WenyinShiMD

Radiation Oncology • Philadelphia, PA

Benign Diseases, Central Nervous System Cancer, Hematologic Malignancies, Melanoma

Associate Professor, Radiation Oncology, Jefferson Medical College-Thos Jefferson Univ

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Office
111 S 11th St
Bodine Center
Philadelphia, PA 19107
Phone+1 215-955-6702
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Education & Training

University of FloridaResidency, Radiation Oncology, 2006 - 2010
University of Florida College of MedicineInternship, Transitional Year, 2005 - 2006
Shanghai Medical UniversityClass of 1997

Certifications & Licensure

NJ State Medical License 2017 - 2025
PA State Medical License 2010 - 2024
American Board of Radiology Radiation Oncology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification Allscripts Enterprise EHR, Allscripts, 2013
CMS Meaningful Use Stage 1 Certification MOSAIQ EMR, Elekta, 2012

Clinical Trials

Using Intensity Modulated Radiation Therapy (IMRT) for Brain Metastases Start of enrollment: 2005 Oct 01
Completed
Phase 1
Study of the Combination of Vorinostat and Radiation Therapy for the Treatment of Patients With Brain Metastases Start of enrollment: 2009 Mar 01
Completed
Phase 1
A Study of Bone Marrow Transplantation Using Fully-Matched Relatives as Donors for Patients With Hematological Malignancies Start of enrollment: 2008 Apr 10
Completed
Phase 2
Panobinostat and Stereotactic Radiation Therapy in Treating Patients With Brain Tumors Start of enrollment: 2012 May 01
Terminated
Phase 1
TheraSphere for the Treatment of Unresectable Hepatocellular Carcinoma Start of enrollment: 2007 Oct 01
Completed
High-Dose Vorinostat and Fractionated Stereotactic Body Radiation Therapy in Treating Patients With Recurrent Glioma Start of enrollment: 2012 Jun 01
Terminated
Phase 1
A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies Start of enrollment: 2011 Aug 04
Completed
Phase 2
Cabazitaxel With Radiation and Hormone Therapy for Prostate Cancer Start of enrollment: 2011 Sep 22
Completed
Phase 1
High-Dose Rate Brachytherapy and Stereotactic Body Radiation Therapy in Treating Patients With Prostate Cancer Start of enrollment: 2012 Oct 04
Active, not recruiting
Not Applicable
Phase I Study of Ipilimumab Combined With Whole Brain Radiation Therapy or Radiosurgery for Melanoma Start of enrollment: 2012 Nov 09
Completed
Phase 1
Caloric Restriction in Treating Patients With Stage 0-I Breast Cancer Undergoing Surgery and Radiation Therapy Start of enrollment: 2013 Mar 08
Completed
Not Applicable
Allogeneic Hematopoietic Stem Cell Transplantation for High-Risk Hematologic Malignancies Using One Haploidentical Donor Start of enrollment: 2013 Nov 04
Completed
Phase 2
Vemurafenib Combined With Whole Brain Radiation Therapy or Radiosurgery in Patients With BRAF Mutation-Positive Melanoma and Brain Metastases
Withdrawn
Phase 1
Measuring Biomarker Response to AMP-514 in Blood Samples From Patients With Solid Tumors Undergoing Radiotherapy Start of enrollment: 2013 Nov 11
Completed
Alisertib and Fractionated Stereotactic Radiosurgery in Treating Patients With Recurrent High Grade Gliomas Start of enrollment: 2015 Jan 30
Completed
Phase 1
Circulating Tumor DNA in Predicting Outcomes in Patients With Stage IV Head and Neck Cancer or Stage III-IV Non-small Cell Lung Cancer Start of enrollment: 2014 Jul 22
Completed
Temozolomide, Radiation Therapy, and Tumor Treating Fields Therapy in Treating Participants With Glioblastoma Start of enrollment: 2018 May 04
Completed
Early Phase 1
Stereotactic Body Radiation Therapy and Aflibercept in Treating Patients With Uveal Melanoma Start of enrollment: 2019 Aug 09
Completed
Phase 2
Neurocognition in Patients With Multiple Brain Metastases Treated With Radiosurgery Start of enrollment: 2017 Feb 21
Recruiting
Phase 2
Roles: Contact, Principal Investigator
Intensity-Modulated Stereotactic Radiation Therapy in Treating Patients With Grade II-IV Glioma Start of enrollment: 2017 Jul 17
Recruiting
Not Applicable
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Emerging insights on management of high-grade glioma.
