Dr. Lesem is on Doximity
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Office
4306 Yoakum Blvd, Suite 330
Suite 330
Houston, TX 77006Phone+1 832-538-1479Fax+1 832-487-9566- Is this information wrong?
Summary
- I graduated from UT Medical School in 1981. I was recognized as Outstanding Student in Psychiatry in my class. I then did one year of Internal Medicine (Internship) at UT Southwestern affliated program. I returned to UT Houston Medical School to complete my 3 years training in psychiatry. Very neuroscience oriented program under Chairman Louis Faillace, MD. My last year I was Chief Resident and acted as junior faculty assisting Ken Reed MD, PhD in re-organizing the Consultation service to our main teaching hospital-Memorial Hermann. I received perhaps the best training possible in psychiatry through the UTMSH residency program under Dr. Faillace. I then was accepted for a 2 year Research Fellowship at NIMH in Bethesda under Dennis Murphy, MD and others such as Bill Potter, MD, PhD in the Laboratory of Clinical Sciences. 1 year on research ward implementing protocols in eating disorder patients, completed a protocol in age/sex/nml weight matched normals who underwent pre and post LP's following 5% weight loss over 6 weeks. Year 2 I help develop assay to measure CSF Dynorphin A1-8 under guidance of Wade Berretini MD, PHD. I returned to UT Houston as Asst. Prof. and ran acute research units at HCPC for 3 yrs. I entered private practice in late 1989 and began mainly as hospitalist. Jim Claghorn, MD asked me to work at his private research clinic, CRA, and I transitioned to full ownership in 1994. Renamed CRA-to CLRC, Ltd. Focus became inpatient early drug developement. We developed our own 24 bed free-standing research unit and 8000 sq. ft. outpt. research center owned by the clinic. We have been one of just 2 sites in first Qtc studies in 2nd generation antipsychotics. We also have a strong reputation in developing medications for psychotic agitation. Recently we have developed infusion capabilities with dedicated space and equipment. We have experience with P-50/MMN. Our staff prides itself on implementing cutting edge protocols. Current website being updated.
Education & Training
- National Institute of Mental HealthFellowship, Research, 1985 - 1987
- University of Texas Health Science Center at HoustonChief Residency, Psychiatry, 1984 - 1985
- University of Texas Health Science Center at HoustonResidency, Psychiatry, 1982 - 1985
- St Paul's HospitalMedicine, 1981 - 1982
- McGovern Medical School at UTHealthClass of 1981
- University of TexasB.A, History, Cum Laude, 1976
Certifications & Licensure
- TX State Medical License 1981 - 2024
- WA State Medical License 2016 - 2018
- MD State Medical License 1985 - 1988
- American Board of Psychiatry and Neurology Psychiatry
Awards, Honors, & Recognition
- Dean's Teaching Excellence List University of Texas Medical School, Houston, TX, 1987, 1988, 1989, 1990
- Inpatient Teaching Award Psychiatry Residents, University of Texas Medical School, Houston, TX, 1989-1990, 1990
- Resident's Service Award University of Texas Medical School, Houston, TX, 1988, 1989
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Clinical Trials
- Treatment-Resistant Depression Registry Start of enrollment: 2006 Jan 01
- Single IV Dose of GLYX-13 in Patients With Treatment-Resistant Depression Start of enrollment: 2011 May 01
- Efficacy and Safety of Extended-release Guanfacine Hydrochloride in Children and Adolescents Aged 6-17 Years With Attention-Deficit/Hyperactivity Disorder (ADHD) Start of enrollment: 2011 Jan 17
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Publications & Presentations
PubMed
- 108 citationsVagus Nerve Stimulation Therapy Randomized to Different Amounts of Electrical Charge for Treatment-Resistant Depression: Acute and Chronic EffectsScott Aaronson, Linda L. Carpenter, Charles R. Conway, Frederick W. Reimherr, Sarah H. Lisanby, Thomas L. Schwartz, Francisco A. Moreno, David L. Dunner, Michael D. Le...> ;Brain Stimulation. 2013 Jul 1
- 69 citationsEfficacy and Safety of Loxapine for Inhalation in the Treatment of Agitation in Patients With Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled TrialMichael H. Allen, David Feifel, Michael D. Lesem, Daniel L. Zimbroff, Ruth Ross, Patrik Munzar, Daniel A. Spyker, James V. Cassella> ;The Journal of Clinical Psychiatry. 2011 Jan 25
- 88 citationsRapid acute treatment of agitation in individuals with schizophrenia: multicentre, randomised, placebo-controlled study of inhaled loxapine.Michael D. Lesem, Tram K. Tran-Johnson, Robert A. Riesenberg, David Feifel, Michael H. Allen, Robert S. Fishman, Daniel A. Spyker, John H. Kehne, James V. Cassella> ;The British Journal of Psychiatry. 2011 Jan 1
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Journal Articles
- Repercussions of Redefining a Consultation-Liaison Service in a General Teaching Hospital.Reed, K., Lesem, M. D., and O'Malley, M, Letter of Hospital and Community Psychiatry, 38:673-674
- Enhanced Thermic Effect of Food after Exercising During Refeeding of Anorexic Patients.Obarzanek, E. O., Lesem, M. D., and Jimerson, D. C, Proceedings of the Annual Meeting of FASEB: 2:A1224
- Gender Differences and the Interpretation of Genetic Instability in Alzheimer's Disease.Cherry, L. M., Funk, J., Lesser, J. M., Lesem, M. D, Mutation Research. 275, 57-67
Books/Book Chapters
Abstracts/Posters
- Neuroendocrine studies with 5 HT agents in bulimia.Brewerton TD, Mueller EA, Brandt HA, Lesem MD, Jimerson DC, Murphy DL, Am Psychiatric Association Annual Meeting Proceedings; 140:85-86 #38E
- Serotonin function in anorexia nervosa; longitudinal perspectives.Jimerson, D.C., Brewerton, T. D., Hegg, A. P., Lesem, M. D., Murphy, D. L, Proceeds AM Coll. Neuropsychopharmacology: 26.74
- Evidence for serotonin dysregulation in anorexia.Brewerton, T. D., Mueller, E. A., Brandt, H. A., Lesem, M. D., Murphy, D. L., Jimerson, D. C, Proceeds Am. Psychiatric Assoc: 140:NR195
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Lectures
- A Case of Schizoaffective Disorder in an Elderly Patient.Department of Psychiatry, Grand Rounds, University of Texas Medical School-Houston
- Alcoholism and Affective Disorders - Two Case Presentations.Department of Psychiatry, Grand Rounds, University of Texas Medical School-Houston
- State-Related Changes in Plasma NE in Anorexia Nervosa.LCS Section, NIMH Seminar
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