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Michael Lesem, MD, Psychiatry, Houston, TX

MichaelDavidLesemMD

Psychiatry Houston, TX

Forensic Psychiatry, Geriatric Psychiatry, Neuropsychiatry, Psychopharmacology

Executive Medical Director CLRC, Ltd.

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Summary

  • I graduated from UT Medical School in 1981. I was recognized as Outstanding Student in Psychiatry in my class. I then did one year of Internal Medicine (Internship) at UT Southwestern affliated program. I returned to UT Houston Medical School to complete my 3 years training in psychiatry. Very neuroscience oriented program under Chairman Louis Faillace, MD. My last year I was Chief Resident and acted as junior faculty assisting Ken Reed MD, PhD in re-organizing the Consultation service to our main teaching hospital-Memorial Hermann. I received perhaps the best training possible in psychiatry through the UTMSH residency program under Dr. Faillace. I then was accepted for a 2 year Research Fellowship at NIMH in Bethesda under Dennis Murphy, MD and others such as Bill Potter, MD, PhD in the Laboratory of Clinical Sciences. 1 year on research ward implementing protocols in eating disorder patients, completed a protocol in age/sex/nml weight matched normals who underwent pre and post LP's following 5% weight loss over 6 weeks. Year 2 I help develop assay to measure CSF Dynorphin A1-8 under guidance of Wade Berretini MD, PHD. I returned to UT Houston as Asst. Prof. and ran acute research units at HCPC for 3 yrs. I entered private practice in late 1989 and began mainly as hospitalist. Jim Claghorn, MD asked me to work at his private research clinic, CRA, and I transitioned to full ownership in 1994. Renamed CRA-to CLRC, Ltd. Focus became inpatient early drug developement. We developed our own 24 bed free-standing research unit and 8000 sq. ft. outpt. research center owned by the clinic. We have been one of just 2 sites in first Qtc studies in 2nd generation antipsychotics. We also have a strong reputation in developing medications for psychotic agitation. Recently we have developed infusion capabilities with dedicated space and equipment. We have experience with P-50/MMN. Our staff prides itself on implementing cutting edge protocols. Current website being updated.

Education & Training

  • National Institute of Mental Health
    National Institute of Mental HealthFellowship, Research, 1985 - 1987
  • University of Texas Health Science Center at Houston
    University of Texas Health Science Center at HoustonChief Residency, Psychiatry, 1984 - 1985
  • University of Texas Health Science Center at Houston
    University of Texas Health Science Center at HoustonResidency, Psychiatry, 1982 - 1985
  • St Paul's Hospital
    St Paul's HospitalMedicine, 1981 - 1982
  • McGovern Medical School at UTHealth
    McGovern Medical School at UTHealthClass of 1981
  • University of Texas
    University of TexasB.A, History, Cum Laude, 1976

Certifications & Licensure

  • TX State Medical License
    TX State Medical License 1981 - 2024
  • WA State Medical License
    WA State Medical License 2016 - 2018
  • MD State Medical License
    MD State Medical License 1985 - 1988
  • American Board of Psychiatry and Neurology Psychiatry

Awards, Honors, & Recognition

  • Dean's Teaching Excellence List University of Texas Medical School, Houston, TX, 1987, 1988, 1989, 1990
  • Inpatient Teaching Award Psychiatry Residents, University of Texas Medical School, Houston, TX, 1989-1990, 1990
  • Resident's Service Award University of Texas Medical School, Houston, TX, 1988, 1989
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Clinical Trials

Publications & Presentations

PubMed

Journal Articles

  • Repercussions of Redefining a Consultation-Liaison Service in a General Teaching Hospital.  
    Reed, K., Lesem, M. D., and O'Malley, M, Letter of Hospital and Community Psychiatry, 38:673-674
  • Enhanced Thermic Effect of Food after Exercising During Refeeding of Anorexic Patients.  
    Obarzanek, E. O., Lesem, M. D., and Jimerson, D. C, Proceedings of the Annual Meeting of FASEB: 2:A1224
  • Gender Differences and the Interpretation of Genetic Instability in Alzheimer's Disease.  
    Cherry, L. M., Funk, J., Lesser, J. M., Lesem, M. D, Mutation Research. 275, 57-67

Books/Book Chapters

Abstracts/Posters

  • Neuroendocrine studies with 5 HT agents in bulimia.
    Brewerton TD, Mueller EA, Brandt HA, Lesem MD, Jimerson DC, Murphy DL, Am Psychiatric Association Annual Meeting Proceedings; 140:85-86 #38E
  • Serotonin function in anorexia nervosa; longitudinal perspectives.
    Jimerson, D.C., Brewerton, T. D., Hegg, A. P., Lesem, M. D., Murphy, D. L, Proceeds AM Coll. Neuropsychopharmacology: 26.74
  • Evidence for serotonin dysregulation in anorexia.
    Brewerton, T. D., Mueller, E. A., Brandt, H. A., Lesem, M. D., Murphy, D. L., Jimerson, D. C, Proceeds Am. Psychiatric Assoc: 140:NR195
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Lectures

  • A Case of Schizoaffective Disorder in an Elderly Patient. 
    Department of Psychiatry, Grand Rounds, University of Texas Medical School-Houston
  • Alcoholism and Affective Disorders - Two Case Presentations. 
    Department of Psychiatry, Grand Rounds, University of Texas Medical School-Houston
  • State-Related Changes in Plasma NE in Anorexia Nervosa. 
    LCS Section, NIMH Seminar
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