., Birnbaum, M. J., Hallows, K. R., Erkan, E.> ;American journal of physiology. Renal physiology. 2014 Sep 26
• 2 citations
  A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation.
  Prakasam, H. S., Gallo, L. I., Li, H., Ruiz, W. G., Hallows, K. R., Apodaca, G.> ;Molecular biology of the cell. 2014 Sep 19
• 8 citations
  Epithelial transport during septic acute kidney injury.
  Morrell, E. D., Kellum, J. A., Hallows, K. R., Pastor-Soler, N. M.> ;Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2014 Jan 1
• Resveratrol inhibits the epithelial sodium channel via phopshoinositides and AMP-activated protein kinase in kidney collecting duct cells.
  Weixel KM, Marciszyn A, Alzamora R, Li H, Fischer O, Edinger RS, Hallows KR, Johnson JP> ;PloS one. 2013-10-24
• Hemodialysis for the treatment of severe accidental hypothermia.
  Singh T, Hallows KR> ;Seminars in dialysis. 2013-10-09
• 1 citation
  Opening lines of communication in the distal nephron.
  Kleyman, T. R., Satlin, L. M., Hallows, K. R.> ;The Journal of clinical investigation. 2013 Sep 21
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Journal Articles

• Design and in vivo characterization of kidney-targeting peptide amphiphile micelles toward renal drug delivery  
  Wang, J., Poon, C., Chin, D., Milkowski, S., Lu, V., Hallows, K.R., and Chung, E.J., Nano Res. 11(10): 5584-5595, 2018.
• Muc1 is protective during kidney ischemia-reperfusion injury  
  Pastor-Soler, N.M., Sutton, T.A., Mang, H.E., Kinlough, C.L., Gendler, S.J., Madsen, C.S., Bastacky, S., Ho, J., Al-bataineh, M.M., Hallows, K.R., Singh, S., Monga, S...., Am. J. Physiol. Renal Physiol.

Lectures

• Metabolic Reprogramming in Polycystic Kidney Disease 
  American Society of Nephrology Kidney Week 2019 - Washington, D.C. - 11/9/2019