PedramHamrahMDFACS, FARVO

Anterior Segment Related, Cataract Related, Cornea & External Disease, Refractive Surgery

Professor of Ophthalmology, Immunology, Neuroscience, and Bioengineering Tufts University School of Medicine Director, Center for Translational Ocular Immunology; Co-Director Cornea Service, Interim Director, New England Eye Center; Department of Ophthalmology, Tufts Medical Center

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Office
800 Washington St
New England Eye Center, Tufts Medical Center
Boston, MA 02111
Phone+1 617-573-5720
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Education & Training

Massachusetts Eye and Ear Infirmary/Harvard Medical SchoolFellowship, Cornea, External Diseases, and Refractive Surgery, 2006 - 2008
University of Louisville School of MedicineChief Residency, Ophthalmology, 2005 - 2006
University of Louisville School of MedicineResidency, Ophthalmology, 2003 - 2006
University of Louisville School of MedicineFellowship, Ocular Immunology/Uveitis, 2002 - 2003
TriHealth (Good Samaritan Hospital)Internship, Internal Medicine, 2001 - 2002
Massachusetts Eye and Ear Infirmary/Harvard Medical SchoolFellowship, Cornea, External Diseases, and Refractive Surgery, 1999 - 2001
Medizinische Fakultät Universität zu KölnClass of 2000

Certifications & Licensure

MA State Medical License 2006 - 2024
OH State Medical License 2001 - 2002
American Board of Ophthalmology Ophthalmology

Awards, Honors, & Recognition

Senior Achievement Award American Academy of Ophthalmology
Gold Fellow (FARVO) Association for Research in Vision and Ophthalmology (ARVO), 2017
Whos Who in Medicine and Healthcare Marquis Whos Who
Fellow (FAAO) American Academy of Ophthalmology
Fellow (FACS) American College of Surgeons
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Clinical Trials

Effect of Contact Lens Wear on Immune Cell Density and Morphology of the Ocular Surface Start of enrollment: 2010 Aug 01
Completed
Phase 4
Effects of Anti-Glaucoma Medications on the Ocular Surface Start of enrollment: 2011 Feb 01
Terminated
Phase 4
In Vivo Confocal Microscopy Study of Pigmented Conjunctival Lesions Start of enrollment: 2011 Sep 01
Terminated
A Multi-Center Study of the Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival Start of enrollment: 2014 Apr 01
Completed
Phase 1, Phase 2
Ocular Surface Immune Response in Dry Eye Disease Start of enrollment: 2014 Jan 01
Completed
Using in Vivo Confocal Microscopy to Assess Cellular Response and Efficacy of Steroid Treatment in Dry Eye Disease Start of enrollment: 2014 Feb 01
The Utility of IVCM to Assess Cellular Response and Efficacy of Long-term Topical Steroid Treatment in Patients With DED Start of enrollment: 2014 Feb 01
Completed
Phase 4
Evaluation of Efficacy of 20 µg/ml rhNGF New Formulation (With Anti-oxidant) in Patients With Stage 2 and 3 NK Start of enrollment: 2015 Feb 01
Completed
Phase 2
Intraductal Meibomian Gland Probing Trial Start of enrollment: 2014 Oct 01
Completed
Phase 4
Intranasal Neurostimulation in Ameliorating Symptoms of Neuropathic Corneal Pain Start of enrollment: 2018 Sep 28
Terminated
Not Applicable
Intracanalicular Dexamethasone Insert for the Treatment of Inflammation and Discomfort in Dry Eye Disease (DEcIDED) Start of enrollment: 2020 Sep 04
Recruiting
Phase 4
Neurosensory Abnormalities in SymptomAtic Ocular Surface Patients (NASA) Start of enrollment: 2021 Jul 02
Enrolling by invitation
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Publications & Presentations

