AaronDavidVinyMDMS

PubMed

• Chromatin Organization in Myelodysplastic Syndrome.
  Jane Jialu Xu, Aaron D Viny> ;Experimental Hematology. 2024 Apr 4
• Yin Yang 1 regulates cohesin complex protein SMC3 in mouse hematopoietic stem cells.
  Zhanping Lu, Yinghua Wang, Anna L F V Assumpção, Peng Liu, Audrey Kopp, Sahitya Saka, Sean J Mcilwain, Marjorie Brand, Xuan Pan, Aaron D Viny> ;Blood Advances. 2024 Mar 26
• Acute myeloid leukemia stratifies as 2 clinically relevant sphingolipidomic subtypes.
  B Bishal Paudel, Su-Fern Tan, Todd E Fox, Johnson Ung, Upendarrao Golla, Jeremy J P Shaw, Wendy Dunton, Irene Lee, Wisam A Fares, Satyam Patel, Arati Sharma, Aaron D V...> ;Blood Advances. 2024 Mar 12
• 1 citations
  Germline predisposition for clonal hematopoiesis.
  Yasuo Kubota, Aaron D Viny> ;Seminars in Hematology. 2024 Feb 1
• 1 citations
  Jak2V617F Reversible Activation Shows Its Essential Requirement in Myeloproliferative Neoplasms.
  Andrew J Dunbar, Robert L Bowman, Young C Park, Kavi O'Connor, Franco Izzo, Robert M Myers, Abdul Karzai, Zach Zaroogian, Won Jun Kim, Ines Fernandez-Maestre, Michael ...> ;Cancer Discovery. 2024 Jan 12
• 1 citations
  BRD9 determines the cell fate of hematopoietic stem cells by regulating chromatin state.
  Xiao, M., Kondo, S., Nomura, M., Kato, S., Nishimura, K., Zang, W., Zhang, Y., Akashi, T., Viny, A., Shigehiro, T., Ikawa, T., Yamazaki, H., Fukumoto, M., Tanaka, A., ...> ;Nature Communications. 2023 Dec 15
• Noncanonical Activity of Med4 as a Gatekeeper of Metastasis through Epigenetic Control of Integrin Signaling.
  Seong-Yeon Bae, Yi Chen, Hong Chen, Dhiraj Kumar, Spyros Karaiskos, Jane Xu, Chao Lu, Filippo G Giancotti, Aaron D Viny> ;Biorxiv. 2024 Jan 10
• ChromaFold predicts the 3D contact map from single-cell chromatin accessibility.
  Vianne R Gao, Rui Yang, Arnav Das, Renhe Luo, Hanzhi Luo, Dylan R McNally, Ioannis Karagiannidis, Martin A Rivas, Zhong-Min Wang, Darko Barisic, Alireza Karbalayghareh...> ;Biorxiv. 2023 Jul 28
• Till SMARCA5 loss do nucleosomes part.
  Jane Jialu Xu, Aaron D Viny> ;Molecular Cell. 2023 Feb 16
• 33 citations
  Subtype-specific 3D genome alteration in acute myeloid leukaemia.
  Jie Xu, Fan Song, Huijue Lyu, Mikoto Kobayashi, Baozhen Zhang, Ziyu Zhao, Ye Hou, Xiaotao Wang, Yu Luan, Bei Jia, Lena Stasiak, Josiah Hiu-Yuen Wong, Qixuan Wang, Qi J...> ;Nature. 2022 Nov 1
• 2 citations
  Molecular predictors of immunophenotypic measurable residual disease clearance in acute myeloid leukemia.
  Maximilian Stahl, Andriy Derkach, Noushin Farnoud, Jan Philipp Bewersdorf, Troy Robinson, Christopher Famulare, Christina Cho, Sean Devlin, Kamal Menghrajani, Minal A ...> ;American Journal of Hematology. 2023 Jan 1
• 19 citations
  The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation.
  Anna Yeaton, Geraldine Cayanan, Sanam Loghavi, Igor Dolgalev, Emmett M Leddin, Christian E Loo, Hedieh Torabifard, Deedra Nicolet, Jingjing Wang, Kate Corrigan, Varvar...> ;Cancer Discovery. 2022 Oct 5
• 2 citations
  Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1;Cohesin mutated AML.
  Alison E Meyer, Cary Stelloh, Kirthi Pulakanti, Robert Burns, Joseph B Fisher, Sergey Tarima, Quinlan Furumo, John Brennan, Yongwei Zheng, Aaron D Viny, George S Vassi...> ;Leukemia. 2022 Aug 1
