MarcStephenLevinMDAGAF

Gastroenterology • Saint Louis, MO

Professor, Internal Medicine, Washington University School of Medicine

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Office
Washington University in St. Louis, School of Medicine
660 South Euclid Ave Campus Box 8124
Saint Louis, MO 63110
Phone+1 314-362-8933

Fax+1 314-362-8959
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Education & Training

Washington University/B-JH/SLCH ConsortiumFellowship, Gastroenterology, 1984 - 1988
Washington University/B-JH/SLCH ConsortiumResidency, Internal Medicine, 1981 - 1984
Columbia University Vagelos College of Physicians and SurgeonsClass of 1981
Massachusetts Institute of TechnologyBS, Molecular Biology, 1977
Massachusetts Institute of TechnologyBS

Certifications & Licensure

MO State Medical License 1985 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Gastroenterology

Awards, Honors, & Recognition

Future Leader Award International Life Sciences Institute, 1990
Alpha Omega Alpha AOA, 1980
Fellow (AGAF) American Gastroenterological Association, 2008

Publications & Presentations

PubMed

12 citations
Fecal Microbiome and Bile Acid Metabolome in Adult Short Bowel Syndrome
Harold J. Boutte, Jacqueline Chen, Todd Wylie, Kristine M. Wylie, Yan Xie, Mackenzie Geisman, Anirudh Prabu, Vered Gazit, Phillip I. Tarr, Marc S. Levin, Brad W. Warne...> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2021 Nov 24
3 citations
Stem cell and niche regulation in human short bowel syndrome
Vered Gazit, Elzbieta A. Swietlicki, Miranda U. Liang, Adam Surti, Raechel McDaniel, Mackenzie Geisman, David M. Alvarado, Matthew A. Ciorba, Grant V. Bochicchio, Obei...> ;JCI Insight. 2020 Dec 3
4 citations
Increased Adiposity and Reduced Lean Body Mass in Patients with Short Bowel Syndrome
Adeeti J. Chiplunker, Ling Chen, Marc S. Levin, Brad W. Warner, Nicholas O. Davidson, Deborah C. Rubin> ;Digestive Diseases and Sciences. 2020 Jan 7
6 citations
Epimorphin regulates the intestinal stem cell niche via effects on the stromal microenvironment.
Courtney Vishy, Elzbieta A. Swietlicki, Vered Gazit, Suneetha Amara, Gabriela Heslop, Jianyun Lu, Marc S. Levin, Deborah C. Rubin> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2018 Apr 6
6 citations
Increased IFRD1 Expression in Human Colon Cancers Predicts Reduced Patient Survival.
Mark A. Lewis, Noura Sharabash, Zhi Feng Miao, Lydia N. Lyons, Jay F. Piccirillo, Donna Kallogjeri, Mario Schootman, Matthew G. Mutch, Yan Yan, Marc S. Levin, Antoni C...> ;Digestive Diseases and Sciences. 2017 Nov 1
71 citations
Mechanisms of intestinal adaptation.
Deborah C. Rubin, Marc S. Levin> ;Best Practice & Research. Clinical Gastroenterology. 2016 Apr 1
1 citations
Proline Absorption and SGK1 Expression are Inhibited in Intestinal Tis7 Transgenic Mice.
Jianyun Lu, Amy M. Garcia, Taylor Geisman, Derek Wakeman, Brad W. Warner, Elzbieta A. Swietlicki, Marc S. Levin, Deborah C. Rubin> ;Cellular Physiology and Biochemistry. 2016 Jan 1
7 citations
Tis7 deletion reduces survival and induces intestinal anastomotic inflammation and obstruction in high-fat diet-fed mice with short bowel syndrome
Amy M. Garcia, Derek Wakeman, Jianyun Lu, Christopher W. Rowley, Taylor Geisman, Catherine Butler, Shashi Bala, Elzbieta A. Swietlicki, Brad W. Warner, Marc S. Levin, ...> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2014 Sep 15
6 citations
Epimorphin(-/-) mice are protected, in part, from acute colitis via decreased interleukin 6 signaling.
Anisa Shaker, Matthew Gargus, Julie Fink, Jana Binkley, Isra Darwech, Elzbieta A. Swietlicki, Marc S. Levin, Deborah C. Rubin> ;Translational Research. 2014 Jul 1
5 citations
Epimorphin deletion inhibits polyposis in the Apcmin/+ mouse model of colon carcinogenesis via decreased myofibroblast HGF secretion.
Elzbieta A. Swietlicki, Shashi Bala, Jianyun Lu, Anisa Shaker, Gowri Kularatna, Marc S. Levin, Deborah C. Rubin> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2013 Oct 15
262 citations
Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer
Deborah C. Rubin, Anisa Shaker, Marc S. Levin> ;Frontiers in Immunology. 2012 May 8
55 citations
Epithelial Expression of the Cytosolic Retinoid Chaperone Cellular Retinol Binding Protein II Is Essential for in Vivo Imprinting of Local Gut Dendritic Cells by Lumen...
Keely G. McDonald, Matthew R. Leach, Kaitlin W.M. Brooke, Caihong Wang, Leroy W. Wheeler, Elyse K. Hanly, Christopher W. Rowley, Marc S. Levin, Michael Wagner, Ellen L...> ;The American Journal of Pathology. 2012 Mar 1
14 citations
Deletion of Tis7 Protects Mice from High-Fat Diet-Induced Weight Gain and Blunts the Intestinal Adaptive Response Postresection
