SamuelFBakhoumMDPh.D.

PubMed

• Molecular and Clinical Determinants of Acquired Resistance and Treatment Duration for Targeted Therapies in Colorectal Cancer.
  Emily Harrold, Fergus Keane, Henry Walch, Joanne F Chou, Jenna Sinopoli, Silvia Palladino, Duaa H Al-Rawi, Kalyani Chadalavada, Paolo Manca, Sree Chalasani, Jessica Ya...> ;Clinical Cancer Research. 2024 Mar 19
• Intratumoral TREX1 induction promotes immune evasion by limiting type I interferon.
  Toufektchan, E., Dananberg, A., Striepen, J., Hickling, J., Shim, A., Chen, Y., Nichols, A., Duran Paez, M., Mohr, L., Maciejowski, J., Bakhoum, S.> ;Cancer Immunology Research. 2024 Feb 26
• Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation.
  Meri Rogava, Tyler J Aprati, Wei-Yu Chi, Johannes C Melms, Clemens Hug, Stephanie H Davis, Ethan M Earlie, Charlie Chung, Sachin K Deshmukh, Sharon Wu, George Sledge, ...> ;Nature Cancer. 2024 Mar 1
• Micronuclei and Cancer.
  Di Bona, M., Bakhoum, S.> ;Cancer Discovery. 2024 Feb 8
• 3 citations
  The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance.
  Deborah R Caswell, Philippe Gui, Manasi K Mayekar, Emily K Law, Oriol Pich, Chris Bailey, Jesse Boumelha, D Lucas Kerr, Collin M Blakely, Tadashi Manabe, Carlos Martin...> ;Nature Genetics. 2024 Jan 1
• 27 citations
  Non-cell-autonomous cancer progression from chromosomal instability.
  Jun Li, Melissa J Hubisz, Ethan M Earlie, Mercedes A Duran, Christy Hong, Austin A Varela, Emanuele Lettera, Matthew Deyell, Bernardo Tavora, Jonathan J Havel, Su M Ph...> ;Nature. 2023 Aug 1
• 30 citations
  Epigenetic dysregulation from chromosomal transit in micronuclei.
  Albert S Agustinus, Duaa Al-Rawi, Bhargavi Dameracharla, Ramya Raviram, Bailey S C L Jones, Stephanie Stransky, Lorenzo Scipioni, Jens Luebeck, Melody Di Bona, Danguol...> ;Nature. 2023 Jul 1
• 11 citations
  Mitotic clustering of pulverized chromosomes from micronuclei.
  Yu-Fen Lin, Qing Hu, Alice Mazzagatti, Jose Espejo Valle-Inclán, Elizabeth G Maurais, Rashmi Dahiya, Alison Guyer, Jacob T Sanders, Justin L Engel, Giaochau Nguyen, Da...> ;Nature. 2023 Jun 1
• Unjamming tumour cell invasion through cGAS-STING.
  Matthew Deyell, Samuel F Bakhoum> ;Nature Materials. 2023 May 1
• 3 citations
  Targeting the undruggable.
  Samuel F Bakhoum> ;Science. 2023 Apr 7
• 3 citations
  Innate immune signaling drives late cardiac toxicity following DNA-damaging cancer therapies.
  Achraf Shamseddine, Suchit H Patel, Valery Chavez, Zachary R Moore, Mutayyaba Adnan, Melody Di Bona, Jun Li, Chau T Dang, Lakshmi V Ramanathan, Kevin C Oeffinger, Jenn...> ;The Journal of Experimental Medicine. 2023 Mar 6
• APOBEC3 as a driver of genetic intratumor heterogeneity.
  Venkatesan, S., Angelova, M., Bartkova, J., Bartek, J., Kanu, N., Swanton, C., Bakhoum, S.> ;Molecular & Cellular Oncology. 2023 Jan 1
• 3 citations
  Intra-tumor heterogeneity, turnover rate and karyotype space shape susceptibility to missegregation-induced extinction.