• 7 citations
  PU.1-Dependent Enhancer Inhibition Separates Tet2-Deficient Hematopoiesis from Malignant Transformation.
  Maria M Aivalioti, Boris A Bartholdy, Kith Pradhan, Tushar D Bhagat, Aliona Zintiridou, Jong Jin Jeong, Victor J Thiruthuvanathan, Mario Pujato, Aditi Paranjpe, Chi Zh...> ;Blood Cancer Discovery. 2022 Sep 6
• DNMT3A-Mutant Leukemia Cells Primed to "Fork It Over" under DNA Damage.
  Aaron D Viny> ;Clinical Cancer Research. 2022 Feb 15
• 5 citations
  Cohesin Core Complex Gene Dosage Contributes to Germinal Center Derived Lymphoma Phenotypes and Outcomes
  Martín A. Rivas, Ceyda Durmaz, Andreas Kloetgen, Cristopher R Chin, Zhengming Chen, Bhavneet Bhinder, Amnon Koren, Aaron D. Viny, Christopher D. Scharer, Jeremy M. Bos...> ;Frontiers in Immunology. 2021 Sep 21
• 11 citations
  Aire regulates chromatin looping by evicting CTCF from domain boundaries and favoring accumulation of cohesin on superenhancers.
  Kushagra Bansal, Daniel A Michelson, Ricardo Ramirez, Aaron D. Viny, Ross L. Levine, Christophe Benoist, Diane Mathis> ;Proceedings of the National Academy of Sciences of the United States of America. 2021 Sep 21
• 4 citations
  Recurrent Mutations in Cyclin D3 Confer Clinical Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia
  Catherine C. Smith, Aaron D. Viny, Evan Massi, Cyriac Kandoth, Nicholas D. Socci, Franck Rapaport, Matthieu Najm, Juan S. Medina-Martinez, Elli Papaemmanuil, Theodore ...> ;Clinical Cancer Research. 2021 Jul 15
• A physician-scientist's call to arms.
  Aaron D. Viny> ;Cell Stem Cell. 2021 May 6
• 8 citations
  DOT1L inhibitors block abnormal self-renewal induced by cohesin loss
  Joseph B. Fisher, Cary Stelloh, Emily Kristine Phillips, Michael Reimer, Adam J. Wargolet, Alison E. Meyer, Kirthi Pulakanti, Aaron D. Viny, Jessica J. Loppnow, Ross L...> ;Scientific Reports. 2021 Mar 31
• 86 citations
  Clinical and molecular predictors of response and survival following venetoclax therapy in relapsed/refractory AML
  Maximilian Stahl, Kamal Menghrajani, Andriy Derkach, Alexander Chan, Wenbin Xiao, Jacob L. Glass, Amber C. King, Anthony F. Daniyan, Christopher Famulare, Bernadette M...> ;Blood Advances. 2021 Mar 9
• 6 citations
  The prognosis and durable clearance of RAS mutations in patients with acute myeloid leukemia receiving induction chemotherapy.
  Brian Ball, Meier Hsu, Sean M. Devlin, Maria E. Arcila, Mikhail Roshal, Yanming Zhang, Chris A Famulare, Aaron D Goldberg, Sheng F. Cai, Andrew Dunbar, Zachary D. Epst...> ;American Journal of Hematology. 2021 Mar 1
• 9 citations
  A cohesive look at leukemogenesis: The cohesin complex and other driving mutations in AML
  Alison E. Meyer, Puja Agrawal, Aaron D. Viny, Sridhar Rao> ;Neoplasia. 2021 Feb 20
• Introductions to the Community: Early-Career Researchers in the Time of COVID-19
  Binyam Mogessie, Kristin A. Knouse, Aaron D. Viny, Murielle Saade, Tomohisa Toda> ;Cell Stem Cell. 2021 Feb 4
• 21 citations
  Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.
  Martín A. Rivas, Cem Meydan, Christopher R. Chin, Matt F. Challman, Daleum Kim, Bhavneet Bhinder, Andreas Kloetgen, Aaron D. Viny, Matt Teater, Dylan R. McNally, Ashle...> ;Nature Immunology. 2021 Jan 11
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Journal Articles

• Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis  
  Viny AD, Ott CJ, Spitzer B, Rivas M, Meydan C, Papalexi E, Yelin D, Shank K, Reyes J, Chiu A, Romin Y, Boyko V, Thota S, Maciejewski JP, Melnick A, Bradner JE, Levine RL, Journal of Experimental Medicine, 1/5/2015
• T/B or not T/B: High frequency of B-cell dyscrasias in T-LGL leukemia  
  Pawarode A and Baer M, Leukemia & Lymphoma, 1/1/2008
• Childhood Cancer Survival: Racial Disparities Persist  
  Viny, AD, Internal Medicine News, 1/15/2007
• Investigators and advocates hunt for collaboration and smart funding  
  Viny, AD and Maciejewski JP, The New Physician, 1/1/2007
• Racial Disparity in Cancer Survival Pronounced in Older Adolescents and Young Adults  
  Viny, AD, Cancer Watch, 1/1/2007
• Racial Gap Widens for Young Adults with Leukemia, Lymphoma  
  Viny, AD, The Cleveland Plain Dealer, 1/15/2006
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Books/Book Chapters

• Cancer epidemiology in older adolescents and young adults 15 to 29 years of age, including SEER incidence and survival: 1975-2000 
  Chapter: Introduction 
  Page 1 - 14Cancer epidemiology in older adolescents and young adults 15 to 29 years of age, including SEER incidence and survival: 1975-2000Editors: Bleyer A, O’Leary M, Barr R, Ries LAG.National Cancer Institute, Bethesda, MD2006

Abstracts/Posters

• PRMT5 Inhibition Modulates E2F1 Methylation and Gene Regulatory Networks Leading to Therapeutic Efficacy in JAK2VF Mutant MPN
  Aaron D Viny, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Single Cell DNA Sequencing Identifies Combinatorial Mutation Patterns and Clonal Architecture in Myeloid Malignancies
  Aaron D Viny, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• RAS Mutations Are Independently Associated with Decreased Overall Survival and Event-Free Survival in Patients with AML Receiving Induction Chemotherapy
  Aaron D Viny, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Combinatorial Genetics Uncovers Novel Targets for the Treatment of Npm1/Cohesin Mutated AML
  Aaron D Viny, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis
  Viny AD, Ott CJ, Spitzer B, Rivas M, Meydan C, Papalexi E, Yelin D, Shank K, Reyes J, Chiu A, Romin Y, Boyko V, Thota S, Maciejewski JP, Melnick A, Bradner JE, Levine RL, Blood, 1/1/2015
• Recurrecnt Mutations in CCND3 Confer Clinical Resistance to FLT3 Inhibitors
  Smith CC, Viny AD, Massi ES, Kandoth C, Socci ND, Hsu H, West, B, Bollag G, Taylor BS, Levine RL, Shah NP, Blood, 1/1/2015
• PHF6 – Somatic Mutations and their Role in Pathophysiology of MDS and AML
  Przychodzen B, Gu X, You D, Hisch CM, Clemente MJ, Viny AD, Levine RL, Haferlach T, Maggendorfer M, Sekeres MA, Carraway HE, Nazha A, Enane F, Maciejewski JP, Blood, 1/1/2015
• The Impact of Clonal Architecture of IDH1 and IDH2 Mutant Cases on the Biology of Myeloid Malignancies
  Thota S, Makishima H, Przychodzen BP, Viny AD, Patel BJ, Radivoyevitch T, Sekeres MA, Carraway HE, Haferlach T, Ogawa S, Maciejewski JP, Blood, 1/1/2014
• Utility of Combined DNA and RNA Next Generation Sequencing in Leukemias for Identification of Prognostic and Therapeutically Relevant Genomic Alterations in Clinical P...
  Coombs CC, Viny AD, He J, Kobos R, Lipson D, Shukla N, Knapp KM, Otto G, Abdel-Wahab O, Stein EM, Rampal RK, Miller, VA, Dogan A, van den Brink MRM, Armstrong SA, Step..., Blood, 1/1/2014
• Predictors of overall survival in patients diagnosed with desmoplastic small round cell tumor (DSRCT)
  Shoushtari AN, Qin LX, Kuk D, Magnan HD, Modak S, Wolden SL, Cho EJ, Pallos V, Grubman O, Viny AD, Carvajal RD, Chi, P, D’Angelo SP, Dickson MA, Keohan ML, Tap, WD, Le..., J Clin Oncol, 1/1/2014
• Optimizing the therapy of desmoplastic small round cell tumor: Combined experience from the two major cancer centers
  Subbiah V, Viny AD, Anderson P, Hayes-Jordan A, Qiao W, Benjamin RS, Maki RG, Ludwig J, J Clin Oncol, 1/1/2012
• Genetic and Functional Investigation of Germline JAK2 Alleles that predispose to Myeloproliferative Neoplasms
  Schram AM, Xu X, Kilpivaara O, Mukherjee S, Viny AD, Guryanova O, Klein RJ, Levine RL, Blood, 1/1/2011
• Various Abnormalities at Chromosome 7 Carry Distinct Biologic and Prognostic Implications in myelodysplastic/myeloproliferative syndromes and related marrow failures
  Viny AD, Pryzchodzen B, O’Keefe C, Makishima H, Sugimoto Y, Mohan S, Wlodarski M, Kojima S, Sekeres M, Maciejewski JP, Blood, 1/1/2010
• Clonotype Switching Indicates Propensity for Clonal Outgrowth From Diverse Components of the T Cell Repertoire In T Cell Large Granular Lymphocyte Leukemia
  Clemente M, Wlodarski M, Viny AD, Shaik M, Bejanyan N, Mohan S, Makishima H, Hsi E, Paquette R, Loughran TJ, Maciejewski JP, Blood, 1/1/2010
• Impact of MICA and Other Immunogenetic Polymorphisms On Clinical Presentation of T Cell Large Granular Lymphocyte Leukemia
  Lazaryan A, Bejanyan N, Viny AD, Askar M, Burnette PK, Maciejewski JP, American Society of Hematology, 1/1/2009
• Expression of MICA by Granulocytes in Neutropenia due to Large Granular Lymphocyte Leukemia Points towards Cytotoxicity Exerted via NKG2D on Clonal Cytotoxic T Cells
  Viny AD, Clemente M, Jasek M, Prince C, Maciejewski JP, American Society of Hematology, 1/1/2008
• High Resolution Karyotyping of Large Granular Lymphocyte Leukemia by SNP Arrays Reveals Clonal Defects Leading to LOH at Loci Integral to Lymphocyte Function
  Viny AD, Makishima H, Huh J, Theil KS, Gondek L, Maciejewski JP, American Society of Hematology, 1/1/2008
• Statistical methodology using random forests for whole genome association studies in rare diseases
  Viny AD, Ishwaran H, Przychodzen B, Dunbar A, Maciejewski JP, Conference on Clinical Research on Rare Diseases, Bethesda, MD, 1/5/2007
• MICA Polymorphism Identified by Whole Genome Array Constitutes a Disease Predisposition Factor in T-Cell Large Granular Lymphocyte Leukemia
  Viny AD, Ishwaran H, Przychodzen, B, Dunbar A, Maciejewski JP, Blood, 1/1/2007
• Chronic B-cell Dyscrasias are and Important Clinical Feature of LGL Leukemia
  Viny AD, Lichtin, A., Pohlman, B., Nearman, Z., Loughran, T., Maciejewski, JP, Blood, 1/1/2007
• Non Synonymous SNP-Array-Based Disease Association Analysis in Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria
  Serio B, Viny AD, Tiu R, Przychodzen B, Lichtin A, O'Keefe C, Maciejewski JP, Blood, 1/1/2007
• Impact of Cytokine Polymorphisms in Aplastic Anemia
  Serio B, Risitano AM, Ramsingh G, Tiu R, Viny A, Rotoli B, Selleri C, Maciejewski JP, Italian Society of Hematology, Bologna, Italy, 1/1/2007
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Lectures

