RobertZOrlowskiMDPhD

PubMed

• MUC20 regulated by extrachromosomal circular DNA attenuates proteasome inhibitor resistance of multiple myeloma by modulating cuproptosis.
  Xiaobin Wang, Yingqing Shi, Hua Shi, Xiaoyu Liu, Aijun Liao, Zhuogang Liu, Robert Z Orlowski, Rui Zhang, Huihan Wang> ;Journal of Experimental & Clinical Cancer Research. 2024 Mar 5
• Daratumumab for patients with myeloma with early or late relapse after initial therapy: subgroup analysis of CASTOR and POLLUX.
  Spencer, A., Moreau, P., Mateos, M., Goldschmidt, H., Suzuki, K., Levin, M., Sonneveld, P., Orlowski, R., Yoon, S., Usmani, S., Weisel, K., Reece, D., Ahmadi, T., Pei,...> ;Blood Advances. 2024 Jan 23
• 1 citations
  Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth.
  Sun, F., Cheng, Y., Wanchai, V., Guo, W., Mery, D., Xu, H., Gai, D., Siegel, E., Bailey, C., Ashby, C., Al Hadidi, S., Schinke, C., Thanendrarajan, S., Ma, Y., Yi, Q.,...> ;Nature Communications. 2024 Jan 19
• Novel Anti-B-cell Maturation Antigen Alpha-Amanitin Antibody-drug Conjugate HDP-101 Shows Superior Activity to Belantamab Mafodotin and Enhanced Efficacy in Deletion 1...
  Singh, R., Jones, R., Shirazi, F., Qin, L., Zou, J., Hong, S., Wang, H., Wan, J., Choudhary, R., Kuiatse, I., Pahl, A., Lee, H., Patel, K., Orlowski, R.> ;Research Square. 2024 Jan 11
• Outcomes of patients with multiple myeloma and 1q gain/amplification receiving autologous hematopoietic stem cell transplant: the MD Anderson cancer center experience.
  Oren Pasvolsky, Sassine Ghanem, Denái R Milton, Mikael Rauf, Mark R Tanner, Qaiser Bashir, Samer Srour, Neeraj Saini, Paul Lin, Jeremy Ramdial, Yago Nieto, Guilin Tang...> ;Blood Cancer Journal. 2024 Jan 10
• Impact of pretransplant minimal residual disease in patients with multiple myeloma and a very good partial response or better receiving autologous hematopoietic stem c...
  Oren Pasvolsky, Sarah Pasyar, Roland L Bassett, Hina N Khan, Mark R Tanner, Qaiser Bashir, Samer Srour, Neeraj Saini, Paul Lin, Jeremy Ramdial, Yago Nieto, Hans C Lee,...> ;Cancer. 2023 Dec 21
• Management and Outcomes of Patients with Refractory Solitary Plasmacytoma after Treatment with Definitive Radiation Therapy.
  Saini, N., Becnel, M., Amini, B., Lin, P., Dabaja, B., Fang, P., Pinnix, C., Wu, S., Lee, H., Patel, K., Kaufman, G., Thomas, S., Orlowski, R., Gunther, J.> ;International Journal of Radiation Oncology, Biology, Physics. 2023 Dec 8
• Cytogenetic Profile in Monoclonal Gammopathy of Undetermined Significance, Smoldering and Symptomatic Multiple Myeloma: A Study of 1087 Patients with Highly Purified P...
  Wu, Y., Ye, C., Medeiros, L., Tang, G., Lin, P., Toruner, G., Hu, S., Li, S., Qazilbash, M., Orlowski, R., Xu, J., Nahmod, K., Tang, Z.> ;Cancers. 2023 Dec 2
• Clinical trial design change implementation for inclusive studies.
  Manuel R Espinoza-Gutarra, Jack Aiello, Robert Z Orlowski, Sikander Ailawadhi> ;The Lancet. Haematology. 2023 Dec 1
• Single-agent lenalidomide maintenance after upfront autologous stem cell transplant for newly diagnosed multiple myeloma: The MD Anderson experience.
  Oren Pasvolsky, Denái R Milton, Adeel Masood, Sophiya S Sami, Mark R Tanner, Qaiser Bashir, Samer Srour, Neeraj Saini, Paul Lin, Jeremy Ramdial, Yago Nieto, Arsalan Sa...> ;American Journal of Hematology. 2023 Oct 1
• 1 citations
  Targeted single-cell proteomic analysis identifies new liquid biopsy biomarkers associated with multiple myeloma.
  Sonia M Setayesh, Libere J Ndacayisaba, Kate E Rappard, Valerie Hennes, Luz Yurany Moreno Rueda, Guilin Tang, Pei Lin, Robert Z Orlowski, David E Symer, Elisabet E Man...> ;NPJ Precision Oncology. 2023 Sep 18
• Outcomes of young adults (aged ≤ 40 years) with newly diagnosed multiple myeloma after up-front autologous stem cell transplant.
  Oren Pasvolsky, Curtis Marcoux, Denái R Milton, Mark R Tanner, Qaiser Bashir, Samer Srour, Neeraj Saini, Paul Lin, Jeremy Ramdial, Yago Nieto, Hans C Lee, Krina K Pate...> ;British Journal of Haematology. 2023 Aug 1
• 6 citations
  Single cell clonotypic and transcriptional evolution of multiple myeloma precursor disease.
  Minghao Dang, Ruiping Wang, Hans C Lee, Krina K Patel, Melody R Becnel, Guangchun Han, Sheeba K Thomas, Dapeng Hao, Yanshuo Chu, Donna M Weber, Pei Lin, Zuzana Lutter-...> ;Cancer Cell. 2023 Jun 12
