ThomasT.PerlsMD

PubMed

• Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease.
  Wisniewski, T., Wisniewski, T., Laura Xicota, Stephanie Cosentino, Badri Vardarajan, Richard Mayeux, Thomas T Perls, Stacy L Andersen, Joseph M Zmuda, Bharat Thyagaraj...> ;Alzheimer's & Dementia. 2024 Apr 1
• The relationship between 11 different polygenic longevity scores, parental lifespan, and disease diagnosis in the UK Biobank.
  Janith Don, Andrew J Schork, Gwênlyn Glusman, Noa Rappaport, Steve R Cummings, David Duggan, Anish Raju, Kajsa-Lotta Georgii Hellberg, Sophia Gunn, Stefano Monti, Thom...> ;Geroscience. 2024 Mar 7
• SuperAger Initiative: unlocking the genetic potential of exceptional longevity.
  Sofiya Milman, Nir Barzilai, Kara A Wilson, Odette Van der Willik, Stephanie Lederman, Thomas Perls, Tina Gao, Aoife McGovern Leahy, Praduman Jain, Aisha Montgomery, A...> ;Nature Aging. 2023 Jun 1
• 1 citations
  Signatures of Neuropsychological Test Results in the Long Life Family Study: A Cluster Analysis.
  Qingyan Xiang, Stacy L Andersen, Benjamin Sweigart, Sophia Gunn, Marianne Nygaard, Thomas T Perls, Paola Sebastiani> ;Journal of Alzheimer's Disease. 2023 Jan 1
• Mosaic Chromosomal Alterations and Human Longevity.
  Anastasia Leshchyk, Qingyan Xiang, Stacy L Andersen, Anastasia Gurinovich, Zeyuan Song, Joseph H Lee, Kaare Christensen, Anatoliy Yashin, Mary Wojczynski, Karen Schwan...> ;The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2023 Aug 27
• 14 citations
  Multi-modal profiling of peripheral blood cells across the human lifespan reveals distinct immune cell signatures of aging and longevity.
  Tanya T Karagiannis, Todd W Dowrey, Carlos Villacorta-Martin, Monty Montano, Eric Reed, Anna C Belkina, Stacy L Andersen, Thomas T Perls, Stefano Monti, George J Murph...> ;Ebiomedicine. 2023 Apr 1
• Successful aging and its subtypes in centenarians: The Chinese experience.
  Thomas Perls> ;Journal of the American Geriatrics Society. 2023 May 1
• Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci.
  de Las Fuentes, L., Schwander, K., Brown, M., Bentley, A., Winkler, T., Sung, Y., Munroe, P., Miller, C., Aschard, H., Aslibekyan, S., Bartz, T., Bielak, L., Chai, J.,...> ;Frontiers in Genetics. 2023 Jan 1
• 1 citations
  A Genome-Wide Association Study of 2304 Extreme Longevity Cases Identifies Novel Longevity Variants.
  Harold Bae, Anastasia Gurinovich, Tanya T Karagiannis, Zeyuan Song, Anastasia Leshchyk, Mengze Li, Stacy L Andersen, Konstantin Arbeev, Anatoliy Yashin, Joseph Zmuda, ...> ;International Journal of Molecular Sciences. 2022 Dec 21
• A metabolomic signature of the APOE2 allele.
  Paola Sebastiani, Zeyuan Song, Dylan Ellis, Qu Tian, Michaela Schwaiger-Haber, Ethan Stancliffe, Michael S Lustgarten, Cory C Funk, Priyanka Baloni, Cong-Hui Yao, Shak...> ;Geroscience. 2023 Feb 1
• Association between late maternal age and age-related endophenotypes in the Long Life Family Study.
  Sandra Barral, Stacy L Andersen, Thomas T Perls, Harold Bae, Paola Sebastiani, Kaare Christensen, Bharat Thyagarajan, Joseph Lee, Nicole Schupf> ;Neuroscience Letters. 2022 Jul 27
• 2 citations
  Evaluation of GENESIS, SAIGE, REGENIE and fastGWA-GLMM for genome-wide association studies of binary traits in correlated data.
  Anastasia Gurinovich, Mengze Li, Anastasia Leshchyk, Harold Bae, Zeyuan Song, Konstantin G Arbeev, Marianne Nygaard, Mary F Feitosa, Thomas T Perls, Paola Sebastiani> ;Frontiers in Genetics. 2022 Jan 1
• 4 citations
  Digitally generated Trail Making Test data: Analysis using hidden Markov modeling.
  Mengtian Du, Stacy L Andersen, Stephanie Cosentino, Robert M Boudreau, Thomas T Perls, Paola Sebastiani> ;Alzheimer's & Dementia. 2022 Jan 1
• 18 citations
  NIA Long Life Family Study: Objectives, Design, and Heritability of Cross Sectional and Longitudinal Phenotypes.
