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Pradeep Mammen, MD, Cardiology, Dallas, TX, William P. Clements, Jr. University Hospital

PradeepPaMammenMDFACC, FAHA, FHFSA

Cardiology • Dallas, TX

Heart Failure & Transplantation, Cardiovascular Disease Genetics

Professor of Internal Medicine; Alfred W. Harris, MD Professorship in Cardiology; Co-Director: UTSW Wellstone Muscular Dystrophy Reseach Center; Medical Director: Neuromuscular Cardiomyopathy Clinic; Director: Translational Research for the Advanced Heart Failure &Transplant Cardiology Program; Member of the UTSW Heart Failure, Ventricular Assist Devices, & Heart Transplant Program.

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  • Office

    UT Southwestern Medical Center (UT Southwestern Cardiomyopathy & Heart Transplant Clinic)
    5323 Harry Hines Blvd
    Dallas, TX 75390
    Phone+1 214-645-5505
    Fax+1 214-645-5640
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Summary

  • I am a clinician-scientist with clinical expertise in advanced heart failure, ventricular assist devices and heart transplantation. From a clinical perspective, I am one of only approximately 1,000 adult cardiologists in the US board certified in advanced heart failure/heart transplantation. I am currently an Associate Professor of Medicine, Co-Director of the UTSW Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center (one of six NIH funded Centers in the country), and the Director for Translational Research for the Advanced Heart Failure and Transplant Cardiology Program at UTSW. Finally, I have developed clinical expertise in the care of patients who develop a familial or genetic form of cardiomyopathy (esp. neuromuscular-associated cardiomyopathies). In 2010, I founded and became the Medical Director of the UTSW Neuromuscular Cardiomyopathy Clinic. This clinic is only one of six adult clinics in the United States exclusively dedicated to addressing the cardiovascular needs of patients with neuromuscular disorders.

    In keeping with my clinical interest in the treatment and management of patients with heart failure, I have developed significant scientific expertise in investigating the molecular mechanisms underlying heart failure and cardiac/skeletal muscle myopathies. In the Fall of 2015, Dr. Eric Olson, Chair of the UTSW Department of Molecular Biology and I became the Co-Directors of the UTSW Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center. The core mission of the Center is to rapidly develop genome editing into a viable and effective therapy for patients with Duchenne muscular dystrophy. In addition, I run a NIH R01-funded molecular laboratory focused on mechanistic studies to enhance our understanding of various signaling pathways that contribute to heart failure and cardiac/skeletal muscle myopathies.

Education & Training

  • University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical CenterFellowship, Advanced Heart Failure and Transplant Cardiology, 2003 - 2004
  • University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical CenterPost-Doctoral Fellowship, Molecular Cardiology, 2000 - 2004
  • University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical CenterFellowship, Cardiovascular Disease, 1998 - 2000
  • University of Iowa Hospitals and Clinics
    University of Iowa Hospitals and ClinicsResidency, Internal Medicine, 1995 - 1998
  • University of Wisconsin School of Medicine & Public Health
    University of Wisconsin School of Medicine & Public HealthClass of 1995, MD, Outstanding Medical Student Research Award (1994), Outstanding Leadership and Service Award (1991)
  • University of Pennsylvania
    University of PennsylvaniaB.S.E., Bioengineering/Electrical Engineering, 1987 - 1990

Certifications & Licensure

  • MO State Medical License
    MO State Medical License 2023 - 2025
  • TX State Medical License
    TX State Medical License 1998 - 2024
  • IA State Medical License
    IA State Medical License 1995 - 2024
  • KS State Medical License
    KS State Medical License 2023 - 2024
  • American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

  • Co-Director: UTSW Wellstone Muscular Dystrophy Specialized Research Center NIH U54/P50 Research Grant: Co-Recipient with Eric N. Olson, PhD
  • Heart Failure Society of America: Fellow Heart Failure Society of America, 2020
  • Recipient of a NIH-NHLBI R01 Research Grant National Institute of Health (NHLBI), 2012-2019
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Publications & Presentations