• Dose Dependency of the Cohesin Complex in Normal and Malignant Hematopoiesis 
  Orlando, FL - 1/8/2015
• Desmoplastic Small Round Cell Tumor: Analysis of 161 Cases at two Major Sarcoma Centers 
  Paris, France - 1/1/2014
• MICA polymorphism identified by whole genome array associated with NKG2D-mediated cytotoxicity in T-cell large granular lymphocyte leukemia 
  New York, NY - 1/8/2012
• T Cell Receptor Variable Beta Chain Analysis in the Diagnosis of Chronic Neutropenias 
  Iraklion, Crete - 1/1/2008
• Statistical methodology using random forests for whole genome association studies in rare diseases 
  Bethesda, MD - 1/5/2007
• Data Show Childhood, Youth Cancer Survival Factors Vary by Race, Follow-up Care 
  1/4/2007
• Analysis of large granular lymphocyte leukemia using high-density single nucleotide arrays 
  1/1/2007
• Disparities in Pediatric Cancers 
  Cleveland, OH - 1/12/2006
• The Racial Disparity Gap in Pediatric Leukemia and Lymphoma Survival Has Been Eliminated in Children But Not in Older Adolescents and Young Adults 
  1/1/2006
• Black-White Racial Disparity in the Survival of Young Adults with Cancer 
  1/1/2006
• High-Resolution Genomic Arrays Facilitate Detection of Novel Cryptic Chromosomal Lesions in MDS 
  1/1/2005
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Other

• Racial Disparity Persists in Survival Data 
  Viny, AD, RSi News
  http://www.rsinewsrxreportingfrom.com/content.asp?myid=62&tid=574
  1/12/2006
• Disparity Gap for Leukemia Patients 
  Viny, AD, National Public Radio
  http://audio2.ideastream.org/wcpn/2006/1211leukemia.mp3
  1/11/2006
• Childhood, Youth Cancer Survival Factors Vary by Race, Follow-Up Care 
  Viny, AD, American Society of Hematology Press Release
  http://www.hematology.org/media/therapy2_release.pdf
  1/11/2006
• Coming Full Circle: In Remission from ALL, Medical Student Focuses His Research on Cancer 
  Viny, AD and Maciejewski, JP, Cancer Consult Magazine
  1/1/2005
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