RussellWJenkinsMDPhD

Oncology • Boston, MA

Hematologic Oncology, Melanoma

Instructor

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Office
MGH Cancer Center
55 Street, Jackson 904B
Boston, MA 02114
Phone+1 617-726-9372

Fax+1 844-542-5959
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Education & Training

Brigham and Women's Hospital/Massachusetts General Hospital/Dana-Farber Cancer InstituteFellowship, Hematology and Medical Oncology, 2014 - 2018
Massachusetts General HospitalResidency, Internal Medicine, 2013 - 2014
Massachusetts General HospitalInternship, Internal Medicine, 2012 - 2013
Medical University of South CarolinaClass of 2012

Certifications & Licensure

MA State Medical License 2015 - 2026
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Publications & Presentations

PubMed

Mesothelin CAR T Cells Secreting Anti-FAP/Anti-CD3 Molecules Efficiently Target Pancreatic Adenocarcinoma and its Stroma.
Marc Wehrli, Samantha Guinn, Filippo Birocchi, Adam Kuo, Yi Sun, Rebecca C Larson, Antonio J Almazan, Irene Scarfò, Amanda A Bouffard, Stefanie R Bailey, Praju Vikas A...> ;Clinical Cancer Research. 2024 May 1
DrugMap: A quantitative pan-cancer analysis of cysteine ligandability.
Mariko Takahashi, Harrison B Chong, Siwen Zhang, Tzu-Yi Yang, Matthew J Lazarov, Stefan Harry, Michelle Maynard, Brendan Hilbert, Ryan D White, Heather E Murrey, Chih-...> ;Cell. 2024 Apr 17
1 citations
Emerging roles of TBK1 in cancer immunobiology.
Alex Miranda, Carl A Shirley, Russell W Jenkins> ;Trends in Cancer. 2024 Mar 21
Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy.
Or-Yam Revach, Angelina M Cicerchia, Ofir Shorer, Boryana Petrova, Seth Anderson, Joshua Park, Lee Chen, Arnav Mehta, Samuel J Wright, Niamh McNamee, Aya Tal-Mason, Gi...> ;Biorxiv. 2024 Mar 26
3 citations
Translational Studies Using the MALT1 Inhibitor ()-Mepazine to Induce Treg Fragility and Potentiate Immune Checkpoint Therapy in Cancer.
Mauro Di Pilato, Yun Gao, Yi Sun, Amina Fu, Carina Grass, Thomas Seeholzer, Regina Feederle, Irina Mazo, Samuel W Kazer, Kevin Litchfield, Ulrich H von Andrian, Thorst...> ;Journal of Immunotherapy and Precision Oncology. 2023 May 1
26 citations
Targeting TBK1 to overcome resistance to cancer immunotherapy.
Yi Sun, Or-Yam Revach, Seth Anderson, Emily A Kessler, Clara H Wolfe, Anne Jenney, Caitlin E Mills, Emily J Robitschek, Thomas G R Davis, Sarah Kim, Amina Fu, Xiang Ma...> ;Nature. 2023 Mar 1
Distinct Dynamics of Migratory Response to PD-1 and CTLA-4 Blockade Reveals New Mechanistic Insights for Potential T-Cell Reinvigoration following Immune Checkpoint Bl...
Fateme Safaeifard, Bahram Goliaei, Amir R Aref, Mohammad-Hadi Foroughmand-Araabi, Sama Goliaei, Russell W Jenkins, David A Barbie, Seyed Peyman Shariatpanahi, Curzio R...> ;Cells. 2022 Nov 8
11 citations
Going with the Flow: Modeling the Tumor Microenvironment Using Microfluidic Technology
Hongyan Xie, Jackson W. Appelt, Russell W. Jenkins> ;Cancers. 2021 Dec 1
42 citations
Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma.
Meng-Ju Wu, Lei Shi, Juan Dubrot, Joshua Merritt, Vindhya Vijay, Ting-Yu Wei, Emily Kessler, Kira E Olander, Ramzi Adil, Amaya Pankaj, Krishna S. Tummala, Vajira Weere...> ;Cancer Discovery. 2021 Nov 30
128 citations
Mapping the immune environment in clear cell renal carcinoma by single-cell genomics.
Ajaykumar Vishwakarma, Andrew P. Voigt, Andrew M. Bellizzi, Jacob Kaplan, Kenneth G. Nepple, Aliasger K. Salem, Russell W. Jenkins, Yousef Zakharia, Weizhou Zhang, Nic...> ;Communications Biology. 2021 Jan 27
29 citations
Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockade
Kartik Sehgal, Andrew Portell, Elena Ivanova, Patrick H. Lizotte, Navin R. Mahadevan, Jonathan R. Greene, Amir Vajdi, Carino Gurjao, Tyler Teceno, Luke J. Taus, Tran C...> ;The Journal of Clinical Investigation. 2021 Jan 19
171 citations
Treatment of Advanced Melanoma in 2020 and Beyond.
Russell W. Jenkins, David E. Fisher> ;The Journal of Investigative Dermatology. 2021 Jan 1
20 citations
Targeting TANK-binding kinase 1 (TBK1) in cancer.
Or-Yam Revach, Shuming Liu, Russell W. Jenkins> ;Expert Opinion on Therapeutic Targets. 2020 Oct 5
75 citations
Mechanisms of Resistance to Immune Checkpoint Blockade.
David Liu, Russell W. Jenkins, Ryan J. Sullivan> ;American Journal of Clinical Dermatology. 2019 Feb 1
152 citations
Erratum: Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma (Cell (2018) 175(4) (998–1013.e20), (S0092867418313941) (10.1016/j.cel...
Moshe Sade-Feldman, Keren Yizhak, Stacey L. Bjorgaard, John P. Ray, Carl G. de Boer, Russell W. Jenkins, David J. Lieb, Jonathan H. Chen, Dennie T. Frederick, Michal B...> ;Cell. 2019 Jan 10
689 citations
A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade
Livnat Jerby-Arnon, Parin Shah, Michael S. Cuoco, Christopher Rodman, Mei-Ju Su, Johannes C. Melms, Rachel Leeson, Abhay Kanodia, Shaolin Mei, Jia-Ren Lin, Shu Wang, B...> ;Cell. 2018 Nov 1
531 citations
Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma.
Moshe Sade-Feldman, Keren Yizhak, Stacey L Bjorgaard, John P Ray, Carl G de Boer, Russell W Jenkins, David J Lieb, Jonathan H Chen, Dennie T Frederick, Michal Barzily-...> ;Cell. 2018 Nov 1
117 citations
3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade
Amir Reza Aref, Marco Campisi, Elena Ivanova, Andrew Portell, Dalia Larios, Brandon Piel, Natasha Mathur, Chensheng Zhou, Raven Vlahos Coakley, Alan Bartels, Michaela ...> ;Lab on a Chip. 2018 Oct 9
38 citations
Assessing Therapeutic Efficacy of MEK Inhibition in a KRASG12C-Driven Mouse Model of Lung Cancer.
Shuai Li, Shengwu Liu, Jiehui Deng, Esra A. Akbay, Josephine Hai, Chiara Ambrogio, Long Zhang, Fangyu Zhou, Russell W. Jenkins, Dennis Adeegbe, Peng Gao, Xiaoen Wang, ...> ;Clinical Cancer Research. 2018 Oct 1
168 citations
Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses
Israel Cañadas, Rohit Thummalapalli, Jong Wook Kim, Shunsuke Kitajima, Russell W. Jenkins, Camilla L. Christensen, Marco Campisi, Yanan Kuang, Yanxi Zhang, Evisa Gjini...> ;Nature Medicine. 2018 Aug 1
31 citations
Molecular and Genomic Determinants of Response to Immune Checkpoint Inhibition in Cancer
Russell W. Jenkins, Rohit Thummalapalli, Jacob Carter, Israel Cañadas, David A. Barbie> ;Annual Review of Medicine. 2018 Jan 29
837 citations
Mechanisms of resistance to immune checkpoint inhibitors.
Russell W. Jenkins, David A. Barbie, Keith T. Flaherty> ;British Journal of Cancer. 2018 Jan 2
402 citations
CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation
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308 citations
Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids
, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , > ;Cancer Discovery. 2017 Nov 3
29 citations
Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States
Jong Wook Kim, Omar O. Abudayyeh, Huwate Yeerna, Chen-Hsiang Yeang, Michelle Stewart, Russell W. Jenkins, Shunsuke Kitajima, David J. Konieczkowski, Kate Medetgul-Erna...> ;Cell Systems. 2017 Aug 23
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Journal Articles

Tumor Innate Immunity Primed by Specific Interferon-Stimulated Endogenous Retroviruses
Scott Rodig, Ewa Sicinska, Thanh Uyen Barbie, David Allen Barbie, Russell William Jenkins, Ravindra Uppaluri, Rohit Thummalapalli, Jacob Sands, Nature