Cong Yu, Shujun Jiang, Jianyun Lu, Carrie C. Coughlin, Yuan Wang, Elzbieta A. Swietlicki, Lihua Wang, Ilja Vietor, Lukas A. Huber, Domagoj Cikes, Trey Coleman, Yan Xie...> ;The Journal of Nutrition. 2010 Nov 1
45 citations
Epimorphin deletion protects mice from inflammation-induced colon carcinogenesis and alters stem cell niche myofibroblast secretion
Anisa Shaker, Elzbieta A. Swietlicki, Lihua Wang, Shujun Jiang, Birce Onal, Shashi Bala, Katherine Deschryver, Rodney D. Newberry, Marc S. Levin, Deborah C. Rubin> ;The Journal of Clinical Investigation. 2010 Jun 1
6 citations
Intestinal redox status of major intracellular thiols in a rat model of chronic alcohol consumption.
Junqiang Tian, Lou Ann S. Brown, Dean P. Jones, Marc S. Levin, Lihua Wang, Deborah C. Rubin, Thomas R. Ziegler> ;JPEN. Journal of Parenteral and Enteral Nutrition. 2009 Nov 1
18 citations
Chronically administered retinoic acid has trophic effects in the rat small intestine and promotes adaptation in a resection model of short bowel syndrome
Lihua Wang, Yuzhu Tang, Deborah C. Rubin, Marc S. Levin> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2007 Feb 15
10 citations
Stimulation of colonic mucosal growth associated with oxidized redox status in rats
Junqiang Tian, Naohiro Washizawa, Li H. Gu, Marc S. Levin, Lihua Wang, Deborah C. Rubin, Simon M. Mwangi, Shanthi Srinivasan, Yuhao Gao, Dean P. Jones, Thomas R. Ziegler> ;American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 2007 Mar 1
11 citations
Local Glutathione Redox Status Does Not Regulate Ileal Mucosal Growth after Massive Small Bowel Resection in Rats
Junqiang Tian, Naohiro Washizawa, Li H. Gu, Marc S. Levin, Lihua Wang, Deborah C. Rubin, Simon M. Mwangi, Shanthi Srinivasan, Dean P. Jones, Thomas R. Ziegler> ;The Journal of Nutrition. 2007 Feb 1
25 citations
Increased apoptosis and accelerated epithelial migration following inhibition of hedgehog signaling in adaptive small bowel postresection.
Yuzhu Tang, Elzbieta A. Swietlicki, Shujun Jiang, Kim K. Buhman, Nicholas O. Davidson, Linda C. Burkly, Marc S. Levin, Deborah C. Rubin> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2006 Jun 1
48 citations
Epimorphin–/– mice have increased intestinal growth, decreased susceptibility to dextran sodium sulfate colitis, and impaired spermatogenesis
Yuan Wang, Lihua Wang, Hristo Iordanov, Elzbieta A. Swietlicki, Qun Zheng, Shujun Jiang, Yuzhu Tang, Marc S. Levin, Deborah C. Rubin> ;The Journal of Clinical Investigation. 2006 Jun 1
22 citations
Targeted intestinal overexpression of the immediate early gene tis7 in transgenic mice increases triglyceride absorption and adiposity.
Yuan Wang, Hristo Iordanov, Elzbieta A. Swietlicki, Lihua Wang, Christine Fritsch, Trey Coleman, Clay F. Semenkovich, Marc S. Levin, Deborah C. Rubin> ;The Journal of Biological Chemistry. 2005 Oct 14
8 citations
Suppression of FGF signaling: a putative mechanism for the chemopreventive effects of acyclic retinoid in hepatocellular carcinoma.
Lihua Wang, Marc S. Levin> ;Gastroenterology. 2005 Jan 1
25 citations
Inhibition of Hedgehog Signaling Protects Adult Mice from Diet-Induced Weight Gain
Kimberly K. Buhman, Li Chun Wang, Yuzhu Tang, Elzbieta A. Swietlicki, Susan Kennedy, Yan Xie, Zhong-Yi Liu, Linda C. Burkly, Marc S. Levin, Deborah C. Rubin, Nicholas ...> ;The Journal of Nutrition. 2004 Nov 1
52 citations
Bax is required for resection-induced changes in apoptosis, proliferation, and members of the extrinsic cell death pathways ☆
Yuzhu Tang, Deborah A. Swartz-Basile, Elzbieta A. Swietlicki, Lu Yi, Deborah C. Rubin, Marc S. Levin> ;Gastroenterology. 2004 Jan 1
56 citations
Vitamin A deficiency inhibits intestinal adaptation by modulating apoptosis, proliferation, and enterocyte migration
Deborah A. Swartz-Basile, Lihua Wang, Yuzhu Tang, Henry A. Pitt, Deborah C. Rubin, Marc S. Levin> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2003 Aug 1
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Grant Support

Bile acid metabolomics and metagenomics in short bowel syndromeNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)2016–2019
Myofibroblast Regulation of the Stem Cell Niche in Short Bowel SyndromeNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)2015–2019
Nutrient Modulation Of Gene Expression In Gut AdaptationNational Institute Of Diabetes And Digestive And Kidney Diseases1995–2011
Molecular And Cellular Analysis Of Intestinal AdaptationNational Institute Of Diabetes And Digestive And Kidney Diseases1995
Gut Nutrient Metabolism--Molecular Cellular ApproachesNational Institute Of Diabetes And Digestive And Kidney Diseases1992–1994
Gut Nutrient METABOLISM: Molecular Cellular ApproachesNational Institute Of Diabetes And Digestive And Kidney Diseases1990–1993