PatrickAThompsonMD
Pediatric Hematology & Oncology • Chapel Hill, NCPediatric Sarcoma Oncology, Pediatric Solid Tumor Oncology
Associate Professor, Pediatrics, University of North Carolina
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Office
170 Manning Drive
Campus Box 7236
Chapel Hill, NC 27599Phone+1 919-966-1178Fax+1 919-966-7629- Is this information wrong?
Education & Training
Baylor College of MedicineFellowship, Pediatric Hematology/Oncology, 2004 - 2007- Baylor College of Medicine (Houston)Residency, Pediatrics, 2001 - 2004
- Baylor College of MedicineClass of 2001
Certifications & Licensure
NC State Medical License 2014 - 2024
TX State Medical License 2007 - 2014- American Board of Pediatrics Pediatrics
- American Board of Pediatrics Pediatric Hematology-Oncology
Clinical Trials
- Isotretinoin With or Without Dinutuximab, Aldesleukin, and Sargramostim Following Stem Cell Transplant in Treating Patients With Neuroblastoma Start of enrollment: 2001 Oct 18
Active, not recruiting
Phase 3
- Vincristine, Dactinomycin, and Cyclophosphamide With or Without Radiation Therapy in Treating Patients With Newly Diagnosed Low-Risk Rhabdomyosarcoma Start of enrollment: 2004 Sep 04
Completed
Phase 3
- Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors Start of enrollment: 2004 Mar 25
Recruiting
- Comparison of Radiation Therapy Regimens in Combination With Chemotherapy in Treating Young Patients With Newly Diagnosed Standard-Risk Medulloblastoma Start of enrollment: 2004 Apr 01
Active, not recruiting
Phase 3
- Combination Chemotherapy, PEG-Interferon Alfa-2b, and Surgery in Treating Patients With Osteosarcoma Start of enrollment: 2005 Nov 14
Completed
Phase 3
- Study to Assess Compliance With Long-Term Mercaptopurine Treatment in Young Patients With Acute Lymphoblastic Leukemia in Remission Start of enrollment: 2005 May 30
Completed
- Radiation Therapy, Amifostine, and Chemotherapy in Treating Young Patients With Newly Diagnosed Nasopharyngeal Cancer Start of enrollment: 2006 Feb 20
Completed
Phase 3
- Cisplatin-Based Chemotherapy and/or Surgery in Treating Young Patients With Adrenocortical Tumor Start of enrollment: 2007 May 03
Completed
Phase 3
- Combination Chemotherapy, Radiation Therapy, and/or Surgery in Treating Patients With High-Risk Kidney Tumors Start of enrollment: 2006 Jun 01
Completed
Phase 2
- Combination Chemotherapy Followed By Peripheral Stem Cell Transplant in Treating Young Patients With Newly Diagnosed Supratentorial Primitive Neuroectodermal Tumors or High-Risk Medulloblastoma Start of enrollment: 2007 Aug 06
Active, not recruiting
Phase 3
- A Phase I/II Study of the Raf Kinase and Receptor Tyrosine Kinase Inhibitor Sorafenib (BAY 43-9006, NSC# 724772, IND# 69896) in Children With Refractory Solid Tumors or Refractory Leukemias Start of enrollment: 2006 May 01
- Vincristine, Dactinomycin, and Doxorubicin With or Without Radiation Therapy or Observation Only in Treating Younger Patients Who Are Undergoing Surgery for Newly Diagnosed Stage I, Stage II, or Stage III Wilms' Tumor Start of enrollment: 2006 Oct 30
Active, not recruiting
Phase 3
- Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma Start of enrollment: 2006 Dec 26
Completed
Phase 3
- Combination Chemotherapy in Treating Young Patients With Down Syndrome and Acute Myeloid Leukemia or Myelodysplastic Syndromes Start of enrollment: 2007 Mar 01
Completed
Phase 3
- Clofarabine and Cytarabine in Treating Young Patients With Refractory or Relapsed Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia Start of enrollment: 2007 Mar 01
Completed
Phase 1, Phase 2
- Combination Chemotherapy With or Without Radiation Therapy in Treating Young Patients With Newly Diagnosed Stage III or Stage IV Wilms' Tumor Start of enrollment: 2007 Feb 26
