WilliamEKarnesJr.MD

PubMed

• 1 citations
  Autologous hematopoietic stem cell transplantation for a patient with multiple autoimmune diseases.
  Pongthep Vittayawacharin, Michael Y Sy, Sanaz Attaripour Isfahani, William E Karnes, Piyanuch Kongtim, Stefan O Ciurea> ;American Journal of Hematology. 2023 Oct 1
• 1 citations
  A survey of colonoscopists with and without in-depth knowledge of water-aided colonoscopy.
  Felix W Leung, Sergio Cadoni, Malcolm Koo, Andrew W Yen, Keith Siau, Yu-Hsi Hsieh, Sauid Ishaq, Chi-Liang Cheng, Francisco C Ramirez, Adrian W Bak, William Karnes, Put...> ;Journal of Gastroenterology and Hepatology. 2022 Sep 1
• 7 citations
  Artificial intelligence for the assessment of bowel preparation.
  Ji Young Lee, Audrey H Calderwood, William Karnes, James Requa, Brian C Jacobson, Michael B Wallace> ;Gastrointestinal Endoscopy. 2022 Mar 1
• 1 citations
  A Polyp Worth Removing: A Paradigm for Measuring Colonoscopy Quality and Performance of Novel Technologies for Polyp Detection.
  William E. Karnes, David A. Johnson, Tyler M. Berzin, Seth A. Gross, John J. Vargo, Prateek Sharma, Robin Zachariah, Jason B. Samarasena, Joseph C. Anderson> ;Journal of Clinical Gastroenterology. 2021 Oct 1
• 2 citations
  Single-Day Low-Residue Diet Prior to Colonoscopy Demonstrates Improved Bowel Preparation Quality and Patient Tolerance over Clear Liquid Diet: A Randomized, Single-Bli...
  Jason B. Samarasena, Nabil El Hage Chehade, Alexander Abadir, Allen R. Yu, Elise Tran, Daniel Mai, Daniel Thieu, Gregory C. Albers, Nimisha K. Parekh, William E. Karne...> ;Digestive Diseases and Sciences. 2021 Jun 10
• 39 citations
  Microbiome distinctions between the CRC carcinogenic pathways.
  Lauren C. Dedecker, Bretton Coppedge, Julio Avelar-Barragan, William E. Karnes, Katrine Whiteson> ;Gut Microbes. 2021 Jan 15
• 27 citations
  Establishing key research questions for the implementation of artificial intelligence in colonoscopy: a modified Delphi method.
  Omer F. Ahmad, Yuichi Mori, Masashi Misawa, Shin-ei Kudo, John T. Anderson, Jorge Bernal, Tyler M. Berzin, Raf Bisschops, Michael F. Byrne, Peng Jen Chen, James E. Eas...> ;Endoscopy. 2021 Sep 1
• 43 citations
  Central Reading of Ulcerative Colitis Clinical Trial Videos Using Neural Networks.
  Klaus Gottlieb, James Requa, William E. Karnes, Ranga Chandra Gudivada, Jie Shen, Efren Rael, Vipin Arora, Tyler Dao, Andrew Ninh, James McGill> ;Gastroenterology. 2021 Feb 1
• 16 citations
  Endoscopy and central reading in inflammatory bowel disease clinical trials: achievements, challenges and future developments.
  Klaus Gottlieb, Marco Daperno, Keith Usiskin, Bruce E. Sands, Harris A. Ahmad, Colin W. Howden, William E. Karnes, Young S Oh, Irene Modesto, Colleen Marano, Ryan W. S...> ;Gut. 2020 Jul 22
• Oral IBGard™ Before Colonoscopy: A Single-Center Double-Blinded, Randomized, Placebo-Controlled Trial
  James Y. Han, Zain Moosvi, Erica Duh, Sunhee Park, Gregory C. Albers, Jason B. Samarasena, William E. Karnes> ;Digestive Diseases and Sciences. 2021 May 1
• Traditional serrated adenomas (TSA) and the company they keep: TSA presence predicts advanced neoplasm states
  Erica Duh, Piotr Sowa, Mary B. Roberts, William E. Karnes> ;International Journal of Colorectal Disease. 2020 May 1
• 45 citations
  Artificial Intelligence in Gastrointestinal Endoscopy.