PubMed

Phase IV Multicenter, Prospective, Open-Label Clinical Trial of Cenegermin (rhNGF) for Stage 1 Neurotrophic Keratopathy (DEFENDO).
Massaro-Giordano, M., Goisis, G., Pasedis, G., Mantelli, F., Hamrah, P., Schanzlin, D., Holland, E., Berdy, G.> ;Ophthalmology and Therapy. 2024 Feb 1
1 citations
Novel Application of Conjunctival Anterior Segment Optical Coherence Tomography Angiography to Assess Ocular Redness.
William W Binotti, Ricardo M Nosé, Nicholas J Pondelis, Arsia Jamali, Paula Kataguiri, Anam Akhlaq, Kenneth R Kenyon, Hamrah, P.> ;Cornea. 2023 Dec 1
3 citations
COVID-19-related Conjunctivitis Review: Clinical Features and Management.
William Binotti, Hamrah, P.> ;Ocular Immunology and Inflammation. 2023 May 1
13 citations
TFOS Lifestyle: Impact of elective medications and procedures on the ocular surface.
José Alvaro P Gomes, Dimitri T Azar, Christophe Baudouin, Etty Bitton, Wei Chen, Farhad Hafezi, Pedram Hamrah, Ruth E Hogg, Jutta Horwath-Winter, Georgios A Kontadakis...> ;The Ocular Surface. 2023 Jul 1
2 citations
Corneal nerve regeneration is affected by scar location in herpes simplex keratitis: A longitudinal in vivo confocal microscopy study.
Matteo Posarelli, Chareenun Chirapapaisan, Rodrigo Muller, Alessandro Abbouda, Nicholas Pondelis, Andrea Cruzat, Bernardo M Cavalcanti, Stephanie M Cox, Arsia Jamali, ...> ;The Ocular Surface. 2023 Apr 1
3 citations
Utility of In Vivo Confocal Microscopy in Diagnosis of Acanthamoeba Keratitis: A Comparison of Patient Outcomes.
Hyunjoo J Lee, Fateme Alipour, Andrea Cruzat, Matteo Posarelli, Lixin Zheng, Hamrah, P.> ;Cornea. 2023 Feb 1
1 citations
Effect of recombinant human nerve growth factor treatment on corneal nerve regeneration in patients with neurotrophic keratopathy.
Ana Balbuena-Pareja, Chloe S Bogen, Stephanie M Cox, Pedram Hamrah> ;Frontiers in Neuroscience. 2023 Jan 1
A novel animal model of neuropathic corneal pain-the ciliary nerve constriction model.
Seyed-Razavi, Y., Kenyon, B., Qiu, F., Harris, D., Hamrah, P.> ;Frontiers in Neuroscience. 2023 Jan 1
1 citations
Autoantibodies Against Trisulfated Heparin Disaccharide and Fibroblast Growth Factor Receptor-3 May Play a Role in the Pathogenesis of Neuropathic Corneal Pain.
Betul N Bayraktutar, Vanessa Atocha, Khosro Farhad, Oscar Soto, Pedram Hamrah> ;Cornea. 2023 Jul 1
6 citations
Density and distribution of dendritiform cells in the peripheral cornea of healthy subjects using in vivo confocal microscopy.
Anam Akhlaq, Clara Colón, Bernardo M Cavalcanti, Shruti Aggarwal, Yureeda Qazi, Andrea Cruzat, Candice Jersey, Douglas B Critser, Amy Watts, Jill Beyer, Christine W Si...> ;The Ocular Surface. 2022 Oct 1
11 citations
Immunomodulatory Role of Neuropeptides in the Cornea.
Sudan Puri, Brendan M Kenyon, Hamrah, P.> ;Biomedicines. 2022 Aug 16
8 citations
Efficacy of Recombinant Human Nerve Growth Factor in Stage 1 Neurotrophic Keratopathy.
Leyla Yavuz Saricay, Betul N Bayraktutar, Jonathan Lilley, Francis S Mah, Mina Massaro-Giordano, Pedram Hamrah> ;Ophthalmology. 2022 Dec 1
6 citations
Understanding chronic ocular surface pain: An unmet need for targeted drug therapy.
Anat Galor, Pedram Hamrah, Sameena Haque, Nadine Attal, Marc Labetoulle> ;The Ocular Surface. 2022 Oct 1
3 citations
Bevacizumab in High-Risk Corneal Transplantation: A Pilot Multicenter Prospective Randomized Control Trial.
Dohlman, T., McSoley, M., Amparo, F., Carreno-Galeano, T., Wang, M., Dastjerdi, M., Singh, R., Coco, G., Di Zazzo, A., Shikari, H., Saboo, U., Sippel, K., Ciralsky, J....> ;Ophthalmology. 2022 Aug 1
3 citations
Automated Image Threshold Method Comparison for Conjunctival Vessel Quantification on Optical Coherence Tomography Angiography.
William W Binotti, Daniel Saukkonen, Yashar Seyed-Razavi, Arsia Jamali, Hamrah, P.> ;Translational Vision Science & Technology. 2022 Jul 8
5 citations
A Single Administration of OC-01 (Varenicline Solution) Nasal Spray Induces Short-Term Alterations in Conjunctival Goblet Cells in Patients with Dry Eye Disease.
Gabriela M Dieckmann, Stephanie M Cox, Maria J Lopez, M Cuneyt Ozmen, Leyla Yavuz Saricay, Betul N Bayrakutar, William W Binotti, Eugenia Henry, Jeffrey Nau, Pedram Ha...> ;Ophthalmology and Therapy. 2022 Aug 1
2 citations
Cutting Edge: Topical Recombinant Nerve Growth Factor for the Treatment of Neurotrophic Keratopathy-Biologicals as a Novel Therapy for Neurotrophic Keratopathy.
Pedram Hamrah, Leyla Yavuz Saricay, M Cuneyt Ozmen> ;Cornea. 2022 Jun 1
13 citations
The use of in vivo confocal microscopy in fungal keratitis - Progress and challenges.
Ingvild M Bakken, Catherine J Jackson, Tor P Utheim, Edoardo Villani, Ahmad Kheirkhah, Esben Nielsen, Scott Hau, Neil S Lagali, Hamrah, P.> ;The Ocular Surface. 2022 Apr 1
5 citations
Exploratory Phase II Multicenter, Open-Label, Clinical Trial of ST266, a Novel Secretome for Treatment of Persistent Corneal Epithelial Defects.
Bennie H Jeng, Pedram Hamrah, Ziv Z Kirshner, Benjamin C Mendez, Howard C Wessel, Larry R Brown, David L Steed> ;Translational Vision Science & Technology. 2022 Jan 3
5 citations
Nectin-1 and Non-muscle Myosin Heavy Chain-IIB: Major Mediators of Herpes Simplex Virus-1 Entry Into Corneal Nerves.
Chenchen Wang, Qi Liang, Dong Sun, Yun He, Jiaxuan Jiang, Rongjie Guo, Tejsu Malla, Xun Liu, Zhenping Huang, Kai Hu, Hamrah, P.> ;Frontiers in Microbiology. 2022 Jan 1
1 citations
Developing a Measure to Quantify Ocular Pain Postoperatively: The Adaptation of the Ocular Pain Assessment Survey.
Ayse Yildiz-Tas, Sadi Can Sonmez, Zeynep Busra Kisakurek, Gulsum Deniz, Arzu Baygül, Cem Kesim, Melisa Zisan Karslioglu, Cem Ozturkmen, Rengin Aslihan Kurt, Pedram Ham...> ;Journal of Ophthalmology. 2022 Jan 1
6 citations
Role of the Phospholipase C Pathway and Calcium Mobilization in Oxytocin-Induced Contraction of Lacrimal Gland Myoepithelial Cells.
Angela Gárriz, Salome Aubry, Quentin Wattiaux, Jeffrey Bair, Michael Mariano, Georgios Hatzipetrou, Maytal Bowman, Junji Morokuma, Gustavo Ortiz, Pedram Hamrah, Darlen...> ;Investigative Ophthalmology & Visual Science. 2021 Nov 1
13 citations
Expert consensus on the identification, diagnosis, and treatment of neurotrophic keratopathy.
Reza Dana, Marjan Farid, Preeya K. Gupta, Pedram Hamrah, Paul M. Karpecki, Cathleen M. McCabe, L. M. Nijm, Jay S. Pepose, Stephen C. Pflugfelder, Christopher J. Rapuan...> ;BMC Ophthalmology. 2021 Sep 8
2 citations
Characteristics of Toxic Keratopathy, an In Vivo Confocal Microscopy Study
Leying Wang, Yang Zhang, Zhenyu Wei, K Cao, Guanyu Su, Pedram Hamrah, Antoine Labbé, Qingfeng Liang> ;Translational Vision Science & Technology. 2021 Sep 1
7 citations
Concurrent ocular pain in patients with neurotrophic keratopathy.
Leyla Yavuz Saricay, Betul Bayraktutar, Brendan Kenyon, Pedram Hamrah> ;The Ocular Surface. 2021 Aug 17
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Journal Articles