Shi, W., Palmer, J., Alnahhas, I., Palmer, J. D.> ;Chinese Clinical Oncology. 2024 Feb 1
Novel frameless LINAC radiosurgery solution for uveal melanoma.
Mehak Khan, Sudheshna Vemula, Christina Hum, Haisong Liu, Yan Yu, Yingxuan Chen, Yechi Zhang, Muhammad Sharif, Louis Cappelli, Wenyin Shi> ;Frontiers in Oncology. 2024 Jan 1
Impact of Apolipoprotein E Genotype on Neurocognitive Function in Patients With Brain Metastases: An Analysis of NRG Oncology's RTOG 0614.
Wefel, J., Deshmukh, S., Brown, P., Grosshans, D., Sulman, E., Cerhan, J., Mehta, M., Khuntia, D., Shi, W., Mishra, M., Suh, J., Laack, N., Chen, Y., Curtis, A., Laba,...> ;International Journal of Radiation Oncology, Biology, Physics. 2023 Dec 13
Case report: durable response of gliomatosis cerebri with concurrent tumor-treating fields (TTFields) and chemoradiotherapy treatment.
DesJarlais, A., Miller, R., Glass, J., Ali, A., Niazi, M., Cappelli, L., Farrell, C., Shi, W.> ;Chinese Clinical Oncology. 2023 Dec 1
Evaluation of a Balloon Implant for Simultaneous Magnetic Nanoparticle Hyperthermia and High-Dose-Rate Brachytherapy of Brain Tumor Resection Cavities.
Wan, S., Rodrigues, D., Kwiatkowski, J., Goldstein, R., Overbeek Bloem, M., Yu, Y., Rooks, S., Hurwitz, M., Stauffer, P., Khanna, O., Judy, K., Shi, W.> ;Cancers. 2023 Dec 1
Research progress on the regulation and mechanism of borneol on the blood-brain barrier in pathological states: a narrative review focused on ischemic stroke and cereb...
Tan, X., Zhang, K., Tang, Z., Shi, W.> ;Translational Cancer Research. 2023 Nov 30
1 citations
NRG/RTOG 0837: Randomized, phase II, double-blind, placebo-controlled trial of chemoradiation with or without cediranib in newly diagnosed glioblastoma.
Batchelor, T., Won, M., Chakravarti, A., Hadjipanayis, C., Shi, W., Ashby, L., Stieber, V., Robins, H., Gray, H., Voloschin, A., Fiveash, J., Robinson, C., Chamarthy, ...> ;Neuro-Oncology Advances. 2023 Oct 11
Integrated feathering for craniospinal irradiation improves patient safety and departmental efficiency.
Amy S Harrison, Angelia Landers, Virginia Nettleton, Katelyn Palermo, Yelena Vakhnenko, Wenyin Shi> ;Medical Dosimetry. 2023 Oct 5
Early Versus Delayed Fractionated Stereotactic Radiotherapy for Nonfunctioning Pituitary Adenoma.
Anish V Sathe, Alan Siu, Allison Kayne, Shreya Vinjamuri, Patrick Kelly, Wenyin Shi, James J Evans, Christopher J Farrell, Kang, K.> ;World Neurosurgery. 2023 Dec 1
2 citations
Cost-effectiveness analysis of 3 radiation treatment strategies for patients with multiple brain metastases.
Victor Eric Chen, Minchul Kim, Nicolas Nelson, Inkyu Kevin Kim, Wenyin Shi> ;Neuro-Oncology Practice. 2023 Aug 1
Efficacy of scalp-sparing volumetric-modulated arc therapy approach in reducing scalp radiation dose for patients with glioblastoma: a cross-sectional study.
Muneeb Niazi, Olga Russial, Louis Cappelli, Ryan Miller, Yingxuan Chen, Yelena Vakhnenko, Haisong Liu, Wenyin Shi> ;Chinese Clinical Oncology. 2023 Aug 1
3 citations
Association of partial T2-FLAIR mismatch sign and isocitrate dehydrogenase mutation in WHO grade 4 gliomas: results from the ReSPOND consortium.
Matthew D Lee, Sohil H Patel, Suyash Mohan, Hamed Akbari, Spyridon Bakas, MacLean P Nasrallah, Evan Calabrese, Jeffrey Rudie, Javier Villanueva-Meyer, Pamela LaMontagn...> ;Neuroradiology. 2023 Sep 1
1 citations
Evaluation of Interfraction Setup Uncertainty of Patients With Glioblastoma Wearing TTFields (Tumor Treating Fields) During Radiation Therapy.
Mingyuan Pan, Yixuan Xiao, Liying Zhu, Shengnan Dong, Liping Liang, Lei Sun, Wenyin Shi, Yang Wang> ;Practical Radiation Oncology. 2023 Jul 10
1 citations
Differences in clinical outcomes based on molecular markers in glioblastoma patients treated with concurrent tumor-treating fields and chemoradiation: exploratory anal...
Louis Cappelli, Mehak Majid Khan, Allison Kayne, Spencer Poiset, Ryan Miller, Ayesha Ali, Muneeb Niazi, Wenyin Shi, Iyad Alnahhas> ;Chinese Clinical Oncology. 2023 Jun 1
