AdamL.BoxerMDPhD

Neurology • San Francisco, CA

Endowed Professor in Memory and Aging, University of California, San Francisco

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Office
675 Nelson Rising Lane
Suite 190
San Francisco, CA 94143
Phone+1 415-353-2057

Fax+1 415-353-8292
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Education & Training

Stanford Health Care-Sponsored Stanford UniversityResidency, Neurology, 1999 - 2002
California Pacific Medical CenterInternship, Internal Medicine, 1998 - 1999
New York University School of MedicineClass of 1998

Certifications & Licensure

CA State Medical License 1999 - 2025
American Board of Psychiatry and Neurology Neurology

Clinical Trials

Memantine (10mg BID) for the Frontal and Temporal Subtypes of Frontotemporal Dementia Start of enrollment: 2007 Oct 01
Completed
Phase 4
Davunetide (AL-108) in Predicted Tauopathies - Pilot Study Start of enrollment: 2010 Jan 01
Completed
Phase 1
Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort Start of enrollment: 2012 Jul 01
Recruiting
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001 Start of enrollment: 2012 Dec 01
Recruiting
Phase 2, Phase 3
4 Repeat Tauopathy Neuroimaging Initiative Start of enrollment: 2014 Jan 01
Active, not recruiting
Dose Finding Study of Nimodipine for the Treatment of Progranulin Insufficiency From GRN Gene Mutations Start of enrollment: 2013 Mar 01
Completed
Phase 1
Progress of Mild Alzheimer's Disease in Participants on Solanezumab Versus Placebo Start of enrollment: 2013 Jul 01
Terminated
Phase 3
A Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy Study of TPI-287 in Alzheimer's Disease Start of enrollment: 2013 Nov 01
Completed
Phase 1
Clinical Trial of Solanezumab for Older Individuals Who May be at Risk for Memory Loss Start of enrollment: 2014 Feb 28
Completed
Phase 3
Safety Study of TPI-287 to Treat CBS and PSP Start of enrollment: 2014 May 01
Completed
Phase 1
A 6 Month, Open-Label, Pilot Futility Clinical Trial of Oral Salsalate for Progressive Supranuclear Palsy Start of enrollment: 2015 Apr 01
Completed
Phase 1
Safety, Tolerability, and Pharmacokinetics of C2N-8E12 in Subjects With Progressive Supranuclear Palsy Start of enrollment: 2015 Jul 01
Completed
Phase 1
Extension Study of BIIB092 in Participants With Progressive Supranuclear Palsy (PSP) Who Participated in CN002003 Start of enrollment: 2016 Feb 22
Terminated
Phase 1
4-Repeat Tauopathy Neuroimaging Initiative - Cycle 2 Start of enrollment: 2016 Jan 01
Active, not recruiting
Intranasal Oxytocin for Frontotemporal Dementia Start of enrollment: 2018 Jan 31
Active, not recruiting
Phase 2
Salsalate in Patients Mild to Moderate Alzheimer's Disease Start of enrollment: 2017 Jul 21
Active, not recruiting
Phase 1
BIIB092 in Primary Tauopathies: CBS, nfvPPA, sMAPT, and TES Start of enrollment: 2018 Sep 12
Terminated
Phase 1
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Publications & Presentations

