AbbotLaptookMD

Neonat/Perinatology • Providence, RI

Professor, Pediatrics, Brown University Program in Medicine

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Office
101 Dudley St
Providence, RI 02905
Phone+1 401-274-1122

Fax+1 401-453-7571
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Education & Training

Women and Infants Hospital of Rhode Island/Brown UniversityFellowship, Neonatal-Perinatal Medicine, 1980 - 1981
Zucker School of Medicine at Hofstra/Northwell at Cohen Children's Medical CenterResidency, Pediatrics, 1976 - 1979
State University of New York Downstate Medical Center College of MedicineClass of 1976

Certifications & Licensure

RI State Medical License 2003 - 2024
MA State Medical License 2003 - 2024
NY State Medical License 1981 - 2022
TX State Medical License 1982 - 2019
CT State Medical License 2008 - 2017
American Board of Pediatrics Pediatrics
American Board of Pediatrics Neonatal-Perinatal Medicine

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014

Clinical Trials

Whole-Body Cooling for Birth Asphyxia in Term Infants Start of enrollment: 1999 Oct 01
Completed
Phase 3
Early Inhaled Nitric Oxide for Respiratory Failure in Newborns Start of enrollment: 1998 Aug 01
Terminated
Phase 3
Glutamine Supplementation to Prevent Death or Infection in Extremely Premature Infants Start of enrollment: 1999 Jul 01
Completed
Phase 3
Follow-up Visit of High Risk Infants Start of enrollment: 1993 Jan 01
Recruiting
Inhaled Nitric Oxide for Preterm Infants With Severe Respiratory Failure Start of enrollment: 2001 Jan 01
Terminated
Phase 3
Generic Database of Very Low Birth Weight Infants Start of enrollment: 1987 Jan 01
Recruiting
Benchmarking Initiative to Reduce Bronchopulmonary Dysplasia Start of enrollment: 2001 Mar 01
Completed
Not Applicable
Early Diagnosis of Candidiasis in Premature Infants Start of enrollment: 2004 Mar 01
Completed
Trial of Aggressive Versus Conservative Phototherapy in Infants <1,000 Grams Birth Weight Start of enrollment: 2002 Sep 01
Completed
Phase 3
Surfactant Positive Airway Pressure and Pulse Oximetry Trial Start of enrollment: 2005 Feb 01
Completed
Phase 3
Single-Dose Intravenous Inositol Pharmacokinetics in Preterm Infants Start of enrollment: 2006 Jun 01
Completed
Phase 2
Late Hypothermia for Hypoxic-Ischemic Encephalopathy Start of enrollment: 2008 Apr 01
Completed
Not Applicable
Cerebral Function Monitoring in Premature Infants Start of enrollment: 2009 Jul 01
Completed
Early-Onset Sepsis Surveillance Study Start of enrollment: 2006 Feb 01
Completed
Early Blood Pressure Management in Extremely Premature Infants Start of enrollment: 2009 Jul 01
Completed
Phase 1
Hypotension in Neonates Start of enrollment: 2009 Apr 01
Completed
Laparotomy vs. Drainage for Infants With Necrotizing Enterocolitis Start of enrollment: 2010 Jan 01
Completed
Not Applicable
Multi-dose Pharmacokinetics and Dose Ranging of Inositol in Premature Infants (INS-2) Start of enrollment: 2010 Jan 01
Completed
Phase 2
Inflammatory Cytokines Associated With Perinatal Brain Injury Start of enrollment: 1999 Jul 01
Completed
Prophylactic Phenobarbital After Neonatal Seizures Start of enrollment: 2010 Sep 01
Terminated
Phase 4
Optimizing (Longer, Deeper) Cooling for Neonatal Hypoxic-Ischemic Encephalopathy(HIE) Start of enrollment: 2010 Sep 01
Terminated
Not Applicable
Vitamin E for Extremely Preterm Infants Start of enrollment: 2010 Oct 01
Completed
Phase 1
Observational Study of Surgical Treatment of Necrotizing Enterocolotis Start of enrollment: 2001 Mar 01
Completed
Physiologic Definition of Bronchopulmonary Dysplasia Start of enrollment: 2005 May 01
Completed
Hydrocortisone for BPD Start of enrollment: 2011 Aug 11
Active, not recruiting
Phase 3
Donor Milk vs. Formula in Extremely Low Birth Weight (ELBW) Infants Start of enrollment: 2012 Aug 01
Completed
Phase 3
Transfusion of Prematures Trial Start of enrollment: 2012 Dec 01
Active, not recruiting
Phase 3
Prospective Research in Infants With Mild Encephalopathy Start of enrollment: 2012 Dec 01
Completed
Generic Database of Moderate Preterm Infants Start of enrollment: 2012 Mar 01
Completed
Preemie Hypothermia for Neonatal Encephalopathy Start of enrollment: 2015 May 01
Completed
Not Applicable
Hydrocortisone for Term Hypotension Start of enrollment: 2014 Jun 19
Completed
Phase 3
Inositol to Reduce Retinopathy of Prematurity Start of enrollment: 2014 Apr 17
Terminated
Phase 3
Neurophysiologic Maturation Index for Moderate and Late Preterm Infants Start of enrollment: 2014 Mar 01
Unknown status
Incubator Weaning of Moderately Preterm Infants Start of enrollment: 2015 Feb 01
Completed
Not Applicable
Neurophysiological Maturation Correlate With Clinical Milestones Start of enrollment: 2013 Aug 05
Completed
Trial to Shorten Pharmacologic Treatment of Newborns With Neonatal Opioid Withdrawal Syndrome (NOWS) Start of enrollment: 2020 Sep 08
Active, not recruiting
Phase 3
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Publications & Presentations