Active, not recruiting
Phase 3
- Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia Start of enrollment: 2007 Mar 01
Completed
Phase 3
- Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma/PNET Start of enrollment: 2007 Mar 26
Active, not recruiting
Phase 3
- Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma Start of enrollment: 2007 Jan 22
Active, not recruiting
Phase 3
- Brain Function in Young Patients Receiving Methotrexate for Acute Lymphoblastic Leukemia Start of enrollment: 2007 Jan 01
Completed
- Combination Chemotherapy, Autologous Stem Cell Transplant, and/or Radiation Therapy in Treating Young Patients With Extraocular Retinoblastoma Start of enrollment: 2008 Feb 04
Active, not recruiting
Phase 3
- Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Start of enrollment: 2008 Jan 15
Active, not recruiting
Phase 3
- Combination Chemotherapy, Radiation Therapy, and an Autologous Peripheral Blood Stem Cell Transplant in Treating Young Patients With Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System Start of enrollment: 2008 Dec 08
Active, not recruiting
Phase 3
- Bortezomib and Combination Chemotherapy in Treating Younger Patients With Recurrent, Refractory, or Secondary Acute Myeloid Leukemia Start of enrollment: 2008 Apr 01
Completed
Phase 2
- Cixutumumab in Treating Patients With Relapsed or Refractory Solid Tumors Start of enrollment: 2009 Jan 01
Completed
Phase 2
- Bortezomib and Combination Chemotherapy in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma Start of enrollment: 2009 Mar 01
Completed
Phase 2
- Cixutumumab and Temsirolimus in Treating Younger Patients With Solid Tumors That Have Recurred or Not Responded to Treatment Start of enrollment: 2009 Apr 01
Completed
Phase 1
- Collecting and Storing Malignant, Borderline Malignant Neoplasms, and Related Samples From Young Patients With Cancer Start of enrollment: 2003 Oct 13
Completed
- Study of Kidney Tumors in Younger Patients Start of enrollment: 2006 Feb 27
Recruiting
- Collecting and Storing Biological Samples From Young Patients With Hodgkin?s Lymphoma Start of enrollment: 2006 Oct 23
Completed
- Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma Start of enrollment: 2000 Nov 06
Recruiting
- Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue Sarcoma Start of enrollment: 1999 Mar 15
Completed
- Pazopanib Hydrochloride in Treating Young Patients With Solid Tumors That Have Relapsed or Not Responded to Treatment Start of enrollment: 2009 Jun 01
Completed
Phase 1
- Obatoclax Mesylate, Vincristine Sulfate, Doxorubicin Hydrochloride, and Dexrazoxane Hydrochloride in Treating Young Patients With Relapsed or Refractory Solid Tumors, Lymphoma, or Leukemia Start of enrollment: 2009 Jun 01
Terminated
Phase 1
- Crizotinib in Treating Younger Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Start of enrollment: 2009 Sep 21
Completed
Phase 1, Phase 2
- Combination Chemotherapy and Surgery in Treating Young Patients With Wilms Tumor Start of enrollment: 2009 Jul 13
Active, not recruiting
Phase 3
- Study of Blood Samples From Newborns With Down Syndrome Start of enrollment: 2009 Feb 23
Completed
- Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer Start of enrollment: 2009 Sep 14
Active, not recruiting
Phase 3
- Collecting and Storing Tissue Samples From Patients With Rare or Cutaneous Non-Hodgkin Lymphoma Start of enrollment: 2005 May 30
Completed
- Monoclonal Antibody Ch14.18, Sargramostim, Aldesleukin, and Isotretinoin After Autologous Stem Cell Transplant in Treating Patients With Neuroblastoma Start of enrollment: 2009 Dec 21
Completed
Phase 3