PubMed

Evaluating the Effect of Alzheimer's Disease-Related Biomarker Change in Corticobasal Syndrome and Progressive Supranuclear Palsy.
Indira Garcia-Cordero, Chloe Anastassiadis, Abeer Khoja, Alonso Morales-Rivero, Simrika Thapa, Anna Vasilevskaya, Carly Davenport, Vishaal Sumra, Blas Couto, Namita Mu...> ;Annals of Neurology. 2024 Apr 5
Reliability and Validity of Smartphone Cognitive Testing for Frontotemporal Lobar Degeneration.
Adam M Staffaroni, Annie L Clark, Jack C Taylor, Hilary W Heuer, Mark Sanderson-Cimino, Amy B Wise, Sreya Dhanam, Yann Cobigo, Amy Wolf, Masood Manoochehri, Leah Forsb...> ;JAMA Network Open. 2024 Apr 1
Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration.
Rowan Saloner, Adam Staffaroni, Eric Dammer, Erik C B Johnson, Emily Paolillo, Amy Wise, Hilary Heuer, Leah Forsberg, Argentina Lario Lago, Julia Webb, Jacob Vogel, Al...> ;Research Square. 2024 Mar 28
Clinicopathological correlation of cerebrospinal fluid alpha-synuclein seed amplification assay in a behavioral neurology autopsy cohort.
Fischer, D. L., Argentina Lario Lago, Julio C Rojas, Adam M Staffaroni, Jonathan Tablante, Fattin Wekselman, Jennifer Lamoureux, Luis Concha-Marambio, Lea T Grinberg, ...> ;Alzheimer's & Dementia. 2024 Mar 27
1 citations
Scalable plasma and digital cognitive markers for diagnosis and prognosis of Alzheimer's disease and related dementias.
Elena Tsoy, Renaud La Joie, Lawren VandeVrede, Julio C Rojas, Claire Yballa, Brandon Chan, Argentina Lario Lago, Anne-Marie Rodriguez, Collette A Goode, Sabrina J Erlh...> ;Alzheimer's & Dementia. 2024 Mar 1
Alterations in Lysosomal, Glial and Neurodegenerative Biomarkers in Patients with Sporadic and Genetic Forms of Frontotemporal Dementia.
Jennifer Hsiao-Nakamoto, Chi-Lu Chiu, Lawren VandeVrede, Ritesh Ravi, Brittany Vandenberg, Jack De Groot, Buyankhishig Tsogtbaatar, Meng Fang, Paul Auger, Neal S Gould...> ;Biorxiv. 2024 Feb 12
Scientific commentary on: "Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer's disease and primary tauopathies".
Frederike C Oertel, Daniel Casillas, Yann Cobigo, Shivany Condor Montes, Hilary W Heuer, Makenna Chapman, Alexandra Beaudry-Richard, Henriette Reinsberg, Ahmed Abdelha...> ;Acta Neuropathologica. 2024 Feb 3
1 citations
Disentangling tau: One protein, many therapeutic approaches.
Courtney Lane-Donovan, Adam L Boxer> ;Neurotherapeutics. 2024 Mar 1
Concomitant Medications for Progressive Supranuclear Palsy: A Secondary Analysis of a Randomized Clinical Trial.
Iyer, J., Gunzler, D., Lang, A., , Golbe, L., Pantelyat, A., Boxer, A., Wills, A.> ;JAMA Neurology. 2024 Mar 1
Spatiotemporal characteristics of neurophysiological changes in patients with four-repeat tauopathies.
Niyatee Samudra, Hannah Lerner, Leslie Yack, Christine M Walsh, Heidi E Kirsch, Kiwamu Kudo, Claire Yballa, Renaud La Joie, Maria L Gorno-Tempini, Salvatore Spina, Wil...> ;Annals of Clinical and Translational Neurology. 2024 Feb 1
Sensitivity of the African neuropsychology battery memory subtests and learning slopes in discriminating APOE 4 and amyloid pathology in adult individuals in the Democ...
Jean Ikanga, Sarah D Patrick, Megan Schwinne, Saranya Sundaram Patel, Emmanuel Epenge, Guy Gikelekele, Nathan Tshengele, Immaculee Kavugho, Samuel Mampunza, Kevin E Ya...> ;Frontiers in Neurology. 2024 Jan 1
Neurite-based white matter alterations in MAPT mutation carriers: A multi-shell diffusion MRI study in the ALLFTD consortium.
Corriveau-Lecavalier, N., Tosakulwong, N., Lesnick, T., Fought, A., Reid, R., Schwarz, C., Senjem, M., Jack, C., Jones, D., Vemuri, P., Rademakers, R., Ramos, E., Gesc...> ;Neurobiology of Aging. 2024 Feb 1
Functional network collapse in neurodegenerative disease.
Jesse A Brown, Alex J Lee, Kristen Fernhoff, Taylor Pistone, Lorenzo Pasquini, Amy B Wise, Adam M Staffaroni, Maria Luisa Mandelli, Suzee E Lee, Adam L Boxer, Katherin...> ;Biorxiv. 2023 Dec 6
Clinical dimensions along the non-fluent variant primary progressive aphasia spectrum.