Radiomic signatures of meningiomas using the Ki-67 proliferation index as a prognostic marker of clinical outcomes.
Omaditya Khanna, Anahita Fathi Kazerooni, Sherjeel Arif, Aria Mahtabfar, Arbaz A Momin, Carrie E Andrews, Karim Hafazalla, Michael P Baldassari, Lohit Velagapudi, Jose...> ;Neurosurgical Focus. 2023 Jun 1
Hemangioblastoma with late leptomeningeal metastasis: a case report.
Spencer J Poiset, Aneesh Reddy, Catherine M Tucker, Lawrence C Kenyon, Kevin D Judy, Wenyin Shi> ;Journal of Medical Case Reports. 2023 Mar 20
1 citations
High local control and low ocular toxicity using ultra-low-dose "boom-boom" radiotherapy for indolent orbital lymphoma.
Sanjna Shelukar, Christian Fernandez, Zeynep Bas, Lydia Komarnicky, Sara E Lally, Carol L Shields, Adam Binder, Pierluigi Porcu, Onder Alpdogan, Ubaldo Martinez-Outsch...> ;Chinese Clinical Oncology. 2022 Dec 1
1 citations
Concurrent chemoradiation and Tumor Treating Fields (TTFields, 200 kHz) for patients with newly diagnosed glioblastoma: patterns of progression in a single institution...
Ayesha S Ali, Joseph Lombardo, Muneeb Z Niazi, Ryan C Miller, Iyad Alnahhas, Nina L Martinez, David W Andrews, Kevin D Judy, Wenyin Shi> ;Journal of Neuro-Oncology. 2022 Nov 1
Tumor treating fields with radiation for glioblastoma: a narrative review.
Ryan Miller, Muneeb Niazi, Olga Russial, Spencer Poiset, Wenyin Shi> ;Chinese Clinical Oncology. 2022 Oct 1
7 citations
Response to Chlormethine/Mechlorethamine gel Maintenance Treatment Regimen in Patients With Mycosis Fungoides: A Single-center Retrospective Study.
Emily Correia, Shalini Krishnasamy, Wenyin Shi, Seyfettin Onder Alpdogan, Joya Sahu, Pierluigi Porcu, Neda Nikbakht, Jayson G Suriano> ;Clinical Lymphoma, Myeloma & Leukemia. 2022 Aug 1
4 citations
The safety profile of Tumor Treating Fields (TTFields) therapy in glioblastoma patients with ventriculoperitoneal shunts.
Nancy Ann Oberheim-Bush, Wenyin Shi, Michael W McDermott, Alexander Grote, Julia Stindl, Leonardo Lustgarten> ;Journal of Neuro-Oncology. 2022 Jul 1
3 citations
Frameless Angiography-Based Gamma Knife Stereotactic Radiosurgery for Cerebral Arteriovenous Malformations: A Proof-of-Concept Study.
Fadi Al Saiegh, Haisong Liu, Kareem El Naamani, Nikolaos Mouchtouris, Omaditya Khanna, Rawad Abbas, Lohit Velagapudi, Michael P Baldassari, Richard F Schmidt, Stavropo...> ;World Neurosurgery. 2022 Aug 1
A case series of primary cutaneous B-cell lymphomas with atypical presentations: diagnostic and therapeutic challenges.
Emily Correia, Jisun Cha, Shalini Krishnasamy, Megan O'Donnell, Wenyin Shi, Pierluigi Porcu, Neda Nikbakht> ;Haematologica. 2022 Apr 1
25 citations
O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation.
Lorela Ciraku, Zachary A Bacigalupa, Jing Ju, Rebecca A Moeller, Giang Le Minh, Rusia H Lee, Michael D Smith, Christina M Ferrer, Sophie Trefely, Luke T Izzo, Mary T D...> ;Oncogene. 2022 Apr 1
Corrigendum to: Impact of lymphopenia on survival for elderly patients with glioblastoma: A secondary analysis of the CCTG CE.6 (EORTC 26062-22061, TROG 08.02) randomi...
Andrew J Song, Keyue Ding, Iyad Alnahhas, Normand J Laperriere, James Perry, Warren P Mason, Chad Winch, Chris J O'Callaghan, Johan J Menten, Alba A Brandes, Claire Ph...> ;Neuro-Oncology Advances. 2022 Jan 27
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Journal Articles

Multi-Institutional Analysis of Prognostic Factors and Outcomes After Hypofractionated Stereotactic Radiotherapy to the Resection Cavity in Patients with Brain Metastases
Simon S Lo, Wenyin Shi, Kristin J Redmond, Mitchell Machtay, JAMA Oncology

Authored Content

A Pilot Trial Using Telemedicine in Radiation Oncology: The Future of Health Care Is VirtualJune 2021

Press Mentions

Updated 2-THE-TOP Data Suggest Improvements in Progression-Free Survival, Overall Survival Compared to Matched-Control Patients from EF-14 TrialMarch 24th, 2022
Why Is Glioblastoma Such a Tough Nut to Crack?December 24th, 2019
Over 1,000 Multiple Brain Metastases Patients Treated with Brainlab Indication-Specific SoftwareNovember 16th, 2017
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