
Simon C. Robson MD PhD, FAASLD (He/Him)
Gastrointestinal Cancer, Hepatology & Liver Transplantation, Inflammatory Bowel Disease
Professor, Medicine and Anesthesiology, Vice Chair Research, Beth Israel Deaconess Medical Center, Harvard Medical School
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330 Brookline AvenueBeth Israel Deaconess Medical CenterBoston, MA 02215
Phone+1 617-632-1070
Fax+1 617-632-1861
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Summary
- Dr. Simon C. Robson is a Physician Scientist based in Boston, MA, with subspecialties in Hepatology, Transplantation, and in GI. He completed his medical education and training at the University of Cape Town/Groote Schuur Hospital and at Addenbrookes Hospital, Cambridge. He held post-doctoral fellowships at Kings College Hospital, London and Beth Israel Deaconess Medical Center in Boston after his Ph.D. was awarded. Dr. Robson holds several prominent positions, including Vice Chairman in Anesthesia at Beth Israel Lahey Health and Professor at Harvard Medical School. His expertise encompasses molecular mechanisms of inflammation. He has contributed extensively to basic research and discovery in the area of purinergic signaling, with numerous publications and involvement in clinical trials. Dr. Robson has received several honors, including plenary lectureships and teaching awards, highlighting his influence in the field.
Clinical Expertise
- Hepatology, Viral hepatitides, Hepatic cirrhosis, Immunophenotyping, Hepatocellular cancer, Colon cancer, Infections and inflammation, MASLD
Education & Training
- Beth Israel Deaconess Medical CenterPost-Doctoral Fellowship, 1993 - 1996
- University of Cape TownPhD, Immunology, 1985 - 1989
- Kings College HospitalMRCP, 1982 - 1983
- University of Cape Town Faculty of MedicineClass of 1978
Work Experience
- Beth Israel Lahey HealthVice Chairman · January 2018 - Current
- HMS and BIDMCProfessor · July 2006 - Current
- Harvard Medical SchoolProfessor · January 1996 - Current
- Harvard Medical SchoolVisiting Associate Professor · January 1995 - Current
- Beth Israel Deaconess Medical Center (Boston, MA)Project Leader And Pi · January 1994 - Current
- Harvard Medical SchoolProfessor · January 1993 - Current
- Beth Israel Deaconess Health SystemAttending Physician ·
- University of Cape Town, Liver CenterSenior Lecturer (Hon.) · January 1997 - Current
- Liver Clinic, Groote Schuur HospitalMedical Staff · January 1995 - January 1996
- Center for Immunobiology, Harvard Medical SchoolAssociate Scientist · January 1993 - January 1997
- Groote Schuur HospitalSenior Specialist · January 1989 - January 1991
- Schuur HospitalSenior Specialist · January 1989 - January 1991
- Saunders and Kirsch FirmsSpecialist Physician · January 1987 - January 1989
- University of Cape Town and MRC, Liver CenterSpecialist Scientist, Medical Research Council (Mrc) · January 1987 - January 1989
- Saunders and Kirsch Firms, GrooteSpecialist Physician · January 1987 - January 1989
- University of Cape Town, Groote Schuur Hospital and Affiliated Teaching HospitalsParticipant And Organizer · January 1987 - January 1993
- University of Cape Town and Medical Research Council of South Africa Liver CenterFull Time Consultant And Specialist Physician · January 1987 - January 1993
- Groote Schuur Hospital and Red Cross Children's HospitalSenior House Officer · - January 1980
- Warwick HospitalMedical Officer · - January 1982
Certifications & Licensure
- MA State Medical License 1997 - 2026
- American Board of Internal Medicine Internal Medicine
Awards, Honors, & Recognition
- Plenary and Keynote Lectures PURINES2018, PURINES2022, 2018, 2022
- John Hedley-Whyte Lectureship Anesthesia, BIDMC, 2021
- Subcommittee of Professors Harvard Medical School, 2018, 2020-2021
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Clinical Trials
- Identification of Genetic Causes of Calcific Aortic Valve Disease Start of enrollment: 2018 Sep 25
- Purinergic Signaling and the Postmenopausal Heart Start of enrollment: 2019 Jul 01
- Safety of PUR001 Monotherapy in Patients With Advanced Solid Tumors Start of enrollment: 2022 Apr 28
Publications & Presentations
PubMed
- NTPDase8 Protects Against Liver Ischemia-Reperfusion Injury in Mice.Taha Kelestemur, Simon C Robson, Zoltán H Németh, Pal Pacher, Muhammed Arif