  Mary K. Wojczynski, Shiow Jiuan Lin, Paola Sebastiani, Thomas T. Perls, Joseph K. T. Lee, Alexander M. Kulminski, Anne B. Newman, J. M. Zmuda, Kaare Christensen, Micha...> ;The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2021 Nov 5
• 14 citations
  Association of fatigue, inflammation, and physical activity on gait speed: the Long Life Family Study
  Sharon W Renner, Yujia (Susanna) Qiao, Theresa Gmelin, Adam J. Santanasto, Robert M. Boudreau, Jeremy D. Walston, Thomas T. Perls, Kaare Christensen, Anne B. Newman, N...> ;Aging Clinical and Experimental Research. 2021 Jul 1
• Correction to: Effect of longevity genetic variants on the molecular aging rate
  Anastasia Gurinovich, Zeyuan Song, William B. Zhang, Anthony Federico, Stefano Monti, Stacy L. Andersen, Lori L. Jennings, David J. Glass, Nir Barzilai, Sofiya Millman...> ;Geroscience. 2021 Jun 18
• 10 citations
  Effect of longevity genetic variants on the molecular aging rate
  Anastasia Gurinovich, Zeyuan Song, William B. Zhang, Anthony Federico, Stefano Monti, Stacy L. Andersen, Lori L. Jennings, David J. Glass, Nir Barzilai, Sofiya Millman...> ;Geroscience. 2021 May 4
• 2 citations
  Slower Decline in Processing Speed Is Associated with Familial Longevity
  Stacy L. Andersen, Mengtian Du, Stephanie Cosentino, Nicole Schupf, Andrea L. Rosso, Thomas T. Perls, Paola Sebastiani, Long Life Family Study> ;Gerontology. 2021 May 4
• 2 citations
  Publisher Correction: A meta-analysis of genome-wide association studies identifies multiple longevity genes (Nature Communications, (2019), 10, 1, (3669), 10.1038/s41...
  Joris Deelen, Daniel S. Evans, Dan E. Arking, Niccolò Tesi, Marianne Nygaard, Xiaomin Liu, Mary K. Wojczynski, Mary L. Biggs, Ashley van der Spek, Gil Atzmon, Erin B. ...> ;Nature Communications. 2021 Apr 23
• 37 citations
  Protein signatures of centenarians and their offspring suggest centenarians age slower than other humans
  Paola Sebastiani, Anthony Federico, Melody Morris, Anastasia Gurinovich, Toshiko Tanaka, Kevin B. Chandler, Stacy L. Andersen, Gerald V. Denis, Catherine E. Costello, ...> ;Aging Cell. 2021 Jan 29
• 3 citations
  Studying the Interplay Between Apolipoprotein E and Education on Cognitive Decline in Centenarians Using Bayesian Beta Regression
  Qingyan Xiang, Stacy L. Andersen, Thomas T. Perls, Paola Sebastiani> ;Frontiers in Genetics. 2021 Jan 8
• 2 citations
  Cognitive Trajectories and Resilience in Centenarians-Findings From the 100-Plus Study.
  Thomas T. Perls> ;JAMA Network Open. 2021 Jan 4
• 4 citations
  APOE E2/E2 Is Associated with Slower Rate of Cognitive Decline with Age.
  Benjamin Sweigart, Stacy L. Andersen, Anastasia Gurinovich, Stephanie Cosentino, Nicole Schupf, Thomas T. Perls, Paola Sebastiani> ;Journal of Alzheimer's Disease. 2021 Jan 1
• 5 citations
  Association Between APOE Alleles and Change of Neuropsychological Tests in the Long Life Family Study.