PubMed

Association of maternal pre-pregnancy or first trimester body mass index with neurodevelopmental impairment or death in extremely low gestational age neonates.
Sanjay Chawla, Abbot R Laptook, Emily A Smith, Sylvia Tan, Girija Natarajan, Myra H Wyckoff, Rachel G Greenberg, Namasivayam Ambalavanan, Edward F Bell, Krisa P Van Me...> ;Journal of Perinatology. 2024 Feb 23
1 citations
Neurodevelopmental Outcomes of Extremely Preterm Infants Fed Donor Milk or Preterm Infant Formula: A Randomized Clinical Trial.
Tarah T Colaizy, Brenda B Poindexter, Scott A McDonald, Edward F Bell, Waldemar A Carlo, Susan J Carlson, Sara B DeMauro, Kathleen A Kennedy, Leif D Nelin, Pablo J Sán...> ;JAMA. 2024 Feb 20
Neonatal thermoregulation: a cornerstone of care or forgotten principles?
Laptook, A.> ;Pediatric Research. 2024 Jan 3
Neuroprotective therapies in the NICU in preterm infants: present and future (Neonatal Neurocritical Care Series).
Molloy, E., El-Dib, M., Soul, J., Juul, S., Gunn, A., Bender, M., Gonzalez, F., Bearer, C., Wu, Y., Robertson, N., Cotton, M., Branagan, A., Hurley, T., Tan, S., Lapto...> ;Pediatric Research. 2023 Dec 19
1 citations
Tissue Oxygenation Changes After Transfusion and Outcomes in Preterm Infants: A Secondary Near-Infrared Spectroscopy Study of the Transfusion of Prematures Randomized ...
Brion, L. P., Chock, V., Kirpalani, H., Bell, E., Tan, S., Hintz, S., Ball, M., Smith, E., Das, A., Loggins, Y., Sood, B., Chalak, L., Wyckoff, M., Kicklighter, S., Ke...> ;JAMA Network Open. 2023 Sep 5
1 citations
Serum ferritin values in neonates <29 weeks' gestation are highly variable and do not correlate with reticulocyte hemoglobin content.
Timothy M Bahr, Sylvia Tan, Emily Smith, Sandra S Beauman, Kurt R Schibler, Cathy A Grisby, Jean R Lowe, Edward F Bell, Abbot R Laptook, Seetha Shankaran, David P Carl...> ;Journal of Perinatology. 2023 Nov 1
2 citations
Pragmatic, randomized, blinded trial to shorten pharmacologic treatment of newborns with neonatal opioid withdrawal syndrome (NOWS).
Adam Czynski, Abbot Laptook, Abhik Das, Brian Smith, Alan Simon, Rachel Greenberg, Robert Annett, Jeannette Lee, Jessica Snowden, Claudia Pedroza, Barry Lester, Barry ...> ;Trials. 2023 Jul 21
2 citations
Antenatal Steroids, Prophylactic Indomethacin, and the Risk of Spontaneous Intestinal Perforation.
Abbot R Laptook, Heather Weydig, Luc P Brion, Myra H Wyckoff, Tamara I Arnautovic, Noelle Younge, William Oh, Dhuly Chowdhury, Martin Keszler, Abhik Das> ;The Journal of Pediatrics. 2023 Aug 1
4 citations