- Seneca Valley Virus-001 and Cyclophosphamide in Treating Young Patients With Relapsed or Refractory Neuroblastoma, Rhabdomyosarcoma, or Rare Tumors With Neuroendocrine Features Start of enrollment: 2009 Sep 01
Completed
Phase 1
- Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Ependymoma Start of enrollment: 2010 May 07
Active, not recruiting
Phase 3
- Temsirolimus, Irinotecan Hydrochloride, and Temozolomide in Treating Younger Patients With Relapsed or Refractory Solid Tumors Start of enrollment: 2010 Jun 01
Completed
Phase 1
- Risk-Based Classification System of Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Start of enrollment: 2010 Aug 09
Completed
- Alisertib in Treating Young Patients With Recurrent or Refractory Solid Tumors or Leukemia Start of enrollment: 2011 Feb 01
Completed
Phase 2
- INCB18424 in Treating Young Patients With Relapsed or Refractory Solid Tumor, Leukemia, or Myeloproliferative Disease Start of enrollment: 2010 Sep 01
Completed
Phase 1
- Vorinostat and Radiation Therapy Followed by Maintenance Therapy With Vorinostat in Treating Younger Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma Start of enrollment: 2010 Aug 09
Completed
Phase 1, Phase 2
- Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma Start of enrollment: 2010 Aug 09
Active, not recruiting
Phase 3
- Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors Start of enrollment: 2010 Nov 22
Completed
Phase 2
- Vinorelbine Tartrate and Cyclophosphamide in Combination With Bevacizumab or Temsirolimus in Treating Patients With Recurrent or Refractory Rhabdomyosarcoma Start of enrollment: 2010 Oct 01
Completed
Phase 2
- Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma Start of enrollment: 2010 Nov 22
Active, not recruiting
Phase 3
- MK2206 in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Leukemia Start of enrollment: 2011 Jan 01
Completed
Phase 1
- Viral Therapy in Treating Young Patients With Relapsed or Refractory Solid Tumors Start of enrollment: 2010 Dec 01
Completed
Phase 1
- Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Start of enrollment: 2011 May 01
Completed
Phase 1
- Caspofungin Versus Fluconazole in Preventing Invasive Fungal Infections (IFI) in Patients Undergoing Chemotherapy for Acute Myeloid Leukemia Start of enrollment: 2011 Apr 04
Completed
Phase 3
- Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Start of enrollment: 2011 Jun 20
Active, not recruiting
Phase 3
- Temsirolimus, Dexamethasone, Mitoxantrone Hydrochloride, Vincristine Sulfate, and Pegaspargase in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma Start of enrollment: 2011 Sep 01
Completed
Phase 1
- A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia (ALL) Testing Clofarabine (IND# 73789, NSC# 606869) in the Very High Risk Stratum Start of enrollment: 2012 Feb 01
- MORAb-004 in Treating Young Patients With Recurrent or Refractory Solid Tumors or Lymphoma Start of enrollment: 2013 Nov 01
Completed
Phase 1
- Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer Start of enrollment: 2009 Sep 01
- Neuroblastoma Biology Study Start of enrollment: 2011 Jul 01
Recruiting
Roles: Contact
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Publications & Presentations
PubMed
- Long-Term Outcomes After Abdominal Radiation for Wilms Tumor: A 20-Year Experience.Brianna Conte, Colette Shen, Patrick Thompson, Ian Davis, Dana L Casey> ;American Journal of Clinical Oncology. 2024 Mar 1
- 1 citationsA phase I trial of metformin in combination with vincristine, irinotecan, and temozolomide in children with relapsed or refractory solid and central nervous system tum...Jonathan L Metts, Matteo Trucco, Daniel A Weiser, Patrick Thompson, Eric Sandler, Tiffany Smith, Jessica Crimella, Samer Sansil, Ram Thapa, Brooke L Fridley, Nicholas ...> ;Cancer Medicine. 2023 Feb 1