  Alexander Abadir, Mohammed F. Ali, William E. Karnes, Jason B. Samarasena> ;Clinical Endoscopy. 2020 Mar 30
• 96 citations
  Artificial intelligence using convolutional neural networks for real-time detection of early esophageal neoplasia in Barrett’s esophagus (with video)
  Rintaro Hashimoto, James Requa, Tyler Dao, Andrew Ninh, Elise Tran, Daniel Mai, Michael Lugo, Nabil El Hage Chehade, Kenneth J. Chang, Williams Karnes, Jason B. Samara...> ;Gastrointestinal Endoscopy. 2020 Jun 1
• 58 citations
  Prediction of Polyp Pathology Using Convolutional Neural Networks Achieves “Resect and Discard” Thresholds
  Robin Zachariah, Jason B. Samarasena, Daniel G. Luba, Erica Duh, Tyler Dao, James Requa, Andrew Ninh, William E. Karnes> ;The American Journal of Gastroenterology. 2020 Jan 1
• 325 citations
  Deep Learning Localizes and Identifies Polyps in Real Time With 96% Accuracy in Screening Colonoscopy.
  Gregor Urban, Priyam V. Tripathi, Talal Alkayali, Mohit Mittal, Farid Jalali, William E. Karnes, Pierre Baldi> ;Gastroenterology. 2018 Oct 1
• 46 citations
  Use of the Endocuff during routine colonoscopy examination improves adenoma detection: A meta-analysis.
  Matthew Chin, William E. Karnes, M. Mazen Jamal, John G. Lee, Robert H. Lee, Jason B. Samarasena, Matthew L Bechtold, Douglas L. Nguyen> ;World Journal of Gastroenterology. 2016 Nov 21
• 20 citations
  Role of Primary Tumor Resection Among Chemotherapy-Treated Patients with Synchronous Stage IV Colorectal Cancer: A Survival Analysis
  Walter Tsang, Argyrios Ziogas, Bruce S. Lin, Tara E. Seery, William E. Karnes, Michael J. Stamos, Jason A. Zell> ;Journal of Gastrointestinal Surgery. 2014 Mar 1
• 14 citations
  Prolonged inhibition of acid secretion causes hypergastrinaemia without altering pH inhibition of gastrin release in humans.
  William E. Karnes, Roger G. Berlin, V. Maxwell, Boyzena Sytnik, Janet K. Root, J.H. Walsh> ;Alimentary Pharmacology & Therapeutics. 2007 Mar 31
• 5 citations
  Prolonged inhibition of meal-stimulated acid secretion and gastrin release following single subcutaneous administration of octreotide (SMS 201-995) in man.
  William E. Karnes, V. Maxwell, B. Sytnik, P. Chew, John H. Walsh> ;Alimentary Pharmacology & Therapeutics. 2007 Mar 31
• 11 citations
  Desmoid tumors in familial adenomatous polyposis: a pilot project evaluating efficacy of treatment with pirfenidone.
  N. M. Lindor, Roger R. Dozois, Heidi Nelson, Bruce G. Wolff, John E. King, Lisa A. Boardman, Melissa L. Wilson, M. H. Greene, William E. Karnes, Ruben Mesa, T. Welch, ...> ;The American Journal of Gastroenterology. 2003 Aug 1
• 15 citations
  Inhibition of Epidermal Growth Factor Receptor Tyrosine Kinase Fails to Suppress Adenoma Formation in ApcMin Mice but Induces Duodenal Injury
  Steve R. Ritland, Sandra J. Gendler, Lawrence J. Burgart, David W. Fry, James Nelson, Alexander J. Bridges, Larry Andress, William E. Karnes> ;Cancer Research. 2000 Sep 1
• 22 citations
  Adenoma-specific alterations of protein kinase C isozyme expression in Apc(MIN) mice
  Irene K. Klein, Steven R. Ritland, Lawrence J. Burgart, Steven C. Ziesmer, Patrick C. Roche, Sandra J. Gendler, William E. Karnes> ;Cancer Research. 2000 Apr 15
• 10 citations
  Implications of low COX-2 expression in colorectal neoplasms with defective DNA mismatch repair.
  William E. Karnes> ;Journal of Cellular Biochemistry. Supplement. 2000 Jan 1
• 30 citations
  Distinct protein kinase C isozymes signal mitogenesis and apoptosis in human colon cancer cells.
  Shaun G. Weller, Irene K. Klein, Robert C. Penington, William E. Karnes> ;Gastroenterology. 1999 Oct 1
• 20 citations
  Cloning and characterization of the murine PKC alpha promoter: identification of a retinoic acid response element.