Evaluation of heterogeneity in effect of therapeutic hypothermia by sex among infants with neonatal encephalopathy.
Elizabeth K Sewell, Seetha Shankaran, Girija Natarajan, Abbot Laptook, Abhik Das, Scott A McDonald, Shannon Hamrick, Michelle Baack, Matthew Rysavy, Rosemary D Higgins...> ;Pediatric Research. 2023 Oct 1
Maternal hypertensive disorders and survival without major morbidities among extremely low gestation newborns.
Martha B Kole-White, Shampa Saha, Erika F Werner, Sanjay Chawla, Martin Keszler, Elisabeth C McGowan, Myra H Wyckoff, Abbot R Laptook> ;Journal of Perinatology. 2023 Apr 1
The effects of betamethasone on the amplitude integrated EEG of infants born at 34- or 35-weeks gestation.
Laptook, A., Chalak, L., Pappas, A., Davis, A., Sanchez, P., Van Meurs, K., Oh, W., Sommers, R., Shankaran, S., Hensman, A., Rouse, D., McDonald, S., Das, A., Goldberg...> ;Journal of Perinatology. 2022 Dec 1
4 citations
Model for severe intracranial hemorrhage and role of early indomethacin in extreme preterm infants.
Sanjay Chawla, Girija Natarajan, Abbot R Laptook, Dhuly Chowdhury, Edward F Bell, Namasivayam Ambalavanan, Waldemar A Carlo, Marie Gantz, Abhik Das, Jose L Tapia, Heid...> ;Pediatric Research. 2022 Dec 1
2 citations
Neuroprotection for hypoxic-ischemic encephalopathy: Contributions from the neonatal research network.
Sonia Lomeli Bonifacio, Lina F Chalak, Krisa P Van Meurs, Abbot R Laptook, Seetha Shankaran> ;Seminars in Perinatology. 2022 Nov 1
17 citations
Neuroprotective therapies in the NICU in term infants: present and future.
Eleanor J Molloy, Mohamed El-Dib, Sandra E Juul, Manon Benders, Fernando Gonzalez, Cynthia Bearer, Yvonne W Wu, Nicola J Robertson, Tim Hurley, Aoife Branagan, C Micha...> ;Pediatric Research. 2023 Jun 1
10 citations
Early brain and abdominal oxygenation in extremely low birth weight infants.
Valerie Y Chock, Emily Smith, Sylvia Tan, M Bethany Ball, Abhik Das, Susan R Hintz, Haresh Kirpalani, Edward F Bell, Lina F Chalak, Waldemar A Carlo, C Michael Cotten,...> ;Pediatric Research. 2022 Oct 1
5 citations
Association of Antenatal Steroid Exposure at 21 to 22 Weeks of Gestation With Neonatal Survival and Survival Without Morbidities.
Brion, L. P., Sanjay Chawla, Myra H Wyckoff, Matthew A Rysavy, Ravi Mangal Patel, Dhuly Chowdhury, Girija Natarajan, Abbot R Laptook, Satyan Lakshminrusimha, Edward F ...> ;JAMA Network Open. 2022 Sep 1
7 citations
Predictive Ability of 10-Minute Apgar Scores for Mortality and Neurodevelopmental Disability.
