
Stephen Douglas Smith MD
Associate Professor, Fred Hutchinson Cancer Center
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825 Eastlake Ave E # G3-200Seattle, WA 98109
Phone+1 206-606-6832
Fax+1 206-606-6831
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Summary
- Dr. Stephen Smith is a hematologist based in Seattle, WA, with a comprehensive background in immunotherapy, lymphoma, stem cell transplantation, and CAR T-cell therapy. He completed his residency in Internal Medicine at USC/LA General, and his fellowship in Hematology and Medical Oncology at Cleveland Clinic Foundation. His research contributions include several publications on lymphoma and hematologic malignancies. Dr. Smith has served as a principal investigator in numerous clinical trials related to B-cell malignancies and lymphoma.
Clinical Expertise
- Immunotherapy, Lymphoma, Stem cell transplantation, CAR T-cell Therapy
Education & Training
Cleveland Clinic FoundationFellowship, Hematology and Medical Oncology, 2005 - 2008
University of Southern California/Los Angeles General Medical Center (USC/LA General)Residency, Internal Medicine, 2002 - 2005
Keck School of Medicine of the University of Southern CaliforniaClass of 2002
Certifications & Licensure
CA State Medical License 2003 - Present
OR State Medical License 2011 - Present
WA State Medical License 2013 - 2028
OH State Medical License 2005 - 2012
American Board of Internal Medicine Hematology
Awards, Honors, & Recognition
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory - Core EMR, Epic Systems Corporation, 2013
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012
Clinical Trials
- Loncastuximab Tesirine for the Treatment of Relapsed or Refractory B-Cell Malignancies Start of enrollment: 2023 Aug 07
Roles: Contact, Principal Investigator
- Tafasitamab, Retifanlimab, and Rituximab in Combination With Standard Therapy for the Treatment of Diffuse Large B-cell Lymphoma Start of enrollment: 2023 Jan 26
Roles: Contact, Principal Investigator
- Modified VR-CAP and Acalabrutinib as First Line Therapy for the Treatment of Transplant-Eligible Patients With Mantle Cell Lymphoma Start of enrollment: 2021 Aug 03
Roles: Principal Investigator, Contact
Publications & Presentations
PubMed
- Outcomes From the Multicenter ACCRU-LY-1804/CARiBOU TRIAL (Cytarabine, Acalabrutinib and Rituximab Integrated With Bortezomib-Based Outpatient Therapy) in 1st Line Man...Stephen D Smith, Suchitra Sundaram, Sharmila Giri, Andy Ness, Yucai Wang
American Journal of Hematology. 2026-09-01 - Incidence and clinical impact of absolute lymphocyte count-only progression in chronic lymphocytic leukemia.Xiancheng Wu, Mazyar Shadman, Jenna M Voutsinas, Daniel S Hippe, Timothy Randolph
Blood Advances. 2026-07-16 - Real-world evidence for pembrolizumab gemcitabine vinorelbine and liposomal doxorubicin in classical Hodgkin lymphoma.Grace Baek, Gaurav Varma, Samuel Yamshon, Herman van Besien, Nancy L Bartlett
Blood Advances. 2026-05-26
Journal Articles
- Twice‐Weekly Ixazomib in Combination with Lenalidomide‐Dexamethasone in Patients with Newly Diagnosed Multiple MyelomaMyo Htut, Michaela Liedtke, Stephen D Smith, Craig C Hofmeister, Rachid Baz, Paul G Richardson, Cara A Rosenbaum, David H Vesole, Ajai Chari, Jesus G Berdeja, Noopur Raje, British Journal of Haematology
Abstracts/Posters
- A Phase 2 Study of the Dual SYK/JAK Inhibitor Cerdulatinib Demonstrates Good Tolerability and Clinical Response in Relapsed/Refractory Peripheral T-Cell Lymphoma and C...Stephen D. Smith, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
- Outcome of Autologous Stem Cell Transplantation Following PD-(L)1 Based Salvage Therapy for Multiply Relapsed Patients with Classic Hodgkin LymphomaStephen D. Smith, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
- Relapsed or Refractory CLL after CD19-Specific CAR-T Therapy: Treatment Patterns and Clinical OutcomesStephen D. Smith, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Lectures
- Rapid and Durable Responses with the SYK/JAK Inhibitor Cerdulatinib in a Phase 2 Study in Relapsed/Refractory Follicular Lymphoma„Alone or in Combination with Rituximab61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
- Exploring the Present and Future of BTK Inhibition in B-Cell Malignancies: Expert Insights on Practical Implications for Patient Management60th American Society of Hematology Annual Meeting - 11/30/2018
Authored Content
- Mantle Cell Lymphoma at ASH 2022 – More Answers, and More QuestionsDecember 2022
Press Mentions
SCCA’s Immunotherapy Leaders Featured at the American Society of Clinical Oncology (ASCO) Annual MeetingMay 31st, 2018
Professional Memberships
- Member
- Member
- NCCNB-Cell Malignancies, Panel Member
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