Ignacio Illán-Gala, Diego L Lorca-Puls, Boon Lead Tee, Zoe Ezzes, Jessica de Leon, Zachary A Miller, Sara Rubio-Guerra, Miguel Santos-Santos, David Gómez-Andrés, Lea T...> ;Brain. 2024 Apr 4
1 citations
[F]PI-2620 Binding Patterns in Patients with Suspected Alzheimer Disease and Frontotemporal Lobar Degeneration.
Ganna Blazhenets, David N Soleimani-Meigooni, Wesley Thomas, Nidhi Mundada, Matthias Brendel, Stephanie Vento, Lawren VandeVrede, Hilary W Heuer, Peter Ljubenkov, Juli...> ;Journal of Nuclear Medicine. 2023 Dec 1
FTLD targets brain regions expressing recently evolved genes.
Lorenzo Pasquini, Felipe L Pereira, Sahba Seddighi, Yi Zeng, Yongbin Wei, Ignacio Illán-Gala, Sarat C Vatsavayai, Adit Friedberg, Alex J Lee, Jesse A Brown, Salvatore ...> ;Medrxiv. 2023 Oct 28
3 citations
Roadmap for C9ORF72 in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis: Report on the C9ORF72 FTD/ALS Summit.
Rita Sattler, Bryan J Traynor, Janice Robertson, Ludo Van Den Bosch, Sami J Barmada, Clive N Svendsen, Matthew D Disney, Tania F Gendron, Philip C Wong, Martin R Turne...> ;Neurology and Therapy. 2023 Dec 1
7 citations
Accelerating Alzheimer's therapeutic development: The past and future of clinical trials.
Adam L Boxer, Reisa Sperling> ;Cell. 2023 Oct 26
2 citations
Neural basis of speech and grammar symptoms in non-fluent variant primary progressive aphasia spectrum.
Diego L Lorca-Puls, Andrea Gajardo-Vidal, Maria Luisa Mandelli, Ignacio Illán-Gala, Zoe Ezzes, Lisa D Wauters, Giovanni Battistella, Rian Bogley, Buddhika Ratnasiri, A...> ;Brain. 2024 Feb 1
1 citations
Head-to-head comparison between plasma p-tau217 and flortaucipir-PET in amyloid-positive patients with cognitive impairment.
Nidhi S Mundada, Julio C Rojas, Lawren Vandevrede, Elisabeth H Thijssen, Leonardo Iaccarino, Obiora C Okoye, Ranjani Shankar, David N Soleimani-Meigooni, Argentina L L...> ;Alzheimer's Research & Therapy. 2023 Sep 22
1 citations
Co-pathology may impact outcomes of amyloid-targeting treatments: clinicopathological results from two patients treated with aducanumab.
Lawren VandeVrede, Renaud La Joie, Sheena Horiki, Nidhi S Mundada, Mary Koestler, Ji-Hye Hwang, Peter A Ljubenkov, Julio C Rojas, Gil D Rabinovici, Adam L Boxer, Willi...> ;Acta Neuropathologica. 2023 Nov 1
6 citations
Large-scale proximity extension assay reveals CSF midkine and DOPA decarboxylase as supportive diagnostic biomarkers for Parkinson's disease.
Wojciech Paslawski, Shervin Khosousi, Ellen Hertz, Ioanna Markaki, Adam Boxer, Per Svenningsson> ;Translational Neurodegeneration. 2023 Sep 4
4 citations
Plasma phosphorylated tau-217 exhibits sex-specific prognostication of cognitive decline and brain atrophy in cognitively unimpaired adults.
Rowan Saloner, Lawren VandeVrede, Breton M Asken, Emily W Paolillo, Eva Q Gontrum, Amy Wolf, Argentina Lario-Lago, Marta Milà-Alomà, Gallen Triana-Baltzer, Hartmuth C ...> ;Alzheimer's & Dementia. 2024 Jan 1
11 citations
Frontotemporal lobar degeneration.
Murray Grossman, William W Seeley, Adam L Boxer, Argye E Hillis, David S Knopman, Peter A Ljubenov, Bruce Miller, Olivier Piguet, Rosa Rademakers, Jennifer L Whitwell,...> ;Nature Reviews. Disease Primers. 2023 Aug 10
1 citations
Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy.
Daniel W Sirkis, Caroline Warly Solsberg, Taylor P Johnson, Luke W Bonham, Virginia E Sturm, Suzee E Lee, Katherine P Rankin, Howard J Rosen, Adam L Boxer, William W S...> ;Genome Medicine. 2023 Jul 18
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Press Mentions

30 Years on, Are We Winning the Fight Against Alzheimer’s?January 3rd, 2023
Top Dementia Scientists Present Key Findings, InitiativesNovember 28th, 2022
Diagnostic Marker Found for Fatal Brain Disease Marked by Dementia, Movement ProblemsNovember 24th, 2022
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Grant Support

Eye Movement Control In Normal Elderly And MCINational Institute On Aging2009–2012
Four Repeat Tauopathy Neuroimaging InitiativeNational Institute On Aging2010–2011
Ocular Motor Function And Decision-Making In FTLDNational Institute Of Neurological Disorders And Stroke2005–2009