  Dinakar S. Desai, Syu-ichi Hirai, William E. Karnes, Richard M. Niles, Shigeo Ohno> ;Biochemical and Biophysical Research Communications. 1999 Sep 16
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Journal Articles

• Role of Primary Tumor Resection Among Chemotherapy-Treated Patients with Synchronous Stage IV Colorectal Cancer: A Survival Analysis  
  Tsang, WY, Ziogas A, Lin BS, Seery TE, Karnes W, Stamos MJ, Zell JA, J Gastrointest Surg, 1/1/2014
• Desmoid tumors in familial adenomatous polyposis: a pilot project evaluating efficacy of treatment with pirfenidone  
  Lindor NM, Dozois R, Nelson H, Wolff B, King J, Boardman L, Wilson M, Greene MH, Karnes W, Mesa R, Welch T, Edmonson J, Limburg P, Am J Gastroenterol, 1/1/2003
• Implications of low COX-2 expression in colorectal neoplasms with defective DNA mismatch repair  
  Karnes WE Jr, J Cell Biochem, 1/1/2000
• Adenoma-specific alterations of protein kinase C isozyme expression in ApcMIN mice  
  Klein IK, Ritland SR, Burgart LJ, Ziesmer SC, Roch, PC, Gendler SJ, Karnes WE Jr (senior author), Cancer Res, 1/1/2000
• Inhibition of epidermal growth factor receptor kinase fails to suppress adenoma formation in ApcMIN mice but induces duodenal injury  
  Ritland SR, Gendler SJ, Burgart LJ, Fry DW, Nelson JM, Bridges AJ, Andress L, Karnes WE Jr (senior author), Cancer Res, 1/1/2000
• Cloning and characterization of the murine PKC alpha promoter: identification of a retinoic acid response element  
  Desai DS, Hirai SI, Karnes WE Jr, Niles RM, Ohno S, Biochem Biophys Res Comm, 1/1/1999
• Distinct protein kinase C isozymes signal mitogenesis and apoptosis in human colon cancer cells  
  Weller SG, Klein IK, Karnes WE Jr (senior author), Gastroenterology, 1/1/1999
• Reduced COX-2 protein in colorectal cancer with defective mismatch repair  
  Karnes WE Jr, Shattuck-Brandt R, Burgart LJ, et al, Cancer Res, 1/1/1998
• Inhibition of epidermal growth factor receptor kinase induces protease-dependent apoptosis in human colon cancer cells  
  Karnes WE Jr, Weller SG, Adjei PN, Kottke TJ, Glenn KS, Gores GJ, Kaufmann SH, Gastroenterology, 1/1/1998
• P53 functional loss in a colon cancer cell line with two missense mutations (218leu and 248 trp) on separate alleles  
  Rand A, Glenn KS, Alvares CP, White MB, Thibodeau SN, Karnes WEJr (senior author), Cancer Letters, 1/1/1996
• Src family of tyrosine kinases: A roles of c-yes in colon carcinogenesis  
  Boardman LA, Karnes WE Jr, Gastroenterology, 1/1/1995
• Epidemiology and etiology of sporadic colorectal adenocarcinoma  
  Karnes WE Jr, Curr Opin Gastroenterol, 1/1/1994
• Paracrine control of gastric epithelial cell growth in culture by transforming growth factor-alpha  
  Chen MC, Lee A, Karnes WE Jr, Avedian D, Sorvillo J, Soll AH, Am J Physiol, 1/1/1993
• Helicobacter pylori secretes a chemotactic factor for monocytes and neutrophils  
  Craig PM, Territo MC, Karnes WE Jr, Walsh JH, Gut, 1/1/1992
• Autonomous proliferation of colon cancer cells that coexpress transforming growth factor-alpha and its receptor  
  Karnes WE Jr, Walsh JH, Wu SV, Kim RS, Martin MG, Wong HC, Mendelsohn J, Gazdar AF, Cuttitta F, Gastroenterology, 1/1/1992
• Effects of aging on gastric acid secretion and on serum pepsinogen concentrations in healthy men and women: Relationships with serum gastrin and Helicobacter pylori i...  