  Gregory J Kimmel, Richard J Beck, Xiaoqing Yu, Thomas Veith, Samuel Bakhoum, Philipp M Altrock, Noemi Andor> ;Plos Computational Biology. 2023 Jan 1
• 44 citations
  Ovarian cancer mutational processes drive site-specific immune evasion.
  Ignacio Vázquez-García, Florian Uhlitz, Nicholas Ceglia, Jamie L P Lim, Michelle Wu, Neeman Mohibullah, Juliana Niyazov, Arvin Eric B Ruiz, Kevin M Boehm, Viktoria Boj...> ;Nature. 2022 Dec 1
• 2 citations
  The pleiotropic roles of cGAS-STING signaling in the tumor microenvironment.
  Jun Li, Samuel F Bakhoum> ;Journal of Molecular Cell Biology. 2022 Aug 5
• 2 citations
  cGAS-STING and the deadly CIN: how chronic inflammation represents a therapeutic vulnerability in chromosomally unstable cancers.
  Samuel F Bakhoum> ;Trends in Cancer. 2022 Oct 1
• 45 citations
  Dissecting the treatment-naive ecosystem of human melanoma brain metastasis.
  Jana Biermann, Johannes C Melms, Amit Dipak Amin, Yiping Wang, Lindsay A Caprio, Alcida Karz, Somnath Tagore, Irving Barrera, Miguel A Ibarra-Arellano, Massimo Andreat...> ;Cell. 2022 Jul 7
• 12 citations
  Chromosomal instability as a source of genomic plasticity.
  Duaa H Al-Rawi, Samuel F Bakhoum> ;Current Opinion in Genetics & Development. 2022 Jun 1
• 184 citations
  Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients.
  Bastien Nguyen, Christopher Fong, Anisha Luthra, Shaleigh A Smith, Renzo G DiNatale, Subhiksha Nandakumar, Henry Walch, Walid K Chatila, Ramyasree Madupuri, Ritika Kun...> ;Cell. 2022 Feb 3
• Biochemical, genomic, and epigenomic profiling of isolated cancer cell lines' micronuclei.
  Albert S Agustinus, Samuel Bakhoum> ;Methods in Cell Biology. 2022 Jan 1
• 1 citations
  APOBEC3A drives STING-dependent metastasis.
  Samuel F Bakhoum> ;Nature Cancer. 2021 Dec 1
• 9 citations
  Author Correction: A molecular single-cell lung atlas of lethal COVID-19.
  , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , > ;Nature. 2021 Oct 8
• 1 citations
  Co-targeting TGF-β and PD-L1 with radiation therapy: The Goldilocks principle.
  Samuel F. Bakhoum, Charles M. Rudin> ;Cell Reports. Medicine. 2021 Sep 21
• 24 citations
  Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression.
  Mathieu F. Bakhoum, Jasmine H. Francis, Albert Agustinus, Ethan M. Earlie, Melody Di Bona, David H. Abramson, Mercedes Duran, Ignas Masilionis, Elsa Molina, Alexander ...> ;Nature Communications. 2021 Sep 13
• 17 citations
  The clinical and molecular significance associated with STING signaling in breast cancer.
  Eileen Parkes, Matthew P. Humphries, Elaine Gilmore, Fatima Abdullahi Sidi, Victoria Bingham, Su M. Phyu, Stephanie G Craig, Catherine Graham, Joseph Miller, Daryl Gri...> ;NPJ Breast Cancer. 2021 Jun 25
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Journal Articles

• A Markov Chain for Numerical Chromosomal Instability in Clonally Expanding Populations  
  Samuel Bakhoum, MD, PLoS One
• Insights into Clonal Haematopoiesis from 8,342 Mosaic Chromosomal Alterations  
  Samuel F Bakhoum, Yakir A Reshef, Nature