PubMed

Lectures

  • Management of Duchenne muscular dystrophy-associated cardiomyopathy. 
    Action Duchenne International Conference-2015 (London, UK) - 11/6/2015
  • Circulating microRNAs in cardiomyopathy 
    CareDx Inc. (San Francisco, CA) - 10/26/2015
  • Development of atrophic cardiomyopathy in neuromuscular disorders: A novel mode of maladaptive cardiac remodeling. 
    Senator Paul D. Wellstone Muscular Dystrophy Center Network Conference (U. of Washington-Seattle) - 10/14/2015
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Authored Content

  • The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organizationJanuary 2021

Press Mentions

  • Catabasis Pharmaceuticals Presents Information on Edasalonexent, a Potential Foundational Therapy for Duchenne Muscular Dystrophy, at the Virtual 25th International Congress of the World Muscle Society
    Catabasis Pharmaceuticals Presents Information on Edasalonexent, a Potential Foundational Therapy for Duchenne Muscular Dystrophy, at the Virtual 25th International Congress of the World Muscle SocietySeptember 28th, 2020
  • Cracking the Code. Transforming Health in Texas
    Cracking the Code. Transforming Health in TexasJanuary 14th, 2019
  • Catabasis, UT Southwestern Collaborate to Explore Effect of Edasalonexent on Heart Function in Muscular Dystrophies
    Catabasis, UT Southwestern Collaborate to Explore Effect of Edasalonexent on Heart Function in Muscular DystrophiesNovember 19th, 2018
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Grant Support

  • UTSW Wellstone Musuclar Dystrophy Center: Myoediting of Duchenne muscular dystrophy.National Institute of Health (U54/P50 Research Grant: Wellstone Muscular Dystrophy Specialized Research Centers)2015–2025
  • Autoantibodies in DMD-Associated CardiomyopathyCatabasis Inc2020–2021
  • Therapeutic effects of NF-kB inhibition in the treatment of DMD-associatedCatabasis Inc.2018–2021
  • Role of VIP Signaling in DMD-Associated CardiomyopathyPhaseBio Inc.2017–2021
  • Cytoglobin: A stress-responsive hemoprotein modulating cardiomyocyte survival.National Institute of Health (R01 Research Grant; NHLBI)2012–2019
  • Discovery of Unique MicroRNA Signatures in Muscular Dystrophy PatientsHeart Failure Society of America2015–2016
  • Cytoglobin: A Stress-Responsive Hemoprotein Modulating Cardiomyocyte SurvivalNational Heart, Lung, And Blood Institute2012
  • Cytoglobin modulates the fate and viability of cardiac progenitor cells within the stressed heart.American Heart Association (South Central Grant-in-Aid Award)2009–2012
  • Regulation of tissue hemoglobins in the heart.National Institute of Health (K08 Research Grant; NHLBI)2005–2011
  • Regulation Of Tissue Hemoglobins In The HeartNational Heart, Lung, And Blood Institute2005–2009
  • Transcriptional regulation & functional roles of cytoglobin in the heart.American Heart Association (Texas Affiliate Beginning Grant-in-Aid Award)2005–2007
  • Transcriptional regulation & functional roles of cytoglobin in the heart.GlaxoSmithKline Research Foundation2005–2007
  • Cardioprotective role of myoglobin in the heart.Donald W. Reynolds Cardiovascular Clinical Research Program2004–2006
  • Molecular mechanisms of cardiac dysfunction in cytochrome c oxidase subunit VIaH deficient mice.Pfizer Research Foundation2001–2004

Professional Memberships

Hospital Affiliations

Dr. Pradeep Mammen, Dr. Pradeep Mammen, MD, Dr. P Mammen, Dr. Pradeep Pa Mammen