Vivek V Shukla, Carla M Bann, Maran Ramani, Namasivayam Ambalavanan, Myriam Peralta-Carcelen, Susan R Hintz, Rosemary D Higgins, Girija Natarajan, Abbot R Laptook, See...> ;Pediatrics. 2022 Apr 1
3 citations
Blanket temperature during therapeutic hypothermia and outcomes in hypoxic ischemic encephalopathy.
John Flibotte, Abbot R Laptook, Seetha Shankaran, Scott A McDonald, Mariana C Baserga, Edward F Bell, C Michael Cotten, Abhik Das, Sara B DeMauro, Tara L DuPont, Eric ...> ;Journal of Perinatology. 2022 Mar 1
3 citations
Placental Findings among Infants with Hypoxic-Ischemic Encephalopathy (HIE): The Importance of the Comparison Group.
Fusun Gundogan, Jessica Farrar, Richard Tucker, Abbot R. Laptook, > ;The Journal of Pediatrics. 2021 Nov 27
1 citations
Implementation of a Nutrition Care Bundle and Improved Weight Gain of Extremely Preterm Infants to 36 Weeks Postmenstrual Age.
Leslie T. McKinley, Lynn Przystac, Richard Tucker, Elizabeth Trail-Burns, Betty R. Vohr, Abbot R. Laptook, Joseph M. Bliss> ;The Journal of Pediatrics. 2021 Oct 21
11 citations
Association of Increased Seizures During Rewarming With Abnormal Neurodevelopmental Outcomes at 2-Year Follow-up: A Nested Multisite Cohort Study.
Brion, L. P., , , , , , , , , , , , , , , , , , , , , , , , , , , , > ;JAMA Neurology. 2021 Oct 18
Association of Increased Seizures During Rewarming With Abnormal Neurodevelopmental Outcomes at 2-Year Follow-up: A Nested Multisite Cohort Study.
Lina F. Chalak, Athina Pappas, Sylvia Tan, Abhik Das, Pablo J. Sánchez, Abbot R. Laptook, Krisa P. Van Meurs, Seetha Shankaran, Edward F. Bell, Alexis S. Davis, Roy J....> ;JAMA Neurology. 2021 Oct 18
1 citations
Hypothermia for neonatal encephalopathy: how do we move forward?
Seetha Shankaran, Abbot R. Laptook, Sudhin Thayyil> ;Archives of Disease in Childhood. Fetal and Neonatal Edition. 2021 Oct 16
43 citations
Initial Laparotomy Versus Peritoneal Drainage in Extremely Low Birthweight Infants With Surgical Necrotizing Enterocolitis or Isolated Intestinal Perforation: A Multic...
Martin L. Blakely, Jon E. Tyson, Kevin P. Lally, Susan R. Hintz, Barry Eggleston, David K. Stevenson, Gail E. Besner, Abhik Das, Robin K. Ohls, William E Truog, Leif D...> ;Annals of Surgery. 2021 Oct 1
2 citations
An E-Textile Respiration Sensing System for NICU Monitoring: Design and Validation
Gozde Cay, Vignesh Ravichandran, Manob Jyoti Saikia, Laurie Hoffman, Abbot R. Laptook, James F. Padbury, Amy L. Salisbury, Anna Gitelson-Kahn, Krishna Venkatasubramani...> ;Journal of Signal Processing Systems. 2021 Jul 17
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