Corneal Pain and Experimental Model Development
Pedram Hamrah, David L Kaplan, ScienceDirect

Other

A Novel Murine Model of Radiation Keratopathy
Pedram Hamrah, MD, Investigative Ophthalmology and Visual Science
https://www.doximity.com/articles/2c5ec736-89ef-41f9-85b7-6a529a08918a
UpToDate, Wolters Kluwer Health - 2012-05-23
A Novel Murine Model of Radiation Keratopathy
Pedram Hamrah, MD, Investigative Ophthalmology and Visual Science
https://www.doximity.com/articles/2c5ec736-89ef-41f9-85b7-6a529a08918a
UpToDate, Wolters Kluwer Health - 2012-04-23
A Novel Murine Model of Radiation Keratopathy
Pedram Hamrah, MD, Investigative Ophthalmology and Visual Science
https://www.doximity.com/articles/2c5ec736-89ef-41f9-85b7-6a529a08918a
UpToDate, Wolters Kluwer Health - 2012-04-23
A Novel Murine Model of Radiation Keratopathy
Pedram Hamrah, MD, Investigative Ophthalmology and Visual Science
https://www.doximity.com/articles/2c5ec736-89ef-41f9-85b7-6a529a08918a
UpToDate, Wolters Kluwer Health - 2013-02-19
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Press Mentions

Oyster Point Pharma Announces Clinical Data Presentations on OC-01 Nasal Spray for Dry Eye Disease at the American Academy of Ophthalmology 2020 Virtual Annual MeetingNovember 13th, 2020
Jeff Manages Corneal Neuralgia While Training for American Ninja WarriorOctober 6th, 2020
W5 Investigates a Rare but Painful Side Effect of Laser Eye SurgeryOctober 20th, 2018
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Grant Support

THE ROLE OF PLASMACYTOID DENDRITIC CELLS IN CORNEAL IMMUNITYNational Eye Institute2013–Present
IMMUNOBIOLOGY OF CORNEAL ANTIGEN-PRESENTING CELLSNational Eye Institute2010–Present