  Goldschmiedt M, Barnett CC, Schwarz BE, Karnes WE Jr, Redfern JS, Feldman M, Gastroenterology, 1/1/1991
• Autocrine growth factors and solid tumor malignancy  
  Karnes WE Jr, Cuttitta F, Walker A., Walsh JH, West J Med, 1/1/1991
• Elevated meal-stimulated gastrin release in subjects with Helicobacter pylori infection: Reversal by low intragastric pH  
  Karnes WE Jr, Ohning GV, Sytnik B, Kim SWR, Walsh JH, Reviews of Infectious Diseases, 1/1/1991
• Positive serum antibody and negative tissue staining for Helicobacter pylori infection in subjects with atrophic body gastritis  
  Karnes WE Jr, Samloff IM, Siurala M, Kekki M, Sipponen P, Kim SWR, Walsh JH, Gastroenterology, 1/1/1991
• Prolonged inhibition of acid secretion causes hypergastrinemia without altering pH inhibition of gastrin release in humans  
  Karnes WE Jr, Berlin RG, Maxwell V, Sytnik B, Root JK, Walsh JH, Aliment Pharmacol Ther, 1/1/1990
• The gastrin hypothesis Implications for selection of drug therapy  
  Karnes WE Jr, Walsh JH, J Clin Gastroenterol, 1/1/1990
• ras gene mutations in colorectal cancer  
  Karnes WE Jr, Jabobs R, Gastroenterology, 1/1/1987
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Books/Book Chapters

• Surgery of the Colon and Rectum 
  Chapter: Colorectal Neoplasms - Epidemiology & Etiology. 
  Karnes WE Jr, Boardman LAEditors: RJ Nicholls, RR Dozois.Churchill-Liviningston, London, UK1997
• Surgery of the Colon and Rectum 
  Chapter: Epidemiology and etiology of colorectal cancer. 
  Boardman LA, Karnes WE JrEditors: RJ Nicholls, RR Dozois.Churchill-Liviningston, London, UK1996
• Gut Peptides 
  Chapter: Growth factors and gastrointestinal malignancies. 
  Page 825 - 850Karnes WE JrEditors: JH Walsh G Dockrey.Raven Press, New York1994
• Gut Peptides 
  Chapter: Epidermal growth factor and transforming growth factor alpha. 
  Page 553 - 586Karnes WE JrEditors: JH Walsh G Dockrey.Raven Press, New York1994
• Debates in Gastroenterology, Volume 3 
  Chapter: C. pylori: innocent until proven guilty. 
  Page 321 - 334Karnes WE Jr, Guth PEditors: G Gitnik.Year Book Medical Publishers, Chicago, IL1990
• Campylobacter Pylori in Gastritis and Peptic Disease 
  Chapter: Perspectives. 
  Page 241 - 249Karnes WE Jr, Walsh JHEditors: M Blaser.Igaku-Shoin Medical Publishers, New York1989
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Abstracts/Posters

• Effect of Delay in Surgical Treatment of Colon Cancer on Survival.
  Farid Jalali, Argyrios Ziogas, Jason A. Zell, Michael J. Stamos, Hoda Anton-Culver, William E. Karnes, DDW, 1/1/2014
• Variable Recognition of Sessile Serrated Adenomas Among Colonoscopists and Pathologists - a Compounded Roadblock to Reducing Interval Colon Cancers
  Sarah L. Flores, Argyrios Ziogas, Gregory Albers, Hoda Anton-Culver, William E. Karnes, DDW, 1/1/2014
• Applications of micro-CT imaging to study tumor neovascularization in murine models of colon cancer.
  Chinery R, Lund PE, Reyes DA, Bentley MD, Karnes WE Jr, Ritman EL, Gastroenterology, 1/1/2000
• Evidence for Fas ligand-mediated tumor immune evasion in a murine model of colorectal carcinogenesis.
  Chinery R, Watson AJ, Karnes WE Jr, Gastroenterology, 1/1/2000
• Physical and functional interaction between beta-catenin and retinoic acid receptor beta.
  Desai DS, Karnes WE Jr, Gastroenterology, 1/1/2000
• Protein kinase C-alpha is a target of beta-catenin/Tcf-4 transcriptional regulation.
  Desai DS, Ritland SH, Klein I, Karnes WE Jr, Gastroenterology, 1/1/2000
• Protein kinase C signals mitogenesis and ERK activation through metalloproteinase-dependent release of autocrine TGF-alpha in SNU-C4 colon cancer cells.
  Penington RC, Weller SG, Karnes WE Jr, Gastroenterology, 1/1/2000
• PMA Induces apoptosis in the SNU-C4 colon cancer cells through caspase-9 independently of caspase-3 and -8.