• Plain language summary of the MAIA study of daratumumab plus lenalidomide and dexamethasone for the treatment of people with newly diagnosed multiple myeloma.
  Thierry Facon, Shaji K Kumar, Torben Plesner, Robert Z Orlowski, Philippe Moreau, Nizar Bahlis, Supratik Basu, Hareth Nahi, Cyrille Hulin, Hang Quach, Hartmut Goldschm...> ;Future Oncology. 2023 Apr 1
• Plasma cell myeloma with RAS/BRAF mutations is frequently associated with a complex karyotype, advanced stage disease, and poorer prognosis.
  Nianyi Li, Pei Lin, Zhuang Zuo, M James You, Wen Shuai, Robert Orlowski, Elisabet E Manasanch, Shaoying Li, Jie Xu, Sofia Garces, Fatima Zahra Jelloul, Zhenya Tang, We...> ;Cancer Medicine. 2023 Jul 1
• 4 citations
  Antibody-Drug Conjugates for Multiple Myeloma: Just the Beginning, or the Beginning of the End?
  Upasana Ray, Robert Z Orlowski> ;Pharmaceuticals. 2023 Apr 14
• Clinicopathologic Features of Therapy-Related Myeloid Neoplasms in Patients with Myeloma in the Era of Novel Therapies.
  Fatima Zahra Jelloul, Andres E Quesada, Richard K Yang, Shaoying Li, Wei Wang, Jie Xu, Guilin Tang, C Cameron Yin, Hong Fang, Siba El Hussein, Joseph Khoury, Roland L ...> ;Modern Pathology. 2023 Jun 1
• 2 citations
  Impact of gender on outcomes of patients with multiple myeloma undergoing autologous Haematopoietic stem cell transplant.
  Oren Pasvolsky, Rima M Saliba, Adeel Masood, Ali H Mohamedi, Mark R Tanner, Qaiser Bashir, Samer Srour, Neeraj Saini, Jeremy Ramdial, Yago Nieto, Hans C Lee, Krina K P...> ;British Journal of Haematology. 2023 May 1
• 4 citations
  Autologous Stem Cell Transplantation for Patients with Multiple Myeloma with Translocation (4;14): The MD Anderson Cancer Center Experience.
  Oren Pasvolsky, Mahmoud R Gaballa, Denái R Milton, Adeel Masood, Sophiya S Sami, Mark R Tanner, Qaiser Bashir, Samer Srour, Neeraj Saini, Jeremy Ramdial, Yago Nieto, G...> ;Transplantation and Cellular Therapy. 2023 Apr 1
• 21 citations
  Overall Survival With Daratumumab, Lenalidomide, and Dexamethasone in Previously Treated Multiple Myeloma (POLLUX): A Randomized, Open-Label, Phase III Trial.
  Meletios A Dimopoulos, Albert Oriol, Hareth Nahi, Jesus San-Miguel, Nizar J Bahlis, Saad Z Usmani, Neil Rabin, Robert Z Orlowski, Kenshi Suzuki, Torben Plesner, Sung-S...> ;Journal of Clinical Oncology. 2023 Mar 10
• Radiation Therapy Can Be Safely Incorporated into Pretransplantation Treatment Regimens for Patients with Multiple Myeloma.
  Ethan P Damron, Muzaffar H Qazilbash, Penny Q Fang, Susan Y Wu, Bouthaina S Dabaja, Gabriela Rondon, Chitra Hosing, Richard E Champlin, Qaiser Bashir, Elizabeth J Shpa...> ;Transplantation and Cellular Therapy. 2023 Jan 1
• 2 citations
  Hyperfractionated Cyclophosphamide and Dexamethasone Alone or in Combination with Daratumumab and/or Carfilzomib for the Treatment of Relapsed or Refractory Multiple M...
  B R Shank, B Primeaux, E K Yeung, S B Horowitz, I Y Lee, L Roccograndi, L Feng, G P Kaufman, H C Lee, E E Manasanch, K K Patel, R Z Orlowski, D M Weber, M R Becnel, S ...> ;Clinical Lymphoma, Myeloma & Leukemia. 2023 Apr 1
• 12 citations
  Stem Cell Mobilization Yields with Daratumumab- and Lenalidomide-Containing Quadruplet Induction Therapy in Newly Diagnosed Multiple Myeloma: Findings from the MASTER ...
  Saurabh Chhabra, Natalie Callander, Nicole L Watts, Luciano J Costa, Bicky Thapa, Jonathan L Kaufman, Jacob Laubach, Douglas W Sborov, Brandi Reeves, Cesar Rodriguez, ...> ;Transplantation and Cellular Therapy. 2023 Mar 1
• Characterization of BCMA Expression in Circulating Rare Single Cells of Patients with Plasma Cell Neoplasms.
  Libere J Ndacayisaba, Kate E Rappard, Stephanie N Shishido, Sonia M Setayesh, Guilin Tang, Pei Lin, Nicholas Matsumoto, Ching-Ju Hsu, Rafael Nevarez, Carmen Ruiz Velas...> ;International Journal of Molecular Sciences. 2022 Nov 3
• 1 citations
  Serologic versus molecular testing for screening for hepatitis C virus infection in patients with hematologic malignancies.
  Harrys A Torres, Georgios Angelidakis, Ying Jiang, Minas Economides, Khalis Mustafayev, Marcel Yibirin, Robert Orlowski, Richard Champlin, Srdan Verstovsek, Issam Raad> ;Medicine. 2022 Sep 16
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Journal Articles