  Mengtian Du, Stacy L. Andersen, Nicole Schupf, Mary F. Feitosa, Megan S. Barker, Thomas T. Perls, Paola Sebastiani> ;Journal of Alzheimer's Disease. 2021 Jan 1
• 7 citations
  Digital Technology Differentiates Graphomotor and Information Processing Speed Patterns of Behavior
  Stacy L. Andersen, Benjamin Sweigart, Nancy W. Glynn, Mary K. Wojczynski, Bharat Thyagarajan, Jonas Mengel-From, Stephen Thielke, Thomas T. Perls, David J. Libon, Rhod...> ;Journal of Alzheimer's Disease. 2021 Jan 1
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Journal Articles

• Reduced Prevalence and Incidence of Cognitive Impairment Among Centenarian Offspring  
  Thomas Perls, MD, The Journals of Gerontology
• Genetics of Human Longevity from Incomplete Data: New Findings from the Long Life Family Study  
  Stephen Thielke, Thomas T Perls, Anne B Newman, The Journals of Gerontology
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  Sebastiani P, Bae H, Sun FX, Andersen SL, Daw EW, Malovini A, Kojima T, Hirose N, Schupf N, Puca A, Perls TT, Aging, 9/1/2013
• Apolipoprotein E and familial longevity  
  Schupf N, Barral S, Perls T, Newman A, Christensen K, Thyagarajan B, Province M, Rossi WK, Mayeux R, Neurobiol Aging, 4/1/2013
• Health span approximates life span amongst many supercentenarians: Compression of morbidity at the approximate limit of life span  
  Andersen S, Sebastiani P, Deworkis D, Feldman L, Perls T, J Gerontol Biol Sci, 1/1/2012
• Genetic Signatures of Exceptional Longevity  
  Sebastiani P, Solovieff N, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Perls TT, Plos One, 1/1/2012
• Whole Genome Sequences of a Male and Female Supercentenarian, ages greater than 114 years  
  Sebastiani P, Riva A, Montano M, Pham P, Torkamani A, Scherba E, Benson G, Milton JN, Baldwin CT, Andersen S, Schork N, Steinberg MH, Perls T, Frontiers in Genetics of Aging, 1/1/2012
• Human longevity and common variations in the LMNA gene: a meta-analysis  
  Conneely KN, Capell BC, Erdos MR, Sebastiani P, Solovieff N, Swift AJ, Baldwin CT, Budagov T, Barzilai N, Atzmon G, Puca AA, Perls TT, Geesaman BJ, Boehnke M, Collins FS, Aging Cell, 1/1/2012
• Within- and between-species study of extreme longevity--comments, commonalities, and goals  
  Michael Anson R, Willcox B, Austad S, Perls T, J Gerontol A Biol Sci Med Sci, 1/1/2012
• The Genetics of Extreme Longevity: Lessons from the New England Centenarian Study  
  Sebastiani P and Perls TT, Front. Gene, 1/1/2012
• 100 Semi-supercentenarians and older as a proposed sample set for the Archon Genomics X PRIZE Validation Protocol  
  Perls T, Barzilai, N, Nature Precedings, 1/1/2011
• Typologies of Extreme Longevity Myths  
  Young RD, Desjardins B, McLaughlin K, Poulain M, Perls T, Current Gerontology and Geriatrics Research, 1/1/2010
• Growth hormone and anabolic steroids: athletes are the tip of the iceberg  
  Perls T, Drug Testing and Analysis, 1/1/2009
• New developments in the illegal provision of growth hormone for "anti-aging" and bodybuilding  
  Olshansky SJ, Perls T, JAMA, 6/1/2008
• Guest editors' response  
  Hayflick L, Olshansky SJ, Perls TT, J Gerontol A Biol Sci Med Sci, 1/1/2005
• Antiaging quackery: Human growth hormone and tricks of the trade, more dangerous than ever  
  Perls, T, J Gerontol Biol Sci, 1/1/2004
• Exceptional Longevity: Winning the environmental-genetic lottery  
  Perls, T, Exp Med, 1/1/2004
• Measuring functional decline in population aging in a changing world and an evolving biology [Commentary on Robine and Michel's "Looking forward to a general theory on...  
  Mor V, Perls TT, J Gerontol Med Sci, 1/1/2004
• Cardiovascular disease delay in centenarian offspring  
  Terry DF, Wilcox MA, McCormick MA, Perls TT, J Gerontol Med Sci, 1/1/2004
• Cardiovascular Disease Delay in Centenarian Offspring: Role of Heat Shock Proteins  
  Terry D, McCormick M, Andersen S, Pennington J, Schoenhofen E, Palaima E, Mambula S, Bausero M, Gor D, Perls T, Asea A, Annals of the New York Acad Sci, 1/1/2004
• Reduced all-cause, cardiovascular and cancer mortality in centenarian offspring  
  Terry DF, Wilcox M, McCormick M, Pennington J, Schoenhofen E, Andersen S, Perls T, J Amer Geriatr Soc, 1/1/2004
• Introduction: Anti-Aging Medicine: The Hype and the Reality—Part I  
  Olshansky SJ, Hayflick L, Perls TT, J Gerontol Series A: Bio Sci Med Sci, 1/1/2004
• Introduction: Anti-Aging Medicine: The Hype and the Reality—Part II  
  Olshansky SJ, Hayflick L, Perls TT, J Gerontol Series A: Bio Sci Med Sci, 1/1/2004
• Centenarians who avoid dementia  
  Perls T, Trends in Neurosciences, 1/1/2004
• Morbidity Profiles of Centenarians: Survivors, Delayers and Escapers  
  Evert J, Lawler E, Bogan H, Perls T, J Gerontol Med Sci, 1/1/2003
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