FASEB Journal. 2025-07-15 - Targeting the CD39/CD73 pathway: New insights into cardiac fibrosis and inflammation in female cardiac surgery patients.Eitezaz Mahmood, Mark Robitaille, Yifan Bu, Adnan Khan, Marie-France Poulin
Journal of Molecular and Cellular Cardiology Plus. 2025-06-01 - Endothelial -targeted CD39 is protective in a mouse model of global forebrain ischaemia.Natasha Ting Lee, Ioanna Savvidou, Carly Selan, David K Wright, Robert Brkljaca
Journal of Neuroinflammation. 2025-04-21
Journal Articles
- Adenosine generation by CD39 and CD73 on T regulatory cells mediates immune suppressionDeaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, Chen JF, Enjyoji K, Linden J, Oukka M, Kuchroo VK, Strom TB, Robson SC, The Journal of Experimental Medicine, 1/1/2007
- Purinergic Signaling during InflammationEltzschig HK, Sitkovsky MV, Robson SC, N Engl J Med, 12/13/2012
- Pulmonary natural killer T cells play an essential role in mediating hyperoxic acute lung injuryNowak-Machen M, Schmelzle M, Hanidziar D, Junger W, Exley M, Otterbein L, Wu Y, Csizmadia E, Doherty G, Sitkovsky M, Robson SC, Am J Respir Cell Mol Biol, 5/1/2013
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Books/Book Chapters
Abstracts/Posters
- Adenosine A1 and A2A Receptors. CD39/CD73KO Influence Granulomatousresponses to BCGKara FM, Montesinos MC, Mor A, Robson SC, Thompson L, Cronstein BN, 8th International Symposium on Adenosine and Adenine Nucleotides, Ferrara, Italy, 5/1/2006
- Lower Risk of Cardiac Rupture in CD39 Null Mice Post-myocardial InfarctionOgawa M, Ogawa N, Nakayama M, Csizmadia E, Enjyoji K, Kohzuki M, Robson SC, J. American College of Cardiology, 1/1/2005
- Transcription Factor YY1 and the Retinoblastoma Protein Are Downstream Targets of CD39/ENTPD1 Signaling Pathways during Liver RegenerationWu Y, Imai M, Sun X, Csizmadia E, Enjyoji K, Choi C, Robson SC,Usheva A, Hepatology, 1/1/2005
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Lectures
- Vascular Biology of CD39 and Transplantation TopicsDepartment of Gastroenterology, BIDMC - 1/1/2021
- Vascular Bed-specific Characteristics of Endothelial CellsDepartment of Gastroenterology, Mount Sinai Hospital, NY - 1/1/2013
- Purinergic Signaling in the LiverLondon, UK - 1/1/2013
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Other
- Hepatic Xenotransplantation. Transplant Report
1/1/1995 - Contributions to Reports in Cape Times, Hepatitis B Immunizations and Liver TransplantationRobson
1/1/1993 - Audio-mix, and Pathways to HealthRadio Today
1/1/1993 - Join now to see all
Grant Support
- T cell genotype/phenotype influence on atherosclerotic cardiovascular disease.NIH2023–2027
- Targeting ENTPD3 to boost extracellular ATP and inflame tumors.Emerson Collective CRF2021–2023
- PGC-1α, Purines and the Postmenopausal Heart.NIH NIA2021–2023
- DAMP-Mediated Innate Immune Failure and Pneumonia .....DoD2016–2022
- Directed Purinergic Signaling as Immunotherapy in LeukemiaNIH NCI2018–2020
- Engineering Inhibitory Antibodies To Ectoenzymes For Cancer TreatmentNational Cancer Institute2012
- Thromboregulatory Barriers To XenotransplantationNational Institute Of Allergy And Infectious Diseases2000–2011
- Purinergic ThromboregulationNational Heart, Lung, And Blood Institute2009–2010
- Thromboregulatory Strategies To Prolong Xenograft Survival.National Institute Of Allergy And Infectious Diseases2006–2009
- Vascular Topography Of Cd39/NtpdasesNational Heart, Lung, And Blood Institute2004–2008
- Core--Histological SupportNational Heart, Lung, And Blood Institute2004–2008
- Functional Analysis Of Vascular NtpdasesNational Heart, Lung, And Blood Institute2000–2007
- Thromboregulatory Strategies To Prolong XenograftsNational Institute Of Allergy And Infectious Diseases2005
- Vascular Ntpdases And TransplantationNational Heart, Lung, And Blood Institute2001–2004
- Vascular Ecto Adpases And TransplantationNational Heart, Lung, And Blood Institute1997–2000
Committees
- Member, SOP HMS 2018 - 2021
Research History
- Vice Chair Research AnesthesiaDirector of Center for Inflammation Research2019 - Present
Professional Memberships
- AASLDMember
- Member
Other Languages
- Dutch
Industry Relationships
- Scientific Founder, ePURINES2018 - Present
- Scientific Founder, Purinomia2017 - Present
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