- 12 citationsDoxorubicin in combination with cisplatin, 5-flourouracil, and vincristine is feasible and effective in unresectable hepatoblastoma: A Children's Oncology Group studyHoward M. Katzenstein, Marcio H. Malogolowkin, Mark Krailo, Jin Piao, Alexander J. Towbin, M. Beth McCarville, Gregory M. Tiao, Stephen P. Dunn, Max R. Langham, Eugene...> ;Cancer. 2021 Nov 11
- 13 citationsPhase II trial of gemcitabine and nab-paclitaxel in patients with recurrent Ewing sarcoma: A report from the National Pediatric Cancer Foundation.Javier Oesterheld, Damon R. Reed, Bhuvana A. Setty, Michael S. Isakoff, Patrick A. Thompson, Hong Yin, Masanori Hayashi, David M. Loeb, Tiffany Smith, Rikesh J Makanji...> ;Pediatric Blood & Cancer. 2020 Jul 1
- 47 citationsA phase I/II study of veliparib (ABT-888) with radiation and temozolomide in newly diagnosed diffuse pontine glioma: a Pediatric Brain Tumor Consortium studyPatricia Baxter, Jack Su, Arzu Onar-Thomas, Catherine A. Billups, Xiao-Nan Li, Tina Young Poussaint, Edward R. Smith, Patrick A. Thompson, Adekunle M. Adesina, P. Anse...> ;Neuro-Oncology. 2020 Jun 9
- 23 citationsThe Population Pharmacokinetics of High-Dose Methotrexate in Infants with Acute Lymphoblastic Leukemia Highlight the Need for Bedside Individualized Dose Adjustment: A...Ryan J. Beechinor, Patrick A. Thompson, Michael F. Hwang, Ryan C. Vargo, Lisa Bomgaars, Jacqueline G Gerhart, ZoAnn E. Dreyer, Daniel Gonzalez> ;Clinical Pharmacokinetics. 2019 Jul 1
- 7 citationsIdiopathic, Refractory Sweet's Syndrome Associated with Common Variable Immunodeficiency: a Case Report and Literature Review.Quindelyn Cook, Carlton J. Zdanski, Craig N. Burkhart, Paul B. Googe, Patrick A. Thompson, Eveline Y. Wu> ;Current Allergy and Asthma Reports. 2019 May 14
- 12 citationsA prospective study of a simple algorithm to individually dose high-dose methotrexate for children with leukemia at risk for methotrexate toxicities.Jennifer Foster, Patrick A. Thompson, M. Brooke Bernhardt, Judith F. Margolin, Susan G. Hilsenbeck, Eunji Jo, Deborah Marquez-Do, Michael E. Scheurer, Eric S. Schafer> ;Cancer Chemotherapy and Pharmacology. 2019 Feb 1
- 46 citationsNovel patient-derived xenograft and cell line models for therapeutic testing of pediatric liver cancerBeatrice Bissig-Choisat, Claudia Kettlun-Leyton, Xavier Legras, Barry Zorman, Mercedes Barzi, Leon Chen, Mansi D. Amin, Yung-Hsin Huang, Robia G. Pautler, Oliver A. Ha...> ;Journal of Hepatology. 2016 Aug 1
- 16 citationsAdverse effects of pegaspargase in pediatric patients receiving doses greater than 3,750 IURachel Lebovic, Natalie Pearce, Laura Lacey, James G. Xenakis, Cassidy B. Faircloth, Patrick A. Thompson> ;Pediatric Blood & Cancer. 2017 Oct 1
- 22 citationsFirst-dose and steady-state pharmacokinetics of orally administered crizotinib in children with solid tumors: a report on ADVL0912 from the Children's Oncology Group P...Frank M. Balis, Patrick A. Thompson, Yael P. Mosse, Susan M. Blaney, Charles G. Minard, Brenda J. Weigel, Elizabeth Fox> ;Cancer Chemotherapy and Pharmacology. 2017 Jan 1
- 130 citationsGenomic analysis of hepatoblastoma identifies distinct molecular and prognostic subgroupsPavel Sumazin, Yi Chen, Lisa R. Trevino, Stephen F. Sarabia, Oliver A. Hampton, Kayuri U. Patel, Toni Ann Mistretta, Barry Zorman, Patrick A. Thompson, Andras Heczey, ...> ;Hepatology. 2017 Jan 1
- 5 citationsUsing a Bedside Algorithm to Individually Dose High-dose Methotrexate for Patients at Risk for Toxicity.Jennifer Foster, Melanie Brooke Bernhardt, Patrick A. Thompson, E OʼBrian Smith, Eric S. Schafer> ;Journal of Pediatric Hematology/oncology. 2017 Jan 1