• Primary Plasma Cell Leukemia: Autologous Stem Cell Transplant in an Era of Novel Induction Drugs  
  Krina Patel, Rohtesh Mehta, Donna M Weber, Sheeba K Thomas, Nina Shah, Hans C Lee, Elisabet E Manasanch, Muzaffar H Qazilbash, Qaiser Bashir, Simrit Parmar, Robert Z O..., Nature
• Targeting Myddosome Signaling in Waldenström's Macroglobulinemia with the Interleukin-1 Receptor-Associated Kinase 1/4 Inhibitor R191  
  Sheeba K Thomas, Robert Z Orlowski, Hans C Lee, Clinical Cancer Research

Abstracts/Posters

• A Multicenter Phase II Single Arm Trial of Isatuximab in Patients with High Risk Smoldering Multiple Myeloma (HRSMM)
  Robert Z. Orlowski, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Daratumumab Plus Lenalidomide and Dexamethasone (D-Rd) Versus Lenalidomide and Dexamethasone (Rd) in Patients with Newly Diagnosed Multiple Myeloma (NDMM) Ineligible f...
  Robert Z. Orlowski, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Comprehensive Investigation of White Blood Cell and Gene Expression Profiles As Risk Factors for Multiple Myeloma in African Americans
  Robert Z. Orlowski, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Depth of Response to Daratumumab (DARA), Lenalidomide, Bortezomib, and Dexamethasone (RVd) Improves over Time in Patients (pts) with Transplant-Eligible Newly Diagnose...
  Robert Z. Orlowski, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Outcomes of Lenalidomide Retreatment with Novel Triplet Regimens in Multiple Myeloma Patients Progressing on Lenalidomide-Based Maintenance Therapy: A Single Center Re...
  Robert Z. Orlowski, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• A Multicenter Phase II Single Arm Trial of Isatuximab in Patients with High Risk Smoldering Multiple Myeloma (HRSMM)
  Robert Z. Orlowski, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Cord Blood Regulatory T Cells Prevent Mutiple Myeloma Progression By Suppressing Inflammation
  Robert Z. Orlowski, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Phase 2 Study of the Response and Safety of P-Bcma-101 CAR-T Cells in Patients with Relapsed/Refractory (r/r) Multiple Myeloma (MM) (PRIME)Clinically Relevant Abstract
  Robert Z. Orlowski, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
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Lectures

• Addressing Current Questions and Controversies in the Management of Multiple Myeloma, Amyloidosis and Waldenstr_m Macroglobulinemia (Part 2 of a 2-Part Series) 
  61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
• Longer Term Follow up of the  Randomized Phase III Trial SWOG S0777: Bortezomib, Lenalidomide and Dexamethasone Vs. Lenalidomide and Dexamethasone in Patients (Pts) w... 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Outcome of Autologous Stem Cell Transplantation in Waldenström's Macroglobulinemia 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Updated Results of a Phase II Study of Lenalidomide-Elotuzumab As Maintenance Therapy Post-Autologous Stem Cell Transplant (AuSCT) in Patients (Pts) with Multiple Myel... 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• African-American Patients with Monoclonal Gammopathy Have a Reduced Risk of Transformation to Clinical Myeloma: Results of a Prospective Study SWOG S0120 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Older Age As a Prognostic Factor for Overall Survival for Multiple Myeloma Patients Undergoing Upfront Autologous Hematopoietic Stem Cell Transplantation 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
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