  Weller SG, Penington RC, Karnes WE Jr, Gastroenterology, 1/1/2000
• P53 overexpression and K-ras mutation in early stage rectal cancer do not correlate with recurrence.
  Boardman L, Rand A, Batts KP, McDonnell SK, Peterson BJ, Zaheer S, Pemberton JH, Karnes WE Jr, Gastroenterology, 1/1/1999
• Potential role of cyclooxygenase-2 products on tumor immune escape.
  Chinery R, Morrow J, Lamps LW, Green DR, Karnes WEJr, Gastroenterology, 1/1/1999
• Relationship between siayl-tn (STN) antigen expression and microsatellite instability (MSI) in sporadic colorectal cancers (SCC).
  Itzkowitz SH, Shattuck R, Thibodeau S, Karnes WEJr, Burgart L, Gastroenterology, 1/1/1999
• Protein kinase C-mediated MAPK activation is mediated through autocrine EGFR activationin SNU-C4 colon cancer cells.
  Penington RC, Weller SG, Karnes WE Jr, Gastroenterology, 1/1/1999
• Inhibition of epidermal growth factor receptor fails to suppress adenoma formation in APCMIN mice but induces flat hyperproliferative duodenal lesions.
  Ritland SR, Gendler, Burgart LJ, Fry DW, Nelson JM, Bridges Aj, Andress L, Karnes WE Jr, Gastroenterology, 1/1/1999
• Apoptosis induced by phorbol ester in SNU-C4 colon cancer cells is associated with, but progresses independently of caspase-3-mediated cleavage of PKC-delta.
  Weller S, Penington R, Karnes WE Jr, Gastroenterology, 1/1/1999
• Reduced COX-2 protein expression in human colorectal cancer exhibiting defective mismatch repair.
  Karnes WE Jr, Dubois RN Jr, Shattuck-Brand R, Burgart LJ, Tester DJ, Thibodeau SN, Gastroenterology, 1/1/1998
• Prospective evaluation of urinary transforming growth factor alpha levels for predicting clinical important colorectal neoplasia.
  Kim KB, Herrington JJ, Devens ME, Grabau Cm, Klee GG, Ahlquist DA, Karnes WE Jr, Gastroenterology, 1/1/1998
• PKC isoforms in intestinal mucosa and adenomas of APCMIN mice.
  Klein IK, Ritland SR, Ziesmer SC, Burgart LJ, Roche PC, Gendler SJ, Karnes WE Jr, Colorectal Neoplasia Group., Gastroenterology, 1/1/1998
• A computerized colorectal cancer registry and risk assessment tool.
  Timmons LJ, Carlson EC, King JE, Lindor NM, Ahlquist DA, Treder CE, Karnes WE Jr, Gastroenterology, 1/1/1998
• PKC agonists stimulate mitogenesis of SNU-C4 colon cancer cells by augmenting autocrine stimulation of epidermal growth factor receptor.
  Weller SG, Klein IK, Graves-Deal R, Bogatcheva G, Coffey R Jr, Karnes WE Jr, Gastroenterology, 1/1/1998
• Distinct PKC isoforms mediate proliferative and apoptotic effects of phorbol esters in human colon cancer cell lines.
  Weller SG, Klein IK, Karnes WE Jr, Gastroenterology, 1/1/1998
• Recurrent paraganglioma: an unusual cause of abdominal pain.
  Sorbi D, Karnes WE Jr, Am J Gastroenterol, 1/1/1997
• Relevance of occult nodal metastases by immunodetection in rectal cancer.
  Boardman LA, Batts KP, Rand A, Ahlquist DA, Zaheer S, Pemberton J, Karnes WE Jr, Gastroenterology, 1/1/1997
• PKC and p21ras-mediated proliferative signaling in autonomous EGFR ligand-independent colon cancer cells.
  Karnes WE Jr, Banoub R, Glenn K, Rand A, Gastroenterology, 1/1/1996
• Constitutive proliferative signals mediated through PKC via p21ras-dependent and -independent pathways in autonomous colon cancer cell lines.
  Karnes WE Jr, Banoub R, Rand A, Glenn KS, Proc Ann Meet Am Assoc Cancer Res, 1/1/1996
• P53 and Waf-1-independent apoptosis induced by selective EGFR kinase inhibitors is associated with proteolysis of Bcl-2 and Cdc-2.
  Karnes WE Jr, Glenn K, Rand A, Banoub R, Gastroenterology, 1/1/1996
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