- 21 citationsRelapsed hepatoblastoma confined to the lung is effectively treated with pulmonary metastasectomyYan Shi, James I. Geller, Irene T. Ma, Rishikesh S. Chavan, Prakash Masand, Alexander J. Towbin, Murali Chintagumpala, Jed G. Nuchtern, Greg Tiao, Patrick A. Thompson,...> ;Journal of Pediatric Surgery. 2016 Apr 1
- 13 citationsEffects of an early referral system on liver transplantation for hepatoblastoma at Texas Children's HospitalMichael L. Kueht, Patrick Thompson, Abbas Rana, Ronald T. Cotton, Christine A. O'Mahony, John A. Goss> ;Pediatric Transplantation. 2016 Mar 27
- 33 citationsAbnormal Myocardial Strain Indices in Children Receiving Anthracycline Chemotherapy.Ricardo H. Pignatelli, Payam Ghazi, S. Chandra-Bose Reddy, Patrick Thompson, Qiqiong Cui, Jacqueline Castro, M.F. Okcu, John L. Jefferies> ;Pediatric Cardiology. 2015 Jun 7
- Erratum to: Abnormal Myocardial Strain Indices in Children Receiving Anthracycline ChemotherapyRicardo H. Pignatelli, Payam Ghazi, S. Chandra-Bose Reddy, Patrick Thompson, Qiqiong Cui, Jacqueline Castro, M.F. Okcu, John L. Jefferies> ;Pediatric Cardiology. 2015 Aug 28
- Reply to: No correlation between estimated and actual glomerular filtration rates in pediatric oncology patients.Melanie Brooke Bernhardt, Patrick A. Thompson> ;Pediatric Blood & Cancer. 2015 Jul 1
- 14 citationsFocal nodular hyperplasia in children: an institutional experience with review of the literatureIrene T. Ma, Yesenia Rojas, Prakash Masand, Eumenia Costa da Cunha Castro, Ryan Himes, Eugene S. Kim, John A. Goss, Jed G. Nuchtern, Milton J. Finegold, Patrick A. Tho...> ;Journal of Pediatric Surgery. 2015 Mar 1
- 6 citationsIdentifying gene disruptions in novel balanced de novo constitutional translocations in childhood cancer patients by whole-genome sequencing.Deborah I. Ritter, Katherine Haines, Hannah Cheung, Caleb F. Davis, Ching C. Lau, Jonathan S. Berg, Chester W. Brown, Patrick A. Thompson, Richard A. Gibbs, David A. W...> ;Genetics in Medicine. 2015 Jan 8
- 14 citationsAgreement among measurements and estimations of glomerular filtration in children with cancer.M. Brooke Bernhardt, Brady S. Moffett, Michael L. Johnson, Vincent H. Tam, Patrick A. Thompson, Kevin W. Garey> ;Pediatric Blood & Cancer. 2015 Jan 1
- 52 citationsA phase I trial of veliparib (ABT-888) and temozolomide in children with recurrent CNS tumors: a Pediatric Brain Tumor Consortium reportJack Su, Patrick A. Thompson, Adekunle M. Adesina, Xiao-Nan Li, Lindsay Kilburn, Arzu Onar-Thomas, Mehmet Kocak, Brenda Chyla, Evelyn McKeegan, Katherine E. Warren, St...> ;Neuro-Oncology. 2014 Dec 1
- 20 citationsPharmacokinetics and pharmacogenomics of daunorubicin in children: a report from the Children’s Oncology GroupPatrick A. Thompson, Heather E. Wheeler, Shannon M. Delaney, Rachel Lorier, Ulrich Broeckel, Meenakshi Devidas, Gregory H. Reaman, Kathleen A. Scorsone, Lillian Sung, ...> ;Cancer Chemotherapy and Pharmacology. 2014 Aug 14
- 15 citationsAngiosarcoma successfully treated with liver transplantation and sirolimusMegan Xue, Prakash Masand, Patrick A. Thompson, Milton J. Finegold, Daniel H. Leung> ;Pediatric Transplantation. 2014 Jun 1
- 25 citationsRelapse surveillance in AFP-positive hepatoblastoma: re-evaluating the role of imaging.Yesenia Rojas, R. Paul Guillerman, Wei Zhang, Sanjeev A. Vasudevan, Jed G. Nuchtern, Patrick A. Thompson> ;Pediatric Radiology. 2014 May 18
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Hospital Affiliations
University of North Carolina HospitalsChapel Hill, North Carolina
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